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1. PI-QUAL version 2: an update of a standardised scoring system for the assessment of image quality of prostate MRI

Author

de Rooij, Maarten, Allen, Clare, Twilt, Jasper J., Thijssen, Linda C. P., Asbach, Patrick, Barrett, Tristan, Brembilla, Giorgio, Emberton, Mark, Gupta, Rajan T., Haider, Masoom A., Kasivisvanathan, Veeru, Løgager, Vibeke, Moore, Caroline M., Padhani, Anwar R., Panebianco, Valeria, Puech, Philippe, Purysko, Andrei S., Renard-Penna, Raphaële, Richenberg, Jonathan, Salomon, Georg, Sanguedolce, Francesco, Schoots, Ivo G., Thöny, Harriet C., Turkbey, Baris, Villeirs, Geert, Walz, Jochen, Barentsz, Jelle, and Giganti, Francesco

Published
2024
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2. ssVERDICT: Self-Supervised VERDICT-MRI for Enhanced Prostate Tumour Characterisation

Author

Sen, Snigdha, Singh, Saurabh, Pye, Hayley, Moore, Caroline M., Whitaker, Hayley, Punwani, Shonit, Atkinson, David, Panagiotaki, Eleftheria, and Slator, Paddy J.

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Machine Learning
Abstract

Purpose: Demonstrating and assessing self-supervised machine learning fitting of the VERDICT (Vascular, Extracellular and Restricted DIffusion for Cytometry in Tumours) model for prostate. Methods: We derive a self-supervised neural network for fitting VERDICT (ssVERDICT) that estimates parameter maps without training data. We compare the performance of ssVERDICT to two established baseline methods for fitting diffusion MRI models: conventional nonlinear least squares (NLLS) and supervised deep learning. We do this quantitatively on simulated data, by comparing the Pearson's correlation coefficient, mean-squared error (MSE), bias, and variance with respect to the simulated ground truth. We also calculate in vivo parameter maps on a cohort of 20 prostate cancer patients and compare the methods' performance in discriminating benign from cancerous tissue via Wilcoxon's signed-rank test. Results: In simulations, ssVERDICT outperforms the baseline methods (NLLS and supervised DL) in estimating all the parameters from the VERDICT prostate model in terms of Pearson's correlation coefficient, bias, and MSE. In vivo, ssVERDICT shows stronger lesion conspicuity across all parameter maps, and improves discrimination between benign and cancerous tissue over the baseline methods. Conclusion: ssVERDICT significantly outperforms state-of-the-art methods for VERDICT model fitting, and shows for the first time, fitting of a complex three-compartment biophysical model with machine learning without the requirement of explicit training labels., Comment: 12 pages, 5 figures. Submitted to Magnetic Resonance in Medicine

Published
2023

3. Mercury in Neotropical birds: a synthesis and prospectus on 13 years of exposure data.

Author

Evers, David, Ruiz-Gutierrez, Viviana, Adams, Evan, Vega, Claudia, Pisconte, Jessica, Tejeda, Vania, Regan, Kevin, Lane, Oksana, Ash, Abidas, Cal, Reynold, Reneau, Stevan, Martínez, Wilber, Welch, Gilroy, Hartwell, Kayla, Teul, Mario, Tzul, David, Arendt, Wayne, Tórrez, Marvin, Watsa, Mrinalini, Erkenswick, Gideon, Moore, Caroline, Gerson, Jacqueline, Sánchez, Victor, Purizaca, Raúl, Yurek, Helen, Burton, Mark, Shrum, Peggy, Tabares-Segovia, Sebastian, Vargas, Korik, Fogarty, Finola, Charette, Mathieu, Martínez, Ari, Bernhardt, Emily, Taylor, Robert, Tear, Timothy, Fernandez, Luis, and Sayers, Christopher

Subjects
Artisanal and small-scale gold mining, Bioaccumulation, Birds, Mercury, Neotropics, Animals, Mercury, Environmental Monitoring, Ecosystem, Environmental Pollution, Gold, Birds
Abstract

Environmental mercury (Hg) contamination of the global tropics outpaces our understanding of its consequences for biodiversity. Knowledge gaps of pollution exposure could obscure conservation threats in the Neotropics: a region that supports over half of the worlds species, but faces ongoing land-use change and Hg emission via artisanal and small-scale gold mining (ASGM). Due to their global distribution and sensitivity to pollution, birds provide a valuable opportunity as bioindicators to assess how accelerating Hg emissions impact an ecosystems ability to support biodiversity, and ultimately, global health. We present the largest database on Neotropical bird Hg concentrations (n = 2316) and establish exposure baselines for 322 bird species spanning nine countries across Central America, South America, and the West Indies. Patterns of avian Hg exposure in the Neotropics broadly align with those in temperate regions: consistent bioaccumulation across functional groups and high spatiotemporal variation. Bird species occupying higher trophic positions and aquatic habitats exhibited elevated Hg concentrations that have been previously associated with reductions in reproductive success. Notably, bird Hg concentrations were over four times higher at sites impacted by ASGM activities and differed by season for certain trophic niches. We developed this synthesis via a collaborative research network, the Tropical Research for Avian Conservation and Ecotoxicology (TRACE) Initiative, which exemplifies inclusive, equitable, and international data-sharing. While our findings signal an urgent need to assess sampling biases, mechanisms, and consequences of Hg exposure to tropical avian communities, the TRACE Initiative provides a meaningful framework to achieve such goals. Ultimately, our collective efforts support and inform local, scientific, and government entities, including Parties of the United Nations Minamata Convention on Mercury, as we continue working together to understand how Hg pollution impacts biodiversity conservation, ecosystem function, and public health in the tropics.

Published
2023

4. Collaborative Quantization Embeddings for Intra-Subject Prostate MR Image Registration

Author

Shen, Ziyi, Yang, Qianye, Shen, Yuming, Giganti, Francesco, Stavrinides, Vasilis, Fan, Richard, Moore, Caroline, Rusu, Mirabela, Sonn, Geoffrey, Torr, Philip, Barratt, Dean, and Hu, Yipeng

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Image registration is useful for quantifying morphological changes in longitudinal MR images from prostate cancer patients. This paper describes a development in improving the learning-based registration algorithms, for this challenging clinical application often with highly variable yet limited training data. First, we report that the latent space can be clustered into a much lower dimensional space than that commonly found as bottleneck features at the deep layer of a trained registration network. Based on this observation, we propose a hierarchical quantization method, discretizing the learned feature vectors using a jointly-trained dictionary with a constrained size, in order to improve the generalisation of the registration networks. Furthermore, a novel collaborative dictionary is independently optimised to incorporate additional prior information, such as the segmentation of the gland or other regions of interest, in the latent quantized space. Based on 216 real clinical images from 86 prostate cancer patients, we show the efficacy of both the designed components. Improved registration accuracy was obtained with statistical significance, in terms of both Dice on gland and target registration error on corresponding landmarks, the latter of which achieved 5.46 mm, an improvement of 28.7\% from the baseline without quantization. Experimental results also show that the difference in performance was indeed minimised between training and testing data., Comment: preprint version, accepted for MICCAI 2022 (25th International Conference on Medical Image Computing and Computer Assisted Intervention)

