2,243 results on '"Ozaki, N."'
Search Results
2. Strength of diamond beyond the elastic limit under dynamic compression
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Katagiri, K., Ozaki, N., Dresselhaus-Marais, L. E., Eggert, J. H., Inubushi, Y., Irifune, T., Koenig, M., Matsuoka, T., Miyanishi, K., Nakamura, H., Nishiyama, N., Okuchi, T., Sekine, T., Seto, Y., Sueda, K., Tange, Y., Togashi, T., Umeda, Y., Yabashi, M., Yabuuchi, T., and Kodama, R.
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Condensed Matter - Materials Science - Abstract
Extremely high pressures over a million of atmospheres are required to deform diamonds permanently. Under dynamic high-pressure conditions, even such strong materials lose their strengths so rapidly that the initially pristine lattice transforms into complex dynamics. Here, we report femtosecond x-ray diffraction observations that directly resolve how shock waves deform the crystal lattice in the isotropic nano-polycrystalline form of diamond. The results show that the nano-grain reinforced diamond retains its strength at shock pressures far beyond its elastic limit until it finally approaches zero at 707 GPa, indicating the existence of brittle-ductile transition of nano-polycrystalline diamond under high-strain rate shock compression. The atomic-level deformation process of the diamond observed in this study is a key benchmark for designing high strength materials and simulating their behavior under extreme conditions.
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- 2022
3. High-power laser experiment on developing supercritical shock propagating in homogeneously magnetized plasma of ambient gas origin
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Matsukiyo, S., Yamazaki, R., Morita, T., Tomita, K., Kuramitsu, Y., Tanaka, S. J., Takezaki, T., Isayama, S., Higuchi, T., Murakami, H., Horie, Y., Katsuki, N., Hatsuyama, R., Edamoto, M., Nishioka, H., Takagi, M., Kojima, T., Tomita, S., Ishizaka, N., Kakuchi, S., Sei, S., Sugiyama, K., Aihara, K., Kambayashi, S., Ota, M., Egashira, S., Izumi, T., Minami, T., Nakagawa, Y., Sakai, K., Iwamoto, M., Ozaki, N., and Sakawa, Y.
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Physics - Plasma Physics ,Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Experiment - Abstract
A developing supercritical collisionless shock propagating in a homogeneously magnetized plasma of ambient gas origin having higher uniformity than the previous experiments is formed by using high-power laser experiment. The ambient plasma is not contaminated by the plasma produced in the early time after the laser shot. While the observed developing shock does not have stationary downstream structure, it possesses some characteristics of a magnetized supercritical shock, which are supported by a one-dimensional full particle-in-cell simulation taking the effect of finite time of laser-target interaction into account., Comment: 7 pages, 6 fitures
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- 2022
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4. Direct imaging of shock wave splitting in diamond at Mbar pressures
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Makarov, S. S., Dyachkov, S. A., Pikuz, T. A., Katagiri, K., Zhakhovsky, V. V., Inogamov, N. A., Khokhlov, V. A., Martynenko, A. S., Albertazzi, B., Rigon, G., Mabey, P., Hartley, N., Inubushi, Y., Miyanishi, K., Sueda, K., Togashi, T., Yabashi, M., Yabuuchi, T., Kodama, R., Pikuz, S. A., Koenig, M., and Ozaki, N.
