24 results on '"Malmros J"'
Search Results
2. Physiciansʼ self‐reported practice behaviour regarding fertility‐related discussions in paediatric oncology in Sweden
- Author
-
Armuand, G.M., Nilsson, J., Rodriguez‐Wallberg, K.A., Malmros, J., Arvidson, J., Lampic, C., and Wettergren, L.
- Published
- 2017
- Full Text
- View/download PDF
3. ‘Will I be able to have a baby?’ Results from online focus group discussions with childhood cancer survivors in Sweden
- Author
-
Nilsson, J., Jervaeus, A., Lampic, C., Eriksson, L.E., Widmark, C., Armuand, G.M., Malmros, J., Marshall Heyman, M., and Wettergren, L.
- Published
- 2014
- Full Text
- View/download PDF
4. Physicians' self-reported practice behaviour regarding fertility-related discussions in paediatric oncology in Sweden
- Author
-
Armuand, G. M., Nilsson, J., Rodriguez-Wallberg, K. A., Malmros, J., Arvidson, Johan, Lampic, C., Wettergren, L., Armuand, G. M., Nilsson, J., Rodriguez-Wallberg, K. A., Malmros, J., Arvidson, Johan, Lampic, C., and Wettergren, L.
- Abstract
Objective: The aim of this study was to investigate practice behaviours of Swedish physicians with regard to discussing the impact of cancer treatment on fertility with paediatric oncology patients and their parents, and to identify factors associated with such discussions. Methods: A cross-sectional survey study was conducted targeting all physicians in Sweden working in paediatric oncology care settings. Participants responded to a questionnaire measuring practice behaviour, attitudes, barriers, and confidence in knowledge. Multivariable logistic regression was used to determine factors associated with seldom discussing fertility. Results: More than half of the physicians routinely talked with their patients/parents about the treatment's potential impact on fertility (male patients: 62%; female patients: 57%; P = 0.570). Factors associated with less frequently discussing fertility with patients/parents were working at a non-university hospital (male patients: OR 11.49, CI 1.98-66.67; female patients: OR 33.18, CI 4.06-271.07), concerns that the topic would cause worry (male patients: OR 8.23, CI 1.48-45.89; female patients: OR 12.38, CI 1.90-80.70), and perceiving the parents as anxious (male patients: OR 7.18, CI 1.20-42.85; female patients: OR 11.65, CI 1.32-103.17). Conclusions: Based on our findings, we recommend structured training in how to communicate about fertility issues in stressful situations, which in turn might increase fertility-related discussions in paediatric oncology.
- Published
- 2017
- Full Text
- View/download PDF
5. Evaluating a quantitative IT maturity self-assessment approach: Does it give a good way of the as-is state?
- Author
-
Björn Johansson, Eckerstein, J., Malmros, J., Vasilenko, Dmitry, and Khazieva, Natalia
- Subjects
IT maturity ,IT Governance ,Information Systems, Social aspects ,Information Technology Infrastructure Library (ITIL) ,Quantitative self- assessment - Abstract
It has become increasingly recognized that IT organizations must ensure that IT services are aligned to business needs and actively support them. Ther efore, the internal IT service management processes are under constant improvement. Information Technology Infrastructure Library (ITIL) is the most commonlyadopted framework for IT service management. The r ecommendation is to start an ITIL implementation or improvement process by defining a baseline of current state - “wher e are we today”. This helps identify the gap to a wanted future state and will become the basis for an ITIL implementation or improvement plan. One of the most commonly used methods to define current state is to do a maturity assessment using a quantitative self-assessment approach. The purpose of this research is to empirically understand how well aqua nti ta ti ve s el f-ass ess ment d efi nes the a s -i s s ta te a nd ther eby th e ma turi ty of a n I T orga ni za ti on. The research was carried out by conducting a quantitative self-assessment in an IT organization. To understand if the self-assessment produced viable results a meta-evaluation of the survey was conducted through interviews and a document study. The main conclusion, is that the use of a quantitative self-assessment does not define the as-is state and maturity well enough. To do so, it has to be complemented by for instanceinterviews or another type of internal knowledge to produce a good enough baseline.
- Published
- 2016
6. Greenland precipitation trends in a long-term instrumental climate context (1890-2012): evaluation of coastal and ice core records
- Author
-
Mernild, S. H., Hanna, E., Mcconnell, J. R., Sigl, M., Beckerman, A. P., Yde, J. C., Cappelen, J., Malmros, J. K., and Steffen, K.
