Search

Your search keyword '"Malats, Nuria"' showing total 567 results
Start Over Author "Malats, Nuria" Publication Year Range Last 50 years
567 results on '"Malats, Nuria"'

4. Tackling the implementation gap for the uptake of NGS and advanced molecular diagnostics into healthcare systems

Author

Horgan, Denis, Van den Bulcke, Marc, Malapelle, Umberto, Troncone, Giancarlo, Normanno, Nicola, Capoluongo, Ettore D., Prelaj, Arsela, Rizzari, Carmelo, Trapani, Dario, Singh, Jaya, Kozaric, Marta, Longshore, John, Ottaviano, Manuel, Boccia, Stefania, Pravettoni, Gabriella, Cattaneo, Ivana, Malats, Núria, Buettner, Reinhard, Lekadir, Karim, de Lorenzo, Francesco, Hofman, Paul, and De Maria, Ruggero

Published
2024
Full Text
View/download PDF

5. Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights

Author

Koutros, Stella, Kiemeney, Lambertus A., Pal Choudhury, Parichoy, Milne, Roger L., Lopez de Maturana, Evangelina, Ye, Yuanqing, Joseph, Vijai, Florez-Vargas, Oscar, Dyrskjøt, Lars, Figueroa, Jonine, Dutta, Diptavo, Giles, Graham G., Hildebrandt, Michelle A.T., Offit, Kenneth, Kogevinas, Manolis, Weiderpass, Elisabete, McCullough, Marjorie L., Freedman, Neal D., Albanes, Demetrius, Kooperberg, Charles, Cortessis, Victoria K., Karagas, Margaret R., Johnson, Alison, Schwenn, Molly R., Baris, Dalsu, Furberg, Helena, Bajorin, Dean F., Cussenot, Olivier, Cancel-Tassin, Geraldine, Benhamou, Simone, Kraft, Peter, Porru, Stefano, Carta, Angela, Bishop, Timothy, Southey, Melissa C., Matullo, Giuseppe, Fletcher, Tony, Kumar, Rajiv, Taylor, Jack A., Lamy, Philippe, Prip, Frederik, Kalisz, Mark, Weinstein, Stephanie J., Hengstler, Jan G., Selinski, Silvia, Harland, Mark, Teo, Mark, Kiltie, Anne E., Tardón, Adonina, Serra, Consol, Carrato, Alfredo, García-Closas, Reina, Lloreta, Josep, Schned, Alan, Lenz, Petra, Riboli, Elio, Brennan, Paul, Tjønneland, Anne, Otto, Thomas, Ovsiannikov, Daniel, Volkert, Frank, Vermeulen, Sita H., Aben, Katja K., Galesloot, Tessel E., Turman, Constance, De Vivo, Immaculata, Giovannucci, Edward, Hunter, David J., Hohensee, Chancellor, Hunt, Rebecca, Patel, Alpa V., Huang, Wen-Yi, Thorleifsson, Gudmar, Gago-Dominguez, Manuela, Amiano, Pilar, Golka, Klaus, Stern, Mariana C., Yan, Wusheng, Liu, Jia, Li, Shengchao Alfred, Katta, Shilpa, Hutchinson, Amy, Hicks, Belynda, Wheeler, William A., Purdue, Mark P., McGlynn, Katherine A., Kitahara, Cari M., Haiman, Christopher A., Greene, Mark H., Rafnar, Thorunn, Chatterjee, Nilanjan, Chanock, Stephen J., Wu, Xifeng, Real, Francisco X., Silverman, Debra T., Garcia-Closas, Montserrat, Stefansson, Kari, Prokunina-Olsson, Ludmila, Malats, Núria, and Rothman, Nathaniel

Published
2023
Full Text
View/download PDF

6. Metagenomic Identification of Microbial Signatures Predicting Pancreatic Cancer From a Multinational Study

Author

Nagata, Naoyoshi, Nishijima, Suguru, Kojima, Yasushi, Hisada, Yuya, Imbe, Koh, Miyoshi-Akiyama, Tohru, Suda, Wataru, Kimura, Moto, Aoki, Ryo, Sekine, Katsunori, Ohsugi, Mitsuru, Miki, Kuniko, Osawa, Tsuyoshi, Ueki, Kohjiro, Oka, Shinichi, Mizokami, Masashi, Kartal, Ece, Schmidt, Thomas S.B., Molina-Montes, Esther, Estudillo, Lidia, Malats, Nuria, Trebicka, Jonel, Kersting, Stephan, Langheinrich, Melanie, Bork, Peer, Uemura, Naomi, Itoi, Takao, and Kawai, Takashi

Published
2022
Full Text
View/download PDF

7. Genome-wide Meta-analysis Identifies Novel Genes Associated with Recurrence and Progression in Non–muscle-invasive Bladder Cancer

Author

Galesloot, Tessel E., Grotenhuis, Anne J., Kolev, Dimitar, Aben, Katja K., Bryan, Richard T., Catto, James W.F., Cheng, Kar K., Conroy, Samantha, Dyrskjøt, Lars, Fleshner, Neil E., James, Nicholas D., Lamy, Philippe, Lindskrog, Sia Viborg, Malats, Núria, Mengual, Lourdes, Verhaegh, Gerald, Zeegers, Maurice P., Kiemeney, Lambertus A.L.M., and Vermeulen, Sita H.

Published
2022
Full Text
View/download PDF

8. A 584 bp deletion in CTRB2 inhibits chymotrypsin B2 activity and secretion and confers risk of pancreatic cancer

Author

Albanes, Demetrius, Arslan, Alan A., Gurrea, Aurelio Barricarte, Beane-Freeman, Laura, Bracci, Paige M., Bueno-de-Mesquita, Bas, Buring, Julie, Canzian, Federico, Gallinger, Stephen, Gaziano, J. Michael, Giles, Graham G., Goodman, Phyllis J., Johansson, Mattias, Kooperberg, Charles, LeMarchand, Loic, Malats, Nuria, Neale, Rachel E., Panico, Salvatore, Peters, Ulrike, Real, Francisco X., Shu, Xiao-Ou, Sund, Malin, Thornquist, Marc, Tjønneland, Anne, Travis, Ruth C., Van Den Eeden, Stephen K., Visvanathan, Kala, Zheng, Wei, Kraft, Peter, Jermusyk, Ashley, Zhong, Jun, Connelly, Katelyn E., Gordon, Naomi, Perera, Sumeth, Abdolalizadeh, Ehssan, Zhang, Tongwu, O’Brien, Aidan, Hoskins, Jason W., Collins, Irene, Eiser, Daina, Yuan, Chen, Risch, Harvey A., Jacobs, Eric J., Li, Donghui, Du, Mengmeng, Stolzenberg-Solomon, Rachael Z., Klein, Alison P., Smith, Jill P., Wolpin, Brian M., Chanock, Stephen J., Shi, Jianxin, Petersen, Gloria M., Westlake, Christopher J., and Amundadottir, Laufey T.

