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1. Is placebo useful in the treatment of major depression in clinical practice?

Author

Marchesi C, De Panfilis C, Tonna M, and Ossola P

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Carlo Marchesi, Chiara De Panfilis, Matteo Tonna, Paolo Ossola University of Parma, Department of Neuroscience, Psychiatric Unit, Parma, Italy Background: For many years, placebo has been defined by its inert content and use in clinical trials. In recent years, several studies have demonstrated its effect in the treatment of major depression. The aim of this paper is to present the conclusions of recent meta-analyses of the placebo effect in major depression, to explain the mechanism by which placebo exerts its effect, and to discuss whether placebo can be used in the treatment of patients with major depression in clinical practice. Recent meta-analyses have demonstrated that the placebo effect is estimated to account for 67% of the treatment effect in patients receiving antidepressants, and furthermore that placebo is as effective as antidepressants in patients with mild to moderate major depression (reporting a Hamilton Depression Rating Scale score lower than 25), whereas placebo is less effective than antidepressants in severely depressed patients. However, several limitations make the translation of these conclusions into clinical practice impracticable. Clinicians should learn from the "placebo lesson" to maximize the nonspecific effects of treatment when they prescribe an antidepressant, particularly in less severely depressed patients, who show a higher placebo response in randomized controlled trials. This strategy can increase the antidepressant effect and may reduce nonadherence with treatment. Keywords: placebo effect, major depressive disorder, subthreshold depressive disorder, antidepressants

Published
2013

2. Identification of hemodynamically stable patients with acute pulmonary embolism at high risk for death: external validation of different models

Author

Becattini, Cecilia, Gulizia, Michele M., Agnelli, Giancarlo, Dentali, Francesco, Di Lenarda, Andrea, Enea, Iolanda, Fabbri, Andrea, Maggioni, Aldo P., Pomero, Fulvio, Ruggeri, Maria Pia, Lucci, Donata, Vedovati, Maria Cristina, Duranti, Michele, Guercini, Francesco, Groff, Paolo, Verso, Melina, Fabbri, Gianna, Savoia, Martina, Baldini, Ester, Mecatti, Barbara Bartolomei, Bianchini, Francesca, Ceseri, Martina, Gonzini, Lucio, Gorini, Marco, Lorimer, Andrea, Orsini, Giampietro, Tricoli, Martina, Cimini, L.A., Becattini, C., Agnelli, G., Cesarini, V., Sanna, M., Pepe, G., Marchetti, C., Roldan, M. Olivan, Lenzi, L., Cozzio, S., Tomio, P., Diamanti, M., Beltrame, A., Glinski, L., Treleani, M., Coppa, A., Vanni, S., Bartalucci, P., Taccone, A., Costacurta, C., Bortolotti, P., Bortolussi, M., De Vecchi, M., Zanardi, F., Greco, I., Cosentini, R., Gerloni, R., Artusi, N., Cominotto, F., Sisto, U.G., Picariello, C., Roncon, L., Maddalozzo, A., Nitti, C., Riccomi, F., Buzzo, M., Bassanelli, G., Savonitto, S., Bianchi, A., Bilato, C., Lobascio, I., Dalla Valle, C., Pomata, D.P., Giostra, F., Tinuper, A.L., Zalunardo, B., Visonà, A., Panzavolta, C., Novelli, A., Bertini, A., Granai, C., Colombo, S., Periti, E., Bonacchini, L., Abrignani, M.G., Casciolo, M.F., D'Amato, A., Scardovi, A.B., Ricci, R., Iosi, S., Fontana, M.C., Marrazzo, A., Borselli, M., Di Fusco, S.A., Colivicchi, F., Enea, I., Triggiani, M., Papa, I., Pasini, G.F., Fioravanti, C., Panarello, S., Raggi, F., Marzolo, M., Cuppini, S., Milan, M., Barchetti, M., De Laura, D., Caldarola, P., Fiorini, R., Rastelli, G., Ameri, P., La Malfa, G., Cinelli, F., Sganzerla, P.C., Ubaldi, S., Sanchez, F.A., Forgione, C., Cuccia, C., Predieri, S., Fusco, S., Mumoli, N., Porta, C., Romei, M., Lucidi, M., Romaniello, A., Volpe, M., Mogni, P., Pizzolato, E., Martino, G.P., Bitti, G., Righini, G., Bandiera, G., Pennacchio, E., Limauro, S., Dachille, A., Ignone, G., Fuscaldo, G.F., De Rosa, F.M., Vazzana, N., Chesi, G., Di Filippo, F., Pierpaoli, L., Corapi, A., Vatrano, M., Angotti, C., Baccetti, F., Harari, S.A., Luisi, F., Daghini, E., De Curtis, E., Lucà, F., Ciancia, F., Blandizzi, S., Lettica, G.V., D'Orazio, S., Cosmi, F., Zaccaroni, S., Silingardi, M., Valeriano, V., Pugliese, F.R., Murgia, A.P., Parpaglia, P. Pinna, Martinelli, L., Caponi, C., Clemente, M.A., Ciccarone, A., Bongarzoni, A., Garagiola, M., Leone, M.C., Veropalumbo, M.R., Sacco, M., Morella, P., Dorigoni, S., Peterlana, D., Di Paola, R., Felis, S., Correale, M., Brunetti, N.D., Petrelli, G., Feliziani, F.T., Mastroiacovo, D., Romualdi, R., Pasin, F., Bonardi, S., Delfino, P., Scifo, C., Savioli, G., Ceresa, I.F., Galeotalanza, M., Benazzi, B., Porzio, M., Rosini, F., Ancona, C., Verrelli, C., Pasini, A. Fratta, Dalle Carbonare, L., Bozza, N., Nacci, F., Scarabelli, M.A., Amico, F., Marchesi, C., Mazzone, A., Di Tommaso, R., Cocco, F., Pezzuto, G., Luciani, A., Zamboni, P., Muriago, M., Del Pesce, L., Lucarini, A.R., Guglielmelli, E., Vannucchi, V., Moroni, F., Fichera, D., Malatino, L., Sgroi, C., Morana, I.M., Cicero, S., La Rosa, D., Mete, F., Gino, M., De Palma, A., Alessandri, M., Maestripieri, V., Battocchio, M., De Santis, M.T., Saladini, F., Corsi, D.C., Macarone Palmieri, N., Pierfranceschi, M. Giorgi, Palmonari, V., Fontanella, L., Airoldi, L., Bonocore, M., Paliani, U., Prat, L. Iogna, Chiecchi, L., Cuonzo, M., Paludo, A., Padula, D., Antonelli, A., Bicchi, M., Tota, G., Ariello, M., Sai, R., Civita, M., Tucci, M., Barbati, G., Conti, M., Cettina, R., Magnani, O., Levato, M., Gessi, V., De Rui, M., Bellizzi, A., Farneti, L., Salomone, P., Mannarini, A., Grifoni, E., Del Ghianda, S., Campodonico, J., De Cesare, N., Mutone, D., Pasoli, P., Meloni, S., Frenda, A., Viola, G., Torromeo, C., Campana, C., Pistone, M.C., Caravita, S., La Creta, C.P., Miscio, F., Loreno, M., Fenu, P., Mazzetti, M., Rossini, D., Brunacci, M., Capuano, A., Tagliamonte, G., Pinelli, M., Ballocca, F., Parca, G., Pasini, S.M., Maragno, M.G., Vecchi, F., Mancinelli, L., Cavalli, A., Di Mare, F., Conficoni, E., Miceli, R., Pecoraro, R., Fonti, C., Pegoraro, S., Piccinni, G.C., Caruso, G., Boriani, G., Lanzillotta, P., Piccolo, P., Calò, L., Stolfo, D., Mangiacapra, S., Marziali, A., Volponi, M.C., Querci, G., Terribile, R., Menabue, M., Fiorentini, A., Musci, R.L., Uras, S., Cicini, M.P., Manetti, S., Francese, G.M., Melchio, R., Scorpiglione, N., Carrara, D., Pani, A., Morisco, C., Rodolico, M., Colombo, Silvia, Vanni, Simone, Abrignani, Maurizio Giuseppe, Scardovi, Angela Beatrice, Marrazzo, Alessandra, Borselli, Matteo, Barchetti, Marco, and Maggioni, Aldo Pietro