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Physics - Plasma Physics ,Condensed Matter - Materials Science - Abstract
The propagation of a shock wave in solids can stress them to ultra-high pressures of millions of atmospheres. Understanding the behavior of matter at these extreme pressures is essential to describe a wide range of physical phenomena, including the formation of planets, young stars and cores of super-Earths, as well as the behavior of advanced ceramic materials subjected to such stresses. Under megabar (Mbar) pressure, even a solid with high strength exhibits plastic properties, causing the shock wave to split in two. This phenomenon is described by theoretical models, but without direct experimental measurements to confirm them, their validity is still in doubt. Here, we present the results of an experiment in which the evolution of the coupled elastic-plastic wave structure in diamond was directly observed and studied with submicron spatial resolution, using the unique capabilities of the X-ray free-electron laser. The direct measurements allowed, for the first time, the fitting and validation of a strength model for diamond in the range of several Mbar by performing continuum mechanics simulations in 2D geometry. The presented experimental approach to the study of shock waves in solids opens up new possibilities for the direct verification and construction of the equations of state of matter in the ultra-high pressure range, which are relevant for the solution of a variety of problems in high energy density physics., Comment: 14 pages, 15 figures, submitted to Nature
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- 2022
5. Assessing the Real-World, Long-Term Impact of Lemborexant on Sleep Quality in a Home-Based Clinical Study
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Miyata S, Iwamoto K, Okada I, Fujimoto A, Kogo Y, Mori D, Amano M, Matsuyama N, Nishida K, Ando M, Taoka T, Naganawa S, and Ozaki N
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insomnia ,lemborexant ,objective sleep evaluation ,portable sleep eeg monitoring ,subjective sleep evaluation ,Psychiatry ,RC435-571 ,Neurophysiology and neuropsychology ,QP351-495 - Abstract
Seiko Miyata,1,* Kunihiro Iwamoto,1,* Ippei Okada,1,* Akihiro Fujimoto,2 Yuki Kogo,2 Daisuke Mori,1,3,4 Manabu Amano,5 Nao Matsuyama,5 Kazuki Nishida,5 Masahiko Ando,5 Toshiaki Taoka,6 Shinji Naganawa,7 Norio Ozaki1,4 1Department of Psychiatry, Nagoya University, Graduate School of Medicine, Nagoya, Japan; 2Medical Headquarters, Eisai Co., Ltd., Tokyo, Japan; 3Brain and Mind Research Center, Nagoya University, Nagoya, Japan; 4Pathophysiology of Mental Disorders, Nagoya University, Graduate School of Medicine, Nagoya, Japan; 5Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan; 6Department of Innovative Biomedical Visualization (Ibmv), Nagoya University, Graduate School of Medicine, Nagoya, Japan; 7Department of Radiology, Nagoya University, Graduate School of Medicine, Nagoya, Japan*These authors contributed equally to this workCorrespondence: Seiko Miyata, Department of Psychiatry, Nagoya University, Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8550, Japan, Tel +81 52 744 2282, Fax +81 52 744 2293, Email miyata.seiko.v4@f.mail.nagoya-u.ac.jpPurpose: Both subjective and objective evaluations are essential for the treatment of insomnia. Lemborexant has been shown to be effective in the long-term based solely on a subjective basis, and no long-term objective measures have been evaluated under natural sleep conditions. Small, lightweight sleep electroencephalogram (EEG) monitor was used, instead of polysomnography, to objectively evaluate sleep at home 4 and 12 weeks after lemborexant treatment.Patients and Methods: Adults and elderly subjects with insomnia disorder, per the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, were enrolled in this open-label, single-arm, single-center trial. Objective and subjective measures of sleep were prospectively assessed. Sleep disturbance, excessive sleepiness, and depressive symptoms were assessed using