Published
2021
Full Text
View/download PDF

9. Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies

Author

Julián-Serrano, Sachelly, Yuan, Fangcheng, Wheeler, William, Benyamin, Beben, Machiela, Mitchell J, Arslan, Alan A, Beane-Freeman, Laura E, Bracci, Paige M, Duell, Eric J, Du, Mengmeng, Gallinger, Steven, Giles, Graham G, Goodman, Phyllis J, Kooperberg, Charles, Marchand, Loic Le, Neale, Rachel E, Shu, Xiao-Ou, Van Den Eeden, Stephen K, Visvanathan, Kala, Zheng, Wei, Albanes, Demetrius, Andreotti, Gabriella, Ardanaz, Eva, Babic, Ana, Berndt, Sonja I, Brais, Lauren K, Brennan, Paul, Bueno-de-Mesquita, Bas, Buring, Julie E, Chanock, Stephen J, Childs, Erica J, Chung, Charles C, Fabiánová, Eleonora, Foretová, Lenka, Fuchs, Charles S, Gaziano, J Michael, Gentiluomo, Manuel, Giovannucci, Edward L, Goggins, Michael G, Hackert, Thilo, Hartge, Patricia, Hassan, Manal M, Holcátová, Ivana, Holly, Elizabeth A, Hung, Rayjean I, Janout, Vladimir, Kurtz, Robert C, Lee, I-Min, Malats, Núria, McKean, David, Milne, Roger L, Newton, Christina C, Oberg, Ann L, Perdomo, Sandra, Peters, Ulrike, Porta, Miquel, Rothman, Nathaniel, Schulze, Matthias B, Sesso, Howard D, Silverman, Debra T, Thompson, Ian M, Wactawski-Wende, Jean, Weiderpass, Elisabete, Wenstzensen, Nicolas, White, Emily, Wilkens, Lynne R, Yu, Herbert, Zeleniuch-Jacquotte, Anne, Zhong, Jun, Kraft, Peter, Li, Dounghui, Campbell, Peter T, Petersen, Gloria M, Wolpin, Brian M, Risch, Harvey A, Amundadottir, Laufey T, Klein, Alison P, Yu, Kai, and Stolzenberg-Solomon, Rachael Z

Published
2021
Full Text
View/download PDF

10. Association of patients’ sex with treatment outcomes after intravesical bacillus Calmette–Guérin immunotherapy for T1G3/HG bladder cancer

Author

D’Andrea, David, Soria, Francesco, Grotenhuis, Anne J., Cha, Eugene K., Malats, Nuria, Di Stasi, Savino, Joniau, Steven, Cai, Tommaso, van Rhijn, Bas W. G., Irani, Jaques, Karnes, Jeffrey, Varkarakis, John, Baniel, Jack, Palou, Joan, Babjuk, Marek, Spahn, Martin, Ardelt, Peter, Colombo, Renzo, Serretta, Vincenzo, Dalbagni, Guido, Gontero, Paolo, Bartoletti, Riccardo, Larré, Stephane, Malmstrom, Per-Uno, Sylvester, Richard, and Shariat, Shahrokh F.

Published
2021
Full Text
View/download PDF

11. A Consensus Molecular Classification of Muscle-invasive Bladder Cancer

Author

Aine, Mattias, Al-Ahmadie, Hikmat, Allory, Yves, Bellmunt, Joaquim, Bernard-Pierrot, Isabelle, Black, Peter C., Castro, Mauro A.A., Chan, Keith S., Choi, Woonyoung, Czerniak, Bogdan, Dinney, Colin P., Dyrskjøt, Lars, Eriksson, Pontus, Fontugne, Jacqueline, Gibb, Ewan A., Groeneveld, Clarice S., Hartmann, Arndt, Hoadley, Katherine A., Höglund, Mattias, Kamoun, Aurélie, Kardos, Jordan, Kim, Jaegil, Kim, William Y., Kwiatkowski, David J., Lebret, Thierry, Lerner, Seth P., Liedberg, Fredrik, Malats, Núria, McConkey, David J., Mo, Qianxing, Powles, Thomas, Radvanyi, François, Real, Francisco X., de Reyniès, Aurélien, Robertson, A. Gordon, Siefker-Radtke, Arlene, Sirab, Nanor, Seiler, Roland, Sjödahl, Gottfrid, Taber, Ann, Weinstein, John, and Zlotta, Alexandre

Published
2020
Full Text
View/download PDF

12. A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants

Author

Earl, Julie, Galindo-Pumariño, Cristina, Encinas, Jessica, Barreto, Emma, Castillo, Maria E., Pachón, Vanessa, Ferreiro, Reyes, Rodríguez-Garrote, Mercedes, González-Martínez, Silvia, Ramon y Cajal, Teresa, Diaz, Luis Robles, Chirivella-Gonzalez, Isabel, Rodriguez, Montse, de Castro, Eva Martínez, García-Seisdedos, David, Muñoz, Gloria, Rosa, Juan Manuel Rosa, Marquez, Mirari, Malats, Nuría, and Carrato, Alfredo

Published
2020
Full Text
View/download PDF

13. Diesel exhaust and bladder cancer risk by pathologic stage and grade subtypes

Author

Koutros, Stella, Kogevinas, Manolis, Friesen, Melissa C., Stewart, Patricia A., Baris, Dalsu, Karagas, Margaret R., Schwenn, Molly, Johnson, Alison, Monawar Hosain, G.M., Serra, Consol, Tardon, Adonina, Carrato, Alfredo, Garcia-Closas, Reina, Moore, Lee E., Nickerson, Michael L., Hewitt, Stephen M., Lenz, Petra, Schned, Alan R., Lloreta, Josep, Allory, Yves, Zhang, Haoyu, Chatterjee, Nilanjan, Garcia-Closas, Montserrat, Rothman, Nathaniel, Malats, Núria, and Silverman, Debra T.