Published
2024
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4. Divergent emotional and autonomic responses to Cyberball in patients with opioid use disorder on opioid agonist treatment

Author

Gerra, M, Ossola, P, Ardizzi, M, Martorana, S, Leoni, V, Riva, P, Preti, E, Marchesi, C, Gallese, V, De Panfilis, C, Gerra M. L., Ossola P., Ardizzi M., Martorana S., Leoni V., Riva P., Preti E., Marchesi C., Gallese V., De Panfilis C., Gerra, M, Ossola, P, Ardizzi, M, Martorana, S, Leoni, V, Riva, P, Preti, E, Marchesi, C, Gallese, V, De Panfilis, C, Gerra M. L., Ossola P., Ardizzi M., Martorana S., Leoni V., Riva P., Preti E., Marchesi C., Gallese V., and De Panfilis C.

Abstract

The perception of social exclusion among patients with opioid use disorder (OUD) could be affected by long-term opioid use. This study explores the emotional and cardiac autonomic responses to an experience of ostracism in a sample of participants with OUD on opioid agonist treatment (OAT).Twenty patients with OUD and twenty healthy controls (HC) performed a ball-tossing game (Cyberball) with two conditions: Inclusion and Ostracism. We measured self-reported ratings of perceived threat towards one's fundamental needs and respiratory sinus arrhythmia (RSA) immediately after the game and 10 min after Ostracism (Reflective stage).Following ostracism, participants with OUD self-reported blunted feelings of threat to the fundamental need to belong. RSA levels were significantly suppressed immediately after ostracism and during the Reflective stage in comparison with HC, indicating an autonomic alteration in response to threatening social situations. Finally, only among HC higher perceived threats towards fundamental needs predicted increases in RSA levels, suggesting an adaptive vagal regulation in response to a perceived threat. Conversely, among patients with OUD the subjective response to ostracism was not associated with the autonomic reaction.OAT may have a protective effect against negative feelings of ostracism. However patients with OUD on OAT present poor autonomic regulation in response to social threats, which could reflect their trait hypersensitivity to social rejection.

Published
2023

7. Disorganization and real-world functioning in schizophrenia: Results from the multicenter study of the Italian Network for Research on Psychoses

Author

Bracale, Nadja, Cardillo, Simona, Brasso, Claudio, Andriola, Ileana, Romano, Raffaella, Caforio, Grazia, Barlati, Stefano, Galluzzo, Alessandro, Deste, Giacomo, Pinna, Federica, Lostia di S. Sofia, Silvia, Lai, Alice, Signorelli, Maria Salvina, Corbo, Mariangela, Baroni, Gaia, Lupi, Matteo, Altamura, Mario, La Montagna, Maddalena, Malerba, Stefania, Murri, Martino Belvederi, Corso, Alessandro, Bugliani, Michele, Pizziconi, Giulia, Rossi, Rodolfo, Serrone, Dario, Giusti, Laura, Ussorio, Donatella, Salza, Anna, Merlotti, Eleonora, Piegari, Giuseppe, Patriarca, Sara, Pietrafesa, Daria, de Bartolomeis, Andrea, Gramaglia, Carla, Gattoni, Eleonora, Marangon, Debora, Grottaroli, Marika, Pigoni, Alessandro, Grassi, Silvia, Cremonese, Carla, Meneguzzo, Paolo, Collantoni, Enrico, Tonna, Matteo, Ossola, Paolo, Gerra, Maria Lidia, Gesi, Camilla, Cremone, IvanMirko, Carpita, Barbara, Brugnoli, Roberto, Comparelli, Anna, Corigliano, Valentina, Di Fabio, Fabio, Buzzanca, Antonio, Girardi, Nicoletta, Niolu, Cinzia, Di Lorenzo, Giorgio, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Diasco, Ferdinando, Fagiolini, Andrea, Bolognesi, Simone, Goracci, Arianna, Rocca, P., Galderisi, S., Rossi, A., Bertolino, A., Rucci, P., Gibertoni, D., Montemagni, C., Bellino, S., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Carpiniello, B., Cuomo, A., D'Ambrosio, E., dell'Osso, L., Girardi, P., Marchesi, C., Monteleone, P., Montemitro, C., Oldani, L., Pacitti, F., Roncone, R., Siracusano, A., Tenconi, E., Vita, A., Zeppegno, P., Steardo, L., Jr, Vignapiano, A., and Maj, M.

Published
2018
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18. Factors Associated With Real-Life Functioning in Persons With Schizophrenia in a 4-Year Follow-up Study of the Italian Network for Research on Psychoses