questionnaires.Results: A total of 45 subjects were screened, of which 33 were enrolled. Paired t-tests were conducted to evaluate changes in sleep variables and compared with the baseline; subjects showed significant improvements in objective sleep efficiency (SE) and subjective sleep parameters at weeks 4 and 12 following treatment with lemborexant. When baseline values were taken into account, a repeated-multivariate analysis of variance (MANOVA) revealed statistically significant changes in the objective measures. Sleep disturbance, excessive sleepiness, and depressive symptoms improved after three months of lemborexant treatment.Conclusion: Furthermore, lemborexant therapy improved nocturnal sleep, when measured objectively using sleep EEG monitoring at home, and improved daytime sleepiness and depressive symptoms in older adults with insomnia disorder.Keywords: insomnia, lemborexant, objective sleep evaluation, portable sleep EEG monitoring, subjective sleep evaluation
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- 2024
6. High-power laser experiment forming a supercritical collisionless shock in a magnetized uniform plasma at rest
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Yamazaki, Ryo, Matsukiyo, S., Morita, T., Tanaka, S. J., Umeda, T., Aihara, K., Edamoto, M., Egashira, S., Hatsuyama, R., Higuchi, T., Hihara, T., Horie, Y., Hoshino, M., Ishii, A., Ishizaka, N., Itadani, Y., Izumi, T., Kambayashi, S., Kakuchi, S., Katsuki, N., Kawamura, R., Kawamura, Y., Kisaka, S., Kojima, T., Konuma, A., Kumar, R., Minami, T., Miyata, I., Moritaka, T., Murakami, Y., Nagashima, K., Nakagawa, Y., Nishimoto, T., Nishioka, Y., Ohira, Y., Ohnishi, N., Ota, M., Ozaki, N., Sano, T., Sakai, K., Sei, S., Shiota, J., Shoji, Y., Sugiyama, K., Suzuki, D., Takagi, M., Toda, H., Tomita, S., Tomiya, S., Yoneda, H., Takezaki, T., Tomita, K., Kuramitsu, Y., and Sakawa, Y.
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Physics - Plasma Physics ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present a new experimental method to generate quasi-perpendicular supercritical magnetized collisionless shocks. In our experiment, ambient nitrogen (N) plasma is at rest and well-magnetized, and it has uniform mass density. The plasma is pushed by laser-driven ablation aluminum (Al) plasma. Streaked optical pyrometry and spatially resolved laser collective Thomson scattering clarify structures of plasma density and temperatures, which are compared with one-dimensional particle-in-cell simulations. It is indicated that just after the laser irradiation, the Al plasma is magnetized by a self-generated Biermann battery field, and the plasma slaps the incident N plasma. The compressed external field in the N plasma reflects N ions, leading to counter-streaming magnetized N flows. Namely we identify the edge of the reflected N ions. Such interacting plasmas form a magnetized collisionless shock., Comment: 17 pages, 12 figures, 1 table. Physical Review E, in press
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- 2022
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7. Exploratory Validation of Sleep-Tracking Devices in Patients with Psychiatric Disorders
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Ogasawara M, Takeshima M, Kosaka S, Imanishi A, Itoh Y, Fujiwara D, Yoshizawa K, Ozaki N, Nakagome K, and Mishima K
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polysomnography ,actigraphy ,portable eeg ,consumer sleep technologies ,psychiatric patients ,Psychiatry ,RC435-571 ,Neurophysiology and neuropsychology ,QP351-495 - Abstract
