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17 results on '"Niu, Guiye"'

1. Genome-Wide Analysis of Protein-Coding Variants in Leprosy

Author

Liu, Hong, Wang, Zhenzhen, Li, Yi, Yu, Gongqi, Fu, Xi’an, Wang, Chuan, Liu, Wenting, Yu, Yongxiang, Bao, Fangfang, Irwanto, Astrid, Liu, Jian, Chu, Tongsheng, Andiappan, Anand Kumar, Maurer-Stroh, Sebastian, Limviphuvadh, Vachiranee, Wang, Honglei, Mi, Zihao, Sun, Yonghu, Sun, Lele, Wang, Ling, Wang, Chaolong, You, Jiabao, Li, Jinghui, Foo, Jia Nee, Liany, Herty, Meah, Wee Yang, Niu, Guiye, Yue, Zhenhua, Zhao, Qing, Wang, Na, Yu, Meiwen, Yu, Wenjun, Cheng, Xiujun, Khor, Chiea Chuen, Sim, Kar Seng, Aung, Tin, Wang, Ningli, Wang, Deyun, Shi, Li, Ning, Yong, Zheng, Zhongyi, Yang, Rongde, Li, Jinlan, Yang, Jun, Yan, Liangbin, Shen, Jianping, Zhang, Guocheng, Chen, Shumin, Liu, Jianjun, and Zhang, Furen

Published
2017
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2. Prevalence, risk factors, and medical costs of Chlamydia trachomatis infections in Shandong Province, China: a population-based, cross-sectional study

Author

Huai, Pengcheng, Li, Furong, Li, Zhen, Sun, Lele, Fu, Xi’an, Pan, Qing, Yu, Gongqi, Chai, Zemin, Chu, Tongsheng, Mi, Zihao, Bao, Fangfang, Wang, Honglei, Zhou, Bingni, Wang, Chuan, Sun, Yonghu, Niu, Guiye, Zhang, Yuan, Fu, Fanghui, Lang, Xiaoqiao, Wang, Xiaoling, Zhao, Hui, Liu, Daina, Liu, Hong, Liu, Dianchang, Liu, Jian, Xu, Aiqiang, and Zhang, Furen

Published
2018
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5. The role of an active surveillance strategy of targeting household and neighborhood contacts related to leprosy cases released from treatment in a low-endemic area of China

Author

Wang, Na, primary, Chu, Tongsheng, additional, Li, Furong, additional, Wang, Zhenzhen, additional, Liu, Dianchang, additional, Chen, Mingfei, additional, Wang, Honglei, additional, Niu, Guiye, additional, Liu, Dan, additional, Zhang, Mingkai, additional, Xu, Yuanyuan, additional, Zhang, Yan, additional, Li, Jinghui, additional, Li, Zhen, additional, You, Jiabao, additional, Mao, Liguo, additional, Li, Huaizhang, additional, Chen, Yongjin, additional, Liu, Hong, additional, and Zhang, Furen, additional

Published
2020
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6. Seroprevalence and associated factors of HSV-2 infection among general population in Shandong Province, China

Author

Huai, Pengcheng, primary, Li, Furong, additional, Li, Zhen, additional, Sun, Lele, additional, Fu, Xi’an, additional, Pan, Qing, additional, Yu, Gongqi, additional, Chai, Zemin, additional, Chu, Tongsheng, additional, Mi, Zihao, additional, Bao, Fangfang, additional, Wang, Honglei, additional, Zhou, Bingni, additional, Wang, Chuan, additional, Sun, Yonghu, additional, Niu, Guiye, additional, Zhang, Yuan, additional, Fu, Fanghui, additional, Lang, Xiaoqiao, additional, Wang, Xiaoling, additional, Zhao, Hui, additional, Liu, Daina, additional, Liu, Hong, additional, Liu, Dianchang, additional, Liu, Jian, additional, Xu, Aiqiang, additional, and Zhang, Furen, additional

Published
2019
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8. Prediction of leprosy in the Chinese population based on a weighted genetic risk score

Author

Wang, Na, primary, Wang, Zhenzhen, additional, Wang, Chuan, additional, Fu, Xi'an, additional, Yu, Gongqi, additional, Yue, Zhenhua, additional, Liu, Tingting, additional, Zhang, Huimin, additional, Li, Lulu, additional, Chen, Mingfei, additional, Wang, Honglei, additional, Niu, Guiye, additional, Liu, Dan, additional, Zhang, Mingkai, additional, Xu, Yuanyuan, additional, Zhang, Yan, additional, Li, Jinghui, additional, Li, Zhen, additional, You, Jiabao, additional, Chu, Tongsheng, additional, Li, Furong, additional, Liu, Dianchang, additional, Liu, Hong, additional, and Zhang, Furen, additional

Published
2018
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9. Two novel TSC2 mutations in Chinese patients with tuberous sclerosis complex

Author

You, Jiabao, Liu, Hong, Fu, Xi'An, Chen, Mingfei, Niu, Guiye, Tian, Hongqing, and Zhang, Furen

Subjects
Gene mutations -- Health aspects -- Research, Calmodulin -- Physiological aspects -- Research, Tuberous sclerosis -- Genetic aspects -- Research, Health
Abstract

Byline: Jiabao. You, Hong. Liu, Xi'an. Fu, Mingfei. Chen, Guiye. Niu, Hongqing. Tian, Furen. Zhang Sir, Tuberous sclerosis complex (TSC, OMIM 191100) is a rare autosomal dominant disorder characterized by [...]