Author

Mucci, A., Galderisi, S., Gibertoni, D., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Blasi, G., Brasso, C., Bucci, P., Carpiniello, B., Cuomo, A., Dell'Osso, L., Giordano, G. M., Marchesi, C., Monteleone, P., Niolu, C., Oldani, L., Pettorruso, M., Pompili, M., Roncone, R., Rossi, R., Tenconi, E., Vita, A., Zeppegno, P., Maj, M., Piegari, G., Aiello, C., Brando, F., Giuliani, L., Palumbo, D., Coccia, C., Papalino, M., Calia, V., Romano, R., Barlati, S., Deste, G., Valsecchi, P., Pinna, F., Lai, A., Lostia di Santa Sofia, S., Salvina Signorelli, M., Fusar Poli, L., Surace, T., Martinotti, G., Montemitro, C., Fraticelli, S., Altamura, M., Angelini, E., Elia, A., Calcagno, P., Belvederi Murri, M., Cattedra, S., Pacitti, F., Talevi, D., Socci, V., Giusti, L., Salza, A., Mammarella, S., de Bartolomeis, A., Favaro, A., Collantoni, E., Meneguzzo, P., Tonna, M., Ossola, P., Gerra, M. L., Gramaglia, C., Binda, V., Gambaro, E., Carmassi, C., Carpita, B., Cremone, I. M., Corrivetti, G., Cascino, G., Del Buono, G., Brugnoli, R., Comparelli, A., Corigliano, V., Buzzanca, A., Gerardi, N., Frascarelli, M., Fagiolini, A., Goracci, A., Bolognesi, S., Siracusano, A., Di Lorenzo, G., Ribolsi, M., Montemagni, C., Riccardi, C., Del Favero, E., Mucci, A., Galderisi, S., Gibertoni, D., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Blasi, G., Brasso, C., Bucci, P., Carpiniello, B., Cuomo, A., Dell'Osso, L., Giordano, G. M., Marchesi, C., Monteleone, P., Niolu, C., Oldani, L., Pettorruso, M., Pompili, M., Roncone, R., Rossi, R., Tenconi, E., Vita, A., Zeppegno, P., Maj, M., Mucci A., Galderisi S., Gibertoni D., Rossi A., Rocca P., Bertolino A., Aguglia E., Amore M., Bellomo A., Biondi M., Blasi G., Brasso C., Bucci P., Carpiniello B., Cuomo A., Dell'Osso L., Giordano G.M., Marchesi C., Monteleone P., Niolu C., Oldani L., Pettorruso M., Pompili M., Roncone R., Rossi R., Tenconi E., Vita A., Zeppegno P., and Maj M.

Subjects
Adult, Hospitals, Psychiatric, Male, Mental Health Services, Social Cognition, Apathy, Psychological intervention, Relapse prevention, schizophrenia, functioning, psychopatology, Structural equation modeling, 03 medical and health sciences, 0302 clinical medicine, Medicine, Humans, Cognitive Dysfunction, Female, Follow-Up Studies, Independent Living, Italy, Middle Aged, Psychotic Disorders, Schizophrenia, Functional Status, Original Investigation, business.industry, Mental health, Hospitals, Cognitive training, 030227 psychiatry, Psychiatry and Mental health, Settore MED/25, schizophrenia, real-life functioning, SEM, Psychiatric, Work Skills, business, Psychosocial, 030217 neurology & neurosurgery, Psychopathology, Clinical psychology
Abstract

Importance: The goal of schizophrenia treatment has shifted from symptom reduction and relapse prevention to functional recovery; however, recovery rates remain low. Prospective identification of variables associated with real-life functioning domains is essential for personalized and integrated treatment programs. Objective: To assess whether baseline illness-related variables, personal resources, and context-related factors are associated with work skills, interpersonal relationships, and everyday life skills at 4-year follow-up. Design, Setting, and Participants: This multicenter prospective cohort study was conducted across 24 Italian university psychiatric clinics or mental health departments in which 921 patients enrolled in a cross-sectional study were contacted after 4 years for reassessment. Recruitment of community-dwelling, clinically stable persons with schizophrenia was conducted from March 2016 to December 2017, and data were analyzed from January to May 2020. Main Outcomes and Measures: Psychopathology, social and nonsocial cognition, functional capacity, personal resources, and context-related factors were assessed, with real-life functioning as the main outcome. Structural equation modeling, multiple regression analyses, and latent change score modeling were used to identify variables that were associated with real-life functioning domains at follow-up and with changes from baseline in these domains. Results: In total, 618 participants (427 male [69.1%]; mean [SD] age, 45.1 [10.5] years) were included. Five baseline variables were directly associated with real-life functioning at follow-up: neurocognition with everyday life (β, 0.274; 95% CI, 0.207-0.341; P

Published
2021

22. Peripersonal space plasticity in Schizophrenia: a motor training

Author

Magnani, F., primary, Ferroni, F., additional, Ferri, F., additional, Ardizzi, M., additional, Langiulli, N., additional, Giustozzi, F., additional, Rasmi, F., additional, Volpe, R., additional, Lucarini, V., additional, Marchesi, C., additional, Gallese, V., additional, and Tonna, M., additional

Published
2022
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23. International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis

Author

Huizen, A.M. van, Menting, S.P., Gyulai, R., Iversen, L., Kraaij, G.E. van der, Middelkamp-Hup, M.A., Warren, R.B., Spuls, P.I., Schejtman, A.A., Egeberg, A., Firooz, A., Kumar, Ashok, Oakley, A., Foulkes, A., Ramos, A.M.C., Fougerousse, A.C., Carija, A., Akman-Karakas, A., Horváth, B., Fábos, B., Matlock, B.H., Claréus, B.W., Castro, C., Ferrándiz, C., Correa, C.C., Marchesi, C., Goujon, C., Gonzalez, C., Maldonado-García, C., Hong, C.H., Griffiths, C.E., Vestergaard, C., Echeverría, C.M., Cruz, C., Conrad, C., Törocsik, D., Drvar, D.L., Balak, D., Jullien, D., Appelen, D., Kim, D.H., Jong, E de, Gamal, E. El, Laffitte, E., Mahé, E., Sonkoly, E., Colombo, E.P., Vilarrasa, E., Willaert, F., Novoa, F.D., Handjani, F., Valenzuela, F., Vílchez-Márquez, F., Gonzalez, G.O., Krisztián, G., Damiani, G., Krnjevic-Pezic, G., Pellerano, G., Carretero, G., Hunter, H.J.A., Riad, H., Oon, H.H., Boonen, H.P.J., Moussa, I.O., García-Doval, I., Csányi, I., Brajac, I., Turchin, I., Grozdev, I., Weinberg, J.M., Nicolopoulos, J., Wells, J., Lambert, J.L.W., Ingram, J.R., Prinz, J.C., Sittart, J.A. de Souza, Sanchez, J.L., Hsiao, J.P., Castro-Ayarza, J.R., Maul, J.T., Reek, J.M.P.A. van den, Trcko, K., Barber, K., Reich, K., Gebauer, K.A., Khobzei, K., Maul, L.V., Massari, L.P., Fardet, L., Cleach, L. le, Misery, L., Chandrashekar, L., Muresanu, L.I., Lecluse, L., Skov, L., Frez, M.L., Babic, L.T., Puig, L., Gomez, L.C., Seijger, M.M.B., Gulliver, W., Veldkamp, W.R., Huizen, A.M. van, Menting, S.P., Gyulai, R., Iversen, L., Kraaij, G.E. van der, Middelkamp-Hup, M.A., Warren, R.B., Spuls, P.I., Schejtman, A.A., Egeberg, A., Firooz, A., Kumar, Ashok, Oakley, A., Foulkes, A., Ramos, A.M.C., Fougerousse, A.C., Carija, A., Akman-Karakas, A., Horváth, B., Fábos, B., Matlock, B.H., Claréus, B.W., Castro, C., Ferrándiz, C., Correa, C.C., Marchesi, C., Goujon, C., Gonzalez, C., Maldonado-García, C., Hong, C.H., Griffiths, C.E., Vestergaard, C., Echeverría, C.M., Cruz, C., Conrad, C., Törocsik, D., Drvar, D.L., Balak, D., Jullien, D., Appelen, D., Kim, D.H., Jong, E de, Gamal, E. El, Laffitte, E., Mahé, E., Sonkoly, E., Colombo, E.P., Vilarrasa, E., Willaert, F., Novoa, F.D., Handjani, F., Valenzuela, F., Vílchez-Márquez, F., Gonzalez, G.O., Krisztián, G., Damiani, G., Krnjevic-Pezic, G., Pellerano, G., Carretero, G., Hunter, H.J.A., Riad, H., Oon, H.H., Boonen, H.P.J., Moussa, I.O., García-Doval, I., Csányi, I., Brajac, I., Turchin, I., Grozdev, I., Weinberg, J.M., Nicolopoulos, J., Wells, J., Lambert, J.L.W., Ingram, J.R., Prinz, J.C., Sittart, J.A. de Souza, Sanchez, J.L., Hsiao, J.P., Castro-Ayarza, J.R., Maul, J.T., Reek, J.M.P.A. van den, Trcko, K., Barber, K., Reich, K., Gebauer, K.A., Khobzei, K., Maul, L.V., Massari, L.P., Fardet, L., Cleach, L. le, Misery, L., Chandrashekar, L., Muresanu, L.I., Lecluse, L., Skov, L., Frez, M.L., Babic, L.T., Puig, L., Gomez, L.C., Seijger, M.M.B., Gulliver, W., and Veldkamp, W.R.

