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1. Successful Thrombectomy Improves Functional Outcome in Tandem Occlusions with a Large Ischemic Core

Author

Lapergue, Bertrand, Wang, Adrien, Consoli, Arturo, Coskun, Oguzhan, Maria, Federico Di, Pizzuto, Silvia, Sgreccia, Alessandro, Benoit, Charline, Gorza, Lucas, Weisenburger-Lile, David, Jabeur, Waliyde, Maia, Tchikviladze, Evrard, Serge, Rodesch, Georges, Blanc, Raphaël, Obadia, Michael, Desilles, Jean-Philippe, Piotin, Michel, Seners, Pierre, Smajda, Stanislas, Escalard, Simon, Maier, Benjamin, Sabben, Candice, Redjem, Hocine, Mikaelmazhigi, Adwan, Grace, Delvoye, François, Raaisi, Amira Al, Boisseau, William, Eker, Omer, Cho, Tae-Hee, Derex, Laurent, Fontaine, Julia, Mechtouff, Laura, Nighoghossian, Norbert, Ong, Elodie, Rascle, Lucie, Riva, Roberto, Turjman, Françis, Laubacher, Morgane, Beyragued, Mehdi, Berthezene, Yves, Hermier, Marc, Roxanna, Ameli, Bani-Sadr, Alexandre, Filip, Andrea, Cappucci, Matteo, Bourcier, Romain, Duport, Benjamin Daumas, Alexandre, Pierre Louis, Lenoble, Cédric, Hubertdesal, Gaalon, Solène De, Guillon, Benoît, Preterre, Cécile, Tessier, Guillaume, Lionnet, Arthur, Gory, Benjamin, Humbertjean-Selton, Lisa, Anxionnat, René, Derelle, Anne-Laure, Liao, Liang, Schmitt, Emmanuelle, Planel, Sophie, Richard, Sébastien, Mione, Gioia, Lacour, Jean-Christophe, Douarinou, Marian, Micard, Emilien, Chen, Bailiang, Audibert, Gérard, Masson, Agnès, Alb, Lionel, Beaumont, Marine, Tabarna, Adriana, Voicu, Marcela, Barthel, Grégoire, Podar, Iona, Brezeanu, Madalina, Reitter, Marie, Zhu, François, Marnat, Gaultier, Liegey, Jean-Sébastien, Briau, Pierre, Papillon, Lisa, Sibon, Igor, Barreau, Xavier, Papaxanthos, Jean, Berge, Jérome, Debruxelles, Sabrina, Olindo, Stephane, Poli, Mathilde, Renou, Pauline, Sagnier, Sharmila, Tourdias, Thomas, Courret, Thomas, Lucas, Ludovic, Milnerowicz, Malgorzata, Dargazanli, Cyril, Costalat, Vincent, Mourand, Isabelle, Arquizan, Caroline, Corti, Lucas, Adrien, Schiphorst, Ter, Federico, Cagnazzo, Derraz, Imad, Mahmoudi, Mehdi, Lefevre, Pierre-Henri, Gascou, Grégory, Spelle, Laurent, Caroff, Jildaz, Denier, Christian, Chalumeau, Vanessa, Mihalea, Cristian, Nicolaslegris, Ozanne, Augustin, Ikka, Leon, Chassin, Olivier, Gallas, Sophie, Venditti, Laura, Marianasarov, Cortese, Jonathan, Ferre, Jean-Christophe, Vannier, Stephane, Ronziere, Thomas, Veronica Lassalle, Maria, Gauvrit, Jean-Yves, Tracol, Clément, Boustia, Abdelghani Fakhreddine, Malrain, Cécile, Beaufreton, Edouard, Lapotre, Thibault, Alias, Quentin, Hissier, Julien, Guillen, Maud, Eugene, François, Chivot, Cyril, Courselle, Audrey, Ouin, Elisa, Lamy, Chantal, Delaforge, Kevin, Fernandez, Manuel, Vial, Jérémie, Laferte, Quentin, Desdoit, Xavier, Timsit, Serge, Jourdain, Aurore, Gentric, Jean-Christophe, Ognard, Julien, Viakhireva, Irina, Coris, Jordan, Prud'hon, Sabine, Merrien, François-Mathias, Marechal, Denis, Bruguet, Marie, Rousseau, Pierre Yves, Goas, Philippe, Boulanger, Marion, Touze, Emmanuel, Vivien, Denis, Barbier, Charlotte, Schneckenburger, Romain, Salaris, Fabrizio, Cogez, Julien, Guettier, Sophie, Porte, Estelle La, Bouchart, Jean, Mounayer, Charbel, Rouchaud, Aymeric, Saleme, Suzana, Forestier, Géraud, Clarencon, Frédéric, Rosso, Charlotte, Leder, Sara, Baronnet, Flore, Crozier, Sophie, Leger, Anne, Premat, Kevin, Eimad, Shotar, Lenck, Stéphanie, Sourour, Nader, Bottin, Laure, Ghazanfari, Sam, Yger, Marion, Alamowitch, Sonia, Delorme, Stephen, Wittwer, Aymeric, Vassilev, Christine, Naggara, Olivier, Turc, Guillaume, Hassen, Wagih Ben, Kerleroux, Basile, Trystram, Denis, Rodriguez-Regent, Christine, Ozkul-Wermester, Ozlem, Papagiannaki, Chrysanthi, Massardier, Evelyne, Triquenot, Aude, Lefebvre, Margaux, Burel, Julien, Viguier, Alain, Cognard, Christophe, Januel, Anne Christine, Albucher, Jean-François, Calviere, Lionel, Olivot, Jean-Marc, Darcourt, Jean, Raposo, Nicolas, Bonneville, Fabrice, Bellanger, Guillaume, Fontaine, Louis, Tall, Philippe, Thalamas, Claire, Geerearts, Thomas, Grepon, Antoine Faurie, Bourdain, Frédéric, Bernady, Patricia, Ballan, Guillaume, Bannier, Stéphanie, Ellie, Emmanuel, Flabeau, Olivier, Potenza, Julia, Soulages, Antoine, Lagoarde-Segot, Laurent, Cailliez, Hélène, Veunac, Louis, Higue, David, Lebras, Anthony, Adam, Sarah, Pegat, Benoit, Guen, Arnaud Le, Chedeville, François, Jouan, Jérémy, Demasles, Stéphanie, Richter, Johann Sebastian, Thierry Barroso, Bruno, Dahan, Camille, Gonnet, Alexis, Hubrecht, Régis, Lepine, Zoé, Castagnet, Hélène, Marasescu, Raluca, Heck, Olivier, Cuisenier, Pauline, Detante, Olivier, Wiki, Isabelle Favre, Bonaz, Clémentine, Garambois, Katia, Legris, Loic, Kastler, Adrian, Boubagra, Kamel, Berthet, Corentin, Charara, Stéphane, Wolff, Valérie, Pop, Raoul, Quenardelle, Véronique, Lauer, Valérie, Pierre-Paul, Irène, Roxanagheoca, Trzeciak, Malwina, Moulin, Solène, Tuan, Hua Vi, Pagano, Paolo, Doucet, Alexandre, Gelmini, Christophe, Manceau, Pierrefrançois, Paiusan, Laurentiu, Serre, Isabelle, Soize, Sébastien, Phuong Nguyen, Thi Ngoc, Sahnoun, Maher, Caucheteux, Nathalie, Ferrier, Anna, Zerroug, Abderrahim, Moreno, Ricardo, Chabert, Emmanuel, Lteif, Elie, Paulineparis, Bourgois, Nathalie, Raquin, Marie, Pasco-Papon, Anne, Girot, Jean Baptiste, Lecluse, Alderic, Godard, Sophie, L'allinec, Vincent, Janot, Kevin, Bibi, Richard, Gaudron, Marie, Bretonniere, Arnaud, Annan, Mariam, Ifergan, Héloïse, Boulouis, Grégoire, Pasi, Marco, Debiais, Séverine, Molinier, Elisabeth, Wietrich, Anthony, Ruche, Valérie, Lavandier, Karine, Bejot, Yannick, Lemogne, Brivale, Ricolfi, Fédéric, Baptiste, Laura, Thouant, Pierre, Duloquin, Gaulthier, Olivier Comby, Pierre, Charbonnier, Guillaume, Bonnet, Louise, Raybaud, Nicolas, Bouamra, Benjamin, Moulin, Thierry, Biondi, Alessandra, Finitsis, Stephanos, and Mazighi, Mikael