Published
2020
Full Text
View/download PDF

14. Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

Author

Machiela, Mitchell J, Zhou, Weiyin, Karlins, Eric, Sampson, Joshua N, Freedman, Neal D, Yang, Qi, Hicks, Belynda, Dagnall, Casey, Hautman, Christopher, Jacobs, Kevin B, Abnet, Christian C, Aldrich, Melinda C, Amos, Christopher, Amundadottir, Laufey T, Arslan, Alan A, Beane-Freeman, Laura E, Berndt, Sonja I, Black, Amanda, Blot, William J, Bock, Cathryn H, Bracci, Paige M, Brinton, Louise A, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie E, Butler, Mary A, Canzian, Federico, Carreon, Tania, Chaffee, Kari G, Chang, I-Shou, Chatterjee, Nilanjan, Chen, Chu, Chen, Constance, Chen, Kexin, Chung, Charles C, Cook, Linda S, Bou, Marta Crous, Cullen, Michael, Davis, Faith G, De Vivo, Immaculata, Ding, Ti, Doherty, Jennifer, Duell, Eric J, Epstein, Caroline G, Fan, Jin-Hu, Figueroa, Jonine D, Fraumeni, Joseph F, Friedenreich, Christine M, Fuchs, Charles S, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, Gaudet, Mia M, Gaziano, J Michael, Giles, Graham G, Gillanders, Elizabeth M, Giovannucci, Edward L, Goldin, Lynn, Goldstein, Alisa M, Haiman, Christopher A, Hallmans, Goran, Hankinson, Susan E, Harris, Curtis C, Henriksson, Roger, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Hsiung, Chao A, Hu, Nan, Hu, Wei, Hunter, David J, Hutchinson, Amy, Jenab, Mazda, Johansen, Christoffer, Khaw, Kay-Tee, Kim, Hee Nam, Kim, Yeul Hong, Kim, Young Tae, Klein, Alison P, Klein, Robert, Koh, Woon-Puay, Kolonel, Laurence N, Kooperberg, Charles, Kraft, Peter, Krogh, Vittorio, Kurtz, Robert C, LaCroix, Andrea, Lan, Qing, Landi, Maria Teresa, Le Marchand, Loic, Li, Donghui, Liang, Xiaolin, Liao, Linda M, Lin, Dongxin, Liu, Jianjun, Lissowska, Jolanta, Lu, Lingeng, Magliocco, Anthony M, and Malats, Nuria

Published
2016

15. Bratislava Statement: consensus recommendations for improving pancreatic cancer care

Author

Prades, Joan, Arnold, Dirk, Brunner, Thomas, Cardone, Antonella, Carrato, Alfredo, Coll-Ortega, Cristina, De Luze, Samuel, Garel, Pascal, Goossens, Maria E., Grilli, Roberto, Harris, Meggan, Louagie, Marleen, Malats, Núria, Minicozzi, Pamela, Partelli, Stefano, Pastorekova, Silvia, Petrulionis, Marius, Price, Richard, Sclafani, Francesco, Smolkova, Bozena, and Borras, Josep M.

Published
2020
Full Text
View/download PDF

16. Disinfection By-Products in Drinking Water and Bladder Cancer: Evaluation of Risk Modification by Common Genetic Polymorphisms in Two Case-Control Studies

Author

Freeman, Laura E. Beane, Kogevinas, Manolis, Cantor, Kenneth P., Villanueva, Cristina M., Prokunina-Olsson, Ludmila, Florez-Vargas, Oscar, Figueroa, Jonine D., Ward, Mary H., Koutros, Stella, Baris, Dalsu, Garcia-Closas, Montserrat, Schwenn, Molly, Johnson, Allison, Serra, Consol, Tardon, Adonina, Garcia-Closas, Reina, Carrato, Alfredo, Malats, Nuria, Karagas, Margaret R., Rothman, Nathaniel, and Silverman, Debra T.

Subjects
Toxicogenomics -- Research, Drinking water -- Contamination -- Health aspects, Bladder cancer -- Risk factors -- Environmental aspects -- Genetic aspects, Single nucleotide polymorphisms -- Health aspects, Trihalomethanes -- Environmental aspects -- Health aspects, Environmental issues, Health
Abstract

Background: By-products are formed when disinfectants react with organic matter in source water. The most common class of disinfection byproducts, trihalomethanes (THMs), have been linked to bladder cancer. Several studies have shown exposure-response associations with THMs in drinking water and bladder cancer risk. Few epidemiologic studies have evaluated gene-environment interactions for total THMs (TTHMs) with known bladder cancer susceptibility variants. Objectives: In this study, we investigated the combined effect on bladder cancer risk contributed by TTHMs, bladder cancer susceptibility variants identified through genome-wide association studies, and variants in several candidate genes. Methods: We analyzed data from two large case-control studies--the New England Bladder Cancer Study (n/n = 989 cases/1,162 controls), a population-based study, and the Spanish Bladder Cancer Study (n/n = 706 cases/772 controls), a hospital-based study. Because of differences in exposure distributions and metrics, we estimated effects of THMs and genetic variants within each study separately using adjusted logistic regression models to calculate odds ratios (ORs) and 95% confidence intervals (CI) with and without interaction terms, and then combined the results using meta-analysis. Results: Of the 16 loci showing strong evidence of association with bladder cancer, rs907611 at 11p15.5 [leukocyte- specific protein 1 (LSP1 region)] showed the strongest associations in the highest exposure category in each study, with evidence of interaction in both studies and in metaanalysis. In the highest exposure category, we observed OR= 1.66 (95% CI: 1.17, 2.34, p- trend = 0.005) for those with the rs907611-GG genotype and p-interaction = 0.02. No other genetic variants tested showed consistent evidence of interaction. Discussion: We found novel suggestive evidence for a multiplicative interaction between a putative bladder carcinogen, TTHMs, and genotypes of rs907611. Given the ubiquitous exposure to THMs, further work is needed to replicate and extend this finding and to understand potential molecular mechanisms. https://doi.org/10.1289/EHP9895, Introduction Worldwide, bladder cancer ranks as the ninth most common incident cancer and the 13th in mortality, with ~400,000 cases diagnosed each year. (1) Approximately 75% of incident cases occur [...]

Published
2022
Full Text
View/download PDF

18. Table S1 from Analysis of Several Common APOBEC-type Mutations in Bladder Tumors Suggests Links to Viral Infection

Author

Rao, Nina, primary, Starrett, Gabriel J., primary, Piaskowski, Mary L., primary, Butler, Kelly E., primary, Golubeva, Yelena, primary, Yan, Wusheng, primary, Lawrence, Scott M., primary, Dean, Michael, primary, Garcia-Closas, Montserrat, primary, Baris, Dalsu, primary, Johnson, Alison, primary, Schwenn, Molly, primary, Malats, Nuria, primary, Real, Francisco X., primary, Kogevinas, Manolis, primary, Rothman, Nathaniel, primary, Silverman, Debra T., primary, Dyrskjøt, Lars, primary, Buck, Christopher B., primary, Koutros, Stella, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
Full Text
View/download PDF

19. Data from Analysis of Several Common APOBEC-type Mutations in Bladder Tumors Suggests Links to Viral Infection

Author

Rao, Nina, primary, Starrett, Gabriel J., primary, Piaskowski, Mary L., primary, Butler, Kelly E., primary, Golubeva, Yelena, primary, Yan, Wusheng, primary, Lawrence, Scott M., primary, Dean, Michael, primary, Garcia-Closas, Montserrat, primary, Baris, Dalsu, primary, Johnson, Alison, primary, Schwenn, Molly, primary, Malats, Nuria, primary, Real, Francisco X., primary, Kogevinas, Manolis, primary, Rothman, Nathaniel, primary, Silverman, Debra T., primary, Dyrskjøt, Lars, primary, Buck, Christopher B., primary, Koutros, Stella, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
Full Text
View/download PDF

