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Mannich reaction of 1,3-indandione-1-phenylhydrazone (1) or 1,3-diphenylhydrazone (5) with morpholine or piperazine gave the Mannich base-phenylhydrazone 2 and 3 or the diphenylhydrazone 6 and 7, respectively. Whereas, such reaction with 1 or 5 using primary amines afforded the indeno[2,1-ƒ]-1,2,4-triazepin-6(2H)-one (4) or its 6-phenylhydrazone (8), respectively. Treatment of 5 with ammonium acetate and formalin afforded 9. The indeno[1,2-ƒ]-1,2,4,5- tetrazepin-10(2H)-one (11) was obtained from the 1,2-diphenylhydrazone 10 and formaldehyde.

Treatment of 2,3a,4,6,7a,8-hexahydrobenzo [1,2-c; 4,5-c] dipyrazole-3,7-dione (1) with chloroacetyl chloride gave the 2,6-bis (chloroacetyl) derivative (2), which on treatment with acetic anhydride pyridine afforded (3). Compound (2) when heated with pyridine afforded (1). Compound (1) underwent Mannich reaction with piperidine or morpholine and formaldehyde to give the 2,6-bis (piperidino or morpholinomethyl) derivatives (4a,b). Hydroxymethylation of (1) with formaldehyde gave the 2,6-bis (hydroxylmethyl) derivative (4), which on heating with piperidine afforded (4a), Reaction of 2,3a,4,6,7a,8-hexahydro- 2,6-bis (phenylsulphonyl) benzo [1,2-c; 4,5-ć] dipyrazole-3,7-dione (7) with phenylmagnesium bromide gave dodecahydro-3,3,4a,7,7,8a-hexaphenyl-2,6- bis (phenylsulphonyl) benzo [1,2-c; 4,5-ć] dipyrazole (8). Derivatives of hexahydrobenzodipyrazolone (9a-g) have been subjected to general screening for their antimicrobial activity.

Mannich reaction of 1,3-indandione-1-phenylhydrazone (1) or 1,3-diphenylhydrazone(5) with morpholine or piperazine gave the Mannich base-phenylhydrazone 2 and 3 or the diphenylhydrazone 6 and 7, respectively. Whereas, such reaction with 1 or 5 using primary amines afforded the indeno [2,1-f]-1,2,4-triazepin-6(2H)-one (4) or its 6-phenylhydrazone (8), respectively. Treatment of 5 with ammonium acetate and formalin afforded 9. The indeno [1,2-f]-1,2,4,5-tetrazepin-10(2H)-one (11) was obtained from the 1,2-diphenylhydrazone 10 and formaldehyde

When β-keto-ester1 a was reacted with dimethyl acetylenedicarboxylate ring expansion occurred to give substituted cyclooctadienones.Michael reactions of the title compounds1 with unsaturated ketones gave adducts, some of which underwent further cyclization reactions. A new route to α-tetralone ring system10 via cyclization of the intermediateMichael adduct9 is described.

Photodimerization of 3,5-diaryl-2-cyclohexenones (1) in benzene solution gave the dimers 3. “Head-to-tail” structures are assigned for 3 on the basis of spectroscopic studies and reasoning from molecular models. Photolysis of the 3-styryl derivatives (5) afforded bicyclo[4,2,0]octan-1,5-dienes (8).

When β-keto-ester1 a was reacted with dimethyl acetylenedicarboxylate ring expansion occurred to give substituted cyclooctadienones.Michael reactions of the title compounds1 with unsaturated ketones gave adducts, some of which underwent further cyclization reactions. A new route to α-tetralone ring system10 via cyclization of the intermediateMichael adduct9 is described.

Photodimerization of 3,5-diaryl-2-cyclohexenones (1) in benzene solution gave the dimers 3. “Head-to-tail” structures are assigned for 3 on the basis of spectroscopic studies and reasoning from molecular models. Photolysis of the 3-styryl derivatives (5) afforded bicyclo[4,2,0]octan-1,5-dienes (8).