- Subjects
F330 Environmental Physics - Abstract
Here, we present an analysis of monthly, seasonal, and annual long-term precipitation time-series compiled from coastal meteorological stations in Greenland and Greenland Ice Sheet (GrIS) ice cores (including three new ice core records from ACT11D, Tunu2013, and Summit2010). The dataset covers the period from 1890 to 2012, a period of climate warming. For approximately the first decade of the new millennium (2001-2012) minimum and maximum mean annual precipitation conditions are found in Northeast Greenland (Tunu2013 c. 120mm water equivalent (w.e.) year-1) and South Greenland (Ikerasassuaq: c. 2300mm w.e. year-1), respectively. The coastal meteorological stations showed on average increasing trends for 1890-2012 (3.5mm w.e. year-2) and 1961-2012 (1.3mm w.e. year-2). Years with high coastal annual precipitation also had a: (1) significant high number of precipitation days (r2 = 0.59); and (2) high precipitation intensity measured as 24-h precipitation (r2 = 0.54). For the GrIS the precipitation estimated from ice cores increased on average by 0.1mm w.e. year-2 (1890-2000), showing an antiphase variability in precipitation trends between the GrIS and the coastal regions. Around 1960 a major shift occurred in the precipitation pattern towards wetter precipitation conditions for coastal Greenland, while drier conditions became more prevalent on the GrIS. Differences in precipitation trends indicate a heterogeneous spatial distribution of precipitation in Greenland. An Empirical Orthogonal Function analysis reveals a spatiotemporal cycle of precipitation that is linked instantaneously to the North Atlantic Oscillation and the Atlantic Multidecadal Oscillation and with an �6 years lag time response to the Greenland Blocking Index. © 2014 Royal Meteorological Society.
- Published
- 2015
7. 'Will I be able to have a baby?' : Results from online focus group discussions with childhood cancer survivors in Sweden.
- Author
-
Nilsson, J, Jervaeus, A, Lampic, Claudia, Eriksson, L E, Widmark, C, Armuand, G M, Malmros, J, Marshall Heyman, M, Wettergren, L, Nilsson, J, Jervaeus, A, Lampic, Claudia, Eriksson, L E, Widmark, C, Armuand, G M, Malmros, J, Marshall Heyman, M, and Wettergren, L
- Abstract
STUDY QUESTION: What do adolescent and young adult survivors of childhood cancer think about the risk of being infertile? SUMMARY ANSWER: The potential infertility, as well as the experience of having had cancer, affects well-being, intimate relationships and the desire to have children in the future. WHAT IS KNOWN ALREADY: Many childhood cancer survivors want to have children and worry about possible infertility. STUDY DESIGN, SIZE, DURATION: For this qualitative study with a cross-sectional design, data were collected through 39 online focus group discussions during 2013. PARTICIPANTS/MATERIALS, SETTING, METHODS: Cancer survivors previously treated for selected diagnoses were identified from The Swedish Childhood Cancer Register (16-24 years old at inclusion, ≥5 years after diagnosis) and approached regarding study participation. Online focus group discussions of mixed sex (n = 133) were performed on a chat platform in real time. Texts from the group discussions were analysed using qualitative content analysis. MAIN RESULTS AND THE ROLE OF CHANCE: The analysis resulted in the main category Is it possible to have a baby? including five generic categories: Risk of infertility affects well-being, Dealing with possible infertility, Disclosure of possible infertility is a challenge, Issues related to heredity and Parenthood may be affected. The risk of infertility was described as having a negative impact on well-being and intimate relationships. Furthermore, the participants described hesitation about becoming a parent due to perceived or anticipated physical and psychological consequences of having had cancer. LIMITATIONS, REASONS FOR CAUTION: Given the sensitive topic of the study, the response rate (36%) is considered acceptable. The sample included participants who varied with regard to received fertility-related information, current fertility status and concerns related to the risk of being infertile. WIDER IMPLICATIONS OF THE FINDINGS: The results may be transfe