20. Figure S1 from Analysis of Several Common APOBEC-type Mutations in Bladder Tumors Suggests Links to Viral Infection

Author

Rao, Nina, primary, Starrett, Gabriel J., primary, Piaskowski, Mary L., primary, Butler, Kelly E., primary, Golubeva, Yelena, primary, Yan, Wusheng, primary, Lawrence, Scott M., primary, Dean, Michael, primary, Garcia-Closas, Montserrat, primary, Baris, Dalsu, primary, Johnson, Alison, primary, Schwenn, Molly, primary, Malats, Nuria, primary, Real, Francisco X., primary, Kogevinas, Manolis, primary, Rothman, Nathaniel, primary, Silverman, Debra T., primary, Dyrskjøt, Lars, primary, Buck, Christopher B., primary, Koutros, Stella, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
Full Text
View/download PDF

21. Predictive signature of response to neoadjuvant chemotherapy in muscle-invasive bladder cancer integrating mRNA expression, taxonomic subtypes, and clinicopathological features

Author

Font, Albert, primary, Domenech, Montserrat, additional, Ramirez, Jose Luis, additional, Marqués, Miriam, additional, Benítez, Raquel, additional, Ruiz de Porras, Vicenç, additional, Gago, José L., additional, Carrato, Cristina, additional, Sant, Francesc, additional, Lopez, Hector, additional, Castellano, Daniel, additional, Malats, Nuria, additional, Calle, M. Luz, additional, and Real, Francisco X., additional

Published
2023
Full Text
View/download PDF

22. Prognostic Impact of a 12-gene Progression Score in Non–muscle-invasive Bladder Cancer: A Prospective Multicentre Validation Study

Author

Dyrskjøt, Lars, Reinert, Thomas, Algaba, Ferran, Christensen, Emil, Nieboer, Daan, Hermann, Gregers G., Mogensen, Karin, Beukers, Willemien, Marquez, Mirari, Segersten, Ulrika, Høyer, Søren, Ulhøi, Benedicte P., Hartmann, Arndt, Stöhr, Robert, Wach, Sven, Nawroth, Roman, Schwamborn, Kristina, Tulic, Cane, Simic, Tatjana, Junker, Kerstin, Harving, Niels, Petersen, Astrid C., Jensen, Jørgen B., Keck, Bastian, Grimm, Marc-Oliver, Horstmann, Marcus, Maurer, Tobias, Steyerberg, Ewout W., Zwarthoff, Ellen C., Real, Francisco X., Malats, Núria, Malmström, Per-Uno, and Ørntoft, Torben F.

Published
2017
Full Text
View/download PDF

25. Analysis of Several Common APOBEC-type Mutations in Bladder Tumors Suggests Links to Viral Infection

Author

Rao, Nina, primary, Starrett, Gabriel J., additional, Piaskowski, Mary L., additional, Butler, Kelly E., additional, Golubeva, Yelena, additional, Yan, Wusheng, additional, Lawrence, Scott M., additional, Dean, Michael, additional, Garcia-Closas, Montserrat, additional, Baris, Dalsu, additional, Johnson, Alison, additional, Schwenn, Molly, additional, Malats, Nuria, additional, Real, Francisco X., additional, Kogevinas, Manolis, additional, Rothman, Nathaniel, additional, Silverman, Debra T., additional, Dyrskjøt, Lars, additional, Buck, Christopher B., additional, Koutros, Stella, additional, and Prokunina-Olsson, Ludmila, additional

Published
2023
Full Text
View/download PDF

27. Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma

Author

Hedegaard, Jakob, Lamy, Philippe, Nordentoft, Iver, Algaba, Ferran, Høyer, Søren, Ulhøi, Benedicte Parm, Vang, Søren, Reinert, Thomas, Hermann, Gregers G., Mogensen, Karin, Thomsen, Mathilde Borg Houlberg, Nielsen, Morten Muhlig, Marquez, Mirari, Segersten, Ulrika, Aine, Mattias, Höglund, Mattias, Birkenkamp-Demtröder, Karin, Fristrup, Niels, Borre, Michael, Hartmann, Arndt, Stöhr, Robert, Wach, Sven, Keck, Bastian, Seitz, Anna Katharina, Nawroth, Roman, Maurer, Tobias, Tulic, Cane, Simic, Tatjana, Junker, Kerstin, Horstmann, Marcus, Harving, Niels, Petersen, Astrid Christine, Calle, M. Luz, Steyerberg, Ewout W., Beukers, Willemien, van Kessel, Kim E.M., Jensen, Jørgen Bjerggaard, Pedersen, Jakob Skou, Malmström, Per-Uno, Malats, Núria, Real, Francisco X., Zwarthoff, Ellen C., Ørntoft, Torben Falck, and Dyrskjøt, Lars

Published
2016
Full Text
View/download PDF

33. Supplementary Tables from Genome-Wide Association Study Data Reveal Genetic Susceptibility to Chronic Inflammatory Intestinal Diseases and Pancreatic Ductal Adenocarcinoma Risk

Author

Yuan, Fangcheng, primary, Hung, Rayjean J., primary, Walsh, Naomi, primary, Zhang, Han, primary, Platz, Elizabeth A., primary, Wheeler, William, primary, Song, Lei, primary, Arslan, Alan A., primary, Beane Freeman, Laura E., primary, Bracci, Paige, primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven, primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Kooperberg, Charles, primary, Le Marchand, Loic, primary, Neale, Rachel E., primary, Rosendahl, Jonas, primary, Scelo, Ghislaine, primary, Shu, Xiao-Ou, primary, Visvanathan, Kala, primary, White, Emily, primary, Zheng, Wei, primary, Albanes, Demetrius, primary, Amiano, Pilar, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Bamlet, William R., primary, Berndt, Sonja I., primary, Brennan, Paul, primary, Bueno-de-Mesquita, Bas, primary, Buring, Julie E., primary, Campbell, Peter T., primary, Chanock, Stephen J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Goggins, Michael G., primary, Hackert, Thilo, primary, Hartge, Patricia, primary, Hassan, Manal M., primary, Holly, Elizabeth A., primary, Hoover, Robert N., primary, Katzke, Verena, primary, Kirsten, Holger, primary, Kurtz, Robert C., primary, Lee, I-Min, primary, Malats, Nuria, primary, Milne, Roger L., primary, Murphy, Neil, primary, Ng, Kimmie, primary, Oberg, Ann L., primary, Porta, Miquel, primary, Rabe, Kari G., primary, Real, Francisco X., primary, Rothman, Nathaniel, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Thompson, Ian M., primary, Wactawski-Wende, Jean, primary, Wang, Xiaoliang, primary, Wentzensen, Nicolas, primary, Wilkens, Lynne R., primary, Yu, Herbert, primary, Zeleniuch-Jacquotte, Anne, primary, Shi, Jianxin, primary, Duell, Eric J., primary, Amundadottir, Laufey T., primary, Li, Donghui, primary, Petersen, Gloria M., primary, Wolpin, Brian M., primary, Risch, Harvey A., primary, Yu, Kai, primary, Klein, Alison P., primary, and Stolzenberg-Solomon, Rachael, primary

