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14 results on '"Mahdavi, Leila"'

4. Data from Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia

Author

Liu, Yiman, primary, Li, Qinglan, primary, Alikarami, Fatemeh, primary, Barrett, Declan R., primary, Mahdavi, Leila, primary, Li, Hangpeng, primary, Tang, Sylvia, primary, Khan, Tanweer A., primary, Michino, Mayako, primary, Hill, Connor, primary, Song, Lele, primary, Yang, Lu, primary, Li, Yuanyuan, primary, Pokharel, Sheela Pangeni, primary, Stamford, Andrew W., primary, Liverton, Nigel, primary, Renzetti, Louis M., primary, Taylor, Simon, primary, Watt, Gillian F., primary, Ladduwahetty, Tammy, primary, Kargman, Stacia, primary, Meinke, Peter T., primary, Foley, Michael A., primary, Shi, Junwei, primary, Li, Haitao, primary, Carroll, Martin, primary, Chen, Chun-Wei, primary, Gardini, Alessandro, primary, Maillard, Ivan, primary, Huggins, David J., primary, Bernt, Kathrin M., primary, and Wan, Liling, primary

Published
2023
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5. Supplementary Data from Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia

Author

Liu, Yiman, primary, Li, Qinglan, primary, Alikarami, Fatemeh, primary, Barrett, Declan R., primary, Mahdavi, Leila, primary, Li, Hangpeng, primary, Tang, Sylvia, primary, Khan, Tanweer A., primary, Michino, Mayako, primary, Hill, Connor, primary, Song, Lele, primary, Yang, Lu, primary, Li, Yuanyuan, primary, Pokharel, Sheela Pangeni, primary, Stamford, Andrew W., primary, Liverton, Nigel, primary, Renzetti, Louis M., primary, Taylor, Simon, primary, Watt, Gillian F., primary, Ladduwahetty, Tammy, primary, Kargman, Stacia, primary, Meinke, Peter T., primary, Foley, Michael A., primary, Shi, Junwei, primary, Li, Haitao, primary, Carroll, Martin, primary, Chen, Chun-Wei, primary, Gardini, Alessandro, primary, Maillard, Ivan, primary, Huggins, David J., primary, Bernt, Kathrin M., primary, and Wan, Liling, primary

Published
2023
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6. Clonal evolution mediates Menin-inhibitor resistance in KMT2A-rearranged leukemias.

Author

Mahdavi, Leila, primary, Lenard, Alexandra, additional, Xie, Hongbo M, additional, Alikarami, Fatemeh, additional, Riedel, Simone S, additional, Libbrecht, Clara, additional, Falkenstein, Catherine, additional, Tasian, Sarah K, additional, Manning, Bryan, additional, Skuli, Sarah, additional, Carroll, Martin P, additional, Wertheim, Gerald, additional, McGeehan, Gerard, additional, and Bernt, Kathrin Maria, additional

Published
2023
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9. Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia

Author

Liu, Yiman, primary, Li, Qinglan, additional, Alikarami, Fatemeh, additional, Barrett, Declan R., additional, Mahdavi, Leila, additional, Li, Hangpeng, additional, Tang, Sylvia, additional, Khan, Tanweer A., additional, Michino, Mayako, additional, Hill, Connor, additional, Song, Lele, additional, Yang, Lu, additional, Li, Yuanyuan, additional, Pokharel, Sheela Pangeni, additional, Stamford, Andrew W., additional, Liverton, Nigel, additional, Renzetti, Louis M., additional, Taylor, Simon, additional, Watt, Gillian F., additional, Ladduwahetty, Tammy, additional, Kargman, Stacia, additional, Meinke, Peter T., additional, Foley, Michael A., additional, Shi, Junwei, additional, Li, Haitao, additional, Carroll, Martin, additional, Chen, Chun-Wei, additional, Gardini, Alessandro, additional, Maillard, Ivan, additional, Huggins, David J., additional, Bernt, Kathrin M., additional, and Wan, Liling, additional

Published
2022
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11. Transcriptomic without Clinical Response to Menin Inhibition As a Mechanism of Upfront Resistance in Samples from Mutliply Relapsed Patients with KMT2A-Rearranged Leukemia

Author

Mahdavi, Leila, Goodrow, Haley, Xie, Hongbo, Lenard, Alexandra, Alikarami, Fatemeh, Riedel, Simone Stefanie, Tasian, Sarah K., Wertheim, Gerald, Skuli, Sarah, Carroll, Martin, McGeehan, Jerry, and Bernt, Kathrin M.

Abstract

Inhibitors of the Menin-KMT2A interaction are emerging as promising agents for the treatment of KMT2A-rearranged ( KMT2A-r) acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Menin is required for the recruitment of the KMT2A-fusion to a subset of its target genes. Early phase clinical trials have shown highly encouraging results in patients with relapsed and refractory leukemias with KMT2Arearrangements and NPM1mutations. In a recently reported early phase clinical trial evaluating the Menin inhibitor revumenib, about 50% of patients failed to show a clinical response despite robust downregulation of known Menin:KMT2A target genes, suggesting on target activity of the drug. This was the most common pattern of upfront resistance.

Published
2023
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14. The effect of sevoflurane versus propofol anesthesia on troponin I after congenital heart surgery, a randomized clinical trial.

Author

Mahdavi L, Abdollahi MH, Entezari A, Salehi E, Hosseini H, Moshtaghioon SH, Rafie A, and Rahimianfar AA

Abstract

Background: The ischemic preconditioning phenomenon can save myocardium against move severe ischemic damages and reduce infarction size and furthermore a heart rhythm disturbance. In this study we examine relationship between troponin I (as a structural myocardial protein) level and anesthetic agents in the children., Materials and Methods: In this study 84 children under 12 years age before cardiac surgery were divided randomly into two groups of 42 each. For anesthetic maintenance sevoflurane with dose of 0.5-1 MAC was used in Group 1 and 100-150 mg/kg/min of intravenous propofol in Group 2 for maintenance of anesthesia. Troponin I level was assessed 2 before and 1 hour after anesthetic induction. Outcome measures included the serum cardiac troponin I level in children before and after surgery in two study groups., Results: There was no significant difference between two groups in indices and both groups were homogenous in this point of view. The troponin I level after surgery was significantly increased in two groups. In the sevoflurane group it was 0.04 ± 0.12 to 0.05 ± 0.09 ng/ml (P value = 0.003) and the propofol group was 0.12 ± 0.26 to 0.19 ± 0.38 ng/ml (P value = 0.001)., Conclusions: In this study two Anesthetic regimens were compared to assess the mean troponin I level before and after pediatric closed heart surgery, and it was shown that mean troponin level before and after surgery in the sevoflurane group was less than the propofol group. But this result was not statistically significant. These results indicate that although more protective effects of sevoflurane on myocardial injuries during pediatric cardiac surgery is predominant but this effect has no significant difference in the propofol group.

Published
2015
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