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227 results on '"O'Neill, Gary"'

5. Calla.

Author

O'Neill, Gary

Subjects
PUBLISHING
Abstract

saragaryoneill@ mac. comCalla A SIXES project by Gary O'Neill A SIXES project by Gary O'Neill A SIXES project by Gary O'Neill A SIXES project by Gary O'Neill A SIXES project by Gary O'Neill [Extracted from the article]

Published
2024

6. Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators

Author

Clapper, Jason R., Henry, Cassandra L., Niphakis, Micah J., Knize, Anna M., Coppola, Aundrea R., Simon, Gabriel M., Ngo, Nhi, Herbst, Rachel A., Herbst, Dylan M., Reed, Alex W., Cisar, Justin S., Weber, Olivia D., Viader, Andreu, Alexander, Jessica P., Cunningham, Mark L., Jones, Todd K., Fraser, Iain P., Grice, Cheryl A., Ezekowitz, R. Alan B., O’Neill, Gary P., and Blankman, Jacqueline L.

Published
2018
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7. Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers.

Author

Wang, I-Ming, Zhang, Bin, Yang, Xia, Zhu, Jun, Stepaniants, Serguei, Zhang, Chunsheng, Meng, Qingying, Peters, Mette, He, Yudong, Ni, Chester, Slipetz, Deborah, Crackower, Michael A, Houshyar, Hani, Tan, Christopher M, Asante-Appiah, Ernest, O'Neill, Gary, Luo, Mingjuan Jane, Thieringer, Rolf, Yuan, Jeffrey, Chiu, Chi-Sung, Lum, Pek Yee, Lamb, John, Boie, Yves, Wilkinson, Hilary A, Schadt, Eric E, Dai, Hongyue, and Roberts, Christopher

Subjects
Animals, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Humans, Mice, Rats, Rats, Sprague-Dawley, Disease Models, Animal, Caspases, Intracellular Signaling Peptides and Proteins, Chemokines, Interleukins, Analysis of Variance, Bayes Theorem, Cohort Studies, Gene Expression Profiling, Computational Biology, Age Factors, Sex Factors, Female, Male, Gene Regulatory Networks, Inflammasomes, Bayesian network, co-expression network, inflammatome, inflammatory diseases, key regulators, Inbred BALB C, Inbred C57BL, Knockout, Sprague-Dawley, Disease Models, Animal, Bioinformatics, Biochemistry and Cell Biology, Other Biological Sciences
Abstract

Common inflammatome gene signatures as well as disease-specific signatures were identified by analyzing 12 expression profiling data sets derived from 9 different tissues isolated from 11 rodent inflammatory disease models. The inflammatome signature significantly overlaps with known drug targets and co-expressed gene modules linked to metabolic disorders and cancer. A large proportion of genes in this signature are tightly connected in tissue-specific Bayesian networks (BNs) built from multiple independent mouse and human cohorts. Both the inflammatome signature and the corresponding consensus BNs are highly enriched for immune response-related genes supported as causal for adiposity, adipokine, diabetes, aortic lesion, bone, muscle, and cholesterol traits, suggesting the causal nature of the inflammatome for a variety of diseases. Integration of this inflammatome signature with the BNs uncovered 151 key drivers that appeared to be more biologically important than the non-drivers in terms of their impact on disease phenotypes. The identification of this inflammatome signature, its network architecture, and key drivers not only highlights the shared etiology but also pinpoints potential targets for intervention of various common diseases.

Published
2012

8. Receptor for Motilin Identified in the Human Gastrointestinal System

Author

Feighner, Scott D., Tan, Carina P., McKee, Karen Kulju, Palyha, Oksana C., Hreniuk, Donna L., Pong, Sheng-Shung, Austin, Christopher P., Figueroa, David, MacNeil, Douglas, Cascieri, Margaret A., Nargund, Ravi, Bakshi, Raman, Abramovitz, Mark, Stocco, Rino, Kargman, Stacia, O'Neill, Gary, Evans, Jilly, Patchett, Arthur A., Smith, Roy G., and Howard, Andrew D.