- Published
- 2014
- Full Text
- View/download PDF
8. Multi decadal glacier area fluctuations in Pan-Arctic
- Author
-
Mernild, S. H., primary and Malmros, J. K., additional
- Published
- 2012
- Full Text
- View/download PDF
9. Thinning and slowdown of Greenland's Mittivakkat Gletscher
- Author
-
Mernild, S. H., primary, Knudsen, N. T., additional, Hoffman, M. J., additional, Yde, J. C., additional, Lipscomb, W. H., additional, Hanna, E., additional, Malmros, J. K., additional, and Fausto, R. S., additional
- Published
- 2012
- Full Text
- View/download PDF
10. Multi-decadal marine- and land-terminating glacier recession in the Ammassalik region, southeast Greenland
- Author
-
Mernild, S. H., primary, Malmros, J. K., additional, Yde, J. C., additional, and Knudsen, N. T., additional
- Published
- 2012
- Full Text
- View/download PDF
11. Recession, thinning, and slowdown of Greenland's Mittivakkat Gletscher
- Author
-
Mernild, S. H., primary, Knudsen, N. T., additional, Yde, J. C., additional, Hoffman, M. J., additional, Lipscomb, W. H., additional, Fausto, R. S., additional, Hanna, E., additional, and Malmros, J. K., additional
- Published
- 2012
- Full Text
- View/download PDF
12. Increasing mass loss from Greenland's Mittivakkat Gletscher
- Author
-
Mernild, S. H., primary, Knudsen, N. T., additional, Lipscomb, W. H., additional, Yde, J. C., additional, Malmros, J. K., additional, Hasholt, B., additional, and Jakobsen, B. H., additional
- Published
- 2011
- Full Text
- View/download PDF
13. Record mass loss from Greenland's best-observed local glacier
- Author
-
Mernild, S. H., primary, Knudsen, N. T., additional, Lipscomb, W. H., additional, Yde, J. C., additional, Malmros, J. K., additional, Jakobsen, B. H., additional, and Hasholt, B., additional
- Published
- 2011
- Full Text
- View/download PDF
14. In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity.
- Author
-
Rooda I, Hassan J, Hao J, Wagner M, Moussaud-Lamodière E, Jääger K, Otala M, Knuus K, Lindskog C, Papaikonomou K, Gidlöf S, Langenskiöld C, Vogt H, Frisk P, Malmros J, Tuuri T, Salumets A, Jahnukainen K, Velthut-Meikas A, and Damdimopoulou P
- Subjects
- Female, Humans, Adult, Child, Oocytes metabolism, MicroRNAs genetics, MicroRNAs metabolism, Gene Expression Profiling, Cyclophosphamide, Cryopreservation, Fertility Preservation methods, Adolescent, Signal Transduction, Child, Preschool, Ovarian Follicle metabolism, Transcriptome
- Abstract
The ovarian cortical reserve of follicles is vital for fertility. Some medical treatments are toxic to follicles, leading to premature ovarian insufficiency. Ovarian tissue cryopreservation is an established method to preserve fertility in adults and even applied in prepuberty despite unproven efficacy. Here, we analyze transcriptomes of 120 cortical follicles from children and adults for detailed comparison. We discover heterogeneity with two main types of follicles in both age groups: one with expected oocyte-granulosa profiles and another with predicted role in signaling. Transcriptional changes during growth to the secondary stage are similar overall in children and adults, but variations related to extracellular matrix, theca cells, and miRNA profiles are found. Notably, cyclophosphamide dose correlates with interferon signaling in child follicles. Additionally, morphology alone is insufficient for follicle categorization suggesting a need for additional markers. Marker genes for early follicle activation are determined. These findings will help refine follicular classification and fertility preservation techniques across critical ages., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
15. Increase in peg-asparaginase clearance as a predictor for inactivation in patients with acute lymphoblastic leukemia.
