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8. The association between human papillomavirus infection, vaginal microecology, and cervical intraepithelial neoplasia in women from Xinjiang, China.

Author

Shi, Yi, Dong, Xiao yang, Yimingjiang, Mai wei li dan, Ma, Wen mei, Ma, Zhi ping, Pang, Xue lian, and Zhang, Wei

Subjects
PAPILLOMAVIRUS diseases, CERVICAL intraepithelial neoplasia, RISK assessment, CERVIX uteri tumors, VAGINA, VIRAL load, VIROLOGY, LOGISTIC regression analysis, EARLY detection of cancer, PSYCHOLOGY of women, REVERSE transcriptase polymerase chain reaction, CHI-squared test, ENZYMES, DESCRIPTIVE statistics, CLINICAL chemistry, GENOTYPES, DISEASE progression, DISEASE risk factors, DISEASE complications
Abstract

Purpose: This study analyzes the relationship between human papillomavirus (HPV) infection, vaginal microecology, and cervical lesions to provide a basis for the prevention and treatment of cervical cancer (CC) in the Xinjiang region. Methods: Real‐time quantitative PCR was used for HPV genotyping and viral load. The Gram staining and dry biochemical enzyme kit were utilized to diagnose vaginal secretions. The χ2 test and Logistic regression analysis were used for statistical analysis. Results: The HPV infection rate among women in the Xinjiang region was 30.29%, of which the single HPV infection accounts for 77%. HPV16 and HPV52 were the main infection types. There was significant differences in the HPV infection rate and infection types among the Han, Uighur, Hui, and Kazakh ethnic groups. The viral load of HPV16 and HPV52 increases with the upgrade of cervical lesions. There were significant differences in vaginal microecology evaluation indicators H2O2, SNA, LE, GUS, trichomonas, clue cells, and lactobacilli among different ethnic groups. HPV negative patients with varying grades of cervical lesions exhibit a notable variance in H2O2 and LE, which is statistically significant. Single HPV infection and high viral load HPV significantly increase the risk of CC. Conclusions: This study indicates that HPV infection and vaginal microecology differ among ethnic groups, which have a strong correlation with the progression of CC, offering guidance on CC screening and interventions in the Xinjiang area. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Self-weighted Multi-task Learning for Subjective Cognitive Decline Diagnosis

Author

Cheng, Nina, Frangi, Alejandro, Zhang, Zhi-Guo, Deng, Denao, Zhao, Lihua, Wang, Tianfu, Wei, Yichen, Yu, Bihan, Mai, Wei, Duan, Gaoxiong, Nong, Xiucheng, Li, Chong, Su, Jiahui, Lei, Baiying, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Martel, Anne L., editor, Abolmaesumi, Purang, editor, Stoyanov, Danail, editor, Mateus, Diana, editor, Zuluaga, Maria A., editor, Zhou, S. Kevin, editor, Racoceanu, Daniel, editor, and Joskowicz, Leo, editor

Published
2020
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18. Self-weighted Multi-task Learning for Subjective Cognitive Decline Diagnosis

Author

Cheng, Nina, primary, Frangi, Alejandro, additional, Zhang, Zhi-Guo, additional, Deng, Denao, additional, Zhao, Lihua, additional, Wang, Tianfu, additional, Wei, Yichen, additional, Yu, Bihan, additional, Mai, Wei, additional, Duan, Gaoxiong, additional, Nong, Xiucheng, additional, Li, Chong, additional, Su, Jiahui, additional, and Lei, Baiying, additional

Published
2020
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27. TMT DCCS.zip

Author

bu, xianzhong, Zhong, Ni, Qin, Baijun, Bu, Baoxian, Yu, Weibo, Zhong, Yuanming, Li, Zhifei, Mai, Wei, and Xu, Wei

Abstract

Among the 1027 detected proteins, 76 DEPs were identified, of which 8 were upregulated and 68 were downregulated. These proteins had a variety of biological functions related to inflammation and bone formation. The complement and coagulation cascades, inflammatory mediators regulating the TRP and IL-17 signalling pathways were related to the pathogenesis of DCCS.

Published
2023
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34. Effects of Moxa Cone Moxibustion Therapy on Cognitive Function and Brain Metabolic Changes in MCI Patients: A Pilot 1H-MRS Study

Author

Mai, Wei, Zhang, Aizhen, Liu, Qiang, Tang, Liying, Wei, Yichen, Su, Jiahui, Duan, Gaoxiong, Teng, Jinlong, Nong, Xiucheng, Yu, Bihan, Li, Chong, Shao, Lijuan, Deng, Demao, Chen, Shangjie, and Zhao, Lihua

