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Your search keyword '"Noseworthy, Michael D."' showing total 505 results
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505 results on '"Noseworthy, Michael D."'

1. State of the Practice for Medical Imaging Software

Author

Smith, W. Spencer, Dong, Ao, Carette, Jacques, and Noseworthy, Michael D.

Subjects
Computer Science - Software Engineering, Computer Science - Computer Vision and Pattern Recognition, D.2.7, I.4.0
Abstract

We selected 29 medical imaging projects from 48 candidates, assessed 10 software qualities by answering 108 questions for each software project, and interviewed 8 of the 29 development teams. Based on the quantitative data, we ranked the MI software with the Analytic Hierarchy Process (AHP). The four top-ranked software products are 3D Slicer, ImageJ, Fiji, and OHIF Viewer. Generally, MI software is in a healthy state as shown by the following: we observed 88% of the documentation artifacts recommended by research software development guidelines, 100% of MI projects use version control tools, and developers appear to use the common quasi-agile research software development process. However, the current state of the practice deviates from the existing guidelines because of the rarity of some recommended artifacts, low usage of continuous integration (17% of the projects), low use of unit testing (about 50% of projects), and room for improvement with documentation (six of nine developers felt their documentation was not clear enough). From interviewing the developers, we identified five pain points and two qualities of potential concern: lack of development time, lack of funding, technology hurdles, ensuring correctness, usability, maintainability, and reproducibility. The interviewees proposed strategies to improve the state of the practice, to address the identified pain points, and to improve software quality. Combining their ideas with ours, we have the following list of recommendations: increase documentation, increase testing by enriching datasets, increase continuous integration usage, move to web applications, employ linters, use peer reviews, design for change, add assurance cases, and incorporate a "Generate All Things" approach., Comment: 73 pages, 14 figures, 12 tables

Published
2024

3. New Insights Into Accelerometer-Measured Habitual Physical Activity and Sedentary Time During Early Recovery in Pediatric Concussion.

Author

Sharma, Bhanu, Obeid, Joyce, DeMatteo, Carol, Noseworthy, Michael D., and Timmons, Brian W.

Subjects
SECONDARY analysis, RESEARCH funding, ACCELEROMETRY, SEDENTARY lifestyles, SEX distribution, CONVALESCENCE, PHYSICAL activity, BRAIN concussion, CHILDREN
Abstract

Purpose: Concussion management is shifting away from a rest-is-best approach, as data now suggest that exercise-is-medicine for this mild brain injury. Despite this, we have limited data on habitual physical activity following concussion. Therefore, our objective was to quantify accelerometer-measured physical activity and sedentary time in children with concussion (within the first month of injury) and healthy controls. We hypothesized that children with concussion would be less active than their healthy peers. Methods: We performed a secondary analysis of prospectively collected accelerometer data. Our sample included children with concussion (n = 60, 31 females) and historical controls (n = 60) matched for age, sex, and season of accelerometer wear. Results: Children with concussion were significantly more sedentary than controls (mean difference [MD], 38.3 min/d, P =.006), and spent less time performing light physical activity (MD, −19.5 min/d, P =.008), moderate physical activity (MD, −9.8 min/d, P <.001), and vigorous physical activity (MD, −12.0 min/d, P <.001); these differences were observed from 8:00 AM to 9:00 PM. Sex-specific analyses identified that girls with concussion were less active and more sedentary than both boys with concussion (P =.010) and healthy girls (P <.010). Conclusion: There is an activity deficit observed within the first month of pediatric concussion. Physical activity guidelines should address this while considering sex effects. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Addressing Dataset Shift for Trustworthy Deep Learning Diagnostic Ultrasound Decision Support

Author

Zhu, Calvin, Noseworthy, Michael D., Doyle, Thomas E., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Gavrilova, Marina, editor, Tan, C. J. Kenneth, editor, Coates, Mark, editor, Hu, Yaoping, editor, Leung, Henry, editor, Mohammadi, Arash, editor, Plataniotis, Konstantinos N., editor, and de Oliveira, Helder Rodrigues, editor

Published
2023
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10. Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease

Author

Ottoy, Julie, Ozzoude, Miracle, Zukotynski, Katherine, Kang, Min Su, Adamo, Sabrina, Scott, Christopher, Ramirez, Joel, Swardfager, Walter, Lam, Benjamin, Bhan, Aparna, Mojiri, Parisa, Kiss, Alex, Strother, Stephen, Bocti, Christian, Borrie, Michael, Chertkow, Howard, Frayne, Richard, Hsiung, Robin, Laforce, Robert Jr, Noseworthy, Michael D, Prato, Frank S, Sahlas, Demetrios J, Smith, Eric E, Kuo, Phillip H, Chad, Jordan A, Pasternak, Ofer, Sossi, Vesna, Thiel, Alexander, Soucy, Jean-Paul, Tardif, Jean-Claude, Black, Sandra E, and Goubran, Maged