- Author
-
Dam M, Centanni M, Friberg LE, Centanni D, Karlsson MO, Stensig Lynggaard L, Johannsdottir IM, Wik HS, Malmros J, Vaitkeviciene GE, Griskevicius L, Hallböök H, Jónsson ÓG, Overgaard U, Schmiegelow K, Hansen SN, Heyman M, and Albertsen BK
- Subjects
- Humans, Asparaginase, Polyethylene Glycols, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Hypersensitivity drug therapy, Antineoplastic Agents therapeutic use
- Abstract
Asparaginase is an essential component of acute lymphoblastic leukemia (ALL) therapy, yet its associated toxicities often lead to treatment discontinuation, increasing the risk of relapse. Hypersensitivity reactions include clinical allergies, silent inactivation, or allergy-like responses. We hypothesized that even moderate increases in asparaginase clearance are related to later inactivation. We therefore explored mandatory monitoring of asparaginase enzyme activity (AEA) in patients with ALL aged 1-45 years treated according to the ALLTogether pilot protocol in the Nordic and Baltic countries to relate mean AEA to inactivation, to build a pharmacokinetic model to better characterize the pharmacokinetics of peg-asparaginase and assess whether an increased clearance relates to subsequent inactivation. The study analyzed 1631 real-time AEA samples from 253 patients, identifying inactivation in 18.2% of the patients. This inactivation presented as mild allergy (28.3%), severe allergy (50.0%), or silent inactivation (21.7%). A pharmacokinetic transit compartment model was used to describe AEA-time profiles, revealing that 93% of patients with inactivation exhibited prior increased clearance, whereas 86% of patients without hypersensitivity maintained stable clearance throughout asparaginase treatment. These findings enable prediction of inactivation and options for either dose increments or a shift to alternative asparaginase formulations to optimize ALL treatment strategies., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
16. ProFertil study protocol for the investigation of gonadotropin-releasing hormone agonists (GnRHa) during chemotherapy aiming at fertility protection of young women and teenagers with cancer in Sweden-a phase III randomised double-blinded placebo-controlled study.
- Author
-
Rodriguez-Wallberg KA, Nilsson HP, Bergh J, Malmros J, Ljungman P, Foukakis T, Stragliotto CL, Friman EI, Linderholm B, Valachis A, Andersson A, Harrysson S, Vennström L, Frisk P, Mörse H, and Eloranta S
- Subjects
- Adolescent, Female, Humans, Clinical Trials, Phase III as Topic, Prospective Studies, Randomized Controlled Trials as Topic, Retrospective Studies, Sweden, Young Adult, Adult, Leukemia drug therapy, Sarcoma drug therapy, Breast Neoplasms drug therapy, Gonadotropin-Releasing Hormone agonists, Lymphoma drug therapy, Fertility Preservation
- Abstract
Background: Gonadotropin-releasing hormone agonists (GnRHa) cotreatment used to transiently suppress ovarian function during chemotherapy to prevent ovarian damage and preserve female fertility is used globally but efficacy is debated. Most clinical studies investigating a beneficial effect of GnRHa cotreatment on ovarian function have been small, retrospective and uncontrolled. Unblinded randomised studies on women with breast cancer have suggested a beneficial effect, but results are mixed with lack of evidence of improvement in markers of ovarian reserve. Unblinded randomised studies of women with lymphoma have not shown any benefit regarding fertility markers after long-term follow-up and no placebo-controlled study has been conducted so far. The aim of this study is to investigate if administration of GnRHa during cancer treatment can preserve fertility in young female cancer patients in a double-blind, placebo-controlled clinical trial., Methods and Analysis: A prospective, randomised, double-blinded, placebo-controlled, phase III study including 300 subjects with breast cancer. In addition, 200 subjects with lymphoma, acute leukemias and sarcomas will be recruited. Women aged 14-42 will be randomised 1:1 to treatment with GnRHa (triptorelin) or placebo for the duration of their gonadotoxic chemotherapy. Follow-up until 5 years from end of treatment (EoT). The primary endpoint will be change in anti-Müllerian hormone (AMH) recovery at follow-up 12 months after EoT, relative to AMH levels at EoT, comparing the GnRHa group and the placebo group in women with breast cancer., Ethics and Dissemination: This study is designed in accordance with the principles of Good Clinical Practice (ICH-GCP E6 (R2)), local regulations (ie, European Directive 2001/20/EC) and the ethical principles of the Declaration of Helsinki. Within 6 months of study completion, the results will be analysed and the study results shall be reported in the EudraCT database., Study Registration: The National Institutional review board in Sweden dnr:2021-03379, approval date 12 October 2021 (approved amendments 12 June 2022, dnr:2022-02924-02 and 13 December 2022, dnr:2022-05565-02). The Swedish Medical Product Agency 19 January 2022, Dnr:5.1-2021-98927 (approved amendment 4 February 2022). Manufacturing authorisation for authorised medicinal products approved 6 December 2021, Dnr:6.2.1-2020-079580. Stockholm Medical Biobank approved 22 June 2022, RBC dnr:202 253., Trial Registration Number: NCT05328258; EudraCT number:2020-004780-71., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.)