Published
2022

5. The Nexus of Climate Change, COVID-19, and Environmental Justice on Children's Health

Author

Pennea, Emma, Anderko, Laura, Moore, Caroline, and McDermott-Levy, Ruth

Abstract

Climate change poses a threat to children, who are increasingly vulnerable, depending on adults to protect them from the impacts of these changes including extreme weather events, poor air and water quality and risk to mental health. Children living in poverty carry additional burdens and risks, living in environments that consistently experience poor air and water quality from polluting industries, compounded by the effects of climate change. COVID-19 has placed additional challenges to children's health and increases the complexity of addressing climate change and environmental justice. The intersection between climate change and COVID-19 exacerbates these existing disparities by impacting children's physical and mental health that are a direct product of poverty and structural racism. This article examines the nexus of climate change, COVID-19, and environmental justice that impacts the mental and physical health of children including anxiety, stress, adverse childhood experiences, and depression; increases in violence and aggression; and the effects of air pollution. Public health professionals and health care providers must be aware of national strategies that protect children from environmental health risks and emerging infectious diseases, such as climate change and COVID-19, respectively. Key Take Away Points: (1) Anthropogenic climate change poses a threat to the health of children, especially of those in marginalized communities; (2) COVID-19 has exacerbated these detrimental health impacts for children experiencing the effects of climate change; and (3) There are opportunities to protect children's health through equitable polices and programs.

Published
2021

6. Improving Maternal Cardiovascular Health in Underserved Populations: a Narrative Review of Behavioral Intervention Trials Targeting Postpartum Weight Retention

Author

Yuhas, Maryam, Moore, Caroline Fletcher, Garay, Jessica, and Brown, Susan D

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Nutrition, Obesity, Prevention, Heart Disease, Behavioral and Social Science, Clinical Trials and Supportive Activities, Mind and Body, Mental Health, Clinical Research, Cardiovascular, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, Prevention of disease and conditions, and promotion of well-being, Good Health and Well Being, Diet, Ethnicity, Exercise, Female, Gestational Weight Gain, Humans, Minority Groups, Pregnancy, Postpartum weight retention, Behavioral intervention, Underserved, Minority, Low-income, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

Purpose of reviewRacial/ethnic minority and socioeconomically disadvantaged individuals experience greater postpartum weight retention, which has been linked to the development of cardiovascular disease. This article reviews recent literature on behavioral interventions targeting postpartum weight retention in these populations.Recent findingsSeven randomized controlled trials published since 2010 were selected for this review. Four were successful in reducing or preventing postpartum weight retention. Recruitment primarily occurred in low-income urban areas. All interventions reported using the Social Cognitive Theory and targeted mostly individual-level behavior change focused on diet and physical activity. Four were technology-based, and most implemented strategies to increase cultural relevance of the intervention. Opportunities for future interventions include expand target population to enroll individuals starting in pregnancy and address rural populations; incorporate empirically tested retention strategies; increase focus on psychosocial factors, particularly chronic stress; utilize multilevel approaches; continue to leverage technology; and maximize efforts to increase cultural relevancy.

Published
2022

7. PRECISE Version 2: Updated Recommendations for Reporting Prostate Magnetic Resonance Imaging in Patients on Active Surveillance for Prostate Cancer

Author

Englman, Cameron, Maffei, Davide, Allen, Clare, Kirkham, Alex, Albertsen, Peter, Kasivisvanathan, Veeru, Baroni, Ronaldo Hueb, Briganti, Alberto, De Visschere, Pieter, Dickinson, Louise, Gómez Rivas, Juan, Haider, Masoom A., Kesch, Claudia, Loeb, Stacy, Macura, Katarzyna J., Margolis, Daniel, Mitra, Anita M., Padhani, Anwar R., Panebianco, Valeria, Pinto, Peter A., Ploussard, Guillaume, Puech, Philippe, Purysko, Andrei S., Radtke, Jan Philipp, Rannikko, Antti, Rastinehad, Art, Renard-Penna, Raphaele, Sanguedolce, Francesco, Schimmöller, Lars, Schoots, Ivo G., Shariat, Shahrokh F., Schieda, Nicola, Tempany, Clare M., Turkbey, Baris, Valerio, Massimo, Villers, Arnauld, Walz, Jochen, Barrett, Tristan, Giganti, Francesco, and Moore, Caroline M.

Published
2024
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8. Mercury in Neotropical birds: a synthesis and prospectus on 13 years of exposure data

Author

Sayers, II, Christopher J., Evers, David C., Ruiz-Gutierrez, Viviana, Adams, Evan, Vega, Claudia M., Pisconte, Jessica N., Tejeda, Vania, Regan, Kevin, Lane, Oksana P., Ash, Abidas A., Cal, Reynold, Reneau, Stevan, Martínez, Wilber, Welch, Gilroy, Hartwell, Kayla, Teul, Mario, Tzul, David, Arendt, Wayne J., Tórrez, Marvin A., Watsa, Mrinalini, Erkenswick, Gideon, Moore, Caroline E., Gerson, Jacqueline, Sánchez, Victor, Purizaca, Raúl Pérez, Yurek, Helen, Burton, Mark E. H., Shrum, Peggy L., Tabares-Segovia, Sebastian, Vargas, Korik, Fogarty, Finola F., Charette, Mathieu R., Martínez, Ari E., Bernhardt, Emily S., Taylor, Robert J., Tear, Timothy H., and Fernandez, Luis E.

Published
2023
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9. Active Surveillance for Men Younger than 60 Years or with Intermediate-risk Localized Prostate Cancer. Descriptive Analyses of Clinical Practice in the Movember GAP3 Initiative.

Author

Remmers, Sebastiaan, Helleman, Jozien, Nieboer, Daan, Trock, Bruce, Hyndman, Matthew E, Moore, Caroline M, Gnanapragasam, Vincent, Shiong Lee, Lui, Elhage, Oussama, Klotz, Laurence, Carroll, Peter, Pickles, Tom, Bjartell, Anders, Robert, Grégoire, Frydenberg, Mark, Sugimoto, Mikio, Ehdaie, Behfar, Morgan, Todd M, Rubio-Briones, Jose, Semjonow, Axel, Bangma, Chris H, Roobol, Monique J, and Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance (GAP3) Consortium

Subjects
Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance (GAP3) Consortium, Active surveillance, Disease progression, Prostatic neoplasms, Patient Safety, Aging, Prostate Cancer, Urologic Diseases, Cancer
Abstract

BackgroundActive surveillance (AS) is a management option for men diagnosed with low-risk prostate cancer. Opinions differ on whether it is safe to include young men (≤60 yr) or men with intermediate-risk disease.ObjectiveTo assess whether reasons for discontinuation, treatment choice after AS, and adverse pathology at radical prostatectomy (RP; N1, or ≥GG3, or ≥pT3) differ for men ≤60 yr or those with European Association of Urology (EAU) intermediate-risk disease from those for men >60 yr or those with EAU low-risk disease.Design setting and participantsWe analyzed data from 5411 men ≤60 yr and 14 959 men >60 yr, 14 064 men with low-risk cancer, and 2441 men with intermediate-risk cancer, originating from the GAP3 database (21 169 patients/27 cohorts worldwide).Outcome measurements and statistical analysisCumulative incidence curves were used to estimate the rates of AS discontinuation and treatment choice.Results and limitationsThe probability of discontinuation of AS due to disease progression at 5 yr was similar for men aged ≤60 yr (22%) and those >60 yr (25%), as well as those of any age with low-risk disease (24%) versus those with intermediate-risk disease (24%). Men with intermediate-risk disease are more prone to discontinue AS without evidence of progression than men with low-risk disease (at 1/5 yr: 5.9%/14.2% vs 2.0%/8.8%). Adverse pathology at RP was observed in 32% of men ≤60 yr compared with 36% of men >60 yr (p = 0.029), and in 34% with low-risk disease compared with 40% with intermediate-risk disease (p = 0.048).ConclusionsOur descriptive analysis of AS practices worldwide showed that the risk of progression during AS is similar across the age and risk groups studied. The proportion of adverse pathology was higher among men >60 yr than among men ≤60 yr. These results suggest that men ≤60 yr and those with EAU intermediate-risk disease should not be excluded from opting for AS as initial management.Patient summaryData from 27 international centers reflecting daily clinical practice suggest that younger men or men with intermediate-risk prostate cancer do not hold greater risk for disease progression during active surveillance.