Abstract

Item does not contain fulltext, IMPORTANCE: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide. OBJECTIVE: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics. DESIGN, SETTING, AND PARTICIPANTS: Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience). MAIN OUTCOMES AND MEASURES: In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree. RESULTS: Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In

Published
2022

24. Availability of open data related to COVID-19 epidemic in Italy.

Author

Di Federico, S., Filippini, T., Marchesi, C., and Vinceti, M.

Subjects
COVID-19 pandemic, PUBLIC health, EPIDEMIOLOGY, PUBLIC opinion, MORTALITY
Abstract

Copyright of Annali di Igiene, Medicina Preventiva e di Comunità is the property of Societa Editrice Universo s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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27. Genome-wide association study detected novel susceptibility genes for social cognition impairment in people with schizophrenia

Author

Gennarelli, M., Monteleone, P., Minelli, A., Monteleone, A. M., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Bellino, S., Bellomo, A., Biondi, M., Bucci, P., Carpiniello, B., Cascino, G., Cuomo, A., Dell'Osso, L., di Giannantonio, M., Giordano, G. M., Marchesi, C., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Tenconi, E., Vita, A., Zeppegno, P., Galderisi, S., Maj, M., Corrivetti, G., Del Buono, G., Torretta, S., Calia, V., Raio, A., Barlati, S., Deste, G., Magri, C., Valsecchi, P., Pinna, F., Muscas, M., Marras, L., Piegari, G., Giuliani, L., Brando, F., Coccia, C., Concerto, C., Poli, L. F., Surace, T., Martinotti, G., Pettorruso, M., Fraticelli, S., Altamura, M., Pasquale Tortorelli, F. M., Mollica, A., Calcagno, P., Murri, M. B., Serafini, G., Pacitti, F., Socci, V., Lucaselli, A., Giusti, L., Mammarella, S., Bianchini, V., Gramaglia, C., Gambaro, E., Martelli, M., Favaro, A., Meneguzzo, P., Collantoni, E., Tonna, M., Ossola, P., Gerra, M. L., Carmassi, C., Carpita, B., Cremone, I. M., Comparelli, A., Brugnoli, R., Corigliano, V., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Ribolsi, M., Niolu, C., Bozzatello, P., Brasso, C., Montemagni, C., Buzzanca, A., Di Fabio, F., Girardi, N., Gennarelli, Massimo, Monteleone, Palmiero, Minelli, Alessandra, Monteleone, Alessio Maria, Rossi, Alessandro, Rocca, Paola, Bertolino, Alessandro, Aguglia, Eugenio, Amore, Mario, Bellino, Silvio, Bellomo, Antonello, Biondi, Massimo, Bucci, Paola, Carpiniello, Bernardo, Cascino, Giammarco, Cuomo, Alessandro, Dell'Osso, Liliana, di Giannantonio, Massimo, Giordano, Giulia Maria, Marchesi, Carlo, Oldani, Lucio, Pompili, Maurizio, Roncone, Rita, Rossi, Rodolfo, Siracusano, Alberto, Tenconi, Elena, Vita, Antonio, Zeppegno, Patrizia, Galderisi, Silvana, and Maj, Mario

Subjects
Treatment outcome, GWAS, Social cognition, TMEM74, meta-analysis, schizophrenia, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Membrane Proteins, Polymorphism, Single Nucleotide, Schizophrenia, Social Cognition, Susceptibility gene, Genome-wide association study, Biology, Affect (psychology), meta-analysi, 03 medical and health sciences, 0302 clinical medicine, medicine, SNP, Polymorphism, Biological Psychiatry, Genetics, Single Nucleotide, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Settore MED/25, Meta-analysis
Abstract

Objectives People with schizophrenia (SCZ) present serious and generalised deficits in social cognition (SC), which affect negatively patients' functioning and treatment outcomes. The genetic background of SC has been investigated in disorders other than SCZ providing weak and sparse results. Thus, our aim was to explore possible genetic correlates of SC dysfunctions in SCZ patients with a genome-wide study (GWAS) approach. Methods We performed a GWAS meta-analysis of data coming from two cohorts made of 242 and 160 SCZ patients, respectively. SC was assessed with different tools in order to cover its different domains. Results We found GWAS significant association between the TMEM74 gene and the patients' ability in social inference as assessed by The Awareness of Social Inference Test; this association was confirmed by both SNP-based analysis (lead SNP rs3019332 p-value = 5.24 × 10-9) and gene-based analysis (p-value = 1.09 × 10-7). Moreover, suggestive associations of other genes with different dimensions of SC were also found. Conclusions Our study shows for the first time GWAS significant or suggestive associations of some gene variants with SC domains in people with SCZ. These findings should stimulate further studies to characterise the genetic underpinning of SC dysfunctions in SCZ.