Published
2023
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2. Case-Fatality and Functional Outcome after Subarachnoid Hemorrhage (SAH) in INternational STRoke oUtComes sTudy (INSTRUCT)

Author

Rehman, Sabah, Phan, Hoang T., Reeves, Mathew J., Thrift, Amanda G., Cadilhac, Dominique A., Sturm, Jonathan, Breslin, Monique, Callisaya, Michele L., Vemmos, Konstantinos, Parmar, Priya, Krishnamurthi, Rita V., Barker-Collo, Suzanne, Feigin, Valery, Chausson, Nicolas, Olindo, Stephane, Cabral, Norberto L., Carolei, Antonio, Marini, Carmine, Degan, Diana, Sacco, Simona, Correia, Manuel, Appelros, Peter, Kõrv, Janika, Vibo, Riina, Minelli, Cesar, Sposato, Luciano, Pandian, Jeyaraj Durai, Kaur, Paramdeep, Azarpazhooh, M. Reza, Morovatdar, Negar, and Gall, Seana

Published
2022
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3. Thrombectomy for Basilar Artery Occlusion with Mild Symptoms

Author

Piotin, Michel, Blanc, Raphael, Redjem, Hocine, Escalard, Simon, Desilles, Jean-Philippe, Ciccio, Gabriele, Smajda, Stanislas, Maier, Benjamin, Hebert, Solene, Delvoye, François, Mazighi, Mikael, Obadia, Mikael, Sabben, Candice, Peres, Roxanne, Corabianu, Ovide, de Broucker, Thomas, Smadja, Didier, Alamowitch, Sonia, Ille, Olivier, Manchon, Eric, Garcia, Pierre-Yves, Taylor, Guillaume, Ben Maacha, Malek, Wang, Adrien, Evrard, Serge, Tchikviladze, Maya, Ajili, Nadia, Lapergue, Bertrand, Weisenburger, David, Gorza, Lucas, Buard, Géraldine, Coskun, Oguzhan, Consoli, Arturo, Di Maria, Federico, Rodesh, Georges, Zimatore, Sergio, Leguen, Morgan, Gratieux, Julie, Pico, Fernando, Rakotoharinandrasana, Haja, Tassan, Philippe, Poll, Roxanna, Marinier, Sylvie, Marnat, Gaultier, Gariel, Florent, Barreau, Xavier, Berge, Jérôme, Veunac, Louis, Menegon, Patrice, Sibon, Igor, Lucas, Ludovic, Olindo, Stéphane, Renou, Pauline, Sagnier, Sharmila, Poli, Mathilde, Debruxelles, Sabrina, Bourcier, Romain, Detraz, Lili, Daumas-Duport, Benjamin, Alexandre, Pierre-Louis, Roy, Monica, Lenoble, Cédric, L'allinec, Vincent, Girot, Jean-Baptiste, Desal, Hubert, Gory, Benjamin, Bracard, Serge, Anxionnat, René, Braun, Marc, Derelle, Anne-Laure, Tonnelet, Romain, Liao, Liang, Zhu, François, Schmitt, Emmanuelle, Planel, Sophie, Richard, Sébastien, Humbertjean, Lisa, Mione, Gioia, Lacour, Jean-Christophe, Bonnerot, Mathieu, Riou-Comte, Nolwenn, Costalat, Vincent, Arquizan, Caroline, Dargazanli, Cyril, Gascou, Grégory, Lefèvre, Pierre-Henri, Derraz, Imad, Riquelme, Carlos, Gaillard, Nicolas, Mourand, Isabelle, Corti, Lucas, François, Eugene, Vannier, Stéphane, Ferre, Jean-Christophe, Raoult, Helene, Ronziere, Thomas, Lassale, Maria, Paya, Christophe, Gauvrit, Jean-Yves, Tracol, Clément, Langnier-Lemercier, Sophie, Guenego, Adrien, Weisenburger-Lile, David, Ducroux, Célina, Labreuche, Julien, Aubertin, Mathilde, Benali, Amel, Guillen, Maud, Eugene, François, Walker, Gregory, Lun, Ronda, and Fahed, Robert

Published
2021
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8. Clinical, imaging, and management features of symptomatic carotid web: Insight from CAROWEB registry.