Masaya Ogasawara,1 Masahiro Takeshima,1 Shumpei Kosaka,2 Aya Imanishi,1 Yu Itoh,1 Dai Fujiwara,1 Kazuhisa Yoshizawa,1 Norio Ozaki,3 Kazuyuki Nakagome,4 Kazuo Mishima1 1Department of Neuropsychiatry, Akita University Graduate School of Medicine, Akita, Japan; 2Department of Psychiatry, Akita Prefectural Center for Rehabilitation and Psychiatric Medicine, Daisen, Japan; 3Department of Pathophysiology of Mental Disorders, Nagoya University Graduate School of Medicine, Nagoya, Japan; 4Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, JapanCorrespondence: Kazuo Mishima, Department of Neuropsychiatry, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan, Tel +81-18-884-6122, Fax +81-18-884-6445, Email clocksclub@gmail.comPurpose: Sleep-tracking devices have performed well in recent studies that evaluated their use in healthy adults by comparing them with the gold standard sleep assessment technique, polysomnography (PSG). These devices have not been validated for use in patients with psychiatric disorders. Therefore, we tested the performance of three sleep-tracking devices against PSG in patients with psychiatric disorders.Patients and methods: In total, 52 patients (32 women; 48.1 ± 17.2 years, mean ± SD; 18 patients diagnosed with schizophrenia, 19 with depressive disorder, 3 with bipolar disorder, and 12 with sleep disorder cases) were tested in a sleep laboratory with PSG, along with portable electroencephalography (EEG) device (Sleepgraph), actigraphy (MTN-220/221) and consumer sleep-tracking device (Fitbit Sense).Results: Epoch-by-epoch sensitivity (for sleep) and specificity (for wake), respectively, were as follows: Sleepgraph (0.95, 0.76), Fitbit Sense (0.95, 0.45) and MTN-220/221 (0.93, 0.40). Portable EEG (Sleepgraph) had the best sleep stage-tracking performance. Sleep-wake summary metrics demonstrated lower performance on poor sleep (ice, shorter total sleep time, lower sleep efficiency, longer sleep latency, longer wake after sleep onset).Conclusion: Devices demonstrated similar sleep-wake detecting performance as compared with previous studies that evaluated sleep in healthy adults. Consumer sleep device may exhibit poor sleep stage-tracking performance in patients with psychiatric disorders due to factors that affect the sleep determination algorithm, such as changes in autonomic nervous system activity. However, Sleepgraph, a portable EEG device, demonstrated higher performance in mental disorders than the Fitbit Sense and actigraphy.Keywords: polysomnography, actigraphy, portable EEG, consumer sleep technologies, psychiatric patients
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- 2023
8. Using Diffuse Scattering to Observe X-Ray-Driven Nonthermal Melting
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Hartley, N. J., Grenzer, J., Huang, L., Inubushi, Y., Kamimura, N., Katagiri, K., Kodama, R., Kon, A., Lu, W., Makita, M., Matsuoka, T., Nakajima, S., Ozaki, N., Pikuz, T., Rode, A., Sagae, D., Schuster, A. K., Tono, K., Voigt, K., Vorberger, J., Yabuuchi, T., McBride, E. E., and Kraus, D.
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Physics - Plasma Physics - Abstract
We present results from the SPring-8 Angstrom Compact free electron LAser (SACLA) XFEL facility, using a high intensity ($\sim\!10^{20}\,$W/cm$^2$) X-ray pump X-ray probe scheme to observe changes in the ionic structure of silicon induced by X-ray heating of the electrons. By avoiding Laue spots in the scattering signal from a single crystalline sample, we observe a rapid rise in diffuse scattering, which we attribute to a loss of lattice order and a transition to a liquid state within 100 fs of irradiation, a timescale which agrees well with first principles simulations, but is faster than that predicted by purely inertial behavior. This method is capable of observing liquid scattering without masking or filtering of signal from the ambient solid, allowing the liquid structure to be measured throughout and beyond the phase change., Comment: 6 pages, 5 figures. Updated title and abstract
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- 2020
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9. All femtosecond optical pump and X-ray probe: holey-axicon for free electron laser
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Anand, V., Maksimovic, J., Katkus, T., Ng, S. H., Ulcinas, O., Mikutis, M., Baltrukonis, J., Urbas, A., Slekys, G., Ogura, H., Sagae, D., Pikuz, T., Somekawa, T., Ozaki, N., Vailionis, A., Seniutinas, G., Mizeikis, V., Glazebrook, K., Brodie, J. P., Stoddart, P. R., Rapp, L., Rode, A. V., Gamaly, E. G., and Juodkazis, S.