Subjects
Aging, Cognitive Neuroscience
Abstract

ObjectiveTo explore the effect of moxa cone moxibustion on N-acetyl aspartate/total creatinine (NAA/tCr) and choline/total creatinine (Cho/tCr) in the bilateral hippocampus (HIP) and bilateral posterior cingulate gyrus (PCG) in patients with mild cognitive impairment (MCI) using hydrogen proton magnetic resonance spectroscopy (1H-MRS) and to provide imaging basis for moxa cone moxibustion treatment for MCI.MethodsOne hundred eight patients with MCI were served as the MCI group, and 67 age-matched subjects were enrolled as the normal control group. The MCI group was randomized and allocated into acupoint group, drug group, and sham acupoint group, with 36 cases in each group. Some patients in each group withdrew. Finally, 25 cases were included in the acupoint group, 24 cases in the drug group, and 20 cases in the sham acupoint group. The drug group was treated with oral donepezil hydrochloride. The acupoint group and sham acupoint group received moxa cone moxibustion treatment. Mini-mental state exam (MMSE) and Montreal cognitive assessment (MoCA) scores were recorded before intervention, at the end of the first and the second months of intervention, and in the 5th month of follow-up. The NAA/tCr and Cho/tCr ratios in the HIP and PCG were bilaterally measured by 1H-MRS before and after intervention.ResultsBefore intervention, compared with the normal control group, the MMSE and MoCA scores, the Cho/tCr ratio in the right HIP, the NAA/tCr ratio in the bilateral HIP, and the NAA/tCr ratio in the left PCG in the three treatment groups decreased significantly (both p < 0.01), and the NAA/tCr ratio in the right PCG significantly reduced in the acupoint and drug groups (p < 0.05). After two months of treatment, compared with the normal control group, there were no differences in the MoCA scores, the NAA/tCr, and Cho/tCr ratios in the bilateral PCG and bilateral HIP in the three treatment groups (p > 0.05). However, the MMSE scores in the drug group decreased when compared with the acupoint group and normal control group (p < 0.05, p < 0.01). The scores of MMSE and MoCA in the acupoint group and sham acupoint group at all time points were better than those in the drug group, which were similar to those in the normal control group.ConclusionOur findings suggest that moxibustion could improve the cognitive function of patients with MCI. The mechanism may be related to the improvement of abnormal brain metabolism in HIP and PCG.

Published
2022

42. Auto-weighted centralised multi-task learning via integrating functional and structural connectivity for subjective cognitive decline diagnosis

Author

Lei, Baiying, primary, Cheng, Nina, additional, Frangi, Alejandro F., additional, Wei, Yichen, additional, Yu, Bihan, additional, Liang, Lingyan, additional, Mai, Wei, additional, Duan, Gaoxiong, additional, Nong, Xiucheng, additional, Li, Chong, additional, Su, Jiahui, additional, Wang, Tianfu, additional, Zhao, Lihua, additional, Deng, Demao, additional, and Zhang, Zhiguo, additional

Published
2021
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44. Corrigendum: A Pilot Study on the Cutoff Value of Related Brain Metabolite in Chinese Elderly Patients With Mild Cognitive Impairment Using MRS

Author

Zhao, Lihua, primary, Teng, Jinlong, additional, Mai, Wei, additional, Su, Jiahui, additional, Yu, Bihan, additional, Nong, Xiucheng, additional, Li, Chong, additional, Wei, Yichen, additional, Duan, Gaoxiong, additional, Deng, Xiangming, additional, Deng, Demao, additional, and Chen, Shangjie, additional

Published
2021
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45. Propensity score–matched comparison between totally laparoscopic right hemicolectomy with transcolonic natural orifice specimen extraction and conventional laparoscopic surgery with mini-laparotomy in the treatment of ascending colon cancer (with video)

Author

Kong, Fan-Biao, primary, Deng, Qiao-Ming, additional, Deng, Hong-Qiang, additional, Li, Lei, additional, Dong, Chen-Cheng, additional, He, Chun-Gang, additional, Mai, Wei, additional, Wang, Xiao-Tong, additional, Xu, Sheng, additional, and Pang, Li-Ming, additional

Published
2021
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47. Synthesis and structure–activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors

Author

Khanwelkar, Rahul R., Chen, Grace Shiahuy, Wang, Hsiao-Chun, Yu, Chao-Wu, Huang, Chiung-Hua, Lee, On, Chen, Chih-Hung, Hwang, Chrong-Shiong, Ko, Ching-Huai, Chou, Nien-Tzu, Lin, Mai-Wei, Wang, Ling-mei, Chen, Yen-Chun, Hseu, Tzong-Hsiung, Chang, Chia-Ni, Hsu, Hui-Chun, Lin, Hui-Chi, Shih, Ying-Chu, Chou, Shuen-Hsiang, Tseng, Hsiang-Wen, Liu, Chih-Peng, Tu, Chia-Mu, Hu, Tsan-Lin, Tsai, Yuan-Jang, and Chern, Ji-Wang

Published
2010
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