Author

Olindo, Stephane, Gaillard, Nicolas, Chausson, Nicolas, Turpinat, Cedric, Dargazanli, Cyril, Bourgeois-Beauvais, Quentin, Signate, Aissatou, Joux, Julien, Mejdoubi, Mehdi, Piotin, Michel, Obadia, Mickael, Desilles, Jean-Philippe, Delvoye, François, Holay, Quentin, Gory, Benjamin, Richard, Sébastien, Denier, Christian, Robinet-Borgomano, Emmanuelle, Carle, Xavier, and Desal, Hubert

Subjects
*TRANSIENT ischemic attack, *CEREBRAL infarction, *ISCHEMIC stroke, *STROKE, *STROKE units, *SECONDARY prevention
Abstract

Background: Although carotid web (CaW) is increasingly diagnosed as a cause of cryptogenic stroke, data are still limited to monocentric small sample cohort. To broaden knowledge on symptomatic CaW, CAROWEB registry has been recently implemented. Aims: In a large cohort of symptomatic CaW patients, we described epidemiologic characteristics, admission clinical and imaging features, and the current management including the secondary preventive strategy choice made in comprehensive French Stroke Units. Methods: CAROWEB is an ongoing French observational multicenter registry enrolling consecutive CaW patients diagnosed after an ipsilateral ischemic stroke (IS) or transient ischemic attack (TIA). Submitted cases were validated by two experienced neurologist and neuroradiologist. Clinical, imaging, and management features were collected for this study. Results: Between June 2019 and December 2021, 244 cases were submitted by 14 centers, 42 rejected, and 202 included (IS, 91.6%; TIA, 7.9%; retinal infarction, 0.5%; mean age, 50.8 ± 12.2 years; female, 62.9%; Caucasian, 47.5%; Afro-Caribbean, 20.3%). IS patients showed median (interquartile range (IQR)) admission National Institutes of Health Stroke Scale (NIHSS) score, 8 (2–15); intracranial artery occlusion, 71.8%; ipsilateral chronic cerebral infarction (CCI), 16.3%; and reperfusion treatment, 57.3%. CaW was not identified during the mechanical thrombectomy procedure in 30 of 85 (35.3%) patients. Secondary prevention was invasive in 55.6% (stenting, n = 80; surgery, n = 30). In multivariable analysis, the invasive therapeutic option was associated with ipsilateral CCI (odds ratio (OR): 4.24 (1.27–14.2), p = 0.019) and inversely associated with risk factors (OR: 0.47 (0.24–0.91), p = 0.025) and admission NIHSS score (OR: 0.93 (0.89–0.97), p = 0.001). Conclusion: CaW must be considered in all ethnic groups including Caucasians. Secondary prevention is heterogeneous in large French Stroke Centers. The absence of risk factors, milder severity strokes, and ipsilateral CCI were predictive variables of secondary invasive treatment. The high rate of invasive treatment suggests that medical treatment alone is deemed ineffective to avoid recurrence and emphasize the need of randomized trials. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Dual-layer carotid stenting for symptomatic carotid web: Results from the Caroweb study

Author

Marnat, Gaultier, primary, Holay, Quentin, additional, Darcourt, Jean, additional, Desilles, Jean-Philippe, additional, Obadia, Michael, additional, Viguier, Alain, additional, Caroff, Jildaz, additional, Denier, Christian, additional, Papillon, Lisa, additional, Barreau, Xavier, additional, Cognard, Christophe, additional, Berge, Jerome, additional, Bourgeois-Beauvais, Quentin, additional, Landais, Anne, additional, Boulanger, Marion, additional, Macian, Francisco, additional, Guillon, Benoit, additional, Pico, Fernando, additional, Lamy, Mathias, additional, Robinet-Borgomano, Emmanuelle, additional, Richard, Sébastien, additional, Gory, Benjamin, additional, Sibon, Igor, additional, Gaillard, Nicolas, additional, Chausson, Nicolas, additional, and Olindo, Stephane, additional

Published
2022
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10. Etiologic and prognostic value of external carotid artery thrombus detection during endovascular therapy for anterior circulation proximal occlusions

Author

Courret, Thomas, primary, Tourdias, Thomas, additional, Papaxanthos, Jean, additional, Labreuche, Julien, additional, Gariel, Florent, additional, Liegey, Jean‐Sebastien, additional, Olindo, Stephane, additional, Renou, Pauline, additional, Berge, Jerome, additional, Barreau, Xavier, additional, Sagnier, Sharmila, additional, Menegon, Patrice, additional, Lucas, Ludovic, additional, Briau, Pierre, additional, Poli, Mathilde, additional, Debruxelles, Sabrina, additional, Rouanet, François, additional, Dousset, Vincent, additional, Sibon, Igor, additional, and Marnat, Gaultier, additional

Published
2022
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13. Factors contributing to sex differences in functional outcomes and participation after stroke

Author

Phan, Hoang T., Blizzard, Christopher L., Reeves, Mathew J., Thrift, Amanda G., Cadilhac, Dominique A., Sturm, Jonathan, Heeley, Emma, Otahal, Petr, Vemmos, Konstantinos, Anderson, Craig, Parmar, Priya, Krishnamurthi, Rita, Barker-Collo, Suzanne, Feigin, Valery, Bejot, Yannick, Cabral, Norberto Luiz, Carolei, Antonio, Sacco, Simona, Chausson, Nicolas, Olindo, Stephane, Rothwell, Peter, Silva, Carolina, Correia, Manuel, Magalhães, Rui, Appelros, Peter, Kõrv, Janika, Vibo, Riina, Minelli, Cesar, and Gall, Seana L.