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Physics - Optics ,High Energy Physics - Experiment - Abstract
We put forward a co-axial pump(optical)-probe(X-rays) experimental concept and show performance of the optical component. A Bessel beam generator with a central 100 micrometers-diameter hole (on the optical axis) was fabricated using femtosecond (fs) laser structuring inside a silica plate. This flat-axicon optical element produces a needle-like axial intensity distribution which can be used for the optical pump pulse. The fs-X-ray free electron laser (X-FEL) beam of sub-1 micrometer diameter can be introduced through the central hole along the optical axis onto a target as a probe. Different realisations of optical pump are discussed. Such optical elements facilitate alignment of ultra-short fs-pulses in space and time and can be used in light-matter interaction experiments at extreme energy densities on the surface and in the volume of targets. Full advantage of ultra-short 10 fs X-FEL probe pulses with fs-pump(optical) opens an unexplored temporal dimension of phase transitions and the fastest laser-induced rates of material heating and quenching. A wider field of applications of fs-laser-enabled structuring of materials and design of specific optical elements for astrophotonics is presented.
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- 2020
10. A Study of Factors Causing Sleep State Misperception in Patients with Depression
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Kawai K, Iwamoto K, Miyata S, Okada I, Ando M, Fujishiro H, Noda A, and Ozaki N
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insomnia ,personality ,sleep architectures ,discrepancy ,sleep disorders ,Psychiatry ,RC435-571 ,Neurophysiology and neuropsychology ,QP351-495 - Abstract
Keita Kawai,1 Kunihiro Iwamoto,1 Seiko Miyata,1 Ippei Okada,1 Motoo Ando,1 Hiroshige Fujishiro,1 Akiko Noda,2 Norio Ozaki1 1Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan; 2Department of Biomedical Sciences, Chubu University Graduate School of Life and Health Sciences, Kasugai, JapanCorrespondence: Kunihiro Iwamoto, Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8550, Japan, Tel +81-52-744-2282, Fax +81-52-744-2293, Email iwamoto@med.nagoya-u.ac.jpPurpose: Sleep state misperception, which is the discrepancy between subjective and objective sleep, is often observed in patients with depression. This phenomenon may delay the remission of depression. Previous studies have focused on the total sleep time (TST) misperception, with many of these studies using actigraphy. Thus, our study investigated depressed patients with the exploratory aim of clarifying factors associated with the sleep state misperception including the wake after sleep onset (WASO) misperception, with their objective sleep additionally evaluated by polysomnography (PSG).Patients and Methods: We conducted a cross-sectional study. Before undergoing overnight PSG monitoring, 40 patients with depression completed questionnaires that included the Beck Depression Inventory (BDI), Epworth sleepiness scale, Temperament and Character Inventory, and the Pittsburgh sleep quality index. Patients were also asked to estimate their subjective sleep duration after they woke up in the morning. Based on this data, we calculated the misperception using the following formula: subjective sleep duration minus objective sleep duration. We compared each factor between negative and positive misperception groups and the multiple regression analysis was performed for TST and WASO misperception, respectively.Results: Although sleep architectures, age, severity of depression and obstructive sleep apnea (OSA) exhibited differences in underestimating or overestimating the WASO, only sex differences were associated with underestimating or overestimating their total sleep time (TST). Moreover, BDI, the severity of OSA, sleep architectures (N1% and N2%), and benzodiazepine (BZD) use were significantly correlated with WASO misperception, whereas only OSA severity was significantly correlated with TST misperception. A subsequent multiple regression analysis demonstrated the BDI was independently correlated with the WASO misperception (β=0.341, p=0.049).Conclusion: In clinical practice, interventions especially for OSA, and the reduction of depressive symptoms are an important method for improving patient sleep perception. Moreover, current results suggest that BZD prescriptions should be avoided as well.Keywords: insomnia, personality, sleep architectures, discrepancy, sleep disorders
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- 2022
11. Shock compression experiments using the DiPOLE 100-X laser on the high energy density instrument at the European x-ray free electron laser: Quantitative structural analysis of liquid Sn