Published
2023
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14. Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota

Author

Ahmed, Basma A., Ong, Frank J., Barra, Nicole G., Blondin, Denis P., Gunn, Elizabeth, Oreskovich, Stephan M., Szamosi, Jake C., Syed, Saad A., Hutchings, Emily K., Konyer, Norman B., Singh, Nina P., Yabut, Julian M., Desjardins, Eric M., Anhê, Fernando F., Foley, Kevin P., Holloway, Alison C., Noseworthy, Michael D., Haman, Francois, Carpentier, Andre C., Surette, Michael G., Schertzer, Jonathan D., Punthakee, Zubin, Steinberg, Gregory R., and Morrison, Katherine M.

Published
2021
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17. The Concussion, Exercise, and Brain Networks (ConExNet) study: a cohort study aimed at understanding the effects of sub-maximal aerobic exercise on resting state functional brain activity in pediatric concussion.

Author

Sharma, Bhanu, Koelink, Eric, DeMatteo, Carol, Noseworthy, Michael D., and Timmons, Brian W.

Subjects
AEROBIC exercises, LARGE-scale brain networks, BRAIN concussion, SYMPTOM burden, FUNCTIONAL magnetic resonance imaging
Abstract

Background: Recent scientific evidence has challenged the traditional "rest-is-best" approach for concussion management. It is now thought that "exercise-is-medicine" for concussion, owing to dozens of studies which demonstrate that sub-maximal, graded aerobic exercise can reduce symptom burden and time to symptom resolution. However, the primary neuropathology of concussion is altered functional brain activity. To date, no studies have examined the effects of sub-maximal aerobic exercise on resting state functional brain activity in pediatric concussion. In addition, although exercise is now more widely prescribed following concussion, its cardiopulmonary response is not yet well understood in this population. Our study has two main goals. The first is to understand whether there are exercise-induced resting state functional brain activity differences in children with concussion vs. healthy controls. The second is to profile the physiological response to exercise and understand whether it differs between groups. Methods: We will perform a single-center, controlled, prospective cohort study of pediatric concussion at a large, urban children's hospital and academic center. Children with sport-related concussion (aged 12–17 years) will be recruited within 4-weeks of injury by our clinical study team members. Key inclusion criteria include: medical clearance to exercise, no prior concussion or neurological history, and no implants that would preclude MRI. Age- and sex-matched healthy controls will be required to meet the same inclusion criteria and will be recruited through the community. The study will be performed over two visits separated by 24–48 h. Visit 1 involves exercise testing (following the current clinical standard for concussion) and breath-by-breath gas collection using a metabolic cart. Visit 2 involves two functional MRI (fMRI) scans interspersed by 10-minutes of treadmill walking at an intensity calibrated to Visit 1 findings. To address sub-objectives, all participants will be asked to self-report symptoms daily and wear a waist-worn tri-axial accelerometer for 28-days after Visit 2. Discussion: Our study will advance the growing exercise-concussion field by helping us understand whether exercise impacts outcomes beyond symptoms in pediatric concussion. We will also be able to profile the cardiopulmonary response to exercise, which may allow for further understanding (and eventual optimization) of exercise in concussion management. Trial registration: Not applicable. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology.

Author

Xhima, Kristiana, Ottoy, Julie, Gibson, Erin, Zukotynski, Katherine, Scott, Christopher, Feliciano, Ginelle J., Adamo, Sabrina, Kuo, Phillip H., Borrie, Michael J., Chertkow, Howard, Frayne, Richard, Laforce, Robert, Noseworthy, Michael D., Prato, Frank S., Sahlas, Demetrios J., Smith, Eric E., Sossi, Vesna, Thiel, Alexander, Soucy, Jean‐Paul, and Tardif, Jean‐Claude