Published
2023
Full Text
View/download PDF

35. Data from Genome-Wide Association Study Data Reveal Genetic Susceptibility to Chronic Inflammatory Intestinal Diseases and Pancreatic Ductal Adenocarcinoma Risk

Author

Yuan, Fangcheng, primary, Hung, Rayjean J., primary, Walsh, Naomi, primary, Zhang, Han, primary, Platz, Elizabeth A., primary, Wheeler, William, primary, Song, Lei, primary, Arslan, Alan A., primary, Beane Freeman, Laura E., primary, Bracci, Paige, primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven, primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Kooperberg, Charles, primary, Le Marchand, Loic, primary, Neale, Rachel E., primary, Rosendahl, Jonas, primary, Scelo, Ghislaine, primary, Shu, Xiao-Ou, primary, Visvanathan, Kala, primary, White, Emily, primary, Zheng, Wei, primary, Albanes, Demetrius, primary, Amiano, Pilar, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Bamlet, William R., primary, Berndt, Sonja I., primary, Brennan, Paul, primary, Bueno-de-Mesquita, Bas, primary, Buring, Julie E., primary, Campbell, Peter T., primary, Chanock, Stephen J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Goggins, Michael G., primary, Hackert, Thilo, primary, Hartge, Patricia, primary, Hassan, Manal M., primary, Holly, Elizabeth A., primary, Hoover, Robert N., primary, Katzke, Verena, primary, Kirsten, Holger, primary, Kurtz, Robert C., primary, Lee, I-Min, primary, Malats, Nuria, primary, Milne, Roger L., primary, Murphy, Neil, primary, Ng, Kimmie, primary, Oberg, Ann L., primary, Porta, Miquel, primary, Rabe, Kari G., primary, Real, Francisco X., primary, Rothman, Nathaniel, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Thompson, Ian M., primary, Wactawski-Wende, Jean, primary, Wang, Xiaoliang, primary, Wentzensen, Nicolas, primary, Wilkens, Lynne R., primary, Yu, Herbert, primary, Zeleniuch-Jacquotte, Anne, primary, Shi, Jianxin, primary, Duell, Eric J., primary, Amundadottir, Laufey T., primary, Li, Donghui, primary, Petersen, Gloria M., primary, Wolpin, Brian M., primary, Risch, Harvey A., primary, Yu, Kai, primary, Klein, Alison P., primary, and Stolzenberg-Solomon, Rachael, primary

Published
2023
Full Text
View/download PDF

37. Data from The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease

Author

Fu, Yi-Ping, primary, Kohaar, Indu, primary, Moore, Lee E., primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Tang, Wei, primary, Porter-Gill, Patricia, primary, Chatterjee, Nilanjan, primary, Scott-Johnson, Alexandra, primary, Garcia-Closas, Montserrat, primary, Muchmore, Brian, primary, Baris, Dalsu, primary, Paquin, Ashley, primary, Ylaya, Kris, primary, Schwenn, Molly, primary, Apolo, Andrea B., primary, Karagas, Margaret R., primary, Tarway, McAnthony, primary, Johnson, Alison, primary, Mumy, Adam, primary, Schned, Alan, primary, Guedez, Liliana, primary, Jones, Michael A., primary, Kida, Masatoshi, primary, Hosain, GM Monawar, primary, Malats, Nuria, primary, Kogevinas, Manolis, primary, Tardon, Adonina, primary, Serra, Consol, primary, Carrato, Alfredo, primary, Garcia-Closas, Reina, primary, Lloreta, Josep, primary, Wu, Xifeng, primary, Purdue, Mark, primary, Andriole, Gerald L., primary, Grubb, Robert L., primary, Black, Amanda, primary, Landi, Maria T., primary, Caporaso, Neil E., primary, Vineis, Paolo, primary, Siddiq, Afshan, primary, Bueno-de-Mesquita, H. Bas, primary, Trichopoulos, Dimitrios, primary, Ljungberg, Börje, primary, Severi, Gianluca, primary, Weiderpass, Elisabete, primary, Krogh, Vittorio, primary, Dorronsoro, Miren, primary, Travis, Ruth C., primary, Tjønneland, Anne, primary, Brennan, Paul, primary, Chang-Claude, Jenny, primary, Riboli, Elio, primary, Prescott, Jennifer, primary, Chen, Constance, primary, De Vivo, Immaculata, primary, Govannucci, Edward, primary, Hunter, David, primary, Kraft, Peter, primary, Lindstrom, Sara, primary, Gapstur, Susan M., primary, Jacobs, Eric J., primary, Diver, W. Ryan, primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Virtamo, Jarmo, primary, Kooperberg, Charles, primary, Hohensee, Chancellor, primary, Rodabough, Rebecca J., primary, Cortessis, Victoria K., primary, Conti, David V., primary, Gago-Dominguez, Manuela, primary, Stern, Mariana C., primary, Pike, Malcolm C., primary, Van Den Berg, David, primary, Yuan, Jian-Min, primary, Haiman, Christopher A., primary, Cussenot, Olivier, primary, Cancel-Tassin, Geraldine, primary, Roupret, Morgan, primary, Comperat, Eva, primary, Porru, Stefano, primary, Carta, Angela, primary, Pavanello, Sofia, primary, Arici, Cecilia, primary, Mastrangelo, Giuseppe, primary, Grossman, H. Barton, primary, Wang, Zhaoming, primary, Deng, Xiang, primary, Chung, Charles C., primary, Hutchinson, Amy, primary, Burdette, Laurie, primary, Wheeler, William, primary, Fraumeni, Joseph, primary, Chanock, Stephen J., primary, Hewitt, Stephen M., primary, Silverman, Debra T., primary, Rothman, Nathaniel, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
Full Text
View/download PDF

38. Supplementary Figure Legend from Polymorphisms in DNA Repair Genes, Smoking, and Bladder Cancer Risk: Findings from the International Consortium of Bladder Cancer