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Gorman, M. G., primary, McGonegle, D., additional, Smith, R. F., additional, Singh, S., additional, Jenkins, T., additional, McWilliams, R. S., additional, Albertazzi, B., additional, Ali, S. J., additional, Antonelli, L., additional, Armstrong, M. R., additional, Baehtz, C., additional, Ball, O. B., additional, Banerjee, S., additional, Belonoshko, A. B., additional, Benuzzi-Mounaix, A., additional, Bolme, C. A., additional, Bouffetier, V., additional, Briggs, R., additional, Buakor, K., additional, Butcher, T., additional, Di Dio Cafiso, S., additional, Cerantola, V., additional, Chantel, J., additional, Di Cicco, A., additional, Clarke, S., additional, Coleman, A. L., additional, Collier, J., additional, Collins, G. W., additional, Comley, A. J., additional, Coppari, F., additional, Cowan, T. E., additional, Cristoforetti, G., additional, Cynn, H., additional, Descamps, A., additional, Dorchies, F., additional, Duff, M. J., additional, Dwivedi, A., additional, Edwards, C., additional, Eggert, J. H., additional, Errandonea, D., additional, Fiquet, G., additional, Galtier, E., additional, Laso Garcia, A., additional, Ginestet, H., additional, Gizzi, L., additional, Gleason, A., additional, Goede, S., additional, Gonzalez, J. M., additional, Harmand, M., additional, Hartley, N. J., additional, Heighway, P. G., additional, Hernandez-Gomez, C., additional, Higginbotham, A., additional, Höppner, H., additional, Husband, R. J., additional, Hutchinson, T. M., additional, Hwang, H., additional, Lazicki, A. E., additional, Keen, D. A., additional, Kim, J., additional, Koester, P., additional, Konopkova, Z., additional, Kraus, D., additional, Krygier, A., additional, Labate, L., additional, Lee, Y., additional, Liermann, H.-P., additional, Mason, P., additional, Masruri, M., additional, Massani, B., additional, McBride, E. E., additional, McGuire, C., additional, McHardy, J. D., additional, Merkel, S., additional, Morard, G., additional, Nagler, B., additional, Nakatsutsumi, M., additional, Nguyen-Cong, K., additional, Norton, A.-M., additional, Oleynik, I. I., additional, Otzen, C., additional, Ozaki, N., additional, Pandolfi, S., additional, Peake, D. J., additional, Pelka, A., additional, Pereira, K. A., additional, Phillips, J. P., additional, Prescher, C., additional, Preston, T. R., additional, Randolph, L., additional, Ranjan, D., additional, Ravasio, A., additional, Redmer, R., additional, Rips, J., additional, Santamaria-Perez, D., additional, Savage, D. J., additional, Schoelmerich, M., additional, Schwinkendorf, J.-P., additional, Smith, J., additional, Sollier, A., additional, Spear, J., additional, Spindloe, C., additional, Stevenson, M., additional, Strohm, C., additional, Suer, T.-A., additional, Tang, M., additional, Toncian, M., additional, Toncian, T., additional, Tracy, S. J., additional, Trapananti, A., additional, Tschentscher, T., additional, Tyldesley, M., additional, Vennari, C. E., additional, Vinci, T., additional, Vogel, S. C., additional, Volz, T. J., additional, Vorberger, J., additional, Walsh, J. P. S., additional, Wark, J. S., additional, Willman, J. T., additional, Wollenweber, L., additional, Zastrau, U., additional, Brambrink, E., additional, Appel, K., additional, and McMahon, M. I., additional
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- 2024
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12. Equation of state and optical properties of shock-compressed C:H:N:O molecular mixtures
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Guarguaglini, M., Hernandez, J. -A., Okuchi, T., Barroso, P., Benuzzi-Mounaix, A., Bolis, R., Brambrink, E., Fujimoto, Y., Kodama, R., Koenig, M., Lefevre, F., Miyanishi, K., Ozaki, N., Sano, T., Umeda, Y., Vinci, T., and Ravasio, A.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Water, ethanol, and ammonia are the key components of the mantles of Uranus and Neptune. To improve structure and evolution models and give an explanation of the magnetic fields and luminosities of the icy giants, those components need to be characterised at planetary conditions (some Mbar and a few $10^3$ K). Those conditions are typical of the Warm Dense Matter regime, which exhibits a rich phase diagram, with the coexistence of many states of matter and a large variety of chemical processes. H$_2$O, C:H:O, and C:H:N:O mixtures have been compressed up to 2.8 Mbar along the principal Hugoniot using laser-driven decaying shocks. The experiments were performed at the GEKKO XII and LULI 2000 laser facilities using standard optical diagnostics (Doppler velocimetry and pyrometry) to characterise equation of state and optical reflectivity of the shocked states. The results show that H$_2$O and the C:H:N:O mixture share the same equation of state with a density scaling, while the reflectivity behaves differently by what concerns both the onset pressures and the saturation values. The reflectivity measurement at two frequencies allows to estimate the conductivity and the complex refractive index using a Drude model.