Published
2022

10. Urinary and Sexual Impact of Robotic Radical Prostatectomy: Reporting of Patient-reported Outcome Measures in the First Year after Radical Prostatectomy in a Contemporary Multicentre Cohort in the United Kingdom

Author

Bridge, Joshua, Labban, Muhieddine, Cole, Alexander P., Adebusoye, Busola, Smith, Sarah C., Protopapa, Evangelia, McCartan, Neil, Brew-Graves, Chris, Trinh, Quoc-Dien, Hamer, Kevin, Mallett, Sue, van der Meulen, Jan, and Moore, Caroline M.

Published
2024
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14. Comparison of outcomes of different biopsy schedules among men on active surveillance for prostate cancer: An analysis of the G.A.P.3 global consortium database

Author

Beckmann, Kerri R, Bangma, Chris H, Helleman, Jozien, Bjartell, Anders, Carroll, Peter R, Morgan, Todd, Nieboer, Daan, Santaolalla, Aida, Trock, Bruce J, Valdagni, Riccardo, Roobol, Monique J, Trock, Bruce, Ehdaie, Behfar, Carroll, Peter, Filson, Christopher, Logothetis, Christopher, Klotz, Laurence, Pickles, Tom, Hyndman, Eric, Moore, Caroline, Gnanapragasam, Vincent, Van Hemelrijck, Mieke, Dasgupta, Prokar, Bangma, Chris, Roobol, Monique, Villers, Arnauld, Robert, Grégoire, Semjonow, Axel, Rannikko, Antti, Perry, Antoinette, Hugosson, Jonas, Rubio‐Briones, Jose, Hefermehl, Lukas, Shiong, Lee Lui, Frydenberg, Mark, Stricker, Phillip, Sugimoto, Mikio, Chung, Byung Ha, van der Kwast, Theo, van der Linden, Wim, Hulsen, Tim, Ruwe, Boris, van Hooft, Peter, Steyerberg, Ewout, Beckmann, Kerri, Denton, Brian, Hayen, Andrew, Boutros, Paul, Guo, Wei, Benfante, Nicole, Cowan, Janet, Patil, Dattatraya, Park, Lauren, Ferrante, Stephanie, Mamedov, Alexandre, LaPointe, Vincent, Crump, Trafford, Stavrinides, Vasilis, Kimberly‐Duffell, Jenna, Olivier, Jonathan, Rancati, Tiziana, Ahlgren, Helén, Mascarós, Juanma, Löfgren, Annica, Lehmann, Kurt, Lin, Catherine Han, Cusick, Thomas, Hirama, Hiromi, Lee, Kwang Suk, Jenster, Guido, Auvinen, Anssi, Haider, Masoom, van Bochove, Kees, Kouspou, Michelle, and Paich, Kellie

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Urologic Diseases, Aging, Prevention, Cancer, Prostate Cancer, Clinical Research, Biopsy, Disease Progression, Humans, Male, Neoplasm Grading, Prostate, Prostate-Specific Antigen, Prostatic Neoplasms, Watchful Waiting, active surveillance, biopsy schedule, prostate cancer, treatment, upgrading, Global Action Plan Active Surveillance Prostate Cancer [G.A.P.3] Consortium, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

BackgroundThe optimal interval for repeat biopsy during active surveillance (AS) for prostate cancer is yet to be defined. This study examined whether risk of upgrading (to grade group ≥ 2) or risk of converting to treatment varied according to intensity of repeat biopsy using data from the GAP3 consortium's global AS database.Materials and methodsIntensity of surveillance biopsy schedules was categorized according to centers' protocols: (a) Prostate Cancer Research International Active Surveillance project (PRIAS) protocols with biopsies at years 1, 4, and 7 (10 centers; 7532 men); (b) biennial biopsies, that is, every other year (8 centers; 4365 men); and (c) annual biopsy schedules (4 centers; 1602 men). Multivariable Cox regression was used to compare outcomes according to biopsy intensity.ResultsOut of the 13,508 eligible participants, 56% were managed according to PRIAS protocols (biopsies at years 1, 4, and 7), 32% via biennial biopsy, and 12% via annual biopsy. After adjusting for baseline characteristics, risk of converting to treatment was greater for those on annual compared with PRIAS biopsy schedules (hazard ratio [HR] = 1.66; 95% confidence interval [CI] = 1.51-1.83; p

Published
2022

15. Knowledge and insights from a maturing international clinical quality registry.

Author

Sampurno, Fanny, Kowalski, Christoph, Connor, Sarah E, Nguyen, Anissa V, Acuña, Àngels Pont, Ng, Chi-Fai, Foster, Claire, Feick, Günter, Boronat, Olatz Garin, Dieng, Sebastian, Brglevska, Silvana, Ferrante, Stephanie, Leung, Steven, Villanti, Paul, Moore, Caroline M, Graham, Ian D, Millar, Jeremy L, Litwin, Mark S, and Papa, Nathan

Subjects
Cancer, Health and social care services research, 8.1 Organisation and delivery of services, Benchmarking, Delivery of Health Care, Humans, Male, Registries, international clinical quality registry, process evaluation, collaborative working group, documentation, audit and feedback, shared-learning, Information and Computing Sciences, Engineering, Medical and Health Sciences, Medical Informatics
Abstract

Since 2017, the TrueNTH Global Registry (TNGR) has aimed to drive improvement in patient outcomes for individuals with localized prostate cancer by collating data from healthcare institutions across 13 countries. As TNGR matures, a systematic evaluation of existing processes and documents is necessary to evaluate whether the registry is operating as intended. The main supporting documents: protocol and data dictionary, were comprehensively reviewed in a series of meetings over a 10-month period by an international working group. In parallel, individual consultations with local institutions regarding a benchmarking quality-of-care report were conducted. Four consensus areas for improvement emerged: updating operational definitions, appraisal of the recruitment process, refinement of data elements, and improvement of data quality and reporting. Recommendations presented were drawn from our collective experience and accumulated knowledge in operating an international registry. These can be readily generalized to other health-related reporting programs beyond clinical registries.