Author

Stern, Mariana C., primary, Lin, Jie, primary, Figueroa, Jonine D., primary, Kelsey, Karl T., primary, Kiltie, Anne E., primary, Yuan, Jian-Min, primary, Matullo, Giuseppe, primary, Fletcher, Tony, primary, Benhamou, Simone, primary, Taylor, Jack A., primary, Placidi, Donatella, primary, Zhang, Zuo-Feng, primary, Steineck, Gunnar, primary, Rothman, Nathaniel, primary, Kogevinas, Manolis, primary, Silverman, Debra, primary, Malats, Nuria, primary, Chanock, Stephen, primary, Wu, Xifeng, primary, Karagas, Margaret R., primary, Andrew, Angeline S., primary, Nelson, Heather H., primary, Bishop, D. Timothy, primary, Sak, Sei Chung, primary, Choudhury, Ananya, primary, Barrett, Jennifer H., primary, Elliot, Faye, primary, Corral, Román, primary, Joshi, Amit D., primary, Gago-Dominguez, Manuela, primary, Cortessis, Victoria K., primary, Xiang, Yong-Bing, primary, Gao, Yu-Tang, primary, Vineis, Paolo, primary, Sacerdote, Carlotta, primary, Guarrera, Simonetta, primary, Polidoro, Silvia, primary, Allione, Alessandra, primary, Gurzau, Eugen, primary, Koppova, Kvetoslava, primary, Kumar, Rajiv, primary, Rudnai, Peter, primary, Porru, Stefano, primary, Carta, Angela, primary, Campagna, Marcello, primary, Arici, Cecilia, primary, Park, Sung Shim Lani, primary, and Garcia-Closas, Montserrat, primary

Published
2023
Full Text
View/download PDF

39. Supplementary Tables 1-8 from Polymorphisms in DNA Repair Genes, Smoking, and Bladder Cancer Risk: Findings from the International Consortium of Bladder Cancer

Author

Stern, Mariana C., primary, Lin, Jie, primary, Figueroa, Jonine D., primary, Kelsey, Karl T., primary, Kiltie, Anne E., primary, Yuan, Jian-Min, primary, Matullo, Giuseppe, primary, Fletcher, Tony, primary, Benhamou, Simone, primary, Taylor, Jack A., primary, Placidi, Donatella, primary, Zhang, Zuo-Feng, primary, Steineck, Gunnar, primary, Rothman, Nathaniel, primary, Kogevinas, Manolis, primary, Silverman, Debra, primary, Malats, Nuria, primary, Chanock, Stephen, primary, Wu, Xifeng, primary, Karagas, Margaret R., primary, Andrew, Angeline S., primary, Nelson, Heather H., primary, Bishop, D. Timothy, primary, Sak, Sei Chung, primary, Choudhury, Ananya, primary, Barrett, Jennifer H., primary, Elliot, Faye, primary, Corral, Román, primary, Joshi, Amit D., primary, Gago-Dominguez, Manuela, primary, Cortessis, Victoria K., primary, Xiang, Yong-Bing, primary, Gao, Yu-Tang, primary, Vineis, Paolo, primary, Sacerdote, Carlotta, primary, Guarrera, Simonetta, primary, Polidoro, Silvia, primary, Allione, Alessandra, primary, Gurzau, Eugen, primary, Koppova, Kvetoslava, primary, Kumar, Rajiv, primary, Rudnai, Peter, primary, Porru, Stefano, primary, Carta, Angela, primary, Campagna, Marcello, primary, Arici, Cecilia, primary, Park, Sung Shim Lani, primary, and Garcia-Closas, Montserrat, primary

Published
2023
Full Text
View/download PDF

40. Supplementary Materials, Figures 1 - 3, Tables 1 - 4, 6 - 8 from The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease

Author

Fu, Yi-Ping, primary, Kohaar, Indu, primary, Moore, Lee E., primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Tang, Wei, primary, Porter-Gill, Patricia, primary, Chatterjee, Nilanjan, primary, Scott-Johnson, Alexandra, primary, Garcia-Closas, Montserrat, primary, Muchmore, Brian, primary, Baris, Dalsu, primary, Paquin, Ashley, primary, Ylaya, Kris, primary, Schwenn, Molly, primary, Apolo, Andrea B., primary, Karagas, Margaret R., primary, Tarway, McAnthony, primary, Johnson, Alison, primary, Mumy, Adam, primary, Schned, Alan, primary, Guedez, Liliana, primary, Jones, Michael A., primary, Kida, Masatoshi, primary, Hosain, GM Monawar, primary, Malats, Nuria, primary, Kogevinas, Manolis, primary, Tardon, Adonina, primary, Serra, Consol, primary, Carrato, Alfredo, primary, Garcia-Closas, Reina, primary, Lloreta, Josep, primary, Wu, Xifeng, primary, Purdue, Mark, primary, Andriole, Gerald L., primary, Grubb, Robert L., primary, Black, Amanda, primary, Landi, Maria T., primary, Caporaso, Neil E., primary, Vineis, Paolo, primary, Siddiq, Afshan, primary, Bueno-de-Mesquita, H. Bas, primary, Trichopoulos, Dimitrios, primary, Ljungberg, Börje, primary, Severi, Gianluca, primary, Weiderpass, Elisabete, primary, Krogh, Vittorio, primary, Dorronsoro, Miren, primary, Travis, Ruth C., primary, Tjønneland, Anne, primary, Brennan, Paul, primary, Chang-Claude, Jenny, primary, Riboli, Elio, primary, Prescott, Jennifer, primary, Chen, Constance, primary, De Vivo, Immaculata, primary, Govannucci, Edward, primary, Hunter, David, primary, Kraft, Peter, primary, Lindstrom, Sara, primary, Gapstur, Susan M., primary, Jacobs, Eric J., primary, Diver, W. Ryan, primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Virtamo, Jarmo, primary, Kooperberg, Charles, primary, Hohensee, Chancellor, primary, Rodabough, Rebecca J., primary, Cortessis, Victoria K., primary, Conti, David V., primary, Gago-Dominguez, Manuela, primary, Stern, Mariana C., primary, Pike, Malcolm C., primary, Van Den Berg, David, primary, Yuan, Jian-Min, primary, Haiman, Christopher A., primary, Cussenot, Olivier, primary, Cancel-Tassin, Geraldine, primary, Roupret, Morgan, primary, Comperat, Eva, primary, Porru, Stefano, primary, Carta, Angela, primary, Pavanello, Sofia, primary, Arici, Cecilia, primary, Mastrangelo, Giuseppe, primary, Grossman, H. Barton, primary, Wang, Zhaoming, primary, Deng, Xiang, primary, Chung, Charles C., primary, Hutchinson, Amy, primary, Burdette, Laurie, primary, Wheeler, William, primary, Fraumeni, Joseph, primary, Chanock, Stephen J., primary, Hewitt, Stephen M., primary, Silverman, Debra T., primary, Rothman, Nathaniel, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
Full Text
View/download PDF

41. Supplementary Figure 1 from Polymorphisms in DNA Repair Genes, Smoking, and Bladder Cancer Risk: Findings from the International Consortium of Bladder Cancer