Abstract

INTRODUCTION: Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology frequently co‐exist. The impact of concurrent pathology on the pattern of hippocampal atrophy, a key substrate of memory impacted early and extensively in dementia, remains poorly understood. METHODS: In a unique cohort of mixed Alzheimer's disease and moderate–severe SVD, we examined whether total and regional neuroimaging measures of SVD, white matter hyperintensities (WMH), and Aβ, as assessed by 18F‐AV45 positron emission tomography, exert additive or synergistic effects on hippocampal volume and shape. RESULTS: Frontal WMH, occipital WMH, and Aβ were independently associated with smaller hippocampal volume. Frontal WMH had a spatially distinct impact on hippocampal shape relative to Aβ. In contrast, hippocampal shape alterations associated with occipital WMH spatially overlapped with Aβ‐vulnerable subregions. DISCUSSION: Hippocampal degeneration is differentially sensitive to SVD and Aβ pathology. The pattern of hippocampal atrophy could serve as a disease‐specific biomarker, and thus guide clinical diagnosis and individualized treatment strategies for mixed dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Big GABA II: Water-referenced edited MR spectroscopy at 25 research sites

Author

Mikkelsen, Mark, Rimbault, Daniel L., Barker, Peter B., Bhattacharyya, Pallab K., Brix, Maiken K., Buur, Pieter F., Cecil, Kim M., Chan, Kimberly L., Chen, David Y.-T., Craven, Alexander R., Cuypers, Koen, Dacko, Michael, Duncan, Niall W., Dydak, Ulrike, Edmondson, David A., Ende, Gabriele, Ersland, Lars, Forbes, Megan A., Gao, Fei, Greenhouse, Ian, Harris, Ashley D., He, Naying, Heba, Stefanie, Hoggard, Nigel, Hsu, Tun-Wei, Jansen, Jacobus F.A., Kangarlu, Alayar, Lange, Thomas, Lebel, R. Marc, Li, Yan, Lin, Chien-Yuan E., Liou, Jy-Kang, Lirng, Jiing-Feng, Liu, Feng, Long, Joanna R., Ma, Ruoyun, Maes, Celine, Moreno-Ortega, Marta, Murray, Scott O., Noah, Sean, Noeske, Ralph, Noseworthy, Michael D., Oeltzschner, Georg, Porges, Eric C., Prisciandaro, James J., Puts, Nicolaas A.J., Roberts, Timothy P.L., Sack, Markus, Sailasuta, Napapon, Saleh, Muhammad G., Schallmo, Michael-Paul, Simard, Nicholas, Stoffers, Diederick, Swinnen, Stephan P., Tegenthoff, Martin, Truong, Peter, Wang, Guangbin, Wilkinson, Iain D., Wittsack, Hans-Jörg, Woods, Adam J., Xu, Hongmin, Yan, Fuhua, Zhang, Chencheng, Zipunnikov, Vadim, Zöllner, Helge J., and Edden, Richard A.E.

Published
2019
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28. Reduced Cognitive Assessment Scores Among Individuals With Magnetic Resonance Imaging–Detected Vascular Brain Injury

Author

Anand, Sonia S., Friedrich, Matthias G., Desai, Dipika, Schulze, Karleen M., Awadalla, Philip, Busseuil, David, Dummer, Trevor J.B., Jacquemont, Sébastien, Dick, Alexander, Kelton, David, Kirpalani, Anish, Lear, Scott A., Leipsic, Jonathan, Noseworthy, Michael D., Parker, Louise, Parraga, Grace, Poirier, Paul, Robson, Paula, Tardif, Jean-Claude, Teo, Koon, Vena, Jennifer, Yusuf, Salim, Moody, Alan R., Black, Sandra E., and Smith, Eric E.

Published
2020
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30. Big GABA: Edited MR spectroscopy at 24 research sites

Author

Mikkelsen, Mark, Barker, Peter B., Bhattacharyya, Pallab K., Brix, Maiken K., Buur, Pieter F., Cecil, Kim M., Chan, Kimberly L., Chen, David Y.-T., Craven, Alexander R., Cuypers, Koen, Dacko, Michael, Duncan, Niall W., Dydak, Ulrike, Edmondson, David A., Ende, Gabriele, Ersland, Lars, Gao, Fei, Greenhouse, Ian, Harris, Ashley D., He, Naying, Heba, Stefanie, Hoggard, Nigel, Hsu, Tun-Wei, Jansen, Jacobus F.A., Kangarlu, Alayar, Lange, Thomas, Lebel, R. Marc, Li, Yan, Lin, Chien-Yuan E., Liou, Jy-Kang, Lirng, Jiing-Feng, Liu, Feng, Ma, Ruoyun, Maes, Celine, Moreno-Ortega, Marta, Murray, Scott O., Noah, Sean, Noeske, Ralph, Noseworthy, Michael D., Oeltzschner, Georg, Prisciandaro, James J., Puts, Nicolaas A.J., Roberts, Timothy P.L., Sack, Markus, Sailasuta, Napapon, Saleh, Muhammad G., Schallmo, Michael-Paul, Simard, Nicholas, Swinnen, Stephan P., Tegenthoff, Martin, Truong, Peter, Wang, Guangbin, Wilkinson, Iain D., Wittsack, Hans-Jörg, Xu, Hongmin, Yan, Fuhua, Zhang, Chencheng, Zipunnikov, Vadim, Zöllner, Helge J., and Edden, Richard A.E.