Published
2022

16. The Lancet Commission on prostate cancer: planning for the surge in cases

Author

James, Nicholas D, Tannock, Ian, N'Dow, James, Feng, Felix, Gillessen, Silke, Ali, Syed Adnan, Trujillo, Blanca, Al-Lazikani, Bissan, Attard, Gerhardt, Bray, Freddie, Compérat, Eva, Eeles, Ros, Fatiregun, Omolara, Grist, Emily, Halabi, Susan, Haran, Áine, Herchenhorn, Daniel, Hofman, Michael S, Jalloh, Mohamed, Loeb, Stacy, MacNair, Archie, Mahal, Brandon, Mendes, Larissa, Moghul, Masood, Moore, Caroline, Morgans, Alicia, Morris, Michael, Murphy, Declan, Murthy, Vedang, Nguyen, Paul L, Padhani, Anwar, Parker, Charles, Rush, Hannah, Sculpher, Mark, Soule, Howard, Sydes, Matthew R, Tilki, Derya, Tunariu, Nina, Villanti, Paul, and Xie, Li-Ping

Published
2024
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17. Prostate Cancer Patients Under Active Surveillance with a Suspicious Magnetic Resonance Imaging Finding Are at Increased Risk of Needing Treatment: Results of the Movember Foundation’s Global Action Plan Prostate Cancer Active Surveillance (GAP3) Consortium

Author

Olivier, Jonathan, Li, Weiyu, Nieboer, Daan, Helleman, Jozien, Roobol, Monique, Gnanapragasam, Vincent, Frydenberg, Mark, Sugimoto, Mikio, Carroll, Peter, Morgan, Todd M, Valdagni, Riccardo, Rubio-Briones, Jose, Robert, Grégoire, Stricker, Phillip, Hayen, Andrew, Schoots, Ivo, Haider, Masoom, Moore, Caroline M, Denton, Brian, Villers, Arnauld, Trock, Bruce, Ehdaie, Behfar, Filson, Christopher, Logothetis, Christopher, Morgan, Todd, Klotz, Laurence, Pickles, Tom, Hyndman, Eric, Van Hemelrijck, Mieke, Dasgupta, Prokar, Bangma, Chris, Semjonow, Axel, Rannikko, Antti, Perry, Antoinette, Hugosson, Jonas, Bjartell, Anders, Hefermehl, Lukas, Shiong, Lee Lui, Chung, Byung Ha, van der Kwast, Theo, Hulsen, Tim, van der Linden, Wim, Ruwe, Boris, van Hooft, Peter, Steyerberg, Ewout, Boutros, Paul, Guo, Wei, Benfante, Nicole, Cowan, Janet, Patil, Dattatraya, Park, Lauren, Ferrante, Stephanie, Mamedov, Alexandre, LaPointe, Vincent, Crump, Trafford, Stavrinides, Vasilis, Kimberly-Duffell, Jenna, Santaolalla, Aida, Rancati, Tiziana, Ahlgren, Helén, Mascarós, Juanma, Löfgren, Annica, Lehmann, Kurt, Lin, Catherine Han, Cusick, Thomas, Hirama, Hiromi, Lee, Kwang Suk, Jenster, Guido, Auvinen, Anssi, van Bochove, Kees, Kouspou, Michelle, and Paich, Kellie

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Prevention, Clinical Research, Biomedical Imaging, Clinical Trials and Supportive Activities, Aging, Cancer, Urologic Diseases, Prostate Cancer, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Magnetic resonance imaging, Prostate cancer, Active surveillance, Discontinuation, Worldwide, Nomogram, Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance GAP3 Consortium, Urology & Nephrology, Clinical sciences
Abstract

BackgroundThe inclusion criterion for active surveillance (AS) is low- or intermediate-risk prostate cancer. The predictive value of the presence of a suspicious lesion at magnetic resonance imaging (MRI) at the time of inclusion is insufficiently known.ObjectiveTo evaluate the percentage of patients needing active treatment stratified by the presence or absence of a suspicious lesion at baseline MRI.Design setting and participantsA retrospective analysis of the data from the multicentric AS GAP3 Consortium database was conducted. The inclusion criteria were men with grade group (GG) 1 or GG 2 prostate cancer combined with prostate-specific antigen

Published
2022

18. A modified Delphi study to develop a practical guide for selecting patients with prostate cancer for active surveillance

Author

Merriel, Samuel WD, Moon, Daniel, Dundee, Phil, Corcoran, Niall, Carroll, Peter, Partin, Alan, Smith, Joseph A, Hamdy, Freddie, Moore, Caroline, Ost, Piet, and Costello, Tony

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Prevention, Clinical Research, Urologic Diseases, Prostate Cancer, Cancer, Management of diseases and conditions, 7.3 Management and decision making, Delphi Technique, Humans, Male, Middle Aged, Patient Selection, Prostatic Neoplasms, Watchful Waiting, Prostate cancer, Cancer treatment protocols, Patient selection, Active surveillance, Urology & Nephrology, Clinical sciences
Abstract

BackgroundActive surveillance (AS) is a management option for men diagnosed with lower risk prostate cancer. There is wide variation in all aspects of AS internationally, from patient selection to investigations and follow-up intervals, and a lack of clear evidence on the optimal approach to AS. This study aimed to provide guidance for clinicians from an international panel of prostate cancer experts.MethodsA modified Delphi approach was undertaken, utilising two rounds of online questionnaires followed by a face-to-face workshop. Participants indicated their level of agreement with statements relating to patient selection for AS via online questionnaires on a 7-point Likert scale. Factors not achieving agreement were iteratively developed between the two rounds of questionnaires. Draft statements were presented at the face-to-face workshop for discussion and consensus building.Results12 prostate cancer experts (9 urologists, 2 academics, 1 radiation oncologist) participated in this study from a range of geographical regions (4 USA, 4 Europe, 4 Australia). Complete agreement on statements presented to the participants was 29.4% after Round One and 69.0% after Round Two. Following robust discussions at the face-to-face workshop, agreement was reached on the remaining statements. PSA, PSA density, Multiparametric MRI, and systematic biopsy (with or without targeted biopsy) were identified as minimum diagnostic tests required upon which to select patients to recommend AS as a treatment option for prostate cancer. Patient factors and clinical parameters that identified patients appropriate to potentially receive AS were agreed. Genetic and genomic testing was not recommended for use in clinical decision-making regarding AS.ConclusionsThe lack of consistency in the practice of AS for men with lower risk prostate cancer between and within countries was reflected in this modified Delphi study. There are, however, areas of common practice and agreement from which clinicians practicing in the current environment can use to inform their clinical practice to achieve the best outcomes for patients.

Published
2021

20. Morphological Change Forecasting for Prostate Glands using Feature-based Registration and Kernel Density Extrapolation

Author

Yang, Qianye, Vercauteren, Tom, Fu, Yunguan, Giganti, Francesco, Ghavami, Nooshin, Stavrinides, Vasilis, Moore, Caroline, Clarkson, Matt, Barratt, Dean, and Hu, Yipeng

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Organ morphology is a key indicator for prostate disease diagnosis and prognosis. For instance, In longitudinal study of prostate cancer patients under active surveillance, the volume, boundary smoothness and their changes are closely monitored on time-series MR image data. In this paper, we describe a new framework for forecasting prostate morphological changes, as the ability to detect such changes earlier than what is currently possible may enable timely treatment or avoiding unnecessary confirmatory biopsies. In this work, an efficient feature-based MR image registration is first developed to align delineated prostate gland capsules to quantify the morphological changes using the inferred dense displacement fields (DDFs). We then propose to use kernel density estimation (KDE) of the probability density of the DDF-represented \textit{future morphology changes}, between current and future time points, before the future data become available. The KDE utilises a novel distance function that takes into account morphology, stage-of-progression and duration-of-change, which are considered factors in such subject-specific forecasting. We validate the proposed approach on image masks unseen to registration network training, without using any data acquired at the future target time points. The experiment results are presented on a longitudinal data set with 331 images from 73 patients, yielding an average Dice score of 0.865 on a holdout set, between the ground-truth and the image masks warped by the KDE-predicted-DDFs., Comment: Accepted by ISBI 2021

