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Your search keyword '"Massimiliano Pietro"' showing total 24 results
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24 results on '"Massimiliano Pietro"'

2. The utility of P53 immunohistochemistry in the diagnosis of Barrett's oesophagus with indefinite for dysplasia

Author

Wladyslaw Januszewicz, Nastazja D Pilonis, Tarek Sawas, Richard Phillips, Maria O'Donovan, Ahmad Miremadi, Shalini Malhotra, Monika Tripathi, Adrienn Blasko, David A Katzka, Rebecca C Fitzgerald, and Massimiliano Pietro

Subjects
Barrett Esophagus, Histology, Hyperplasia, Esophageal Neoplasms, Disease Progression, Humans, General Medicine, Tumor Suppressor Protein p53, Immunohistochemistry, Precancerous Conditions, Pathology and Forensic Medicine
Abstract

Barrett's oesophagus with indefinite for dysplasia (BE-IND) is a subjective diagnosis with a low interobserver agreement (IOA) among pathologists and uncertain clinical implications. This study aimed to assess the utility of p53 immunohistochemistry (p53-IHC) in assessing BE-IND specimens.Archive endoscopic biopsies with a BE-IND diagnosis from two academic centres were analysed. First, haematoxylin and eosin-stained slides (HE) were reviewed by four expert gastrointestinal (GI) pathologists allocated into two groups (A and B). After a washout period of at least 8 weeks, HE slides were reassessed side-to-side with p53-IHC available. We compared the rate of changed diagnosis and the IOA for all BE grades before and after p53-IHC. We included 216 BE-IND specimens from 185 patients, 44.0 and 32.9% of which were confirmed after HE slide revision by groups A and B, respectively. More than half the cases were reclassified to a non-dysplastic BE (NDBE), while 5.6% of cases in group A and 7.4% in group B were reclassified to definite dysplasia. The IOA for NDBE, BE-IND, low-grade dysplasia (LGD) and high-grade dysplasia (HGD)/intramucosal cancer (IMC) was 0.31, 0.21, -0.03 and -0.02, respectively. Use of p53-IHC led to a40% reduction in BE-IND diagnoses (P 0.001) and increased IOA for all BE grades [κ = 0.46 (NDBE), 0.26 (BE-IND), 0.49 (LGD), 0.35 (HGD/IMC)]. An aberrant p53-IHC pattern significantly increased the likelihood of reclassifying BE-IND to definite dysplasia (odds ratio = 44.3, 95% confidence interval = 18.8-113.0).P53-IHC reduces the rate of BE-IND diagnoses and improves the IOA among pathologists when reporting BE with equivocal epithelial changes.

Published
2022

4. Micro product and process fingerprints for zero-defect net-shape micromanufacturing

Author

Guido, Tosello, Mert, Gulcur, Ben, Whiteside, Phil, Coates, Antonio, Luca, Pablo Vinícius de Sousa Lia Fook, Oltmann, Riemer, Igor, Danilov, Matin Yahyavi Zanjani, Matthias, Hackert‐oschätzchen, Andreas, Schubert, Baruffi, Federico, Soufian Ben Achour, Matteo, Calaon, Chris Valentin Nielsen, Giuliano, Bissacco, Anette, Rasmussen, Mattia, Bellotti, Krishna, Saxena, Jun, Qian, Dominiek, Reynaerts, Teguh, Santoso, Syam, WAHYUDIN PERMANA, Richard, Leach, Kuriakose, Sandeep, Parenti, Paolo, Annoni, MASSIMILIANO PIETRO GIOVANNI, Yukui, Cai, Xichun, Luo, Qin, Yi, and Henning, Zeidler

Subjects
Micro and nano manufacturing process chains, Micro production quality assurance, Process monitoring and control, Micro and nano metrology
Published
2019

7. Green-state micromilling of AISI316L feedstock

Author

Parenti, Paolo, Kuriakose, Sandeep, Mussi, Valerio, Strano, Matteo, and Annoni, MASSIMILIANO PIETRO GIOVANNI

Subjects
powder metallurgy, surface quality, AISI 316L feedstock, micromilling, process chain, powder metallurgy, surface quality, AISI 316L feedstock, micromilling, process chain
Published
2017

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