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- 2018
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13. Dust impact and attitude analysis for JAXA’s probe on the Comet Interceptor mission
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Machuca, P., Ozaki, N., Sánchez, J.P., and Felicetti, L.
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- 2022
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14. Chemical bonding properties of liquid methane under high-density conditions.
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Murayama, D., Ohmura, S., Kodama, R., and Ozaki, N.
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CHEMICAL bonds ,CHEMICAL properties ,ELECTRONIC density of states ,ELECTRON distribution ,TRANSITION metals ,ELECTRON density ,OXYGEN carriers - Abstract
We present the chemical bonding and electronic properties of liquid methane at temperatures from 2000 to 4000 K and high densities of up to 3.0 g/cm
3 , calculated using ab initio molecular dynamics simulations in combination with the Mulliken population analysis. Bond-overlap populations and pair distribution functions are studied to investigate the evolution of electron delocalization accompanying atomic structure change as the density is increased. In addition, we also investigated the bandgap energy, electronic density of states, and spatial distribution of electron density. We observed that molecular hydrogen and C‒C bonds are formed after methane dissociates, and then the system undergoes a nonmetal–metal transition coinciding with hydrogen being transformed from the molecular to the atomic state. The C‒C bonds in the system retain covalent character, even at the highest density of 3.0 g/cm3 . [ABSTRACT FROM AUTHOR]- Published
- 2023
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15. Author Correction: Direct observations of pure electron outflow in magnetic reconnection
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Sakai, K., Moritaka, T., Morita, T., Tomita, K., Minami, T., Nishimoto, T., Egashira, S., Ota, M., Sakawa, Y., Ozaki, N., Kodama, R., Kojima, T., Takezaki, T., Yamazaki, R., Tanaka, S. J., Aihara, K., Koenig, M., Albertazzi, B., Mabey, P., Woolsey, N., Matsukiyo, S., Takabe, H., Hoshino, M., and Kuramitsu, Y.
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- 2022
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16. Direct observations of pure electron outflow in magnetic reconnection
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Sakai, K., Moritaka, T., Morita, T., Tomita, K., Minami, T., Nishimoto, T., Egashira, S., Ota, M., Sakawa, Y., Ozaki, N., Kodama, R., Kojima, T., Takezaki, T., Yamazaki, R., Tanaka, S. J., Aihara, K., Koenig, M., Albertazzi, B., Mabey, P., Woolsey, N., Matsukiyo, S., Takabe, H., Hoshino, M., and Kuramitsu, Y.
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- 2022
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17. Advanced spectroscopic investigation of colour centres in LiF crystals irradiated with monochromatic hard x-rays
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Vincenti, M A, primary, Montereali, R M, additional, Bonfigli, F, additional, Nichelatti, E, additional, Nigro, V, additional, Piccinini, M, additional, Koenig, M, additional, Mabey, P, additional, Rigon, G, additional, Dabrowski, H J, additional, Benkadoum, Y, additional, Mercere, P, additional, Da Silva, P, additional, Pikuz, T, additional, Ozaki, N, additional, Makarov, S, additional, Pikuz, S, additional, and Albertazzi, B, additional
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- 2024
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18. Decaying shock studies of phase transitions in MgOSiO2 systems: implications for the Super-Earths interiors
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Bolis, R. M., Morard, G., Vinci, T., Ravasio, A., Bambrink, E., Guarguaglini, M., Koenig, M., Musella, R., Remus, F., Bouchet, J., Ozaki, N., Miyanishi, K., Sekine, T., Sakawa, Y., Sano, T., Kodama, R., Guyot, F., and Benuzzi-Mounaix, A.