Published
2018
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14. Sex Differences in Long-Term Mortality After Stroke in INSTRUCT (INternational STRoke oUtComes sTudy): A Meta-Analysis of Individual Participant Data

Author

Phan, Hoang T., Blizzard, Christopher L., Reeves, Mathew J., Thrift, Amanda G., Cadilhac, Dominique, Sturm, Jonathan, Heeley, Emma, Otahal, Petr, Konstantinos, Vemmos, Anderson, Craig, Parmar, Priya, Krishnamurthi, Rita, Barker-Collo, Suzanne, Feigin, Valery, Bejot, Yannick, Cabral, Norberto L., Carolei, Antonio, Sacco, Simona, Chausson, Nicolas, Olindo, Stephane, Rothwell, Peter, Silva, Carolina, Correia, Manuel, Magalhães, Rui, Appelros, Peter, Kõrv, Janika, Vibo, Riina, Minelli, Cesar, and Gall, Seana

Published
2017
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18. Etiologic and prognostic value of external carotid artery thrombus detection during endovascular therapy for anterior circulation proximal occlusions.

Author

Courret, Thomas, Tourdias, Thomas, Papaxanthos, Jean, Labreuche, Julien, Gariel, Florent, Liegey, Jean‐Sebastien, Olindo, Stephane, Renou, Pauline, Berge, Jerome, Barreau, Xavier, Sagnier, Sharmila, Menegon, Patrice, Lucas, Ludovic, Briau, Pierre, Poli, Mathilde, Debruxelles, Sabrina, Rouanet, François, Dousset, Vincent, Sibon, Igor, and Marnat, Gaultier

Subjects
PROGNOSIS, CAROTID artery, INTERNAL carotid artery, ENDOVASCULAR surgery, THROMBOSIS, STROKE, ANGIOGRAPHY
Abstract

Background and purpose: An early understanding of stroke mechanism may improve treatment and outcome in patients presenting with large vessel occlusion stroke (LVOS) treated with mechanical thrombectomy (MT). We aimed to investigate whether spontaneous external carotid artery (ECA) embolism detection during MT is associated with stroke etiology and clinical outcome. Methods: We retrospectively reviewed our prospectively maintained institutional database including consecutive patients with anterior circulation LVOS treated with MT between January 2015 and August 2020. Results: An ECA embolus was detected in 68 of 1298 patients (5.2%). The kappa coefficient for interobserver agreement was 0.89 (95% confidence interval [CI] 0.82–0.95). ECA embolism was significantly associated with intracranial internal carotid artery (ICA) occlusion (p < 0.001), cardioembolic etiology (p < 0.001) and a lower clot burden score (p < 0.001). Day‐1 variation of National Institutes of Health Stroke Scale score (adjusted odds ratio [OR] −2.7, 95% CI −4.9 to 0.3; p = 0.021) and delta Alberta Stroke Program Early Computed Tomography Score (adjusted OR 0.9, 95% CI 0.2 to 1.5; p = 0.004) were worse among patients with ECA emboli. There was no significant difference in 90‐day functional outcome between groups (adjusted OR 0.8, 95% CI 0.42 to 1.52; p = 0.50). Conclusion: In patients with anterior circulation LVOS treated with MT, ECA embolism was significantly associated with cardioembolic etiology, high thrombus burden and proximal intracranial ICA occlusions. This underexplored angiographic pattern might provide a valuable etiologic clue to the underlying cause of anterior circulation LVOS and may also help determine the appropriate revascularization strategy. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Stroke Recurrence in First-Ever Symptomatic Carotid Web: A Cohort Study

Author

Olindo, Stephane, primary, Chausson, Nicolas, additional, Signate, Aissatou, additional, Mecharles, Sylvie, additional, Hennequin, Jean-Luc, additional, Saint-Vil, Martine, additional, Edimonana-Kaptue, Mireille, additional, Jeannin, Severine, additional, Landais, Anne, additional, Cabre, Philippe, additional, Sibon, Igor, additional, Smadja, Didier, additional, and Joux, Julien, additional

Published
2021
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25. Abstract P38: Pooled Analysis of Long and Short Term Outcomes After Subarachnoid Hemorrhage - International Stroke Outcomes Study (INSTRUCT)

Author

Rehman, Sabah, primary, Phan, Hoang T, additional, Reeves, Mathew J, additional, Thrift, Amanda G, additional, Cadilhac, Dominique A, additional, Sturm, Jonathan, additional, Breslin, Monique, additional, Callisaya, Michele, additional, Vemmos, Kostas N, additional, Parmar, Priya G, additional, Krishnamurthi, Rita V, additional, Barker-Collo, Suzanne, additional, Feigin, Valery L, additional, Chausson, Nicolas, additional, Olindo, Stephane, additional, Cabral, Norberto, additional, Carolei, Antonio, additional, Marini, Carmine, additional, Sacco, Simona, additional, Correia, Manuel, additional, Appelros, Peter, additional, Korv, Janika, additional, Vibo, Riina, additional, Minelli, Cesar, additional, Sposato, Luciano, additional, Pandian, Jeyaraj D, additional, Kaur, Paramdeep, additional, Azarpazhooh, M. Reza, additional, Morovatdar, Negar, additional, and Gall, Seana L, additional

Published
2021
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31. Functional Outcome, Recanalization, and Hemorrhage Rates After Large Vessel Occlusion Stroke Treated With Tenecteplase Before Thrombectomy.

Author

Gerschenfeld, Gaspard, Smadja, Didier, Turc, Guillaume, Olindo, Stephane, Laborne, François-Xavier, Yger, Marion, Caroff, Jildaz, Gonçalves, Bruno, Seners, Pierre, Cantier, Marie, l'Hermitte, Yann, Aghasaryan, Manvel, Alecu, Cosmin, Marnat, Gaultier, Ben Hassen, Wagih, Kalsoum, Erwah, Clarençon, Frédéric, Piotin, Michel, Spelle, Laurent, and Denier, Christian

Published
2021
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32. Intravenous thrombolysis and thrombectomy decisions in acute ischemic stroke: An interrater and intrarater agreement study