Published
2021
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21. Utilization of focal therapy for patients discontinuing active surveillance of prostate cancer: Recommendations of an international Delphi consensus

Author

Tan, Wei Phin, Rastinehad, Ardeshir R, Klotz, Laurence, Carroll, Peter R, Emberton, Mark, Feller, John F, George, Arvin K, Gill, Inderbir S, Gupta, Rajan T, Katz, Aaron E, Lebastchi, Amir H, Marks, Leonard S, Marra, Giancarlo, Pinto, Peter A, Song, Daniel Y, Sidana, Abhinav, Ward, John F, Sanchez-Salas, Rafael, de la Rosette, Jean, Polascik, Thomas J, Authors, Focal Therapy Group, Katz, Aaron, Aminsharifi, Alireza, Lebastchi, Amir, Abreu, Andre, Villers, Arnauld, Schulman, Ariel, Rastinehad, Ardeshir, George, Arvin, Oto, Aytekin, Turkbey, Baris, Malavaud, Bernard, Muller, Berrend, Moore, Caroline, Eberli, Daniel, Margolis, Daniel, Song, Daniel, Lomas, Derek, Orabi, Hazem, Lepor, Herbert, Tan, Hui Meng, Jambor, Ivan, Grummet, Jeremy, Feller, John, Ward, John, Colemen, Jonathan, Gregg, Justin, Tay, Kae Jack, Marks, Leonard, Deane, Leslie, Laguna, M Pilar, Kimura, Masaki, Tsivian, Matvey, Gorin, Michael, Siddiqui, Minhaj, Ukimura, Osamu, Gontero, Paolo, Carroll, Peter, Pinto, Peter, Mozer, Pierre, Arcot, Ro, Taneja, Samir, Ghai, Sangeet, Crouzet, Sebastian, Mehralivand, Sherif, Joniau, Steven, Shoji, Sunao, Shiraishi, Takumi, Polascik, Thomas, Shin, Toshitaka, Lindnet, Uri, Tammisetti, Varaha, van den Bos, Willemien, and Matsuoka, Yoh

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Urologic Diseases, Prostate Cancer, Clinical Research, Ablation Techniques, Aged, Aged, 80 and over, Consensus, Delphi Technique, Humans, Male, Middle Aged, Prostatic Neoplasms, Watchful Waiting, Localized prostate cancer, Focal therapy, Partial gland ablation, Active surveillance, Focal Therapy Group Authors, Urology & Nephrology, Clinical sciences, Oncology and carcinogenesis
Abstract

BackgroundWith the advancement of imaging technology, focal therapy (FT) has been gaining acceptance for the treatment of select patients with localized prostate cancer (CaP). We aim to provide details of a formal physician consensus on the utilization of FT for patients with CaP who are discontinuing active surveillance (AS).MethodsA 3-stage Delphi consensus on CaP and FT was conducted. Consensus was defined as agreement by ≥80% of physicians. An in-person meeting was attended by 17 panelists to formulate the consensus statement.ResultsFifty-six respondents participated in this interdisciplinary consensus study (82% urologist, 16% radiologist, 2% radiation oncology). The participants confirmed that there is a role for FT in men discontinuing AS (48% strongly agree, 39% agree). The benefit of FT over radical therapy for men coming off AS is: less invasive (91%), has a greater likelihood to preserve erectile function (91%), has a greater likelihood to preserve urinary continence (91%), has fewer side effects (86%), and has early recovery post-treatment (80%). Patients will need to undergo mpMRI of the prostate and/or a saturation biopsy to determine if they are potential candidates for FT. Our limitations include respondent's biases and that the participants of this consensus may not represent the larger medical community.ConclusionsFT can be offered to men coming off AS between the age of 60 to 80 with grade group 2 localized cancer. This consensus from a multidisciplinary, multi-institutional, international expert panel provides a contemporary insight utilizing FT for CaP in select patients who are discontinuing AS.

Published
2021

23. The Role of Multiparametric MRI and MRI–targeted Biopsy in the Diagnosis of Radiorecurrent Prostate Cancer: An Analysis from the FORECAST Trial

Author

Light, Alexander, Kanthabalan, Abi, Otieno, Marjorie, Pavlou, Menelaos, Omar, Rumana, Adeleke, Sola, Giganti, Francesco, Brew-Graves, Chris, Williams, Norman R., Emara, Amr, Haroon, Athar, Latifoltojar, Arash, Sidhu, Harbir, Freeman, Alex, Orczyk, Clement, Nikapota, Ashok, Dudderidge, Tim, Hindley, Richard G., Virdi, Jaspal, Arya, Manit, Payne, Heather, Mitra, Anita V., Bomanji, Jamshed, Winkler, Mathias, Horan, Gail, Moore, Caroline M., Emberton, Mark, Punwani, Shonit, Ahmed, Hashim U., and Shah, Taimur T.

Published
2024
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25. Establishing a global quality of care benchmark report

Author

Sampurno, Fanny, Cally, Justin, Opie, Jacinta L, Kannan, Ashwini, Millar, Jeremy L, Finelli, Antonio, Vickers, Andrew J, Moore, Caroline M, Kowalski, Christoph, Foster, Claire, Barocas, Dan A, Galvin, David, Van Basten, Jean-Paul, Gore, John L, Ferencz, Julia, Lawson, Keith A, Ghani, Khurshid R, Kwan, Lorna, Saarela, Olli, Connor, Sarah E, Dieng, Sebastian, Linsell, Susan, Soeterik, Timo FW, Villanti, Paul, Litwin, Mark S, and Evans, Sue M

Subjects
Health Services and Systems, Health Sciences, Generic health relevance, Benchmarking, Delivery of Health Care, Humans, Male, Quality Indicators, Health Care, Registries, Surveys and Questionnaires, international registry, benchmarking, data display, data science, quality indicators, R Markdown, Information Systems, Library and Information Studies, Medical Informatics, Health services and systems, Applied computing
Abstract

BackgroundThe Movember funded TrueNTH Global Registry (TNGR) aims to improve care by collecting and analysing a consistent dataset to identify variation in disease management, benchmark care delivery in accordance with best practice guidelines and provide this information to those in a position to enact change. We discuss considerations of designing and implementing a quality of care report for TNGR.MethodsEleven working group sessions were held prior to and as reports were being built with representation from clinicians, data managers and investigators contributing to TNGR. The aim of the meetings was to understand current data display approaches, share literature review findings and ideas for innovative approaches. Preferred displays were evaluated with two surveys (survey 1: 5 clinicians and 5 non-clinicians, 83% response rate; survey 2: 17 clinicians and 18 non-clinicians, 93% response rate).ResultsConsensus on dashboard design and three data-display preferences were achieved. The dashboard comprised two performance summary charts; one summarising site's relative quality indicator (QI) performance and another to summarise data quality. Binary outcome QIs were presented as funnel plots. Patient-reported outcome measures of function score and the extent to which men were bothered by their symptoms were presented in bubble plots. Time series graphs were seen as providing important information to supplement funnel and bubble plots. R Markdown was selected as the software program principally because of its excellent analytic and graph display capacity, open source licensing model and the large global community sharing program code enhancements.ConclusionsInternational collaboration in creating and maintaining clinical quality registries has allowed benchmarking of process and outcome measures on a large scale. A registry report system was developed with stakeholder engagement to produce dynamic reports that provide user-specific feedback to 132 participating sites across 13 countries.