Published
2022

31. A different protein corona cloaks 'true-to-life' nanoplastics with respect to synthetic polystyrene nanobeads

Author

Paolo Bergese, Stefania Federici, Serena Ducoli, Marchesi C, Laura E. Depero, Lucia Paolini, Andrea Zendrini, Nicsanu R, and Annalisa Radeghieri

Subjects
Materials science, Biological systems, Mechanical fragmentation, Materials Science (miscellaneous), Nanoparticle, Protein Corona, Nanotechnology, Interface, Human health, chemistry.chemical_compound, chemistry, Human plasma, Protein corona, Polystyrene, Nanoplastics, Nanobeads, Biological systems, Interface, Protein corona, Nanoplastics, Fourier transform infrared spectroscopy, Nanobeads, True insight, General Environmental Science
Abstract

Given the complexity of separating nanoplastics from environmental samples, studies have usually been conducted using synthetic polystyrene nanobeads. By mechanical fragmentation in cryogenic conditions of daily-life plastic items, we produced “true-to-life” nanoplastics (T2LNPs), that promises to give a true insight into the interaction with biological systems. T2LNPs have been fully characterized by Fourier transform Infrared spectroscopy and by Atomic Force Microscopy. They result in populations of spheroidal nanoparticles with a broad multimodal size distribution. The mandatory need for a representative sample to evaluate the potential effects of nanoparticles on human health and the environment is demonstrated by the different protein corona identified on T2LNPs and synthetic polystyrene nanobeads upon incubation with human plasma.

Published
2022

34. Prevalence of antipsychotic-induced extrapyramidal symptoms and their association with neurocognition and social cognition in outpatients with schizophrenia in the 'real-life'

Author

Monteleone, P., Cascino, G., Monteleone, A. M., Rocca, P., Rossi, A., Bertolino, A., Aguglia, E., Amore, M., Collantoni, E., Corrivetti, G., Cuomo, A., Bellomo, A., D'Ambrosio, E., Dell'Osso, L., Frascarelli, M., Giordano, G. M., Giuliani, L., Marchesi, C., Montemagni, C., Oldani, L., Pinna, F., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Galderisi, S., Maj, M., Del Buono, G., Marciello, F., Di Palo, P., Sangiuliano, M., Di Gioia, C., Barlati, S., Deste, G., Turrina, C., Carpiniello, B., Marras, L., Muscas, M., Bucci, P., Piegari, G., Brando, F., Aiello, C., Poli, L. F., Saitta, G., Surace, T., Altamura, M., Malerba, S., Padalino, F., Calcagno, P., Murri, M. B., Escelsior, A., Giusti, L., Bianchini, V., Salza, A., Pacitti, F., Socci, V., Lucaselli, A., De Bartolomeis, A., Gramaglia, C., Feggi, A., Jona, A., Favaro, A., Tenconi, E., Meneguzzo, P., Ossola, P., Tonna, M., Gerra, M. L., Carmassi, C., Cremone, I. M., Carpita, B., Biondi, M., Di Fabio, F., Accinni, T., Brugnoli, R., Comparelli, A., Corigliano, V., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Ribolsi, M., Niolu, C., Brasso, C., Riccardi, C., Del Favero, E., Monteleone, P., Cascino, G., Monteleone, A. M., Rocca, P., Rossi, A., Bertolino, A., Aguglia, E., Amore, M., Collantoni, E., Corrivetti, G., Cuomo, A., Bellomo, A., D'Ambrosio, E., Dell'Osso, L., Frascarelli, M., Giordano, G. M., Giuliani, L., Marchesi, C., Montemagni, C., Oldani, L., Pinna, F., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Galderisi, S., and Maj, M.

Subjects
Adult, Male, Social Cognition, Extrapyramidal symptoms, Chlorpromazine, medicine.medical_treatment, Antipsychotic, 03 medical and health sciences, 0302 clinical medicine, Cognition, Basal Ganglia Diseases, Social cognition, Prevalence, Medicine, Antipsychotics, Humans, Extrapyramidal symptom, Neurocognition, Biological Psychiatry, Pharmacology, business.industry, Parkinsonism, Middle Aged, medicine.disease, Risperidone, 030227 psychiatry, Settore MED/25, Schizophrenia, Female, Schizophrenic Psychology, medicine.symptom, business, Neurocognitive, Antipsychotic Agents, Psychopathology, Clinical psychology
Abstract

First generation antipsychotics (FGAs) are more likely to induce extrapyramidal side-effects (EPS) than second generation antipsychotics (SGAs), and EPS have been shown associated to cognitive deficits in schizophrenia. So far, no study has explored the relationships between EPS and social cognition (SC) in people with schizophrenia. Therefore, we assessed the prevalence of EPS in a large sample of drug-treated community-dwelling persons with schizophrenia and explored their relationships with patients' neurocognitive and SC abilities. 875 patients underwent EPS, psychopathological, neurocognitive and SC assessments by means of standardized measures. Relationships between EPS, psychopathology and neurocognitive and SC measures were investigated by correlation tests. Moreover, a partial correlation network was computed by means of a network analysis. 256 patients were treated with FGAs alone or in combination with SGA and 619 with SGAs. EPS were significantly more frequent in FGA-treated group than in the SGA-treated one. Patients with EPS disclosed a more severe psychopathology and were more impaired in neurocognitive and SC measures compared to those without EPS. Disorganization, expressive deficit, and duration of illness were significantly associated to both neurocognitive and SC measures while EPS were associated to neurocognitive measures only. The network analysis showed that parkinsonism was the sole EPS directly connected to both psychopathological and neurocognitive indices whereas no direct connection emerged between EPS and SC measures. Present findings confirm that EPS are still present in the era of SGAs and contribute, together with other clinical variables, to the neurocognitive but not to the SC impairment of patients with schizophrenia.

Published
2021

38. The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study

Author

Vita, A., Barlati, S., Deste, G., Rocca, P., Rossi, A., Bertolino, A., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Carpiniello, B., Collantoni, E., Cuomo, A., D'Ambrosio, E., dell' Osso, L., di Giannantonio, M., Giordano, G. M., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Zeppegno, P., Nibbio, G., Galderisi, S., Maj, M., Ceraso, A., Galluzzo, A., Lisoni, J., Di Palo, P., Papalino, M., Romano, R., Pinna, F., Lai, A., di Santa Sofia, S. L., Bucci, P., Piegari, G., Brando, F., Giuliani, L., Signorelli, M. S., Poli, L. F., Martinotti, G., Pettorruso, M., Montemitro, C., Altamura, M., Malerba, S., Padalino, F., Amerio, A., Cal-Cagno, P., Zampogna, D., Giusti, L., Salza, A., Mammarella, S., Pacitti, F., Socci, V., Talevi, D., Gramaglia, C., Feggi, A., Jona, A., Favaro, A., Tenconi, E., Meneguzzo, P., Ossola, P., Tonna, M., Gerra, M. L., Carmassi, C., Gesi, C., Carpita, B., Corrivetti, G., Cascino, G., del Buono, G., Di Fabio, F., Buzzanca, A., Girardi, N., Brugnoli, R., Comparelli, A., Corigliano, V., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Niolu, C., Ribolsi, M., Brasso, C., Riccardi, C., Del Favero, E., Vita, A., Barlati, S., Deste, G., Rocca, P., Rossi, A., Bertolino, A., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Carpiniello, B., Collantoni, E., Cuomo, A., D'Ambrosio, E., dell' Osso, L., di Giannantonio, M., Giordano, G. M., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Zeppegno, P., Nibbio, G., Galderisi, S., Maj, M., Ceraso, A., Galluzzo, A., Lisoni, J., Di Palo, P., Papalino, M., Romano, R., Pinna, F., Lai, A., di Santa Sofia, S. L., Bucci, P., Piegari, G., Brando, F., Giuliani, L., Signorelli, M. S., Poli, L. F., Martinotti, G., Pettorruso, M., Montemitro, C., Altamura, M., Malerba, S., Padalino, F., Amerio, A., Cal-Cagno, P., Zampogna, D., Giusti, L., Salza, A., Mammarella, S., Pacitti, F., Socci, V., Talevi, D., Gramaglia, C., Feggi, A., Jona, A., Favaro, A., Tenconi, E., Meneguzzo, P., Ossola, P., Tonna, M., Gerra, M. L., Carmassi, C., Gesi, C., Carpita, B., Corrivetti, G., Cascino, G., del Buono, G., Di Fabio, F., Buzzanca, A., Girardi, N., Brugnoli, R., Comparelli, A., Corigliano, V., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Niolu, C., Ribolsi, M., Brasso, C., Riccardi, C., and Del Favero, E.

