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Your search keyword '"Natural selection signal"' showing total 2 results
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2 results on '"Natural selection signal"'

1. Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion.

Author

Garzón-Ospina, Diego, Forero-Rodríguez, Johanna, and Patarroyo, Manuel A.

Subjects
*NATURAL selection, *PLASMODIUM vivax, *MEROZOITES, *GENETIC code, *NUCLEOTIDE sequencing, *ALLELES
Abstract

Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax -Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses. [ABSTRACT FROM AUTHOR]

Published
2015
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2. Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion

Author

Diego Garzón-Ospina, Manuel A. Patarroyo, and Johanna Forero-Rodríguez

Subjects
Host parasite interaction, Physiology, Natural selection, Plasmodium vivax, Protozoan Proteins, Genetic selection, Dna sequence, Gene mutation, Signal transduction, dna, Genome, Plasmodium, Computational biology, Microbial gene, Phylogeny, Priority journal, Genetics, Allele, biology, Sequence analysis, Anti-malarial vaccine, Infectious Diseases, Multigene family, Plasmodium parasites, Host-parasite interactions, Merozoite, Microbiology (medical), Protozoan proteins, Protozoal protein, Microbiology, Dna polymorphism, DNA sequencing, Article, Host-Parasite Interactions, Natural selection signal, parasitic diseases, Allele-specific response, Genetic variation, Selection, Genetic, Polymorphism, Molecular Biology, Gene, Biology, Selection, Ecology, Evolution, Behavior and Systematics, Selection (genetic algorithm), Polymorphism, Genetic, Genetic polymorphism, Computational Biology, Genetic Variation, Sequence Analysis, DNA, biology.organism_classification, Nonhuman, Metabolism, Genetic variability, genetic
Abstract

Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses. © 2015 Elsevier B.V.

Published
2015

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