Published
1999

9. Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis

Author

Strack, Alison M., Carballo-Jane, Ester, Wang, Sheng-ping, Xue, Jiyan, Ping, Xiaoli, McNamara, Lesley Ann, Thankappan, Anil, Price, Olga, Wolff, Michael, Wu, T.J., Kawka, Douglas, Mariano, Michele, Burton, Charlotte, Chang, Ching H., Chen, Jing, Menke, John, Luell, Silvi, Zycband, Emanuel I., Tong, Xinchun, Raubertas, Richard, Sparrow, Carl P., Hubbard, Brian, Woods, John, O'Neill, Gary, Waters, M. Gerard, and Sitlani, Ayesha

Published
2013
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13. Multilingualism and occluded diversities within the superdiverse conditions of the United Arab Emirates: a study of the multiple language resources, practices and ideologies of young Emirati women

Author

O'Neill, Gary Thomas

Subjects
Other education not elsewhere classified
Abstract

This thesis by publication explores multilingual language choices in oracy and literacy in a superdiverse context, the Emirate of Dubai in the United Arab Emirates (UAE). Much of the literature to date on multilingualism in superdiverse societies has been based on research conducted in contexts in which migration has risen rapidly in the last twenty years (e.g. London, UK or Antwerp, Belgium), bringing the opportunities and perceived threats of languages and cultures in contact, even though the traditional inhabitants of these countries represent the majority of the population, and their languages continue to be used and valorized. There is relatively little literature focusing on contexts in which recent accelerated migration has led to the minoritization of the resident dominant population and the marginalization of its language or dialect. One such context is the UAE, which is a quintessential superdiverse society in that the traditional inhabitants of the region are now a minority in their own country, albeit a powerful minority, and their variety of Arabic, Emirati Arabic, has become just one of many languages and dialects that are in daily use in its cities, including Dubai. The study examines how this superdiversity manifests itself in the language choices of young Emirati women. It employs an ethnographically-inspired methodology, incorporating both qualitative and quantitative methods, in order to describe the choices made by female Emirati undergraduates and graduates of a national university, in (varieties of) Arabic, English and other languages, and the reasons for these choices. It also explores the opportunities and tensions inherent in these language choices in an increasingly superdiverse context. The thesis consists of three main parts. Firstly, there is an analysis of Emirati women’s reported preferences with regard to reading and writing for pleasure in Arabic and English, along with their preferences regarding languages of university study. The study finds that predispositions developed in the home and at school significantly influence these women’s orientations towards Arabic or English, but also that leisure time interests developed through either language can influence their preferences. The second part of the thesis examines changes in language and literacy across three generations and then goes on to examine language choices in Emirati homes. It finds that there have been significant changes in terms of first and second languages used by Emiratis, along with a major change in literacy levels. With regard to languages of the home, the study finds that a variety of language ideologies affect home language policy. For some families, Emirati Arabic and Modern Standard Arabic index their identities as Arabs, Muslims and Emiratis, while English may be seen as an invasive force, necessary for economic development and personal success, but appropriate only outside the home. In contrast, other families adopt a language ideology, and home language policy, that sanction drawing on wider language repertoires while still identifying as Arab, Muslim and Emirati. The third part of the thesis is a case study of the language choices of one Emirati woman in her early thirties. The study finds that factors influencing language choice are complex and individual, and that while superdiversity may present many opportunities for Emirati citizens, there are also tensions, particularly for those Emiratis with links to other communities. Such Emiratis must constantly negotiate their identities using the linguistic choices at their disposal, either by aligning with the key indexicalities and ‘performing’ their Emirati identity, or by deliberately constructing other identities.

Published
2022
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21. Characterization of the human cysteinyl leukotriene CysLT1 receptor

Author

Lynch, Kevin R., O'Neill, Gary P., Liu, Qingyun, Im, Dong-Soon, Sawyer, Nicole, Metters, Kathleen M., Coulombe, Nathalie, Abramovitz, Mark, Figueroa, David J., Zeng, Zhizhen, Connolly, Brett M., Bai, Chang, Austin, Christopher P., Chateauneuf, Anne, Stocco, Rino, Greig, Gillian M., Kargman, Stacia, Hooks, Shelley B., Hosfield, Elizabeth, Williams, David L., Jr., Ford-Hutchinson, Anthony W., Caskey, C. Thomas, and Evans, Jilly F.