Subjects
schizophrenia, autism spectrum disorders, cognition, psychosocial functioning, social cognition, Adult, Male, Social Cognition, Interpersonal Relation, autism spectrum disorders, cognition, psychosocial functioning, schizophrenia, social cognition, Disease, Autism spectrum disorders, Cognition, Psychosocial functioning, Schizophrenia, Social cognition, Psychotic Disorder, behavioral disciplines and activities, 03 medical and health sciences, Interpersonal relationship, 0302 clinical medicine, mental disorders, Medicine, Humans, Interpersonal Relations, Autism spectrum disorder, Autistic Disorder, business.industry, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Multicenter study, Settore MED/25, Italy, Psychotic Disorders, Autism, Female, Verbal memory, business, 030217 neurology & neurosurgery, Research Article, Clinical psychology, Human
Abstract

Background Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs), although conceptualized as separate entities, may share some clinical and neurobiological features. ASD symptoms may have a relevant role in determining a more severe clinical presentation of schizophrenic disorder but their relationships with cognitive aspects and functional outcomes of the disease remain to be addressed in large samples of individuals. Aims To investigate the clinical, cognitive, and functional correlates of ASD symptoms in a large sample of people diagnosed with schizophrenia. Methods The severity of ASD symptoms was measured with the PANSS Autism Severity Scale (PAUSS) in 921 individuals recruited for the Italian Network for Research on Psychoses multicenter study. Based on the PAUSS scores, three groups of subjects were compared on a wide array of cognitive and functional measures. Results Subjects with more severe ASD symptoms showed a poorer performance in the processing speed (p = 0.010), attention (p = 0.011), verbal memory (p = 0.035), and social cognition (p = 0.001) domains, and an overall lower global cognitive composite score (p = 0.010). Subjects with more severe ASD symptoms also showed poorer functional capacity (p = 0.004), real-world interpersonal relationships (p p Conclusions These findings strengthen the notion that ASD symptoms may have a relevant impact on different aspects of the disease, crucial to the life of people with schizophrenia. Prominent ASD symptoms may characterize a specific subpopulation of individuals with SSD.

Published
2020

39. The association between insight and depressive symptoms in schizophrenia: Undirected and Bayesian network analyses

Author

Amore, M., Murri, M. B., Calcagno, P., Rocca, P., Rossi, A., Aguglia, E., Bellomo, A., Blasi, G., Carpiniello, B., Cuomo, A., Dell'Osso, L., Di Giannantonio, M., Giordano, G. M., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Corso, A., Arzani, C., Galderisi, S., Maj, M., Petrilli, G., Respino, M., Papalino, M., Falsetti, A., Calia, V. M., Barlati, S., Deste, G., Turrina, C., Pinna, F., Lai, A., Di Santa Sofia, S. L., Signorelli, M. S., Petralia, A., Pettorruso, M., Barone, G., Salone, A., Piegari, G., Aiello, C., Brando, F., Giuliani, L., Altamura, M., Carnevale, R., Padalino, F., Giusti, L., Salza, A., Ussorio, D., Pizziconi, G., Santarelli, V., Pacitti, F., De Bartolomeis, A., Gambaro, E., Gattoni, E., Gramaglia, C., De Panfilis, C., Ossola, P., Tonna, M., Carmassi, C., Carpita, B., Cremone, I., Comparelli, A., Corigliano, V., Brugnoli, R., Corrivetti, G., Cascino, G., Del Buono, G., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Niolu, C., Ribolsi, M., Bellino, S., Bozzatello, P., Brasso, C., Amore, M., Murri, M. B., Calcagno, P., Rocca, P., Rossi, A., Aguglia, E., Bellomo, A., Blasi, G., Carpiniello, B., Cuomo, A., Dell'Osso, L., di Giannantonio, M., Giordano, G. M., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Corso, A., Arzani, C., Galderisi, S., and Maj, M.

Subjects
Adult, Male, media_common.quotation_subject, Social Stigma, Hostility, NO, Suicidal Ideation, Extrapyramidal symptoms, Demoralization, depression, insight, sadness, schizophrenia, self-esteem, Sadness, Self-esteem, medicine, Humans, Suicidal ideation, media_common, Depression, Insight, Schizophrenia, Bayes Theorem, Cross-Sectional Studies, Diagnostic and Statistical Manual of Mental Disorders, Female, Middle Aged, Self Concept, Social Class, Guilt, Schizophrenic Psychology, Positive and Negative Syndrome Scale, Sadne, medicine.disease, Psychiatry and Mental health, Settore MED/25, medicine.symptom, Psychology, Neurocognitive, Research Article, Clinical psychology, Diagnosis of schizophrenia
Abstract

Background. Greater levels of insight may be linked with depressive symptoms among patients with schizophrenia, however, it would be useful to characterize this association at symptom-level, in order to inform research on interventions. Methods. Data on depressive symptoms (Calgary Depression Scale for Schizophrenia) and insight (G12 item from the Positive and Negative Syndrome Scale) were obtained from 921 community-dwelling, clinically-stable individuals with a DSM-IV diagnosis of schizophrenia, recruited in a nationwide multicenter study. Network analysis was used to explore the most relevant connections between insight and depressive symptoms, including potential confounders in the model (neurocognitive and social-cognitive functioning, positive, negative and disorganization symptoms, extrapyramidal symptoms, hostility, internalized stigma, and perceived discrimination). Bayesian network analysis was used to estimate a directed acyclic graph (DAG) while investigating the most likely direction of the putative causal association between insight and depression. Results. After adjusting for confounders, better levels of insight were associated with greater self-depreciation, pathological guilt, morning depression and suicidal ideation. No difference in global network structure was detected for socioeconomic status, service engagement or illness severity. The DAG confirmed the presence of an association between greater insight and self-depreciation, suggesting the more probable causal direction was from insight to depressive symptoms. Conclusions. In schizophrenia, better levels of insight may cause self-depreciation and, possibly, other depressive symptoms. Person-centered and narrative psychotherapeutic approaches may be particularly fit to improve patient insight without dampening self-esteem., Highlights Better insight seems associated with depressive symptoms in schizophrenia.Network analyses were used to explore this association in a large sample.Insight was associated with self-depreciation, guilt, and suicidal ideation.Although cross-sectional, data suggest causal direction from insight to depression.