- Published
- 2023
- Full Text
- View/download PDF
17. Reference standards for follicular density in ovarian cortex from birth to sexual maturity.
- Author
-
Hassan J, Knuus K, Lahtinen A, Rooda I, Otala M, Tuuri T, Gidlöf S, Edlund E, Menezes J, Malmros J, Byström P, Sundin M, Langenskiöld C, Vogt H, Frisk P, Petersen C, Damdimopoulou P, and Jahnukainen K
- Subjects
- Female, Humans, Aged, Infant, Child, Preschool, Child, Adolescent, Young Adult, Adult, Ovary, Reference Standards, Quality Control, Antineoplastic Agents, Alkylating, Turner Syndrome
- Abstract
Research Question: Are age-normalized reference values for human ovarian cortical follicular density adequate for tissue quality control in fertility preservation?, Design: Published quantitative data on the number of follicles in samples without known ovarian pathology were converted into cortical densities to create reference values. Next, a sample cohort of 126 girls (age 1-24 years, mean ± SD 11 ± 6) with cancer, severe haematological disease or Turner syndrome were used to calculate Z-scores for cortical follicular density based on the reference values., Results: No difference was observed between Z-scores in samples from untreated patients (0.3 ± 3.5, n = 30) and patients treated with (0.5 ± 2.9, n = 48) and without (0.1 ± 1.3, n = 6) alkylating chemotherapy. Z-scores were not correlated with increasing cumulative exposure to cytostatics. Nevertheless, Z-scores in young treated patients (0-2 years -2.1 ± 3.1, n = 10, P = 0.04) were significantly lower than Z-scores in older treated patients (11-19 years, 2 ± 1.9, n = 15). Samples from patients with Turner syndrome differed significantly from samples from untreated patients (-5.2 ± 5.1, n = 24, P = 0.003), and a Z-score of -1.7 was identified as a cut-off showing good diagnostic value for identification of patients with Turner syndrome with reduced ovarian reserve. When this cut-off was applied to other patients, analysis showed that those with indications for reduced ovarian reserve (n = 15) were significantly younger (5.9 ± 4.2 versus 10.7 ± 5.9 years, P = 0.004) and, when untreated, more often had non-malignant haematologic diseases compared with those with normal ovarian reserve (n = 24, 100% versus 19%, P = 0.009)., Conclusion: Z-scores allow the estimation of genetic- and treatment-related effects on follicular density in cortical tissue from young patients stored for fertility preservation. Understanding the quality of cryopreserved tissue facilitates its use during patient counselling. More research is needed regarding the cytostatic effects found in this study., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
18. Fertility preservation for young adults, adolescents, and children with cancer.
- Author
-
Rodriguez-Wallberg KA, Anastacio A, Vonheim E, Deen S, Malmros J, and Borgström B
- Subjects
- Adolescent, Adult, Child, Combined Modality Therapy, Cryopreservation methods, Female, Humans, Male, Middle Aged, Young Adult, Fertility Preservation methods, Neoplasms therapy
- Abstract
Options for fertility preservation (FP) through cryopreservation methods are currently available for young adults, adolescents, and children. Guidelines for FP have been provided by international clinical societies, and emergency procedures aimed at FP have been implemented into clinical practice worldwide. In this article, we review the current data on clinical standards of emergency FP in patients who are facing gonadotoxic effects of cancer treatment, and we also describe the methods that are still under development, usually denoted as experimental. In Sweden, programmes for FP have been established at large university hospitals, thus covering the whole country. The Swedish publicly financed health care covers both assisted reproduction for treatment of infertility and the cryopreservation of gametes or gonadal tissue when there is a medical indication, such as the risk to become infertile due to oncologic treatment; hence the access to FP is ensured for the whole population. At our centre at Karolinska University Hospital in Stockholm, methods for FP have been offered since 1988. In this article, we also review the oncologic indications for FP in our patient cohort of >3000 individuals during the period 1988-2018.
- Published
- 2020
- Full Text
- View/download PDF
19. Ways of understanding the ability to have children among young adult survivors of childhood cancer - A phenomenographic study.