Published
2021

26. Active Surveillance for Men Younger than 60 Years or with Intermediate-risk Localized Prostate Cancer. Descriptive Analyses of Clinical Practice in the Movember GAP3 Initiative

Author

Trock, Bruce, Ehdaie, Behfar, Carroll, Peter, Filson, Christopher, Logothetis, Christopher, Morgan, Todd, Klotz, Laurence, Pickles, Tom, Hyndman, Eric, Moore, Caroline, Gnanapragasam, Vincent, Van Hemelrijck, Mieke, Dasgupta, Prokar, Bangma, Chris, Roobol, Monique, Villers, Arnauld, Robert, Grégoire, Semjonow, Axel, Rannikko, Antti, Valdagni, Riccardo, Perry, Antoinette, Hugosson, Jonas, Rubio-Briones, Jose, Bjartell, Anders, Hefermehl, Lukas, Lui Shiong, Lee, Frydenberg, Mark, Stricker, Phillip, Sugimoto, Mikio, Ha Chung, Byung, van der Kwast, Theo, van der Linden, Wim, Hulsen, Tim, Ruwe, Boris, Peter van Hooft, Steyerberg, Ewout, Nieboer, Daan, Beckmann, Kerri, Denton, Brian, Hayen, Andrew, Boutros, Paul, Guo, Wei, Benfante, Nicole, Cowan, Janet, Patil, Dattatraya, Park, Lauren, Ferrante, Stephanie, Mamedov, Alexandre, LaPointe, Vincent, Crump, Trafford, Stavrinides, Vasilis, Kimberly-Duffell, Jenna, Santaolalla, Aida, Olivier, Jonathan, Rancati, Tiziana, Ahlgren, Helén, Mascarós, Juanma, Löfgren, Annica, Lehmann, Kurt, Han Lin, Catherine, Cusick, Thomas, Hirama, Hiromi, Suk Lee, Kwang, Jenster, Guido, Auvinen, Anssi, Haider, Masoom, van Bochove, Kees, Kouspou, Michelle, Paich, Kellie, Helleman, Jozien, Remmers, Sebastiaan, Hyndman, Matthew E., Moore, Caroline M., Shiong Lee, Lui, Elhage, Oussama, Morgan, Todd M., Bangma, Chris H., and Roobol, Monique J.

Published
2022
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27. Prostate MR image quality of apparent diffusion coefficient maps versus fractional intracellular volume maps from VERDICT MRI using the PI-QUAL score and a dedicated Likert scale for artefacts

Author

Singh, Saurabh, Giganti, Francesco, Dickinson, Louise, Rogers, Harriet, Kanber, Baris, Clemente, Joey, Pye, Hayley, Heavey, Susan, Stopka-Farooqui, Urszula, Johnston, Edward W., Moore, Caroline M, Freeman, Alex, Whitaker, Hayley C, Alexander, Daniel C, Panagiotaki, Eleftheria, and Punwani, Shonit

Published
2023
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28. Magnetic Resonance Imaging Follow-up of Targeted Biopsy–negative Prostate Lesions

Author

Stavrinides, Vasilis, Eksi, Ece, Finn, Ron, Texeira-Mendes, Larissa, Rana, Sarina, Trahearn, Nick, Grey, Alistair, Giganti, Francesco, Huet, Eric, Fiard, Gaelle, Freeman, Alex, Haider, Aiman, Allen, Clare, Kirkham, Alex, Cole, Alexander P., Collins, Tom, Pendse, Douglas, Dickinson, Louise, Punwani, Shonit, Pashayan, Nora, Emberton, Mark, Moore, Caroline M., and Orczyk, Clement

Published
2023
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29. Promoting the use of the PI-QUAL score for prostate MRI quality: results from the ESOR Nicholas Gourtsoyiannis teaching fellowship

Author

Giganti, Francesco, Cole, Alexander P., Fennessy, Fiona M., Clinton, Timothy, Moreira, Pedro Lopes Da Frota, Bernardes, Mariana Costa, Westin, Carl-Fredrik, Krishnaswamy, Deepa, Fedorov, Andriy, Wollin, Daniel A., Langbein, Bjoern, Frego, Nicola, Labban, Muhieddine, Badaoui, Joy S., Chang, Steven L., Briggs, Logan G., Tokuda, Junichi, Ambrosi, Alessandro, Kirkham, Alex, Emberton, Mark, Kasivisvanathan, Veeru, Moore, Caroline M., Allen, Clare, and Tempany, Clare M.

Published
2023
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30. Prostate Cancer Patients Under Active Surveillance with a Suspicious Magnetic Resonance Imaging Finding Are at Increased Risk of Needing Treatment: Results of the Movember Foundation’s Global Action Plan Prostate Cancer Active Surveillance (GAP3) Consortium

Author

Trock, Bruce, Ehdaie, Behfar, Carroll, Peter, Filson, Christopher, Logothetis, Christopher, Morgan, Todd, Klotz, Laurence, Pickles, Tom, Hyndman, Eric, Moore, Caroline M, Gnanapragasam, Vincent, Van Hemelrijck, Mieke, Dasgupta, Prokar, Bangma, Chris, Roobol, Monique, Villers, Arnauld, Robert, Grégoire, Semjonow, Axel, Rannikko, Antti, Valdagni, Riccardo, Perry, Antoinette, Hugosson, Jonas, Rubio-Briones, Jose, Bjartell, Anders, Hefermehl, Lukas, Lui Shiong, Lee, Frydenberg, Mark, Stricker, Phillip, Sugimoto, Mikio, Ha Chung, Byung, van der Kwast, Theo, Hulsen, Tim, van der Linden, Wim, Ruwe, Boris, van Hooft, Peter, Steyerberg, Ewout, Nieboer, Daan, Denton, Brian, Hayen, Andrew, Boutros, Paul, Guo, Wei, Benfante, Nicole, Cowan, Janet, Patil, Dattatraya, Park, Lauren, Ferrante, Stephanie, Mamedov, Alexandre, LaPointe, Vincent, Crump, Trafford, Stavrinides, Vasilis, Kimberly-Duffell, Jenna, Santaolalla, Aida, Olivier, Jonathan, Rancati, Tiziana, Ahlgren, Helén, Mascarós, Juanma, Löfgren, Annica, Lehmann, Kurt, Han Lin, Catherine, Cusick, Thomas, Hirama, Hiromi, Suk Lee, Kwang, Jenster, Guido, Auvinen, Anssi, Haider, Masoom, van Bochove, Kees, Kouspou, Michelle, Paich, Kellie, Helleman, Jozien, Li, Weiyu, Morgan, Todd M., Schoots, Ivo, and Moore, Caroline M.

Published
2022
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31. A Systematic Review of Patient Race, Ethnicity, Socioeconomic Status, and Educational Attainment in Prostate Cancer Treatment Randomised Trials—Is the Evidence Base Applicable to the General Patient Population?

Author

Patki, Siddhant, Aquilina, Julian, Thorne, Rebecca, Aristidou, Isaac, Rodrigues, Filipe Brogueira, Warren, Hannah, Bex, Axel, Kasivisvanathan, Veeru, Moore, Caroline, Gurusamy, Kurinchi, Emberton, Mark, Best, Lawrence M.J., and Tran, Maxine G.B.