Published
2020

41. Is overwork weakness relevant in Charcot–Marie–Tooth disease?

Author

Piscosquito, G, Reilly, M M, Schenone, A, Fabrizi, G M, Cavallaro, T, Santoro, L, Vita, G, Quattrone, A, Padua, L, Gemignani, F, Visioli, F, Laurà, M, Calabrese, D, Hughes, R A C, Radice, D, Solari, A, Pareyson, D, Marchesi, C, Salsano, E, Nanetti, L, Marelli, C, Scaioli, V, Ciano, C, Rimoldi, M, Lauria, G, Rizzetto, E, Camozzi, F, Narciso, E, Grandis, M, Monti-Bragadin, M, Nobbio, L, Casano, A, Bertolasi, L, Cabrini, I, Corrà, K, Rizzuto, N, Manganelli, F, Pisciotta, C, Nolano, M, Mazzeo, A, Di Leo, R, Majorana, G, Russo, M, Valentino, P, Nisticò, R, Pirritano, D, Lucisano, A, Canino, M, Pazzaglia, C, Granata, G, Foschini, M, Brindani, F, Vitetta, F, Allegri, I, Bogani, P, Blake, J, Koltzenburg, M, Hutton, E, and Lunn, M

Published
2014
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42. Manejo sustentable del arroz resistente a las imidazolinonas

Author

SALDAIN, N.E., MARCHESI, C., ROSAS, J.E., PEREIRA, A.L., SARAVIA, H., and MESONES, B. (Ed.).

Subjects
IMIDAZOLINONAS, CONTROL DE MALEZAS, IMAZAPIR, ARROZ, IMAZAPiC
Abstract

En la siguiente publicación se consolida el conocimiento generado en el marco de la ejecución de varios proyectos relacionados con la utilización de los arrocesresistentes a las imidazolinonas, más la experiencia de campo obtenida por los usuarios y las medidas de cuidado de la tecnología recomendada por la empresaBASF. El objetivo de esta publicación es exponer lo aprendido respecto a esta tecnología y ahondar en la elaboración de pautas claras para promover un manejo sustentable de la misma.

Published
2021

43. Sodium and potassium content of foods consumed in an italian population and the impact of adherence to a mediterranean diet on their intake

Author

Malavolti, M. Naska, A. Fairweather-Tait, S.J. Malagoli, C. Vescovi, L. Marchesi, C. Vinceti, M. Filippini, T.

Abstract

High sodium and low potassium intakes are associated with increased levels of blood pressure and risk of cardiovascular diseases. Assessment of habitual dietary habits are helpful to evaluate their intake and adherence to healthy dietary recommendations. In this study, we determined sodium and potassium food-specific content and intake in a Northern Italy community, focusing on the role and contribution of adherence to Mediterranean diet patterns. We collected a total of 908 food samples and measured sodium and potassium content using inductively coupled plasma mass spectrometry. Using a validated semi-quantitative food frequency questionnaire, we assessed habitual dietary intake of 719 adult individuals of the Emilia-Romagna region. We then estimated sodium and potassium daily intake for each food based on their relative contribution to the overall diet, and their link to Mediterranean diet patterns. The estimated mean sodium intake was 2.15 g/day, while potassium mean intake was 3.37 g/day. The foods contributing most to sodium intake were cereals (33.2%), meat products (24.5%, especially processed meat), and dairy products (13.6%), and for potassium they were meat (17.1%, especially red and white meat), fresh fruits (15.7%), and vegetables (15.1%). Adherence to a Mediterranean diet had little influence on sodium intake, whereas potassium intake was greatly increased in subjects with higher scores, resulting in a lower sodium/potassium ratio. Although we may have underestimated dietary sodium intake by not including discretionary salt use and there may be some degree of exposure misclassification as a result of changes in food sodium content and dietary habits over time, our study provides an overview of the contribution of a wide range of foods to the sodium and potassium intake in a Northern Italy community and of the impact of a Mediterranean diet on intake. The mean sodium intake was above the dietary recommendations for adults of 1.5–2 g/day, whilst potassium intake was only slightly lower than the recommended 3.5 g/day. Our findings suggest that higher adherence to Mediterranean diet patterns has limited effect on restricting sodium intake, but may facilitate a higher potassium intake, thereby aiding the achievement of healthy dietary recommendations. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Published
2021

46. Native copper formation associated with serpentinization in the Cheshmeh-Bid ophiolite massif (Southern Iran)

Author

Eslami, A, Malvoisin, B, Grieco, G, Aradi, L, Marchesi, C, Cavallo, A, Montanini, A, Borghini, G, Mathur, R, Ikehata, K, Davis, D, Li, C, Szabó, C, Eslami, Alireza, Malvoisin, Benjamin, Grieco, Giovanni, Aradi, László Előd, Marchesi, Claudio, Cavallo, Alessandro, Montanini, Alessandra, Borghini, Giulio, Mathur, Ryan, Ikehata, Kei, Davis, Donald W., Li, Chun-Hui, Szabó, Csaba, Eslami, A, Malvoisin, B, Grieco, G, Aradi, L, Marchesi, C, Cavallo, A, Montanini, A, Borghini, G, Mathur, R, Ikehata, K, Davis, D, Li, C, Szabó, C, Eslami, Alireza, Malvoisin, Benjamin, Grieco, Giovanni, Aradi, László Előd, Marchesi, Claudio, Cavallo, Alessandro, Montanini, Alessandra, Borghini, Giulio, Mathur, Ryan, Ikehata, Kei, Davis, Donald W., Li, Chun-Hui, and Szabó, Csaba

Abstract

In the Cheshmeh-Bid district of the Khajeh-Jamali ophiolitic massifs (Southern Iran), mantle peridotites are intruded by abundant pyroxenite dykes. A few of these dykes are remarkable for the occurrence of native copper associated with the development of a metasomatic reaction zone. The dykes are progressively reacted, from their margins towards the center, with an amphibole + antigorite selvage, followed by a centimeter-thick clinopyroxene + antigorite assemblage and, finally, by the native copper-bearing zone consisting of clinopyroxene + chlorite + antigorite. Native Cu occurs along cleavages and partially healed fractures in clinopyroxene, and as massive grains intergrown with antigorite. Copper isotope signatures and thermodynamic calculations show that the main driver for reaction zone formation is Ca-metasomatism. Native copper forms at the expense of chalcocite in the reaction zone. Such a reaction can only occur in reducing conditions, in agreement with the analysis of fluid inclusions composition displaying H2 and CH4. Such fluids presumably originated from the hydration of mantle rocks. The observed reaction zone and native copper mineralization are thus interpreted as the result of Ca-metasomatism during hydrothermal alteration of the oceanic lithosphere. This is consistent with U/Pb dating of titanite, suggesting formation during the Albian when the dykes were exposed on the seafloor in a supra-subduction setting. The source for copper mineralization, as revealed by Cu isotopes, is probably mantle-like.