Author

Stern, Mariana C., primary, Lin, Jie, primary, Figueroa, Jonine D., primary, Kelsey, Karl T., primary, Kiltie, Anne E., primary, Yuan, Jian-Min, primary, Matullo, Giuseppe, primary, Fletcher, Tony, primary, Benhamou, Simone, primary, Taylor, Jack A., primary, Placidi, Donatella, primary, Zhang, Zuo-Feng, primary, Steineck, Gunnar, primary, Rothman, Nathaniel, primary, Kogevinas, Manolis, primary, Silverman, Debra, primary, Malats, Nuria, primary, Chanock, Stephen, primary, Wu, Xifeng, primary, Karagas, Margaret R., primary, Andrew, Angeline S., primary, Nelson, Heather H., primary, Bishop, D. Timothy, primary, Sak, Sei Chung, primary, Choudhury, Ananya, primary, Barrett, Jennifer H., primary, Elliot, Faye, primary, Corral, Román, primary, Joshi, Amit D., primary, Gago-Dominguez, Manuela, primary, Cortessis, Victoria K., primary, Xiang, Yong-Bing, primary, Gao, Yu-Tang, primary, Vineis, Paolo, primary, Sacerdote, Carlotta, primary, Guarrera, Simonetta, primary, Polidoro, Silvia, primary, Allione, Alessandra, primary, Gurzau, Eugen, primary, Koppova, Kvetoslava, primary, Kumar, Rajiv, primary, Rudnai, Peter, primary, Porru, Stefano, primary, Carta, Angela, primary, Campagna, Marcello, primary, Arici, Cecilia, primary, Park, Sung Shim Lani, primary, and Garcia-Closas, Montserrat, primary

Published
2023
Full Text
View/download PDF

42. Supplementary Table 5 from The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease

Author

Fu, Yi-Ping, primary, Kohaar, Indu, primary, Moore, Lee E., primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Tang, Wei, primary, Porter-Gill, Patricia, primary, Chatterjee, Nilanjan, primary, Scott-Johnson, Alexandra, primary, Garcia-Closas, Montserrat, primary, Muchmore, Brian, primary, Baris, Dalsu, primary, Paquin, Ashley, primary, Ylaya, Kris, primary, Schwenn, Molly, primary, Apolo, Andrea B., primary, Karagas, Margaret R., primary, Tarway, McAnthony, primary, Johnson, Alison, primary, Mumy, Adam, primary, Schned, Alan, primary, Guedez, Liliana, primary, Jones, Michael A., primary, Kida, Masatoshi, primary, Hosain, GM Monawar, primary, Malats, Nuria, primary, Kogevinas, Manolis, primary, Tardon, Adonina, primary, Serra, Consol, primary, Carrato, Alfredo, primary, Garcia-Closas, Reina, primary, Lloreta, Josep, primary, Wu, Xifeng, primary, Purdue, Mark, primary, Andriole, Gerald L., primary, Grubb, Robert L., primary, Black, Amanda, primary, Landi, Maria T., primary, Caporaso, Neil E., primary, Vineis, Paolo, primary, Siddiq, Afshan, primary, Bueno-de-Mesquita, H. Bas, primary, Trichopoulos, Dimitrios, primary, Ljungberg, Börje, primary, Severi, Gianluca, primary, Weiderpass, Elisabete, primary, Krogh, Vittorio, primary, Dorronsoro, Miren, primary, Travis, Ruth C., primary, Tjønneland, Anne, primary, Brennan, Paul, primary, Chang-Claude, Jenny, primary, Riboli, Elio, primary, Prescott, Jennifer, primary, Chen, Constance, primary, De Vivo, Immaculata, primary, Govannucci, Edward, primary, Hunter, David, primary, Kraft, Peter, primary, Lindstrom, Sara, primary, Gapstur, Susan M., primary, Jacobs, Eric J., primary, Diver, W. Ryan, primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Virtamo, Jarmo, primary, Kooperberg, Charles, primary, Hohensee, Chancellor, primary, Rodabough, Rebecca J., primary, Cortessis, Victoria K., primary, Conti, David V., primary, Gago-Dominguez, Manuela, primary, Stern, Mariana C., primary, Pike, Malcolm C., primary, Van Den Berg, David, primary, Yuan, Jian-Min, primary, Haiman, Christopher A., primary, Cussenot, Olivier, primary, Cancel-Tassin, Geraldine, primary, Roupret, Morgan, primary, Comperat, Eva, primary, Porru, Stefano, primary, Carta, Angela, primary, Pavanello, Sofia, primary, Arici, Cecilia, primary, Mastrangelo, Giuseppe, primary, Grossman, H. Barton, primary, Wang, Zhaoming, primary, Deng, Xiang, primary, Chung, Charles C., primary, Hutchinson, Amy, primary, Burdette, Laurie, primary, Wheeler, William, primary, Fraumeni, Joseph, primary, Chanock, Stephen J., primary, Hewitt, Stephen M., primary, Silverman, Debra T., primary, Rothman, Nathaniel, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
Full Text
View/download PDF

43. Urinary tract cancer survival in Europe 1999–2007: Results of the population-based study EUROCARE-5

Author

Hackl, M., Zielonke, N., Oberaigner, W., Van Eycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Zvolský, M., Dušek, L., Storm, H., Engholm, G., Mägi, M., Aareleid, T., Malila, N., Seppä, K., Velten, M., Troussard, X., Bouvier, V., Launoy, G., Guizard, A.V., Faivre, J., M. Bouvier, A., Arveux, P., Maynadié, M., Woronoff, A.S., Robaszkiewicz, M., Baldi, I., Monnereau, A., Tretarre, B., Bossard, N., Belot, A., Colonna, M., Molinié, F., Bara, S., Schvartz, C., Lapôtre-Ledoux, B., Grosclaude, P., Meyer, M., Stabenow, R., Luttmann, S., Eberle, A., Brenner, H., Nennecke, A., Engel, J., Schubert-Fritschle, G., Kieschke, J., Heidrich, J., Holleczek, B., Katalinic, A., Jónasson, J.G., Tryggvadóttir, L., Comber, H., Mazzoleni, G., Bulatko, A., Buzzoni, C., Giacomin, A., Sutera Sardo, A., Mazzei, A., Ferretti, S., Crocetti, E., Manneschi, G., Gatta, G., Sant, M., Amash, H., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Di Salvo, F., Foschi, R., Margutti, C., Meneghini, E., Minicozzi, P., Trama, A., Serraino, D., Zucchetto, A., De Angelis, R., Caldora, M., Capocaccia, R., Carrani, E., Francisci, S., Mallone, S., Pierannunzio, D., Roazzi, P., Rossi, S., Santaquilani, M., Tavilla, A., Pannozzo, F., Busco, S., Bonelli, L., Vercelli, M., Gennaro, V., Ricci, P., Autelitano, M., Randi, G., Ponz De Leon, M., Marchesi, C., Cirilli, C., Fusco, M., Vitale, M.F., Usala, M., Traina, A., Zarcone, M., Vitale, F., Cusimano, R., Michiara, M., Tumino, R., Giorgi Rossi, P., Vicentini, M., Falcini, F., Iannelli, A., Sechi, O., Cesaraccio, R., Piffer, S., Madeddu, A., Tisano, F., Maspero, S., Fanetti, A.C., Zanetti, R., Rosso, S., Candela, P., Scuderi, T., Stracci, F., Rocca, A., Tagliabue, G., Contiero, P., Dei Tos, A.P., Tognazzo, S., Pildava, S., Smailyte, G., Calleja, N., Micallef, R., Johannesen, T.B., Rachtan, J., Gózdz, S., Mezyk, R., Blaszczyk, J., Kepska, K., Bielska-Lasota, M., Forjaz de Lacerda, G., Bento, M.J., Antunes, L., Miranda, A., Mayer-da-Silva, A., Nicula, F., Coza, D., Safaei Diba, C., Primic-Zakelj, M., Almar, E., Mateos, A., Errezola, M., Larrañaga, N., Torrella-Ramos, A., Díaz García, J.M., Marcos-Navarro, A.I., Marcos-Gragera, R., Vilardell, L., Sanchez, M.J., Molina, E., Navarro, C., Chirlaque, M.D., Moreno-Iribas, C., Ardanaz, E., Galceran, J., Carulla, M., Lambe, M., Khan, S., Mousavi, M., Bouchardy, C., Usel, M., Ess, S.M., Frick, H., Lorez, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Aben, K., Coleman, M., Allemani, C., Rachet, B., Verne, J., Easey, N., Lawrence, G., Moran, T., Rashbass, J., Roche, M., Wilkinson, J., Gavin, A., Fitzpatrick, D., Brewster, D.H., Huws, D.W., White, C., Otter, R., Marcos-Gragera, Rafael, Mallone, Sandra, Kiemeney, Lambertus A., Vilardell, Loreto, Malats, Núria, Allory, Yves, and Sant, Milena

