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Dyslipidemia due to genetic and multifactorial dyslipidemia has a predisposition to early-onset atherosclerotic cardiovascular disease (ASCVD), and consensus and guidelines regarding lipid lowering in adults are well established, but the benefits of lipid screening and treatment in childhood and adolescence for this population are not well established. The United States Preventive Medicine Task Force (USPSTF) issued the Recommendation Statement: Screening for Dyslipidemia in Children and Adolescents based on a systematic review of evidence with meta-analysis conducted in a large number of randomized controlled trials, large cohort studies in European and American countries, with the aim of assessing evidences whether initiation of lipid screening and early initiation of treatment in childhood and adolescence has long-term benefits for this population. This article provides a detailed interpretation of the guideline, which aims to provide reference to clinical healthcare workers to improve the understanding of dyslipidaemia in children and to decide whether to screen them with a view to reducing the incidence of cardiovascular disease in adulthood.

In order to study the effect of heat treatment in air on the hydrogen permeation in/through Pd membrane, Pd membrane was deposited via the electroless plating method and the hydrogen permeation flux of Pd membrane before and after heat treatment in air at 573 K was measured. The membranes were characterized by XRD, SEM, AFM and hydrogen permeation tests. The results show that Pd membrane is compact and defect-free and has a thickness of 5 μm. The hydrogen permeability of Pd membrane at 673 K, 723 K and 773 K are 3.62×10-9, 5.12×10-9 mol/(m·s·Pa0.5) and 6.80×10-9 mol/(m·s·Pa0.5), respectively. The membrane treated in air at 573 K has higher surface roughness, larger surface area and more dissociation adsorption sites than the as-deposited membrane, thus improving the hydrogen permeability of the Pd membrane. After heat treatment, the hydrogen permeability of Pd membrane at 673, 723 K and 773 K are 5.32×10-9, 6.44×10-9 mol/(m·s·Pa0.5) and 7.31×10-9 mol/(m·s·Pa0.5), respectively. The hydrogen permeability of such Pd membrane is 1.1-1.5 times higher than that of the as-deposited one.

By connecting the consumption and demand of the city and the countryside through the use of e-commerce platforms and logistics as an intermediary bridge, this study creates a model for the synergistic growth of rural e-commerce and logistics. A multi-dimensional index system is created by combining the actual state of rural e-commerce and logistics, using Shaanxi Province as an example. The degree of coordination between logistics and e-commerce can be ascertained by applying the coupling coordination model. Determine the weights of the indicators to solve for the level of coordinated development, the degree of linked coordination, the degree of rural e-commerce and logistics coupling, and the coordination level of each year using the entropy value technique. Together with the gray correlation degree, we will examine the crucial elements of optimizing the logistics chain for rural e-commerce. According to the study, rural e-commerce and logistics have a coupling coordination degree of 0.0913 in 2010 and 0.6347 in 2019. The degree of coupling coordination between the two is increasing, indicating a major coordination degree in 2019.

The ability to selectively target disease-related tissues with molecules is critical to the design of effective therapeutic and diagnostic reagents. Recognizing the differences between the in vivo environment and in vitro conditions, we employed an in vivo selection strategy to identify RNA aptamers (targeting motifs) that could localize to tumor in situ. One of the selected molecules is an aptamer that binds to the protein DHX9, an RNA helicase that is known to be upregulated in colorectal cancer. Upon systemic administration, the aptamer preferentially localized to the nucleus of cancer cells in vivo and thus has the potential to be used for targeted delivery.

As an important pillar industry to protect people's livelihood, livestock and poultry industry plays an important role in promoting the agricultural quality and efficiency and promoting rural comprehensive revitalization. Under the background of the rural revitalization strategy, the supply capacity of livestock and poultry products in Chinese livestock and poultry industry has been gradually enhanced, the level of industrial scientific and technological innovation has been continuously improved, and the prevention and control of livestock and poultry diseases have been consistently reinforced, laying a solid foundation for enabling the high-quality development of the entire livestock and poultry industry chain. As the rural revitalization strategy gains momentum, the strategic focus of the high-quality development of the entire livestock and poultry industry chain is to vigorously promote the revitalization of livestock and poultry seed industry and effectively ensure that the livestock and poultry provenances are independently controllable, promote the sustainable development of livestock and poultry breeding industry and achieve a win-win situation of economic and ecological benefits, improve the processing and circulation system of livestock and poultry products, and strengthen the docking of supply and demand and the connection between production and marketing. In the future, we should focus on three aspects: Strengthening organizational guarantee, improving factor guarantee system and accelerating brand building, so as to lead the high-quality development of the entire livestock and poultry industry chain and provide strong support for driving rural comprehensive revitalization. [ABSTRACT FROM AUTHOR]

A series of novel quinoline-O-carbamate derivatives was rationally designed for treating Alzheimer's disease (AD) by multi-target-directed ligands (MTDLs) strategy. The target compounds were synthesised and evaluated by AChE/BuChE inhibition and anti-inflammatory property. The in vitro activities showed that compound 3f was a reversible dual eeAChE/eqBuChE inhibitor with IC50 values of 1.3 µM and 0.81 µM, respectively. Moreover, compound 3f displayed good anti-inflammatory property by decreasing the production of IL-6, IL-1β and NO. In addition, compound 3f presented significant neuroprotective effect on Aβ25-35-induced PC12 cell injury. Furthermore, compound 3f presented good stabilities in artificial gastrointestinal fluids, liver microsomes in vitro and plasma. Furthermore, compound 3f could improve AlCl3-induced zebrafish AD model by increasing the level of ACh. Therefore, compound 3f was a promising multifunctional agent for the treatment of AD. [ABSTRACT FROM AUTHOR]