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Background: Oral lesions contribute a major part in head neck diseases. In India, head and neck cancers (HNCA) account for 30-40% cancers at all sites, out of which 9.4% being oral cancers. Oral cavity and oropharynx lesions have a major impact on physical, social and economic condition of the patient. Aims: To study the etiological and clinical profile of patients with lesions of oral cavity and oropharynx. Settings and Design: Prospective study. Materials and Methods: Total 100 samples of oral cavity and oropharynx lesions were studied. Data collected with pre tested questionnaire. Data included sociodemographic data, history, risk factors associated with disease, clinical examination and pathological report of the patient. Statistical Analysis Used: Appropriate statistical tests. Results and Conslusion: Present study includes 100 cases of oral cavity and oropharyngeal lesions out of which 19% were inflammatory lesions, 10% tumour like lesions, 4% benign lesions, 4% premalignant lesions and 63% malignant lesions. Male to female ratio of 1.7:1. Among malignant lesions in our study, 60.3% had history of tobacco consumption, 17.5% consumed both alcohol and tobacco, 9.5% were alcoholics and 12.7% patients did not have any habits. Keywords: Clinical, Etiology, Lesions, Oral cavity, Oropharynx.

Background: Oropharyngeal cancers are most commonly observed cancers in Indian population. Oropharyngeal cancers have a poor prognosis. A histopathological study of lesions will give the exact cause and helps in initiation of optimal therapy at the earliest. Settings and design: Prospective study Aims: To study the histopathological changes in tumour and tumour like lesions of oral cavity and oropharynx Material and Methods: A prospective study was carried out in patients of oral cavity and oropharynx lesions. Total 100 biopsies and resected specimens were studied. Data included sociodemographic data, clinical features and histopathological diagnosis of the specimen. Statistical analysis used: Appropriate statistical tests Results and Conclusion: In our study we observed 10% tumor like lesions, 4% benign lesions, 4% premalignant lesions and 63% malignant lesions. Mucocele was the commonest tumor like lesion. Squamous cell carcinoma was the most common malignant lesion in our study seen in 95.2% cases. Out of 60 Squamous cell carcinoma cases, 11.6% had lymph node metastases and 3.3% showed lymphovascular invasion. In TNM staging of 14 cases who underwent resection with modified radical neck dissection, maximum number of cases belonged to Stage II (35.71%) and Stage IV (35.71%). Keywords: Histopathology, Oral cavity, Oropharynx, Tumor, Tumorlike.