Subjects
Drug receptors -- Research, Protein research -- Analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

It has been possible to characterize the human orphan G-protein-coupled receptor HG55 as the CysLT1 receptor. Two different Xenopus laevis functional systems were used to characterize GH55 (CysLT1)-receptor activation. It was found that all three marketed cysteinyl leukotriene antagonists, zafirlukast (Accolate), montelukast (Singulair) and pranlukast (Onon) are potent competitors for the binding of radiolabelled leukotriene D4 to the CysLT1 receptor.

Published
1999

26. Supplemental_Reardon_et_al – Supplemental material for Quantification of In Vivo Target Engagement Using Microfluidic Activity-Based Protein Profiling

Author

Reardon, Holly T., Herbst, Rachel A., Henry, Cassandra L., Herbst, Dylan M., Ngo, Nhi, Cisar, Justin S., Weber, Olivia D., Niphakis, Micah J., and O’Neill, Gary P.

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, Supplemental_Reardon_et_al for Quantification of In Vivo Target Engagement Using Microfluidic Activity-Based Protein Profiling by Holly T. Reardon, Rachel A. Herbst, Cassandra L. Henry, Dylan M. Herbst, Nhi Ngo, Justin S. Cisar, Olivia D. Weber, Micah J. Niphakis and Gary P. O’Neill in SLAS Technology

Published
2019
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28. Molecular Characterization and Expression of Cloned Human Galanin Receptors GALR2 and GALR3

Author

Kolakowski, Lee F., Jr., O'Neill, Gary P., Howard, Andrew D., Broussard, Suzanne R., Sullivan, Kathleen A., Feighner, Scott D., Sawzdargo, Marek, Nguyen, Tuan, Kargman, Stacia, Shiao, Lin-Lin, Hreniuk, Donna L., Tan, Carina P., Evans, Jilly, Abramovitz, Mark, Chateauneuf, Anne, Coulombe, Nathalie, Ng, Gordon, Johnson, Michael P., Tharian, Anita, Khoshbouei, Habibeh, George, Susan R., Smith, Roy G., and O'Dowd, Brian F.

Published
1998

30. Characterization of the Human Cysteinyl Leukotriene 2 Receptor

Author

Heise, Christopher E., O'Dowd, Brian F., Figueroa, David J., Sawyer, Nicole, Nguyen, Tuan, Im, Dong-Soon, Stocco, Rino, Bellefeuille, Julie N., Abramovitz, Mark, Cheng, Regina, Williams, David L., Jr., Zeng, Zhizhen, Liu, Qingyun, Ma, Lei, Clements, Michelle K., Coulombe, Nathalie, Liu, Yuan, Austin, Christopher P., George, Susan R., O'Neill, Gary P., Metters, Kathleen M., Lynch, Kevin R., and Evans, Jilly F.

Published
2000
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31. Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders

Author

Cisar, Justin S., primary, Weber, Olivia D., additional, Clapper, Jason R., additional, Blankman, Jacqueline L., additional, Henry, Cassandra L., additional, Simon, Gabriel M., additional, Alexander, Jessica P., additional, Jones, Todd K., additional, Ezekowitz, R. Alan B., additional, O’Neill, Gary P., additional, and Grice, Cheryl A., additional

Published
2018
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37. READERS WRITE: U.S.must not abandon Iran deal Schools chief fails to see truth about Nice

Author

Shields, Joshuah and O'Neill, Gary S.

Subjects
Iranian foreign relations, General interest, News, opinion and commentary
Abstract

Byline: JOSHUAH SHIELDS, GARY S. O'NEILL, One year ago, Iran and the United States announced that they had accomplished a historic diplomatic victory. The Joint Comprehensive Plan of Action, more [...]