Author

Ducroux, C., Fahed, R., Khoury, N. N., Gevry, G., Kalsoum, E., Labeyrie, M-A, Ziegler, D., Sauve, C., Chagnon, M., Darsaut, T. E., Raymond, J., Niclot, Philippe, Ameri, Alain, Hodel, Jerome, Gentric, Jean-Christophe, Merrien, Francois-Mathias, Jourdain, Aurore, Rouhart, Francois, Viakhireva, Irina, Timsit, Serge, Clarencon, Frederic, Pistocchi, Silvia, Rosso, Charlotte, Zavanone, Chiara, Houdart, Emmanuel, Labeyrie, Marc-Antoine, Reiner, Peggy, Gory, Benjamin, Riva, Roberto, Nighoghossian, Norbert, Cho, Tae-Hee, Derex, Laurent, Eugene, Francois, Ferré, Jean-Christophe, Le Bras, Anthony, Vannier, Stephane, Lassalle, Maria, Chivot, Cyril, Arnoux, Audrey, Alla, Philippe, Veyrieres, Jean-Brice, Marnat, Gaultier, Berge, Jerome, Olindo, Stephane, Sibon, Igor, Lapergue, Bertrand, Wang, Adrien, Consoli, Arturo, Di Maria, Federico, Obadia, Michael, Sabben, Candice, Mazighi, Mikael, Redjem, Hocine, Piotin, Michel, Boisseau, William, Razlog, Lilia, Pop, Raoul, Beaujeux, Remy, Mihoc, Dan, Richter, Sebastian, Manisor, Monica, Wolff, Valerie, Quenardelle, Veronique, Zinchenko, Lisa, Diaconu, Mihaela, Yger, Marion, Delorme, Stephen, Iosif, Christina, Moulin, Thierry, Zekri, Hatem, Lallement, Francois, Vercruysse, Olivier, Papagiannaki, Christanthi, Ozkul-Wermester, Ozlem, Dargazanli, Cyril, Costalat, Vincent, Gaillard, Nicolas, Arquizan, Caroline, Cayrecastel, Mireille, Bracard, Serge, Derelle, Anne-Laure, Richard, Sebastien, Humbertjean, Lisa, Herve, Yann, Favrole, Pascal, Le Coz, Patrick, de Brouker, Thomas, Force, Marie-Isabelle, Akono, Serge, Cakmak, Serkan, Florea, Alexandru, Lalu, Thibault, Taurin, Gregory, Duong, Duc Long, Chadenat, Marie-Laure, Pico, Fernando, Allibert, Remi, Evain, Sarah, Tassan, Philippe, Berthier, Eric, Ducrocq, Xavier, Rigal, Matthieu, Boulanger, Marion, Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), CHU Henri Mondor [Créteil], Service de Neuroradiologie [CHU Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Département de Mathématiques et de statistique [UdeM- Montréal] (DMS), Université du Québec à Montréal = University of Québec in Montréal (UQAM), Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CIC Brest, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche, Service de Neurologie [Brest], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Génétique et Physiopathologie des Maladies Cérébro-Vasculaires (U1161 / UMR_S 1161), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB), EFS-Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Hôpital Lariboisière-Fernand-Widal [APHP], Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Hospices Civils de Lyon (HCL), Department of Stroke Medicine [Lyon], Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Hospices Civils de Lyon, Departement de Neurologie (HCL), Cerebrovascular Unit [Lyon], Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Health Service and Performance Research (HESPER), Université de Lyon-Université de Lyon, Service de radiologie et imagerie médicale [Rennes] = Radiology [Rennes], CHU Pontchaillou [Rennes], Neuroimagerie: méthodes et applications (Empenn), Institut National de la Santé et de la Recherche Médicale (INSERM)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE (IRISA-D5), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Département de Radiologie [CHU de Rennes], Université de Rennes (UR), Institut de Recherche Technologique b-com (IRT b-com), Service de Neurologie [CHU Rennes], Laboratoire de Psychologie et NeuroCognition (LPNC ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), CHU Bordeaux [Bordeaux], Centre Hospitalier Universitaire de Bordeaux (CHU de Bordeaux), Université de Bordeaux (UB), Hôpital Foch [Suresnes], CHU Rothschild [AP-HP], Fondation Ophtalmologique Adolphe de Rothschild [Paris], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), L'Institut hospitalo-universitaire de Strasbourg (IHU Strasbourg), Institut National de Recherche en Informatique et en Automatique (Inria)-l'Institut de Recherche contre les Cancers de l'Appareil Digestif (IRCAD)-Les Hôpitaux Universitaires de Strasbourg (HUS)-La Fédération des Crédits Mutuels Centre Est (FCMCE)-L'Association pour la Recherche contre le Cancer (ARC)-La société Karl STORZ, Département de Neuroradiologie [Strasbourg], Les Hôpitaux Universitaires de Strasbourg (HUS), Mitochondrie, stress oxydant et protection musculaire (MSP), Université de Strasbourg (UNISTRA), CHU Saint-Antoine [AP-HP], Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Equipe de Recherche Médicale Appliquée (ERMA), Université de Limoges (UNILIM)-CHU Limoges-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Service de neurologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Département de Neuroradiologie[Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université de Montpellier (UM), Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy], Service de neurologie [CHRU Nancy], Service de Neurologie [Aix-en-Provence], Centre Hospitalier du Pays d'Aix, Neuroépidémiologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de radiologie [Vannes], Centre hospitalier Bretagne Atlantique (Morbihan) (CHBA), Centre hospitalier régional Metz-Thionville (CHR Metz-Thionville), Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)

Subjects
medicine.medical_specialty, Consensus, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Decision Making, Single Center, law.invention, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Combined treatment, Cohen's kappa, Randomized controlled trial, Fibrinolytic Agents, law, Medicine, Humans, Thrombolytic Therapy, 030212 general & internal medicine, Infusions, Intravenous, Acute ischemic stroke, Thrombectomy, business.industry, Reproducibility of Results, Thrombolysis, Mechanical thrombectomy, Stroke, Inter-rater reliability, Neurology, Acute Disease, Physical therapy, Administration, Intravenous, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