- Author
-
Nilsson J, Röing M, Malmros J, and Winterling J
- Subjects
- Adolescent, Adult, Female, Humans, Male, Risk Factors, Sweden, Young Adult, Adaptation, Psychological, Cancer Survivors psychology, Fertility, Infertility psychology
- Abstract
Purposes: The aim was to explore the ways young adult survivors of childhood cancer with risk of being infertile understand their ability to have children., Method: The study has a qualitative design with a phenomenographic approach. Interviews with a purposeful sample of 19 childhood cancer survivors who did not have children (age range 17-27) were carried out and analysed., Results: We identified four qualitatively different ways in which young adult survivors of childhood cancer understand their ability to have children: difficulty in having children is not as important as surviving cancer, having a biological child may be a complicated procedure, having children may be affected by hereditary concerns, having children in the future is a difficult topic to deal with., Conclusions: The four different ways in which young adult childhood cancer survivors understand their ability to have children did not appear to be solely related to information they had or had not received during treatment but appeared to reflect their current life situation and how they were coping with their cancer experience. Using survivors' understandings of their ability to have children is recommended as a starting point when healthcare personnel initiate communication about fertility issues in survivorship care. Some survivors need psychosocial support for the acceptance and management of both cancer and fertility problems., Competing Interests: Declaration of competing interest None declared., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
20. Asparaginase-Associated Pancreatitis in Acute Lymphoblastic Leukemia: Results From the NOPHO ALL2008 Treatment of Patients 1-45 Years of Age.
- Author
-
Rank CU, Wolthers BO, Grell K, Albertsen BK, Frandsen TL, Overgaard UM, Toft N, Nielsen OJ, Wehner PS, Harila-Saari A, Heyman MM, Malmros J, Abrahamsson J, Norén-Nyström U, Tomaszewska-Toporska B, Lund B, Jarvis KB, Quist-Paulsen P, Vaitkevičienė GE, Griškevičius L, Taskinen M, Wartiovaara-Kautto U, Lepik K, Punab M, Jónsson ÓG, and Schmiegelow K
- Subjects
- Adolescent, Adult, Antineoplastic Agents administration & dosage, Antineoplastic Agents adverse effects, Asparaginase adverse effects, Child, Child, Preschool, Estonia epidemiology, Female, Humans, Incidence, Infant, Lithuania epidemiology, Male, Middle Aged, Pancreatitis chemically induced, Polyethylene Glycols adverse effects, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Randomized Controlled Trials as Topic, Scandinavian and Nordic Countries epidemiology, Young Adult, Asparaginase administration & dosage, Pancreatitis epidemiology, Polyethylene Glycols administration & dosage, Precursor Cell Lymphoblastic Leukemia-Lymphoma epidemiology
- Abstract
Purpose: Asparaginase-associated pancreatitis (AAP) is common in patients with acute lymphoblastic leukemia (ALL), but risk differences across age groups both in relation to first-time AAP and after asparaginase re-exposure have not been explored., Patients and Methods: We prospectively registered AAP (n = 168) during treatment of 2,448 consecutive ALL patients aged 1.0-45.9 years diagnosed from July 2008 to October 2018 and treated according to the Nordic Society of Pediatric Hematology and Oncology (NOPHO) ALL2008 protocol., Results: Compared with patients aged 1.0-9.9 years, adjusted AAP hazard ratios (HRa) were associated with higher age with almost identical HRa (1.6; 95% CI, 1.1 to 2.3; P = .02) for adolescents (10.0-17.9 years) and adults (18.0-45.9 years). The day 280 cumulative incidences of AAP were 7.0% for children (1.0-9.9 years: 95% CI, 5.4 to 8.6), 10.1% for adolescents (10.0 to 17.9 years: 95% CI, 7.0 to 13.3), and 11.0% for adults (18.0-45.9 years: 95% CI, 7.1 to 14.9; P = .03). Adolescents had increased odds of both acute (odds ratio [OR], 5.2; 95% CI, 2.1 to 13.2; P = .0005) and persisting complications (OR, 6.7; 95% CI, 2.4 to 18.4; P = .0002) compared with children (1.0-9.9 years), whereas adults had increased odds of only persisting complications (OR, 4.1; 95% CI, 1.4 to 11.8; P = .01). Fifteen of 34 asparaginase-rechallenged patients developed a second AAP. Asparaginase was truncated in 17/21 patients with AAP who subsequently developed leukemic relapse, but neither AAP nor the asparaginase truncation was associated with increased risk of relapse., Conclusion: Older children and adults had similar AAP risk, whereas morbidity was most pronounced among adolescents. Asparaginase re-exposure should be considered only for patients with an anticipated high risk of leukemic relapse, because multiple studies strongly indicate that reduction of asparaginase treatment intensity increases the risk of relapse.
