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20 results on '"Mullin, Donncha S."'

3. Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health

Author

Smith, Hannah M., primary, Moodie, Joanna E., additional, Monterrubio-Gómez, Karla, additional, Gadd, Danni A., additional, Hillary, Robert F., additional, Chybowska, Aleksandra D., additional, McCartney, Daniel L., additional, Campbell, Archie, additional, Redmond, Paul, additional, Page, Danielle, additional, Taylor, Adele, additional, Corley, Janie, additional, Harris, Sarah E., additional, Valdés Hernández, Maria, additional, Muñoz Maniega, Susana, additional, Bastin, Mark E., additional, Wardlaw, Joanna M., additional, Deary, Ian J., additional, Boardman, James P., additional, Mullin, Donncha S., additional, Russ, Tom C., additional, Cox, Simon R., additional, and Marioni, Riccardo E., additional

Published
2024
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7. Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health

Author

Smith, Hannah M, primary, Moodie, Joanna E, additional, Monterrubio-Gomez, Karla, additional, Gadd, Danni A, additional, Hillary, Robert F, additional, Chybowska, Aleksandra D, additional, McCartney, Daniel L, additional, Campbell, Archie, additional, Redmond, Paul, additional, Page, Danielle, additional, Taylor, Adele, additional, Corley, Janie, additional, Harris, Sarah E, additional, Valdes Hernandez, Maria, additional, Munoz Maniega, Susana, additional, Bastin, Mark, additional, Wardlaw, Joanna M, additional, Deary, Ian J, additional, Boardman, James P, additional, Mullin, Donncha S, additional, Russ, Tom C, additional, Cox, Simon R, additional, and Marioni, Riccardo E, additional

Published
2023
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10. Additional file 1 of Identifying dementia using medical data linkage in a longitudinal cohort study: Lothian Birth Cohort 1936

Author

Mullin, Donncha S., Stirland, Lucy E., Buchanan, Emily, Convery, Catherine-Anne, Cox, Simon R., Deary, Ian J., Giuntoli, Cinzia, Greer, Holly, Page, Danielle, Robertson, Elizabeth, Shenkin, Susan D., Szalek, Anna, Taylor, Adele, Weatherdon, Georgina, Wilkinson, Tim, and Russ, Tom C.

Abstract

Additional file 1. Dementia ascertainment protocol - Lothian Birth Cohort 1936 Study.

Published
2023
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11. Additional file 3 of Identifying dementia using medical data linkage in a longitudinal cohort study: Lothian Birth Cohort 1936

Author

Mullin, Donncha S., Stirland, Lucy E., Buchanan, Emily, Convery, Catherine-Anne, Cox, Simon R., Deary, Ian J., Giuntoli, Cinzia, Greer, Holly, Page, Danielle, Robertson, Elizabeth, Shenkin, Susan D., Szalek, Anna, Taylor, Adele, Weatherdon, Georgina, Wilkinson, Tim, and Russ, Tom C.

Abstract

Additional file 3. Comparable prevalence rates for all-cause dementia.

Published
2023
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12. Additional file 2 of Identifying dementia using medical data linkage in a longitudinal cohort study: Lothian Birth Cohort 1936

Author

Mullin, Donncha S., Stirland, Lucy E., Buchanan, Emily, Convery, Catherine-Anne, Cox, Simon R., Deary, Ian J., Giuntoli, Cinzia, Greer, Holly, Page, Danielle, Robertson, Elizabeth, Shenkin, Susan D., Szalek, Anna, Taylor, Adele, Weatherdon, Georgina, Wilkinson, Tim, and Russ, Tom C.

Abstract

Additional file 2. Approximate number of person-hours required for each ascertainment phase.

Published
2023
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13. Dementia diagnosis and prevalence in the Lothian Birth Cohort 1936 using medical data linkage

Author

Mullin, Donncha S., primary, Stirland, Lucy E., additional, Buchanan, Emily, additional, Convery, Catherine-Anne, additional, Cox, Simon R., additional, Deary, Ian J., additional, Giuntoli, Cinzia, additional, Greer, Holly, additional, Page, Danielle, additional, Robertson, Elizabeth, additional, Shenkin, Susan D., additional, Szalek, Anna, additional, Taylor, Adele, additional, Weatherdon, Georgina, additional, Wilkinson, Tim, additional, and Russ, Tom C., additional

Published
2022
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15. Trajectories of Frailty With Aging: Coordinated Analysis of Five Longitudinal Studies

Author

Jenkins, Natalie D. Hoogendijk, Emiel O. Armstrong, Joshua J. and Lewis, Nathan A. Ranson, Janice M. Rijnhart, Judith J. M. and Ahmed, Tamer Ghachem, Ahmed Mullin, Donncha S. Ntanasi, Eva Welstead, Miles Auais, Mohammad Bennett, David A. and Bandinelli, Stefania Cesari, Matteo Ferrucci, Luigi French, Simon D. Huisman, Martijn Llewellyn, David J. Scarmeas, Nikolaos Piccinin, Andrea M. Hofer, Scott M. Muniz-Terrera, Graciela