International audience; Purpose. - We aimed to assess agreement on intravenous tissue-plasminogen activator (IV tPA) and mechanical thrombectomy (MT) management decisions in acute ischemic stroke (AIS) patients. Secondary objectives were to assess agreement on Diffusion-Weighted-Imaging-Alberta-Stroke-Program-EArly-CT-Score (DWI-ASPECTS), and clinicians' willingness to recruit patients in a randomized controlled trial (RCT) comparing medical management with or without MT. Materials and Methods. - Studies assessing agreement of IV tPA and MT were systematically reviewed. An electronic portfolio of 41 AIS patients was sent to randomly selected providers at French stroke centers. Raters were asked 4 questions for each case: (1) What is the DWI-ASPECTS? (2) Would you perform IV tPA? (3) Would you perform MT? (4) Would you include the patient in a RCT comparing standard medical therapy with or without MT? Twenty responders were randomly selected to study intrarater agreement. Agreement was assessed using Fleiss' Kappa statistics. Results. - The review yielded two single center studies involving 2-5 raters, with various results. The electronic survey was answered by 86 physicians (60 vascular neurologists and 26 interventional neuroradiologists). The interrater agreement was moderate for IV tPA treatment decisions (kappa = 0.565 [0.420-0.680]), but only fair for MT (kappa = 0.383 [0.289-0.491]) and for combined treatment decisions (kappa = 0.399 [0.320-0.486]). The intrarater agreement was at least substantial for the majority of raters. The interrater agreement for DWI-ASPECTS was fair (kappa = 0.325 [0.276-0.387]). Physicians were willing to include a mean of 14 +/- 9 patients (33.1% +/- 21.7%) in a RCT. Conclusion. - Disagreements regarding the use of IVtPA or MT in the management of AIS patients remain frequent. Further trials are needed to resolve the numerous areas of uncertainty. (C) 2019 Elsevier Masson SAS. All rights reserved.

Published
2018

33. Sex differences in long-term mortality after stroke in INSTRUCT (INternational STRoke oUtComes sTudy)

Author

Phan, Hoang T., Blizzard, Christopher L., Reeves, Mathew J., Thrift, Amanda G., Cadilhac, Dominique, Sturm, Jonathan, Heeley, Emma, Otahal, Petr, Konstantinos, Vemmos, Anderson, Craig, Parmar, Priya, Krishnamurthi, Rita, Barker-Collo, Suzanne, Feigin, Valery, Bejot, Yannick, Cabral, Norberto L., Carolei, Antonio, Sacco, Simona, Chausson, Nicolas, Olindo, Stephane, Rothwell, Peter, Silva, Carolina, Correia, Manuel, Magalhães, Rui, Appelros, Peter, Kõrv, Janika, Vibo, Riina, Minelli, Cesar, and Gall, Seana

Subjects
Male, Time Factors, Australasia, Incidence, Age Factors, Health Status Disparities, Middle Aged, South America, Prognosis, mortality, stroke, Risk Assessment, Severity of Illness Index, Europe, incidence, risk factors, women, Aged, Caribbean Region, Female, Humans, Odds Ratio, Risk Factors, Sex Factors, Stroke, Cardiology and Cardiovascular Medicine
Published
2017

35. Temporal trends in Human T-Lymphotropic virus 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) incidence in Martinique over 25 years (1986-2010)

Author

Olindo, Stephane, primary, Jeannin, Severine, additional, Saint-Vil, Martine, additional, Signate, Aissatou, additional, Edimonana-Kaptue, Mireille, additional, Joux, Julien, additional, Merle, Harold, additional, Richard, Pascale, additional, Granjeaud, Samuel, additional, Cabre, Philippe, additional, Smadja, Didier, additional, Cesaire, Raymond, additional, and Lezin, Agnes, additional

Published
2018
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37. Abstract TP171: Differences Between Men and Women in Long-term Participation Restriction After Stroke: The International Stroke Outcomes Study (INSTRUCT)

Author

Phan, Hoang T, primary, Blizzard, Leigh, additional, Reeves, Mathew J, additional, Thrift, Amanda G, additional, Cadilhac, Dominique, additional, Sturm, Jonathan, additional, Heeley, Emma, additional, Feigin, Valery, additional, Parmar, Priya, additional, Krishnamurthi, Rita, additional, Barker-Collo, Suzanne, additional, Parag, Varsha, additional, Konstantinos, Vemmos, additional, Anderson, Craig, additional, Bejot, Yannick, additional, Cabral, Norberto, additional, Carolei, Antonio, additional, Sacco, Simona, additional, Chausson, Nicolas, additional, Olindo, Stephane, additional, Silva, Carolina, additional, Correia, Manuel, additional, Magalhães, Rui, additional, Appelros, Peter, additional, Korv, Janika, additional, Vibo, Riina, additional, Minelli, Cesar, additional, Otahal, Petr, additional, and Gall, Seana, additional

Published
2017
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38. Sex Differences in Long-Term Mortality After Stroke in the INSTRUCT (INternational STRoke oUtComes sTudy)

Author

Phan, Hoang T., primary, Blizzard, Christopher L., additional, Reeves, Mathew J., additional, Thrift, Amanda G., additional, Cadilhac, Dominique, additional, Sturm, Jonathan, additional, Heeley, Emma, additional, Otahal, Petr, additional, Konstantinos, Vemmos, additional, Anderson, Craig, additional, Parmar, Priya, additional, Krishnamurthi, Rita, additional, Barker-Collo, Suzanne, additional, Feigin, Valery, additional, Bejot, Yannick, additional, Cabral, Norberto L., additional, Carolei, Antonio, additional, Sacco, Simona, additional, Chausson, Nicolas, additional, Olindo, Stephane, additional, Rothwell, Peter, additional, Silva, Carolina, additional, Correia, Manuel, additional, Magalhães, Rui, additional, Appelros, Peter, additional, Kõrv, Janika, additional, Vibo, Riina, additional, Minelli, Cesar, additional, and Gall, Seana, additional

Published
2017
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40. Incidence and predictors of intracranial hemorrhage after intravenous thrombolysis with tenecteplase

Author

Marnat, Gaultier, Gerschenfeld, Gaspard, Olindo, Stephane, Sibon, Igor, Seners, Pierre, Clarençon, Frederic, Smadja, Didier, Chausson, Nicolas, Ben Hassen, Wagih, Piotin, Michel, Caroff, Jildaz, Alamowitch, Sonia, and Turc, Guillaume