- Published
- 2020
- Full Text
- View/download PDF
21. Hearing Status in Survivors of Childhood Acute Myeloid Leukemia Treated With Chemotherapy Only: A NOPHO-AML Study.
- Author
-
Skou AS, Olsen SØ, Nielsen LH, Glosli H, Jahnukainen K, Jarfelt M, Jónmundsson GK, Malmros J, Nysom K, and Hasle H
- Subjects
- Adolescent, Adult, Cancer Survivors, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Retrospective Studies, Siblings, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Antineoplastic Combined Chemotherapy Protocols adverse effects, Hearing drug effects, Hearing Disorders chemically induced, Hearing Disorders epidemiology, Leukemia, Myeloid, Acute drug therapy, Leukemia, Myeloid, Acute epidemiology
- Abstract
Background: As more children survive acute myeloid leukemia (AML) it is increasingly important to assess possible late effects of the intensive treatment. Hearing loss has only sporadically been reported in survivors of childhood AML. We assessed hearing status in survivors of childhood AML treated with chemotherapy alone according to 3 consecutive NOPHO-AML trials., Procedure: A population-based cohort of children treated according to the NOPHO-AML-84, NOPHO-AML-88, and NOPHO-AML-93 trials included 137 eligible survivors among whom 101 (74%) completed a questionnaire and 99 (72%) had otologic and audiologic examination performed including otoscopy (72%), pure tone audiometry (70%), and tympanometry (60%). Eighty-four of 93 (90%) eligible sibling controls completed a similar questionnaire., Results: At a median of 11 years (range, 4 to 25) after diagnosis, hearing disorders were rare in survivors of childhood AML and in sibling controls, with no significant differences. None had severe or profound hearing loss diagnosed at audiometry. Audiometry detected a subclinical hearing loss ranging from slight to moderate in 19% of the survivors, 5% had low-frequency hearing loss, and 17% had high-frequency hearing loss., Conclusions: The frequency of hearing disorders was low, and hearing thresholds in survivors of childhood AML were similar to background populations of comparable age.
- Published
- 2019
- Full Text
- View/download PDF
22. Cardiac function in survivors of childhood acute myeloid leukemia treated with chemotherapy only: a NOPHO-AML study.
- Author
-
Jarfelt M, Andersen NH, Glosli H, Jahnukainen K, Jónmundsson GK, Malmros J, Nysom K, and Hasle H
- Subjects
- Adolescent, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Child, Child, Preschool, Echocardiography, Female, Heart Diseases diagnosis, Heart Diseases epidemiology, Humans, Infant, Infant, Newborn, Male, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma epidemiology, Self Report, Ventricular Function, Left, Antineoplastic Combined Chemotherapy Protocols adverse effects, Heart Diseases etiology, Heart Diseases physiopathology, Precursor Cell Lymphoblastic Leukemia-Lymphoma complications
- Abstract
Objectives: We report cardiac function of patients treated for Childhood acute myeloid leukemia with chemotherapy only according to three consecutive Nordic protocols., Methods: Ninety-eight of 138 eligible patients accepted examination with standardized echocardiography. Results were compared with age- and sex-matched controls., Results: The median age was 3 yr at diagnosis (range 0-15), and the median time from diagnosis to study was 11 yr (4-25). All but one patient had received doxorubicin and 90% had received mitoxantrone. The median cumulative dose of daunorubicin equivalents was 300 mg/m(2) (210-525). Left ventricular fractional shortening (LVFS) and ejection fraction (LVEF) were lower in patients than in controls (32.6% (SD 4.0) vs. 35.2% (SD 3.4), P = 0.002 and 59.9% (SD 5.5) vs. 64.2% (SD 4.4), P = 0.001). The myocardial performance index (MPI) was higher in patients than in controls (0.32 (SD 0.081) vs. 0.26 (SD 0.074), P < 0.0001). Cumulative dose of doxorubicin but not mitoxantrone was related to lower LVFS (P = 0.037) and LVEF (P = 0.016). Longer follow-up was associated with lower LVFS (P = 0.034). Higher MPI was associated with young age at diagnosis (P = 0.04) and longer follow-up (P = 0.031)., Conclusions: In this study, most patients had cardiac function within normal limits and reported very few cardiac symptoms. However, compared with healthy controls, they had significantly reduced left ventricular function., (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2016
- Full Text
- View/download PDF
23. Clinical significance in self-rated HRQoL among survivors after childhood cancer - demonstrated by anchor-based thresholds.
