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Your search keyword '"Malmberg, L. Pekka"' showing total 195 results
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195 results on '"Malmberg, L. Pekka"'

2. Expiratory variability index (EVI) is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms

Author

Seppä, Ville-Pekka, Gracia-Tabuenca, Javier, Kotaniemi-Syrjänen, Anne, Malmström, Kristiina, Hult, Anton, Pelkonen, Anna, Mäkelä, Mika J., Viik, Jari, and Malmberg, L. Pekka

Subjects
Quantitative Biology - Quantitative Methods, Physics - Medical Physics
Abstract

Recurrent respiratory symptoms are common in infants but the paucity of lung function tests suitable for routine use in infants is a widely acknowledged clinical problem. In this study we evaluated tidal breathing variability (expiratory variability index, EVI) measured at home during sleep using impedance pneumography (IP) as a marker of lower airway obstruction in 36 infants (mean age 12.8 [range 6-23] months) with recurrent respiratory symptoms. Lowered EVI was associated with lower lung function (VmaxFRC), higher asthma risk, and obstructive symptoms, but not with nasal congestion. EVI measured using IP is a potential technique for lung function testing in infants.

Published
2020

6. Nonlinear Dynamics of Heart Rate Variability in Children with Asthmatic Symptoms

Author

Milagro, Javier, Gil, Eduardo, Bolea, Juan, Seppä, Ville-Pekka, Malmberg, L. Pekka, Pelkonen, Anna S., Kotaniemi-Syrjänen, Anne, Mäkelä, Mika J., Viik, Jari, Bailón, Raquel, Magjarevic, Ratko, Editor-in-chief, Ładyżyński, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Eskola, Hannu, editor, Väisänen, Outi, editor, Viik, Jari, editor, and Hyttinen, Jari, editor

Published
2018
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11. Intermittent Tiotropium Bromide for Episodic Wheezing: A Randomized Trial

Author

Kotaniemi-Syrjänen, Anne, primary, Klemola, Timo, additional, Koponen, Petri, additional, Jauhola, Outi, additional, Aito, Henrikka, additional, Malmström, Kristiina, additional, Malmberg, L. Pekka, additional, Rahiala, Eero, additional, Sarna, Seppo, additional, Pelkonen, Anna S., additional, and Mäkelä, Mika J., additional

Published
2022
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16. The continuous laryngoscopy exercise test in severe or in difficult-to-treat asthma in adults: a systematic review.

Author

Thomander, Tuuli, Malmberg, L. Pekka, Toppila-Salmi, Sanna, Aaltonen, Leena-Maija, and Kauppi, Paula

Subjects
*EXERCISE tests, *VOCAL cord dysfunction, *ASTHMA, *ASTHMATICS, *LARYNGOSCOPY, *ADULTS
Abstract

A systematic review was performed to determine if the continuous laryngoscopy exercise test (CLE) has been used in the diagnostics of exercise dyspnea in adults with asthma, and whether inducible laryngeal obstruction (ILO) is found in those with asthma or with severe or difficult-to-treat asthma. We used Scopus and PubMed databases. The articles published up to 13 August 2019 were considered. We excluded manuscripts that did not contain information about adult patients with asthma. We included six studies from 59 search results in Scopus and none from the 17 search results in PubMed. The articles included 455 study individuals. Of these, 229 (50.3%) had diagnosed asthma or were treated with asthma medication. Altogether 31/229 (13.5%) subjects with diagnosis of asthma or previous asthma treatment had exercise-induced laryngeal obstruction (EILO) as comorbidity. The CLE test was performed on 229 patients with asthma. The method was used only for differential diagnosis of exercise-induced dyspnea to confirm EILO. At least 10/455 (2.2%) out of the 455 subjects experienced adverse events. This systematic review revealed that only a small proportion of patients with asthma had undergone the CLE test to assess exercise-induced dyspnea. None of the selected manuscripts reported severity of asthma. Whether CLE provides a valuable diagnostic tool for patients with severe or difficult-to-treat asthma cannot be determined according to this review. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Expiratory variability index is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms

Author

Seppä, Ville-Pekka, Gracia-Tabuenca, Javier, Kotaniemi-Syrjänen, Anne, Malmström, Kristiina, Hult, Anton, Pelkonen, Anna S., Makela, Mika J., Viik, Jari, Malmberg, L. Pekka, HUS Inflammation Center, and Department of Dermatology, Allergology and Venereology

Subjects
3121 General medicine, internal medicine and other clinical medicine, education, FLOW PATTERN COMPLEXITY
Abstract

Non

Published
2020

21. Expiratory variability index (EVI) is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms

Author

Sepp��, Ville-Pekka, Gracia-Tabuenca, Javier, Kotaniemi-Syrj��nen, Anne, Malmstr��m, Kristiina, Hult, Anton, Pelkonen, Anna, M��kel��, Mika J., Viik, Jari, and Malmberg, L. Pekka

Subjects
FOS: Biological sciences, FOS: Physical sciences, Medical Physics (physics.med-ph), respiratory system, Quantitative Biology - Quantitative Methods, Physics - Medical Physics, Quantitative Methods (q-bio.QM), respiratory tract diseases
Abstract

Recurrent respiratory symptoms are common in infants but the paucity of lung function tests suitable for routine use in infants is a widely acknowledged clinical problem. In this study we evaluated tidal breathing variability (expiratory variability index, EVI) measured at home during sleep using impedance pneumography (IP) as a marker of lower airway obstruction in 36 infants (mean age 12.8 [range 6-23] months) with recurrent respiratory symptoms. Lowered EVI was associated with lower lung function (VmaxFRC), higher asthma risk, and obstructive symptoms, but not with nasal congestion. EVI measured using IP is a potential technique for lung function testing in infants.