Abstract

Background: Despite its increasing use, there are limited data on the risk of intracranial hemorrhage (ICH) after intravenous thrombolysis with tenecteplase in the setting of acute ischemic stroke. Our aim was to investigate the incidence and predictors of ICH after tenecteplase administration.Methods: We reviewed data from the prospective ongoing multicenter TETRIS (Tenecteplase Treatment in Ischemic Stroke) registry. Patients with available day-1 imaging were included in this study. Clinical, imaging and biological variables were collected. Follow-up imaging performed 24 h after IVT was locally reviewed by senior neuroradiologists and neurologists. The incidence of parenchymal hematoma (PH) and any ICH were investigated. Potential predictors of PH and any ICH were assessed in multivariable logistic regressions. Subgroup analyses focusing on patients intended for endovascular treatment were performed.Results: PH and any ICH occurred in 126/1321 (incidence rate: 9.5%, 95% CI 8.1–11.2) and 521/1321 (39.4%, 95% CI 36.8–42.1) patients, respectively. Symptomatic ICH was observed in 77/1321 (5.8%; 95% CI 4.7–7.2). PH occurrence was significantly associated with poorer functional outcomes (p< 0.0001) and death (p< 0.0001) after 3 months. Older age (aOR = 1.03; 95% CI 1.01–1.05), male gender (aOR = 2.07; 95% CI 1.28–3.36), a history of hypertension (aOR = 2.08; 95% CI 1.19–3.62), a higher baseline NIHSS (aOR = 1.07; 95% CI 1.03–1.10) and higher admission blood glucose level (aOR = 1.12; 95% CI 1.05–1.19) were independently associated with PH occurrence. Similar associations were observed in the subgroup of patients intended for endovascular treatment.Conclusion: We quantified the incidence of ICH after IVT with tenecteplase in a real-life prospective registry and determined independent predictors of ICH. These findings allow to identify patients at high risk of ICH.

Published
2024
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41. Factors contributing to sex differences in functional outcomes and participation after stroke.

Author

Hoang T. Phan, Blizzard, Christopher L., Reeves, Mathew J., Thrift, Amanda G., Cadilhac, Dominique A., Sturm, Jonathan, Heeley, Emma, Otahal, Petr, Vemmos, Konstantinos, Anderson, Craig, Parmar, Priya, Krishnamurthi, Rita, Barker-Collo, Suzanne, Feigin, Valery, Bejot, Yannick, Cabral, Norberto Luiz, Carolei, Antonio, Sacco, Simona, Chausson, Nicolas, and Olindo, Stephane

Published
2018
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47. Functional Outcome and Hemorrhage Rates After Bridging Therapy With Tenecteplase or Alteplase in Patients With Large Ischemic Core.

Author

Gerschenfeld G, Turc G, Obadia M, Chausson N, Consoli A, Olindo S, Caroff J, Marnat G, Blanc R, Ben Hassen W, Seners P, Guillon B, Wiener E, Bourcier R, Yger M, Cho TH, Checkouri T, Gory B, Smadja D, Sibon I, Richard S, Piotin M, Eker OF, Pico F, Lapergue B, and Alamowitch S

Subjects
Humans, Aged, Male, Female, Middle Aged, Retrospective Studies, Aged, 80 and over, Treatment Outcome, Intracranial Hemorrhages chemically induced, Thrombectomy methods, Registries, Tenecteplase therapeutic use, Tissue Plasminogen Activator therapeutic use, Tissue Plasminogen Activator adverse effects, Fibrinolytic Agents therapeutic use, Fibrinolytic Agents adverse effects, Ischemic Stroke drug therapy
Abstract

Background and Objectives: IV tenecteplase is an alternative to alteplase before mechanical thrombectomy (MT) in patients with large-vessel occlusion (LVO) ischemic stroke. Little data are available on its use in patients with large ischemic core. We aimed to compare the efficacy and safety of both thrombolytics in this population., Methods: We conducted a retrospective analysis of patients with anterior circulation LVO strokes and diffusion-weighed imaging Alberta Stroke Program Early CT Score (DWI-ASPECTS) ≤5 treated with tenecteplase or alteplase before MT from the TETRIS (tenecteplase) and ETIS (alteplase) French multicenter registries. Primary outcome was reduced disability at 3 months (ordinal analysis of the modified Rankin scale [mRS]). Safety outcomes were 3-month mortality, parenchymal hematoma (PH), and symptomatic intracranial hemorrhage (sICH). We used propensity score overlap weighting to reduce baseline differences between treatment groups., Results: We analyzed 647 patients (tenecteplase: n = 194; alteplase: n = 453; inclusion period 2015-2022). Median (interquartile range) age was 71 (57-81) years, with NIH Stroke Scale score 19 (16-22), DWI-ASPECTS 4 (3-5), and last seen well-to-IV thrombolysis and puncture times 165 minutes (130-226) and 260 minutes (203-349), respectively. After MT, the successful reperfusion rate was 83.1%. After propensity score overlap weighting, all baseline variables were well balanced between both treatment groups. Compared with patients treated with alteplase, patients treated with tenecteplase had better 3-month mRS (common odds ratio [OR] for reduced disability: 1.37, 1.01-1.87, p = 0.046) and lower 3-month mortality (OR 0.52, 0.33-0.81, p < 0.01). There were no significant differences between thrombolytics for PH (OR 0.84, 0.55-1.30, p = 0.44) and sICH incidence (OR 0.70, 0.42-1.18, p = 0.18)., Discussion: Our data are encouraging regarding the efficacy and reassuring regarding the safety of tenecteplase compared with that of alteplase in bridging therapy for patients with LVO strokes and a large ischemic core in routine clinical care. These results support its consideration as an alternative to alteplase in bridging therapy for patients with large ischemic cores., Trials Registration Information: NCT03776877 (ETIS registry) and NCT05534360 (TETRIS registry)., Classification of Evidence: This study provides Class III evidence that patients with anterior circulation LVO stroke and DWI-ASPECTS ≤5 treated with tenecteplase vs alteplase before MT experienced better functional outcomes and lower mortality at 3 months.

Published
2024
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48. Dual-layer carotid stenting for symptomatic carotid web: Results from the Caroweb study.