Published
2013

10. A large-scale genome-wide association and meta-analysis identified four novel susceptibility loci for leprosy

Author

Wang, Zhenzhen, primary, Sun, Yonghu, additional, Fu, Xi’an, additional, Yu, Gongqi, additional, Wang, Chuan, additional, Bao, Fangfang, additional, Yue, Zhenhua, additional, Li, Jianke, additional, Sun, Lele, additional, Irwanto, Astrid, additional, Yu, Yongxiang, additional, Chen, Mingfei, additional, Mi, Zihao, additional, Wang, Honglei, additional, Huai, Pengcheng, additional, Li, Yi, additional, Du, Tiantian, additional, Yu, Wenjun, additional, Xia, Yang, additional, Xiao, Hailu, additional, You, Jiabao, additional, Li, Jinghui, additional, Yang, Qing, additional, Wang, Na, additional, Shang, Panpan, additional, Niu, Guiye, additional, Chi, Xiaojun, additional, Wang, Xiuhuan, additional, Cao, Jing, additional, Cheng, Xiujun, additional, Liu, Hong, additional, Liu, Jianjun, additional, and Zhang, Furen, additional

Published
2016
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11. Prediction of leprosy in the Chinese population based on a weighted genetic risk score.

Author

Fu, Xi'an, Wang, Na, Yue, Zhenhua, Wang, Honglei, Niu, Guiye, Li, Jinghui, Li, Zhen, You, Jiabao, Liu, Hong, Zhang, Furen, Chen, Mingfei, Li, Furong, Wang, Zhenzhen, Wang, Chuan, Yu, Gongqi, Liu, Tingting, Zhang, Huimin, Li, Lulu, Liu, Dan, and Zhang, Mingkai

Subjects
HANSEN'S disease, GENETICS -- Risk factors, PREDICTION models, ACCURACY, POPULATION, DISEASE risk factors
Abstract

Genome wide association studies (GWASs) have revealed multiple genetic variants associated with leprosy in the Chinese population. The aim of our study was to utilize the genetic variants to construct a risk prediction model through a weighted genetic risk score (GRS) in a Chinese set and to further assess the performance of the model in identifying higher-risk contact individuals in an independent set. The highest prediction accuracy, with an area under the curve (AUC) of 0.743 (95% confidence interval (CI): 0.729–0.757), was achieved with a GRS encompassing 25 GWAS variants in a discovery set that included 2,144 people affected by leprosy and 2,671 controls. Individuals in the high-risk group, based on genetic factors (GRS > 28.06), have a 24.65 higher odds ratio (OR) for developing leprosy relative to those in the low-risk group (GRS≤18.17). The model was then applied to a validation set consisting of 1,385 people affected by leprosy and 7,541 individuals in contact with leprosy, which yielded a discriminatory ability with an AUC of 0.707 (95% CI: 0.691–0.723). When a GRS cut-off value of 22.38 was selected with the optimal sensitivity and specificity, it was found that 39.31% of high risk contact individuals should be screened in order to detect leprosy in 64.9% of those people affected by leprosy. In summary, we developed and validated a risk model for the prediction of leprosy that showed good discrimination capabilities, which may help physicians in the identification of patients coming into contact with leprosy and are at a higher-risk of developing this condition. [ABSTRACT FROM AUTHOR]

Published
2018
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12. Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy

Author

Liu, Hong, primary, Irwanto, Astrid, additional, Fu, Xi'an, additional, Yu, Gongqi, additional, Yu, Yongxiang, additional, Sun, Yonghu, additional, Wang, Chuan, additional, Wang, Zhenzhen, additional, Okada, Yukinori, additional, Low, Huiqi, additional, Li, Yi, additional, Liany, Herty, additional, Chen, Mingfei, additional, Bao, Fangfang, additional, Li, Jinghui, additional, You, Jiabao, additional, Zhang, Qilin, additional, Liu, Jian, additional, Chu, Tongsheng, additional, Andiappan, Anand Kumar, additional, Wang, Na, additional, Niu, Guiye, additional, Liu, Dianchang, additional, Yu, Xiulu, additional, Zhang, Lin, additional, Tian, Hongqing, additional, Zhou, Guizhi, additional, Rotzschke, Olaf, additional, Chen, Shumin, additional, Zhang, Xuejun, additional, Liu, Jianjun, additional, and Zhang, Furen, additional

Published
2015
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14. Genome-Wide Linkage, Exome Sequencing and Functional Analyses Identify ABCB6 as the Pathogenic Gene of Dyschromatosis Universalis Hereditaria