Abstract

Background and Objectives There is an urgent need to better understand frailty and its predisposing factors. Although numerous cross-sectional studies have identified various risk and protective factors of frailty, there is a limited understanding of longitudinal frailty progression. Furthermore, discrepancies in the methodologies of these studies hamper comparability of results. Here, we use a coordinated analytical approach in 5 independent cohorts to evaluate longitudinal trajectories of frailty and the effect of 3 previously identified critical risk factors: sex, age, and education. Research Design and Methods We derived a frailty index (FI) for 5 cohorts based on the accumulation of deficits approach. Four linear and quadratic growth curve models were fit in each cohort independently. Models were adjusted for sex/gender, age, years of education, and a sex/gender-by-age interaction term. Results Models describing linear progression of frailty best fit the data. Annual increases in FI ranged from 0.002 in the Invecchiare in Chianti cohort to 0.009 in the Longitudinal Aging Study Amsterdam (LASA). Women had consistently higher levels of frailty than men in all cohorts, ranging from an increase in the mean FI in women from 0.014 in the Health and Retirement Study cohort to 0.046 in the LASA cohort. However, the associations between sex/gender and rate of frailty progression were mixed. There was significant heterogeneity in within-person trajectories of frailty about the mean curves. Discussion and Implications Our findings of linear longitudinal increases in frailty highlight important avenues for future research. Specifically, we encourage further research to identify potential effect modifiers or groups that would benefit from targeted or personalized interventions.

Published
2022

16. Mechanisms of motoric cognitive risk—Hypotheses based on a systematic review and meta‐analysis of longitudinal cohort studies of older adults.

Author

Mullin, Donncha S., Cockburn, Alastair, Welstead, Miles, Luciano, Michelle, Russ, Tom C., and Muniz‐Terrera, Graciela

Abstract

We aimed to refine the hypothesis that motoric cognitive risk (MCR), a syndrome combining measured slow gait speed and self‐reported cognitive complaints, is prognostic of incident dementia and other major causes of morbidity in older age. We propose mechanisms on the relationship between motor and cognitive function and describe a roadmap to validate these hypotheses. We systematically searched major electronic databases from inception to August 2021 for original longitudinal cohort studies of adults aged ≥60 years that compared an MCR group to a non‐MCR group with any health outcome. Fifteen cohorts were combined by meta‐analysis. Participants with MCR were at an increased risk of cognitive impairment (adjusted hazard ratio [aHR] 1.76, 95% CI 1.49–2.08; I2 = 24.9%), dementia (aHR 2.12, 1.85–2.42; 33.1%), falls (adjusted Relative Risk 1.38, 1.15–1.66; 62.1%), and mortality (aHR 1.49, 1.16–1.91; 79.2%). The prognostic value of MCR is considerable and mechanisms underlying the syndrome are proposed. [ABSTRACT FROM AUTHOR]

Published
2022
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17. Trajectories of Frailty With Aging: Coordinated Analysis of Five Longitudinal Studies

Author

Jenkins, Natalie D, primary, Hoogendijk, Emiel O, additional, Armstrong, Joshua J, additional, Lewis, Nathan A, additional, Ranson, Janice M, additional, Rijnhart, Judith J M, additional, Ahmed, Tamer, additional, Ghachem, Ahmed, additional, Mullin, Donncha S, additional, Ntanasi, Eva, additional, Welstead, Miles, additional, Auais, Mohammad, additional, Bennett, David A, additional, Bandinelli, Stefania, additional, Cesari, Matteo, additional, Ferrucci, Luigi, additional, French, Simon D, additional, Huisman, Martijn, additional, Llewellyn, David J, additional, Scarmeas, Nikolaos, additional, Piccinin, Andrea M, additional, Hofer, Scott M, additional, and Muniz-Terrera, Graciela, additional

Published
2022
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20. Mechanisms of motoric cognitive risk-Hypotheses based on a systematic review and meta-analysis of longitudinal cohort studies of older adults.

Author

Mullin DS, Cockburn A, Welstead M, Luciano M, Russ TC, and Muniz-Terrera G

Subjects
Humans, Aged, Longitudinal Studies, Cohort Studies, Risk Factors, Cognition, Cognition Disorders, Cognitive Dysfunction epidemiology, Dementia
Abstract

We aimed to refine the hypothesis that motoric cognitive risk (MCR), a syndrome combining measured slow gait speed and self-reported cognitive complaints, is prognostic of incident dementia and other major causes of morbidity in older age. We propose mechanisms on the relationship between motor and cognitive function and describe a roadmap to validate these hypotheses. We systematically searched major electronic databases from inception to August 2021 for original longitudinal cohort studies of adults aged ≥60 years that compared an MCR group to a non-MCR group with any health outcome. Fifteen cohorts were combined by meta-analysis. Participants with MCR were at an increased risk of cognitive impairment (adjusted hazard ratio [aHR] 1.76, 95% CI 1.49-2.08; I 2  = 24.9%), dementia (aHR 2.12, 1.85-2.42; 33.1%), falls (adjusted Relative Risk 1.38, 1.15-1.66; 62.1%), and mortality (aHR 1.49, 1.16-1.91; 79.2%). The prognostic value of MCR is considerable and mechanisms underlying the syndrome are proposed., (© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)

Published
2022
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