Author

Marnat G, Holay Q, Darcourt J, Desilles JP, Obadia M, Viguier A, Caroff J, Denier C, Papillon L, Barreau X, Cognard C, Berge J, Bourgeois-Beauvais Q, Landais A, Boulanger M, Macian F, Guillon B, Pico F, Lamy M, Robinet-Borgomano E, Richard S, Gory B, Sibon I, Gaillard N, Chausson N, and Olindo S

Subjects
Humans, Middle Aged, Retrospective Studies, Fibrinolytic Agents, Treatment Outcome, Stents adverse effects, Risk Factors, Carotid Stenosis diagnostic imaging, Carotid Stenosis surgery, Stroke etiology, Stroke prevention & control, Stroke surgery, Endarterectomy, Carotid adverse effects, Endarterectomy, Carotid methods
Abstract

Background & Purpose: Carotid Web (CaW) is a growingly recognized cause of ischemic stroke, associated with a high recurrence risk. Several therapeutic strategies have been proposed as a tertiary prevention including carotid stenting, endarterectomy and antithrombotic medications. Among these, carotid stenting with dual-layer stent may be promising to adequately cover the focal arterial dysplasia. Our aim was to investigate the safety and efficacy of the Casper stent in the treatment of symptomatic CaW., Methods: We conducted a retrospective analysis of consecutive patients presenting with a symptomatic CaW and included in the ongoing prospective observational multicenter CAROWEB registry. The study period was January 2015 to December 2021. Inclusion criteria were CaW treated with dual-layer Casper stent. Patients treated with other types of carotid stent, endarterectomy or antithrombotic medication were excluded. Clinical and radiological initial data and outcomes were recorded., Results: twenty-seven patients (with 28 caw) were included. median age was 52 (iqr: 46-68). median delay between index cerebrovascular event and cervical stenting was 9 days (IQR: 6-101). In all cases, the cervical carotid stenting was successfully performed. No major perioperative complication was recorded. No recurrent stroke or transient ischemic attack was observed during a median follow-up time of 272 days (IQR: 114-635). Long-term imaging follow-up was available in 25/28 (89.3%) stented CaW with a median imaging follow-up of 183 days (IQR: 107-676; range: 90-1542). No in-stent occlusion or stenosis was detected., Conclusion: In this study, carotid stenting with dual-layer Casper stent in the treatment of symptomatic CaW was effective regarding stroke recurrence prevention and safe, without procedural nor delayed detected adverse event. However, the optimal therapeutic approach of symptomatic CaW still needs to be explored through randomized trials., (Copyright © 2022 Elsevier Masson SAS. All rights reserved.)

Published
2023
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49. Retinal nerve fiber layer thickness and spatial and temporal contrast sensitivity in multiple sclerosis.

Author

Merle H, Olindo S, Donnio A, Beral L, Richer R, Smadja D, and Cabre P

Subjects
Adult, Female, Humans, Male, Scotoma physiopathology, Tomography, Optical Coherence, Visual Acuity, Visual Field Tests, Visual Fields physiology, Contrast Sensitivity physiology, Multiple Sclerosis, Relapsing-Remitting physiopathology, Nerve Fibers pathology, Optic Disk pathology, Optic Neuritis physiopathology, Retinal Ganglion Cells pathology
Abstract

Purpose: To measure peripapillary retinal nerve fiber layer (RNFL) thickness and spatial and temporal contrast sensitivity in multiple sclerosis (MS) taking into account previous history of optic neuropathy (ON)., Methods: Thirty patients (60 eyes) with relapsing-remitting MS were selected (MS group). The MS ON group was composed of 31 eyes with previous history of optic neuropathy and the MS non-ON group of 29 eyes was without previous history of optic neuropathy. Thickness of the RNFL was measured with optical coherence tomography (OCT) with the Stratus OCT. As for sensitivity to spatial contrast,we used Pelli-Robson and Sloan charts. Sensitivity to temporal contrast was explored using frequency doubling technology perimetry (FDTP)., Results: The average thickness of RNFL in the MS, MS ON, MS non-ON, and control groups were 88.2 +/= 18.9 microm, 80.81 +/- 18.4 microm, 96.7 +/- 15.8 microm, and 106 +/- 12.2 microm, respectively. The spatial contrast vision and FDTP results were less in the MS non-ON group than in the control group. The average thickness of RNFL correlated to the scores of spatial and temporal contrast vision., Conclusions: MS is accompanied by visual function alteration even in the absence of acute optic neuropathy. The important correlation between functional and anatomic aspect confirms the value of OCT to appreciate the subclinical involvement of the optic nerve. Associated with tests exploring visual function, the OCT could reveal itself pertinent in evaluation of the different therapeutics used in MS ON.

Published
2010
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50. Gene activation therapy: from the BLV model to HAM/TSP patients.

Author

Lezin A, Olindo S, Belrose G, Signate A, Cesaire R, Smadja D, Macallan D, Asquith B, Bangham C, Bouzar A, Gillet N, Defoiche J, Florins A, Verlaeten O, Burny A, and Willems L

Subjects
Animals, Humans, Leukemia Virus, Bovine genetics, Paraparesis, Tropical Spastic genetics, Sheep, Gene Expression, Genetic Therapy, Leukemia Virus, Bovine physiology, Models, Biological, Paraparesis, Tropical Spastic therapy
Abstract

HTLV-1 (human T-lymphotropic virus type 1) and BLV (bovine leukemia virus) are two related retroviruses infecting CD4+ and B lymphocytes in humans and ruminants, respectively. During infection, the host-pathogen interplay is characterized by very dynamic kinetics resulting in equilibrium between the virus, which attempts to proliferate, and the immune response, which seeks to exert tight control of the virus. A major determinant of disease induction by both viruses is the accumulation of provirus in peripheral blood. In the absence of viral proteins, virus infected cells escape recognition and destruction by the host immune response. We propose a novel therapeutic strategy based on transient activation of viral expression using epigenetic modulators; this exposes infected cells to the immune response and results in significant reductions in proviral loads. In the absence of satisfactory therapies, this viral gene-activation strategy might delay progression, or even be curative, for HTLV-1 induced myelopathy / tropical spastic paraparesis (HAM/TSP).

Published
2009
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