Published
2021

47. Autonomic vulnerability to biased perception of social inclusion in borderline personality disorder

Author

Gerra, M, Ardizzi, M, Martorana, S, Leoni, V, Riva, P, Preti, E, Marino, B, Ossola, P, Marchesi, C, Gallese, V, De Panfilis, C, Gerra, ML., Marino, BFM, De Panfilis, C., Gerra, M, Ardizzi, M, Martorana, S, Leoni, V, Riva, P, Preti, E, Marino, B, Ossola, P, Marchesi, C, Gallese, V, De Panfilis, C, Gerra, ML., Marino, BFM, and De Panfilis, C.

Abstract

Background: Individuals with Borderline Personality Disorder (BPD) feel rejected even when socially included. The pathophysiological mechanisms of this rejection bias are still unknown. Using the Cyberball paradigm, we investigated whether patients with BPD, display altered physiological responses to social inclusion and ostracism, as assessed by changes in Respiratory Sinus Arrhythmia (RSA). Methods: The sample comprised 30 patients with BPD, 30 with remitted Major Depressive Disorder (rMDD) and 30 Healthy Controls (HC). Self-report ratings of threats toward one’s fundamental need to belong and RSA reactivity were measured immediately after each Cyberball condition. Results: Participants with BPD showed lower RSA at rest than HC. Only patients with BPD, reported higher threats to fundamental needs and exhibited a further decline in RSA after the Inclusion condition. Conclusions: Individuals with BPD experience a biased appraisal of social inclusion both at the subjective and physiological level, showing higher feelings of ostracism and a breakdown of autonomic regulation to including social scenarios.

Published
2021

48. Application of DNA mini-barcoding and infrared spectroscopy for the authentication of the Italian product 'Bottarga'

Author

Frigerio, J, Marchesi, C, Magoni, C, Saliu, F, Ballabio, D, Consonni, V, Gorini, T, DE MATTIA, F, Galli, P, Labra, M, Jessica Frigerio, Claudio Marchesi, Chiara Magoni, Francesco Saliu, Davide Ballabio, Viviana Consonni, Tommaso Gorini, Fabrizio De Mattia, Paolo Galli, Massimo Labra, Frigerio, J, Marchesi, C, Magoni, C, Saliu, F, Ballabio, D, Consonni, V, Gorini, T, DE MATTIA, F, Galli, P, Labra, M, Jessica Frigerio, Claudio Marchesi, Chiara Magoni, Francesco Saliu, Davide Ballabio, Viviana Consonni, Tommaso Gorini, Fabrizio De Mattia, Paolo Galli, and Massimo Labra

Abstract

Tuna “Bottarga” is an artisanal food speciality prepared from the roe of Bluefin Tuna (Thunnus thynnus). Due to the recent restriction of Tuna catches fixed by EU, cheaper substitutes from yellowfin tuna (Thunnus albacares) are currently available in the mass distribution. Since the product is sold sliced or grated, morphological distinctive features may be lost, and fraudulent substitution is possible. In this study we tested DNA mini-barcoding and infrared spectroscopy as tools to trace its authenticity. A certified chemical standard, fresh (n = 4) and processed (n = 11) ovarian identified by the morphological observation of the tuna catches, commercial bottargasamples (n = 5) and artificial aged aliquots of all these samples (n = 50) were used in the experiments. The results showed that infrared spectroscopy failed in the taxonomic distinction, whereas enabled PLS-DA classification of aged samples (and thus the identification of fresh prepared artisanal products) with model non-error rate in fitting equal to 0.96, and 0.89 in cross-validation. Conversely, DNA mini-barcoding with mtDNA control region, success in species identification (100% maximum identity by the standard comparison BLAST approach against GenBank), regardless the processing state of the product.

Published
2021

49. Assessment of integrated aerosol sampling techniques in indoor, confined and outdoor environments characterized by specific emission sources

Author

Borgese, L., Chiesa, Maria, Assi, A., Marchesi, C., Mutahi, A. W., Kasemi, F., Federici, S., Finco, Angelo, Gerosa, Giacomo Alessandro, Zappa, D., Comini, E., Carnevale, C., Volta, M., Placidi, D., Lucchini, R., Bontempi, E., Depero, L. E., Chiesa M. (ORCID:0000-0002-5636-4212), Finco A. (ORCID:0000-0002-2252-5129), Gerosa G. (ORCID:0000-0002-5352-3222), Borgese, L., Chiesa, Maria, Assi, A., Marchesi, C., Mutahi, A. W., Kasemi, F., Federici, S., Finco, Angelo, Gerosa, Giacomo Alessandro, Zappa, D., Comini, E., Carnevale, C., Volta, M., Placidi, D., Lucchini, R., Bontempi, E., Depero, L. E., Chiesa M. (ORCID:0000-0002-5636-4212), Finco A. (ORCID:0000-0002-2252-5129), and Gerosa G. (ORCID:0000-0002-5352-3222)

Abstract

This paper highlights advantages and drawbacks due to the use of portable and low-cost devices for aerosol sampling, showing their performances during an aerosol monitoring campaign with the parallel use of the gravimetric sampling reference method and a cascade impactor. A specific monitoring campaign was held running all instruments in parallel in indoor, confined, and outdoor environments characterized by local emission sources or particulate matter background concentra-tions. PM2.5 concentrations were used to compare data emerging from the different instruments adopted. Significant underestimation of PM2.5 emerged when comparing data coming from optical sensors with those estimated by the cascade impactor, whose data resulted in being coherent with gravimetric determination, integrated over the same sampling time. A cause–effect relationship between PM2.5 concentrations and specific emission sources was found when observing the daily patterns of all the real-time sampling devices. It emerged that optical devices are useful for detecting concentration trends, the presence of peak values, or changes in the background value, even if with limited accuracy and precision. The comparison with particle size distributions obtained by the cascade impactor data allowed us to define which particle sizes are not detected by different optical devices, evidencing a low representativeness of optical low-cost sensors for health exposure measurements. The correlations among the specific particle size fractions detected by the cascade im-pactor and their specific emission sources were particularly high for car emissions in a semi-confined garage area.

Published
2021

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