Author

Liu, Hong, primary, Li, Yi, additional, Hung, Ken Kwok Hon, additional, Wang, Na, additional, Wang, Chuan, additional, Chen, Xuechao, additional, Sheng, Donglai, additional, Fu, Xi’an, additional, See, Kelvin, additional, Foo, Jia Nee, additional, Low, Huiqi, additional, Liany, Herty, additional, Irwan, Ishak Darryl, additional, Liu, Jian, additional, Yang, Baoqi, additional, Chen, Mingfei, additional, Yu, Yongxiang, additional, Yu, Gongqi, additional, Niu, Guiye, additional, You, Jiabao, additional, Zhou, Yan, additional, Ma, Shanshan, additional, Wang, Ting, additional, Yan, Xiaoxiao, additional, Goh, Boon Kee, additional, Common, John E. A., additional, Lane, Birgitte E., additional, Sun, Yonghu, additional, Zhou, Guizhi, additional, Lu, Xianmei, additional, Wang, Zhenhua, additional, Tian, Hongqing, additional, Cao, Yuanhua, additional, Chen, Shumin, additional, Liu, Qiji, additional, Liu, Jianjun, additional, and Zhang, Furen, additional

Published
2014
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16. Identification of IL18RAP/IL18R1 and IL12B as Leprosy Risk Genes Demonstrates Shared Pathogenesis between Inflammation and Infectious Diseases

Author

Liu, Hong, primary, Irwanto, Astrid, additional, Tian, Hongqing, additional, Fu, Xi'an, additional, Yu, Yongxiang, additional, Yu, Gongqi, additional, Low, Huiqi, additional, Chu, Tongsheng, additional, Li, Yi, additional, Shi, Benqing, additional, Chen, Mingfei, additional, Sun, Yonghu, additional, Yuan, Chunying, additional, Lu, Nan, additional, You, Jiabao, additional, Bao, Fangfang, additional, Li, Jinghui, additional, Liu, Jian, additional, Liu, Huaxu, additional, Liu, Dianchang, additional, Yu, Xiulu, additional, Zhang, Lin, additional, Yang, Qing, additional, Wang, Na, additional, Niu, Guiye, additional, Ma, Shanshan, additional, Zhou, Yan, additional, Wang, Chuan, additional, Chen, Shumin, additional, Zhang, Xuejun, additional, Liu, Jianjun, additional, and Zhang, Furen, additional

Published
2012
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17. Genome-Wide Linkage, Exome Sequencing and Functional Analyses Identify ABCB6 as the Pathogenic Gene of Dyschromatosis Universalis Hereditaria.

Author

Liu, Hong, Li, Yi, Hung, Ken Kwok Hon, Wang, Na, Wang, Chuan, Chen, Xuechao, Sheng, Donglai, Fu, Xi’an, See, Kelvin, Foo, Jia Nee, Low, Huiqi, Liany, Herty, Irwan, Ishak Darryl, Liu, Jian, Yang, Baoqi, Chen, Mingfei, Yu, Yongxiang, Yu, Gongqi, Niu, Guiye, and You, Jiabao

Subjects
NUCLEOTIDE sequence, GENETIC disorders, MOLECULAR biology, AXONS, IMMUNOHISTOCHEMISTRY, REVERSE transcriptase polymerase chain reaction, HUMAN genetics, COMPUTATIONAL biology
Abstract

Background: As a genetic disorder of abnormal pigmentation, the molecular basis of dyschromatosis universalis hereditaria (DUH) had remained unclear until recently when ABCB6 was reported as a causative gene of DUH. Methodology: We performed genome-wide linkage scan using Illumina Human 660W-Quad BeadChip and exome sequencing analyses using Agilent SureSelect Human All Exon Kits in a multiplex Chinese DUH family to identify the pathogenic mutations and verified the candidate mutations using Sanger sequencing. Quantitative RT-PCR and Immunohistochemistry was performed to verify the expression of the pathogenic gene, Zebrafish was also used to confirm the functional role of ABCB6 in melanocytes and pigmentation. Results: Genome-wide linkage (assuming autosomal dominant inheritance mode) and exome sequencing analyses identified ABCB6 as the disease candidate gene by discovering a coding mutation (c.1358C>T; p.Ala453Val) that co-segregates with the disease phenotype. Further mutation analysis of ABCB6 in four other DUH families and two sporadic cases by Sanger sequencing confirmed the mutation (c.1358C>T; p.Ala453Val) and discovered a second, co-segregating coding mutation (c.964A>C; p.Ser322Lys) in one of the four families. Both mutations were heterozygous in DUH patients and not present in the 1000 Genome Project and dbSNP database as well as 1,516 unrelated Chinese healthy controls. Expression analysis in human skin and mutagenesis interrogation in zebrafish confirmed the functional role of ABCB6 in melanocytes and pigmentation. Given the involvement of ABCB6 mutations in coloboma, we performed ophthalmological examination of the DUH carriers of ABCB6 mutations and found ocular abnormalities in them. Conclusion: Our study has advanced our understanding of DUH pathogenesis and revealed the shared pathological mechanism between pigmentary DUH and ocular coloboma. [ABSTRACT FROM AUTHOR]

Published
2014
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