Published
2015
Full Text
View/download PDF

44. Reply to ‘Mosaic loss of chromosome Y in leukocytes matters’

Author

Zhou, Weiyin, Machiela, Mitchell J., Freedman, Neal D., Rothman, Nathaniel, Malats, Nuria, Dagnall, Casey, Caporaso, Neil, Teras, Lauren T., Gaudet, Mia M., Gapstur, Susan M., Stevens, Victoria L., Jacobs, Kevin B., Sampson, Joshua, Albanes, Demetrius, Weinstein, Stephanie, Virtamo, Jarmo, Berndt, Sonja, Hoover, Robert N., Black, Amanda, Silverman, Debra, Figueroa, Jonine, Garcia-Closas, Montserrat, Real, Francisco X., Earl, Julie, Marenne, Gaelle, Rodriguez-Santiago, Benjamin, Karagas, Margaret, Johnson, Alison, Schwenn, Molly, Wu, Xifeng, Gu, Jian, Ye, Yuanqing, Hutchinson, Amy, Tucker, Margaret, Perez-Jurado, Luis A., Dean, Michael, Yeager, Meredith, and Chanock, Stephen J.

Published
2019
Full Text
View/download PDF

48. A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer: A case-control study

Author

Debernardi, Silvana, O'Brien, Harrison, Algahmdi, Asma S., Malats, Nuria, Stewart, Grant D., Pljesa-Ercegovac, Marija, Costello, Eithne, Greenhalf, William, Saad, Amina, Roberts, Rhiannon, Ney, Alexander, Pereira, Stephen P., Kocher, Hemant M., Duffy, Stephen, Blyuss, Oleg, and Crnogorac-Jurcevic, Tatjana

Subjects
Urine -- Analysis, Biological markers -- Health aspects -- Case studies, Pancreatic cancer -- Case studies -- Diagnosis, Biological sciences
Abstract

Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with around 9% of patients surviving >5 years. Asymptomatic in its initial stages, PDAC is mostly diagnosed late, when already a locally advanced or metastatic disease, as there are no useful biomarkers for detection in its early stages, when surgery can be curative. We have previously described a promising biomarker panel (LYVE1, REG1A, and TFF1) for earlier detection of PDAC in urine. Here, we aimed to establish the accuracy of an improved panel, including REG1B instead of REG1A, and an algorithm for data interpretation, the PancRISK score, in additional retrospectively collected urine specimens. We also assessed the complementarity of this panel with CA19-9 and explored the daily variation and stability of the biomarkers and their performance in common urinary tract cancers. Methods and findings Clinical specimens were obtained from multiple centres: Barts Pancreas Tissue Bank, University College London, University of Liverpool, Spanish National Cancer Research Center, Cambridge University Hospital, and University of Belgrade. The biomarker panel was assayed on 590 urine specimens: 183 control samples, 208 benign hepatobiliary disease samples (of which 119 were chronic pancreatitis), and 199 PDAC samples (102 stage I-II and 97 stage III-IV); 50.7% were from female individuals. PDAC samples were collected from patients before treatment. The samples were assayed using commercially available ELISAs. Statistical analyses were performed using non-parametric Kruskal-Wallis tests adjusted for multiple comparisons, and multiple logistic regression. Training and validation datasets for controls and PDAC samples were obtained after random division of the whole available dataset in a 1:1 ratio. The substitution of REG1A with REG1B enhanced the performance of the panel to detect resectable PDAC. In a comparison of controls and PDAC stage I-II samples, the areas under the receiver operating characteristic curve (AUCs) increased from 0.900 (95% CI 0.843-0.957) and 0.926 (95% CI 0.843-1.000) in the training (50% of the dataset) and validation sets, respectively, to 0.936 in both the training (95% CI 0.903-0.969) and the validation (95% CI 0.888-0.984) datasets for the new panel including REG1B. This improved panel showed both sensitivity (SN) and specificity (SP) to be >85%. Plasma CA19-9 enhanced the performance of this panel in discriminating PDAC I-II patients from controls, with AUC = 0.992 (95% CI 0.983-1.000), SN = 0.963 (95% CI 0.913-1.000), and SP = 0.967 (95% CI 0.924-1.000). We demonstrate that the biomarkers do not show significant daily variation, and that they are stable for up to 5 days at room temperature. The main limitation of our study is the low number of stage I-IIA PDAC samples (n = 27) and lack of samples from individuals with hereditary predisposition to PDAC, for which specimens collected from control individuals were used as a proxy. Conclusions We have successfully validated our urinary biomarker panel, which was improved by substituting REG1A with REG1B. At a pre-selected cutoff of >80% SN and SP for the affiliated PancRISK score, we demonstrate a clinically applicable risk stratification tool with a binary output for risk of developing PDAC ('elevated' or 'normal'). PancRISK provides a step towards precision surveillance for PDAC patients, which we will test in a prospective clinical study, UroPanc., Author(s): Silvana Debernardi 1, Harrison O'Brien 1, Asma S. Algahmdi 1, Nuria Malats 2,3, Grant D. Stewart 4, Marija Pljesa-Ercegovac 5, Eithne Costello 6, William Greenhalf 6, Amina Saad 7, [...]

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results