Published
2016

40. Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases

Author

Gallant, Michel, Beaulieu, Christian, Berthelette, Carl, Colucci, John, Crackower, Michael A., Dalton, Chad, Denis, Danielle, Ducharme, Yves, Friesen, Richard W., Guay, Daniel, Gervais, François G., Hamel, Martine, Houle, Robert, Krawczyk, Connie M., Kosjek, Birgit, Lau, Stephen, Leblanc, Yves, Lee, Ernest E., Levesque, Jean-François, Mellon, Christophe, Molinaro, Carmela, Mullet, Wayne, O’Neill, Gary P., O’Shea, Paul, Sawyer, Nicole, Sillaots, Susan, Simard, Daniel, Slipetz, Deborah, Stocco, Rino, Sørensen, Dan, Truong, Vouy Linh, Wong, Elizabeth, Wu, Jin, Zaghdane, Helmi, and Wang, Zhaoyin

Published
2011
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42. Genes related to emphysema are enriched for ubiquitination pathways

Author

Stepaniants, Sergey, primary, Wang, I-Ming, additional, Boie, Yves, additional, Mortimer, James, additional, Kennedy, Brian, additional, Elliott, Mark, additional, Hayashi, Shizu, additional, Luo, Honglin, additional, Wong, Jerry, additional, Loy, Leanna, additional, Coulter, Silvija, additional, Roberts, Christopher J, additional, Hogg, James C, additional, Sin, Don D, additional, O’Neill, Gary, additional, Crackower, Michael, additional, Morris, Melody, additional, Paré, Peter D, additional, and Obeidat, Ma’en, additional

Published
2014
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44. Solubility modelling

Author

O'Neill, Gary

Subjects
Pharmaceutical industry -- Production processes, Business, Business, international, Chemicals, plastics and rubber industries, Engineering and manufacturing industries
Abstract

The importance of solubility modeling and prediction in drug development are discussed. Solubility is key to drug production at the initial solubilization of reactants. Solubility modeling helps pharmaceutical firms select the most appropriate solvent system for a given compound.

Published
2010

45. Producing food ingredients by extrusion cooking

Author

Byrne, Briege, O'Neill, Gary, Troy, Declan J., and Lyng, James G.

Subjects
Consumer studies, Extrusion cooking, Convenience foods, food and beverages, Sensory analysis, Food quality
Abstract

End of Project Report The objective of the project was to improve the quality and acceptability of convenience foods produced by extrusion cooking. A range of acceptable, quality ingredients and food products was produced by extrusion cooking. These products had acceptable textural properties and were received favourably in consumer pre-test studies. However, a trade and consumer market analysis suggests that it would be difficult to develop a market for extruded meat products.

Published
2001

49. Using Systems Engineering to Develop Responsive Logistics for Future Space Missions

Author

Bennett, Gisele, O'Neill, Gary S., Bennett, Gisele, and O'Neill, Gary S.

Abstract

The goal of establishing a long term manned presence on the Moon and eventual exploration of Mars brings the practice of logistics to a whole new level. We describe an approach to logistics as a 'system of systems' that integrates logistic system development with vehicle design and mission planning, and provides the basis for a data management architecture that can provide Health Monitoring for the entire logistic system using data from enterprise systems and other resources., This conference features the work of authors from: Georgia Tech’s Space Systems Design Lab, Aerospace Systems Design Lab, School of Aerospace Engineering, Georgia Tech Research Institute; NASA’s Jet Propulsion Laboratory, Marshall Space Flight Center, Goddard Space Flight Center, Langley Research Center; and other aerospace industry and academic institutions, AIAA Space Systems Technical Committee ; AIAA Space Transportation Systems Technical Committee ; Space Technology Advanced Research Center

Published
2006

50. Saturday Talk: Iraq war

Author

Goodden, Ron, O'Neill, Gary, Soloway, Robert, Rechtman, Don, Roeber, Charlie, Kaple, Barry, Profili, Phil, Roth, Meme, Robinowitz, Michael, and Thomas, Robert J.

Subjects
General interest, News, opinion and commentary
Abstract

Remember, battle will be long, hard Those now wringing their hands over the sacrifices necessary to defend against Islamist terrorism owe us a clear explanation of just how they would [...]

Published
2007

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