Published
2023
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32. Best Current Practice and Research Priorities in Active Surveillance for Prostate Cancer—A Report of a Movember International Consensus Meeting

Author

Moore, Caroline M., King, Lauren E., Withington, John, Amin, Mahul B., Andrews, Mark, Briers, Erik, Chen, Ronald C., Chinegwundoh, Francis I., Cooperberg, Matthew R., Crowe, Jane, Finelli, Antonio, Fitch, Margaret I., Frydenberg, Mark, Giganti, Francesco, Haider, Masoom A., Freeman, John, Gallo, Joseph, Gibbs, Stephen, Henry, Anthony, James, Nicholas, Kinsella, Netty, Lam, Thomas B.L., Lichty, Mark, Loeb, Stacy, Mahal, Brandon A., Mastris, Ken, Mitra, Anita V., Merriel, Samuel W.D., van der Kwast, Theodorus, Van Hemelrijck, Mieke, Palmer, Nynikka R., Paterson, Catherine C., Roobol, Monique J., Segal, Phillip, Schraidt, James A., Short, Camille E., Siddiqui, M. Minhaj, Tempany, Clare M.C., Villers, Arnaud, Wolinsky, Howard, and MacLennan, Steven

Published
2023
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37. Online Study: Postgraduate Student Perceptions of Core Skills Development

Author

Grounds, Patricia E. and Moore, Caroline

Abstract

In this qualitative study, we analyze postgraduate students' perceptions of strategic behaviors they developed during their online studies and their ability to extend this behavior to their own praxis. Findings suggest that strategic behavior centers around the development of four core skills: engaging in self-directed thinking; fostering effective communication; fostering leadership and shared responsibility; and using technology to reinforce, extend, and deepen learning. Through a dialogic process, where the presence of a supportive online community of practice plays a central role, participants appear to use these skills to engage in a process of un-learning and re-learning. The asynchronous modality of the online medium, allowing delayed rather than immediate responses, appeared to facilitate deeper, more considered constructions of new understandings. Ultimately, this online modality appears propitious in building self-confidence, thus empowering participants to act in their professional domain. [For the complete volume, see ED578177.]

Published
2017

40. Weakly-Supervised Convolutional Neural Networks for Multimodal Image Registration

Author

Hu, Yipeng, Modat, Marc, Gibson, Eli, Li, Wenqi, Ghavami, Nooshin, Bonmati, Ester, Wang, Guotai, Bandula, Steven, Moore, Caroline M., Emberton, Mark, Ourselin, Sébastien, Noble, J. Alison, Barratt, Dean C., and Vercauteren, Tom

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Artificial Intelligence, Computer Science - Machine Learning, Computer Science - Neural and Evolutionary Computing
Abstract

One of the fundamental challenges in supervised learning for multimodal image registration is the lack of ground-truth for voxel-level spatial correspondence. This work describes a method to infer voxel-level transformation from higher-level correspondence information contained in anatomical labels. We argue that such labels are more reliable and practical to obtain for reference sets of image pairs than voxel-level correspondence. Typical anatomical labels of interest may include solid organs, vessels, ducts, structure boundaries and other subject-specific ad hoc landmarks. The proposed end-to-end convolutional neural network approach aims to predict displacement fields to align multiple labelled corresponding structures for individual image pairs during the training, while only unlabelled image pairs are used as the network input for inference. We highlight the versatility of the proposed strategy, for training, utilising diverse types of anatomical labels, which need not to be identifiable over all training image pairs. At inference, the resulting 3D deformable image registration algorithm runs in real-time and is fully-automated without requiring any anatomical labels or initialisation. Several network architecture variants are compared for registering T2-weighted magnetic resonance images and 3D transrectal ultrasound images from prostate cancer patients. A median target registration error of 3.6 mm on landmark centroids and a median Dice of 0.87 on prostate glands are achieved from cross-validation experiments, in which 108 pairs of multimodal images from 76 patients were tested with high-quality anatomical labels., Comment: Accepted manuscript in Medical Image Analysis

Published
2018
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41. Adversarial Deformation Regularization for Training Image Registration Neural Networks

Author

Hu, Yipeng, Gibson, Eli, Ghavami, Nooshin, Bonmati, Ester, Moore, Caroline M., Emberton, Mark, Vercauteren, Tom, Noble, J. Alison, and Barratt, Dean C.

Subjects
Computer Science - Machine Learning, Computer Science - Computer Vision and Pattern Recognition, Statistics - Machine Learning
Abstract

We describe an adversarial learning approach to constrain convolutional neural network training for image registration, replacing heuristic smoothness measures of displacement fields often used in these tasks. Using minimally-invasive prostate cancer intervention as an example application, we demonstrate the feasibility of utilizing biomechanical simulations to regularize a weakly-supervised anatomical-label-driven registration network for aligning pre-procedural magnetic resonance (MR) and 3D intra-procedural transrectal ultrasound (TRUS) images. A discriminator network is optimized to distinguish the registration-predicted displacement fields from the motion data simulated by finite element analysis. During training, the registration network simultaneously aims to maximize similarity between anatomical labels that drives image alignment and to minimize an adversarial generator loss that measures divergence between the predicted- and simulated deformation. The end-to-end trained network enables efficient and fully-automated registration that only requires an MR and TRUS image pair as input, without anatomical labels or simulated data during inference. 108 pairs of labelled MR and TRUS images from 76 prostate cancer patients and 71,500 nonlinear finite-element simulations from 143 different patients were used for this study. We show that, with only gland segmentation as training labels, the proposed method can help predict physically plausible deformation without any other smoothness penalty. Based on cross-validation experiments using 834 pairs of independent validation landmarks, the proposed adversarial-regularized registration achieved a target registration error of 6.3 mm that is significantly lower than those from several other regularization methods., Comment: Accepted to MICCAI 2018

Published
2018
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42. Reasons for Discontinuing Active Surveillance: Assessment of 21 Centres in 12 Countries in the Movember GAP3 Consortium

Author

Van Hemelrijck, Mieke, Ji, Xi, Helleman, Jozien, Roobol, Monique J, van der Linden, Wim, Nieboer, Daan, Bangma, Chris H, Frydenberg, Mark, Rannikko, Antti, Lee, Lui S, Gnanapragasam, Vincent J, Kattan, Mike W, Trock, Bruce, Ehdaie, Behfar, Carroll, Peter, Filson, Christopher, Kim, Jeri, Logothetis, Christopher, Morgan, Todd, Klotz, Laurence, Pickles, Tom, Hyndman, Eric, Moore, Caroline M, Gnanapragasam, Vincent, Dasgupta, Prokar, Bangma, Chris, Roobol, Monique, Villers, Arnauld, Valdagni, Riccardo, Perry, Antoinette, Hugosson, Jonas, Rubio-Briones, Jose, Bjartell, Anders, Hefermehl, Lukas, Shiong, Lee Lui, Kakehi, Yoshiyuki, Chung, Byung Ha, van der Kwast, Theo, Obbink, Henk, Hulsen, Tim, de Jonge, Cees, Kattan, Mike, Xinge, Ji, Muir, Kenneth, Lophatananon, Artitaya, Fahey, Michael, Steyerberg, Ewout, Zhang, Liying, Santa Olalla, Aida, Beckmann, Kerri, Denton, Brian, Hayen, Andrew, Boutros, Paul, Guo, Wei, Benfante, Nicole, Cowan, Janet, Patil, Dattatraya, Tolosa, Emily, Kim, Tae-Kyung, Mamedov, Alexandre, La Pointe, Vincent, Crump, Trafford, Kimberly-Duffell, Jenna, Santaolalla, Aida, Olivier, Jonathan, Rancati, Tiziana, Ahlgren, Helén, Mascarós, Juanma, Löfgren, Annica, Lehmann, Kurt, Lin, Catherine Han, Hirama, Hiromi, Lee, Kwang Suk, Jenster, Guido, Auvinen, Anssi, Haider, Masoom, van Bochove, Kees, Carter, Ballentine, Gledhill, Sam, Buzza, Mark, and Bruinsma, Sophie