- Author
-
Jervaeus A, Lampic C, Johansson E, Malmros J, and Wettergren L
- Subjects
- Adolescent, Adult, Case-Control Studies, Child, Cohort Studies, Female, Follow-Up Studies, Health Status, Humans, Male, Neoplasms psychology, Prognosis, Self Report, Surveys and Questionnaires, Young Adult, Neoplasms physiopathology, Quality of Life, Survivors psychology
- Abstract
Background: There is a need to establish clinically relevant thresholds (anchors) for identification of differences in health-related quality of life (HRQoL) and thereby provide stronger evidence regarding the HRQoL of childhood cancer survivors., Aim: To investigate HRQoL in childhood cancer survivors with a standardised instrument and to establish thresholds for clinically significant differences by using qualitative interviews as anchors. An additional aim was to investigate survivors' HRQoL in relation to an age-matched comparison group without cancer experience., Material and Methods: Self-rated HRQoL (KIDSCREEN-27) was assessed in a national cohort of survivors (n = 63, aged 12-22) and a comparison group (n = 257, aged 11-23). Findings from qualitative interview data were also used (n = 61); three subgroups ("Feeling like anyone else"; "Feeling almost like others"; "Feeling different") were identified based on survivors own perception of influence on daily life. Effect size calculations based on means from the KIDSCREEN-27 dimensions were performed using the subgroups as anchors to indicate clinical importance. Furthermore, standard multiple regression analyses were performed. Results. Effect sizes between the subgroups "Feeling like anyone else" and "Feeling almost like others" and the group "Feeling different" were large for all dimensions (1.04-2.07). The multiple regression models showed that being a survivor was significantly associated with one of the dimensions, School Environment, where survivors scored higher HRQoL. Furthermore, female sex and older age (17-23 years) significantly contributed to lower self-rated HRQoL. Conclusion. In clinical practice the KIDSCREEN-27 could be a useful screening tool to identify survivors of childhood cancer in need of extra support, using KIDSCREEN dimension mean values of 45 or less as thresholds. Larger scale studies are recommended to identify and test thresholds with regard to different age groups and time since diagnosis.
- Published
- 2014
- Full Text
- View/download PDF
24. Pubertal development and fertility in survivors of childhood acute myeloid leukemia treated with chemotherapy only: a NOPHO-AML study.
- Author
-
Molgaard-Hansen L, Skou AS, Juul A, Glosli H, Jahnukainen K, Jarfelt M, Jónmundsson GK, Malmros J, Nysom K, and Hasle H
- Subjects
- Adolescent, Adult, Anti-Mullerian Hormone blood, Child, Child, Preschool, Female, Follicle Stimulating Hormone blood, Follow-Up Studies, Humans, Male, Primary Ovarian Insufficiency chemically induced, Primary Ovarian Insufficiency epidemiology, Surveys and Questionnaires, Young Adult, Antineoplastic Combined Chemotherapy Protocols adverse effects, Fertility drug effects, Leukemia, Myeloid, Acute drug therapy, Puberty drug effects, Survivors statistics & numerical data
- Abstract
Background: More than 60% of children with acute myeloid leukemia (AML) become long-term survivors. Most are cured using chemotherapy without hematopoietic stem cell transplantation (HSCT). We report on pubertal development and compare self-reported parenthood among AML survivors and their siblings., Procedure: We included 137 children treated for AML according to the Nordic Society of Pediatric Hematology and Oncology (NOPHO)-AML-84, -88, and -93 trials, who were alive by June 2007. Patients with relapse or treated with HSCT were excluded. AML survivors participated in a physical and biochemical examination (n = 102) and completed a questionnaire (n = 101). One of their siblings completed an identical questionnaire (n = 84)., Results: At a median follow-up of 11 years (range 5-25) after diagnosis of AML the survivors (median age 16 years, range 5-36) were either prepubertal or had entered puberty normally. Serum levels of FSH, LH, testosterone, estradiol, sex hormone binding globulin (SHBG), inhibin A and B, and testicular volumes were within normal ranges. Anti-Müllerian hormone (AMH) levels were decreased in 5 of 40 postpubertal females. Mean reported age at menarche was 13.1 (range 11-17) years. Among survivors 15 years of age or older 31% of females reported pregnancies and 9% of males reported pregnancies in their partners, rates comparable with the frequency reported by their siblings., Conclusions: Most AML survivors treated with chemotherapy had normal pubertal development and fertility, however, AMH levels were decreased in 13% of postpubertal females. Longer follow-up is necessary to evaluate possible risk of premature ovarian failure., (© 2013 Wiley Periodicals, Inc.)
- Published
- 2013
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.