Published
2020

28. Airway hyperresponsiveness in young children with respiratory symptoms A five-year follow-up

Author

Kalliola, Satu, Malmberg, L. Pekka, Malmstrom, Kristiina, Pelkonen, Anna S., Mäkelä, Mika J., HUS Children and Adolescents, Children's Hospital, Clinicum, Lohja Hospital Area, Department of Dermatology, Allergology and Venereology, and HUS Inflammation Center

Subjects
BRONCHIAL RESPONSIVENESS, INFANTS, EXERCISE, respiratory system, 1ST 6 YEARS, IMPEDANCE, respiratory tract diseases, LUNG-FUNCTION, 3123 Gynaecology and paediatrics, 3121 General medicine, internal medicine and other clinical medicine, METHACHOLINE, ASTHMA, WHEEZING PHENOTYPES, CHALLENGE
Abstract

Background: Recurrent wheezing in early life is transient in most children. The significance of airway hyper-responsiveness (AHR) in persistence of respiratory symptoms from infancy to early childhood is controversial. Objective: We evaluated whether AHR in wheezy infants predicts doctor-diagnosed asthma (DDA) or AHR at the age of 6 years. Methods: Sixty-one wheezy infants (age 6-24 months) were followed up to the median age of 6 years. Lung function and AHR with methacholine challenge test were assessed at infancy and 6 years. The exercise challenge test was performed at the age of 6 years. Atopy was assessed with skin prick tests. Results: At 6 years, 21 (34%) of the children had DDA. Children with DDA had higher logarithmic transformed dose-response slope (LOGDRS) to methacholine in infancy than children without DDA (0.047 vs 0.025; P = .033). Furthermore, AHR to methacholine in infancy and at 6 years were associated with each other (r = 0.324, P = .011). Children with exercise-induced bronchoconstriction (EIB) at 6 years were more reactive to methacholine in infancy than those without EIB (P = .019). Conclusion: Increased AHR in symptomatic infants was associated with increased AHR, DDA, and EIB at median the age of 6 years, suggesting early establishment of AHR. (C) 2019 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Published
2019

43. A rapid dosimetric method with controlled tidal breathing for histamine challenge: repeatability and distribution of bronchial reactivity in a clinical material

Author

Sovijarvi, Anssi R.A., Malmberg, L. Pekka, Reinikainen, Kaija, Rytila, Paula, and Poppius, Hakan

Subjects
Bronchial spasm -- Diagnosis, Bronchoconstrictor agents -- Usage, Health, Diagnosis, Usage
Abstract

A rapid dosimetric method with controlled tidal breathing for histamine challenge was evaluated by assessment of its repeatability, by comparing to a present nondosimetric standard method, and by application to [...]

Published
1993

46. Hs-CRP in early childhood wheezing

Author

Määttä, Anette, primary, Kotaniemi-Syrjänen, Anne, additional, Malmström, Kristiina, additional, Malmberg, L. Pekka, additional, Pelkonen, Anna S., additional, and Mäkelä, Mika J., additional

Published
2016
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47. Influence of mouthwashes on extended exhaled nitric oxide (FENO) analysis.

Author

Lassmann-Klee, Paul Guenther, Lehtimäki, Lauri, Lindholm, Tuula, Malmberg, L. Pekka, Sovijärvi, Anssi Raimo Antero, and Piirilä, Päivi

Subjects
WATER analysis, NITRIC oxide analysis, ASTHMA, BREATH tests, EOSINOPHILS, MOUTHWASHES, NITRIC oxide, PULMONARY alveoli, RESPIRATION, RESPIRATORY measurements, SPIROMETRY, WATER supply, CASE-control method
Abstract

Fractional exhaled nitric oxide (FENO) is used to assess eosinophilic inflammation of the airways. FENO values are influenced by the expiratory flow rate and orally produced NO. We measured FENO at four different expiratory flow levels after two different mouthwashes: tap water and carbonated water. Further, we compared the alveolar NO concentration (CANO), maximum airway NO flux (J'awNO) and airway NO diffusion (DawNO) after these two mouthwashes. FENO was measured in 30 volunteers (healthy or asthmatic) with a chemiluminescence NO-analyser at flow rates of 30, 50, 100 and 300 mL/s. A mouthwash was performed before the measurement at every flow rate. The carbonated water mouthwash significantly reduced FENO compared to the tap water mouthwash at all expiratory flows: 50 mL/s (p < .001), 30 mL/s (p = .001), 100 mL/s (p < .001) and 300 mL/s (p = .004). J'awNO was also significantly reduced (p = .017), however, there were no significant differences in CANO and DawNO. In conclusion, a carbonated water mouthwash can significantly reduce oropharyngeal NO compared to a tap water mouthwash at expiratory flows of 30-300 mL/s without affecting the CANO and DawNO. Therefore, mouthwashes need to be taken into account when comparing FENO results. [ABSTRACT FROM AUTHOR]

Published
2018
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