Published
2017
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31. EFFECTS OF VASCULAR BURDEN ON COGNITION ARE MEDIATED BY ATROPHY, AMYLOID, AND GLUCOSE METABOLISM: A MULTI-CENTRE MIXED COHORT OF SMALL VESSEL DISEASE AND ALZHEIMER'S PATHOLOGY

Author

Ottoy, Julie, Ozzoude, Miracle, Zukotynski, Katherine, Adamo, Sabrina, Scott, Christopher, Gaudet, Vincent, Ramirez, Joel, Swardfager, Walter, Cogo-Moreira, Hugo, Lam, Benjamin, Bhan, Aparna, Mojiri, Parisa, Kang, Min Su, Rabin, Jennifer, Kiss, Alex, Strother, Stephen, Bocti, Christian, Borrie, Michael, Chertkow, Howard, Frayne, Richard, Hsiung, Robin, Laforce, Robert, Jr., Noseworthy, Michael D., Prato, Frank S., Sahlas, Demetrios J., Smith, Eric E., Kuo, Phillip H., Sossi, Vesna, Thiel, Alexander, Soucy, Jean-Paul, Tardif, Jean-Claude, Black, Sandra E., and Goubran, Maged

Published
2024
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32. Comparison of ventilation defects quantified by Technegas SPECT and hyperpolarized 129Xe MRI

Author

Radadia, Nisarg, primary, Friedlander, Yonni, additional, Priel, Eldar, additional, Konyer, Norman B., additional, Huang, Chynna, additional, Jamal, Mobin, additional, Farncombe, Troy, additional, Marriott, Christopher, additional, Finley, Christian, additional, Agzarian, John, additional, Dolovich, Myrna, additional, Noseworthy, Michael D., additional, Nair, Parameswaran, additional, Shargall, Yaron, additional, and Svenningsen, Sarah, additional

Published
2023
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36. The Use of Random Forests to Classify Amyloid Brain PET

Author

Zukotynski, Katherine, Gaudet, Vincent, Kuo, Phillip H., Adamo, Sabrina, Goubran, Maged, Scott, Christopher, Bocti, Christian, Borrie, Michael, Chertkow, Howard, Frayne, Richard, Hsiung, Robin, Laforce, Robert, Jr, Noseworthy, Michael D., Prato, Frank S., Sahlas, Demetrios J., Smith, Eric E., Sossi, Vesna, Thiel, Alexander, Soucy, Jean-Paul, Tardif, Jean-Claude, and Black, Sandra E.

Published
2019
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43. sj-pdf-1-jcb-10.1177_0271678X231152001 - Supplemental material for Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease

Author

Ottoy, Julie, Ozzoude, Miracle, Zukotynski, Katherine, Kang, Min Su, Adamo, Sabrina, Scott, Christopher, Ramirez, Joel, Swardfager, Walter, Lam, Benjamin, Bhan, Aparna, Mojiri, Parisa, Kiss, Alex, Strother, Stephen, Bocti, Christian, Borrie, Michael, Chertkow, Howard, Frayne, Richard, Hsiung, Robin, Laforce, Robert Jr, Noseworthy, Michael D, Prato, Frank S, Sahlas, Demetrios J, Smith, Eric E, Kuo, Phillip H, Chad, Jordan A, Pasternak, Ofer, Sossi, Vesna, Thiel, Alexander, Soucy, Jean-Paul, Tardif, Jean-Claude, Black, Sandra E, and Goubran, Maged

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231152001 for Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease by Julie Ottoy, Miracle Ozzoude, Katherine Zukotynski, Min Su Kang, Sabrina Adamo, Christopher Scott, Joel Ramirez, Walter Swardfager, Benjamin Lam, Aparna Bhan, Parisa Mojiri, Alex Kiss, Stephen Strother, Christian Bocti, Michael Borrie, Howard Chertkow, Richard Frayne, Robin Hsiung, Robert Jr Laforce, Michael D Noseworthy, Frank S Prato, Demetrios J Sahlas, Eric E Smith, Phillip H Kuo, Jordan A Chad, Ofer Pasternak, Vesna Sossi, Alexander Thiel, Jean-Paul Soucy, Jean-Claude Tardif, Sandra E Black, Maged Goubran in Journal of Cerebral Blood Flow & Metabolism

Published
2023
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