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Prostate Cancer, Aging, Prevention, Urologic Diseases, Cancer, Good Health and Well Being, Aged, Asia, Australia, Biopsy, Cause of Death, Clinical Decision-Making, Databases, Factual, Disease Progression, Early Detection of Cancer, Europe, Humans, Kallikreins, Male, Middle Aged, North America, Patient Dropouts, Predictive Value of Tests, Prostate-Specific Antigen, Prostatic Neoplasms, Risk Assessment, Risk Factors, Time Factors, Watchful Waiting, Prostate cancer, Active surveillance, Discontinuation, Worldwide, Members of the Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance GAP3 consortium, Urology & Nephrology, Clinical sciences
Abstract

BackgroundCareful assessment of the reasons for discontinuation of active surveillance (AS) is required for men with prostate cancer (PCa).ObjectiveUsing Movember's Global Action Plan Prostate Cancer Active Surveillance initiative (GAP3) database, we report on reasons for AS discontinuation.Design, setting, and participantsWe compared data from 10296 men on AS from 21 centres across 12 countries.Outcome measurements and statistical analysisCumulative incidence methods were used to estimate the cumulative incidence rates of AS discontinuation.Results and limitationsDuring 5-yr follow-up, 27.5% (95% confidence interval [CI]: 26.4-28.6%) men showed signs of disease progression, 12.8% (95% CI: 12.0-13.6%) converted to active treatment without evidence of progression, 1.7% (95% CI: 1.5-2.0%) continued to watchful waiting, and 1.7% (95% CI: 1.4-2.1%) died from other causes. Of the 7049 men who remained on AS, 2339 had follow-up for >5yr, 4561 had follow-up for

Published
2019

44. Magnetic Resonance Imaging and Targeted Biopsies Compared to Transperineal Mapping Biopsies Before Focal Ablation in Localised and Metastatic Recurrent Prostate Cancer After Radiotherapy

Author

Shah, Taimur T., Kanthabalan, Abi, Otieno, Marjorie, Pavlou, Menelaos, Omar, Rumana, Adeleke, Sola, Giganti, Francesco, Brew-Graves, Chris, Williams, Norman R., Grierson, Jack, Miah, Haroon, Emara, Amr, Haroon, Athar, Latifoltojar, Arash, Sidhu, Harbir, Clemente, Joey, Freeman, Alex, Orczyk, Clement, Nikapota, Ashok, Dudderidge, Tim, Hindley, Richard G., Virdi, Jaspal, Arya, Manit, Payne, Heather, Mitra, Anita, Bomanji, Jamshed, Winkler, Mathias, Horan, Gail, Moore, Caroline M., Emberton, Mark, Punwani, Shonit, and Ahmed, Hashim U.

Published
2022
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45. Promoting the use of the PRECISE score for prostate MRI during active surveillance: results from the ESOR Nicholas Gourtsoyiannis teaching fellowship

Author

Giganti, Francesco, Aupin, Laurene, Thoumin, Camille, Faouzi, Ingrid, Monnier, Hippolyte, Fontaine, Matthieu, Navidi, Alexandre, Ritvo, Paul-Gydéon, Ong, Valentin, Chung, Cecile, Bibi, Imen, Lehrer, Raphaële, Hermieu, Nicolas, Barret, Eric, Ambrosi, Alessandro, Kasivisvanathan, Veeru, Emberton, Mark, Allen, Clare, Kirkham, Alex, Moore, Caroline M., and Renard-Penna, Raphaële

Published
2022
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46. Amazon forests capture high levels of atmospheric mercury pollution from artisanal gold mining

Author

Gerson, Jacqueline R., Szponar, Natalie, Zambrano, Angelica Almeyda, Bergquist, Bridget, Broadbent, Eben, Driscoll, Charles T., Erkenswick, Gideon, Evers, David C., Fernandez, Luis E., Hsu-Kim, Heileen, Inga, Giancarlo, Lansdale, Kelsey N., Marchese, Melissa J., Martinez, Ari, Moore, Caroline, Pan, William K., Purizaca, Raúl Pérez, Sánchez, Victor, Silman, Miles, Ury, Emily A., Vega, Claudia, Watsa, Mrinalini, and Bernhardt, Emily S.

Published
2022
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48. Cancer Control Outcomes Following Focal Therapy Using High-intensity Focused Ultrasound in 1379 Men with Nonmetastatic Prostate Cancer: A Multi-institute 15-year Experience

Author

Reddy, Deepika, Peters, Max, Shah, Taimur T., van Son, Marieke, Tanaka, Mariana Bertoncelli, Huber, Philipp M., Lomas, Derek, Rakauskas, Arnas, Miah, Saiful, Eldred-Evans, David, Guillaumier, Stephanie, Hosking-Jervis, Feargus, Engle, Ryan, Dudderidge, Tim, Hindley, Richard G., Emara, Amr, Nigam, Raj, McCartan, Neil, Valerio, Massimo, Afzal, Naveed, Lewi, Henry, Orczyk, Clement, Ogden, Chris, Shergill, Iqbal, Persad, Raj, Virdi, Jaspal, Moore, Caroline M., Arya, Manit, Winkler, Mathias, Emberton, Mark, and Ahmed, Hashim U.

Published
2022
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49. Label-driven weakly-supervised learning for multimodal deformable image registration

Author

Hu, Yipeng, Modat, Marc, Gibson, Eli, Ghavami, Nooshin, Bonmati, Ester, Moore, Caroline M., Emberton, Mark, Noble, J. Alison, Barratt, Dean C., and Vercauteren, Tom

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Learning
Abstract

Spatially aligning medical images from different modalities remains a challenging task, especially for intraoperative applications that require fast and robust algorithms. We propose a weakly-supervised, label-driven formulation for learning 3D voxel correspondence from higher-level label correspondence, thereby bypassing classical intensity-based image similarity measures. During training, a convolutional neural network is optimised by outputting a dense displacement field (DDF) that warps a set of available anatomical labels from the moving image to match their corresponding counterparts in the fixed image. These label pairs, including solid organs, ducts, vessels, point landmarks and other ad hoc structures, are only required at training time and can be spatially aligned by minimising a cross-entropy function of the warped moving label and the fixed label. During inference, the trained network takes a new image pair to predict an optimal DDF, resulting in a fully-automatic, label-free, real-time and deformable registration. For interventional applications where large global transformation prevails, we also propose a neural network architecture to jointly optimise the global- and local displacements. Experiment results are presented based on cross-validating registrations of 111 pairs of T2-weighted magnetic resonance images and 3D transrectal ultrasound images from prostate cancer patients with a total of over 4000 anatomical labels, yielding a median target registration error of 4.2 mm on landmark centroids and a median Dice of 0.88 on prostate glands., Comment: Accepted to ISBI 2018

Published
2017
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