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Physics - Geophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
We report an experimental study of the phase diagrams of periclase (MgO), enstatite (MgSiO3) and forsterite (Mg2SiO4) at high pressures. We investigated with laser driven decaying shocks the pressure/temperature curves of MgO, MgSiO3 and Mg2SiO4 between 0.2-1.2 TPa, 0.12-0.5 TPa and 0.2-0.85 TPa respectively. A melting signature has been observed in MgO at 0.47 TPa and 9860 K, while no phase changes were observed neither in MgSiO3 nor in Mg2SiO4. An increasing of reflectivity of MgO, MgSiO3 and Mg2SiO4 liquids have been detected at 0.55 TPa -12 760 K, 0.15 TPa - 7540 K, 0.2 TPa - 5800 K, respectively. In contrast to SiO2, melting and metallization of these compounds do not coincide implying the presence of poor electrically conducting liquids close to the melting lines. This has important implications for the generation of dynamos in Super-earths mantles.
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- 2016
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19. Abnormal asymmetries in subcortical brain volume in schizophrenia
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Okada, N, Fukunaga, M, Yamashita, F, Koshiyama, D, Yamamori, H, Ohi, K, Yasuda, Y, Fujimoto, M, Watanabe, Y, Yahata, N, Nemoto, K, Hibar, DP, van Erp, TGM, Fujino, H, Isobe, M, Isomura, S, Natsubori, T, Narita, H, Hashimoto, N, Miyata, J, Koike, S, Takahashi, T, Yamasue, H, Matsuo, K, Onitsuka, T, Iidaka, T, Kawasaki, Y, Yoshimura, R, Suzuki, M, Turner, JA, Takeda, M, Thompson, PM, Ozaki, N, Kasai, K, and Hashimoto, R
- Subjects
Clinical Research ,Mental Health ,Brain Disorders ,Neurosciences ,Schizophrenia ,Aetiology ,2.1 Biological and endogenous factors ,Mental health ,Adult ,Amygdala ,Basal Ganglia ,Brain ,Brain Mapping ,Cohort Studies ,Cross-Sectional Studies ,Female ,Functional Laterality ,Hippocampus ,Humans ,Image Processing ,Computer-Assisted ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Psychiatric Status Rating Scales ,Putamen ,Thalamus ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry - Abstract
Subcortical structures, which include the basal ganglia and parts of the limbic system, have key roles in learning, motor control and emotion, but also contribute to higher-order executive functions. Prior studies have reported volumetric alterations in subcortical regions in schizophrenia. Reported results have sometimes been heterogeneous, and few large-scale investigations have been conducted. Moreover, few large-scale studies have assessed asymmetries of subcortical volumes in schizophrenia. Here, as a work completely independent of a study performed by the ENIGMA consortium, we conducted a large-scale multisite study of subcortical volumetric differences between patients with schizophrenia and controls. We also explored the laterality of subcortical regions to identify characteristic similarities and differences between them. T1-weighted images from 1680 healthy individuals and 884 patients with schizophrenia, obtained with 15 imaging protocols at 11 sites, were processed with FreeSurfer. Group differences were calculated for each protocol and meta-analyzed. Compared with controls, patients with schizophrenia demonstrated smaller bilateral hippocampus, amygdala, thalamus and accumbens volumes as well as intracranial volume, but larger bilateral caudate, putamen, pallidum and lateral ventricle volumes. We replicated the rank order of effect sizes for subcortical volumetric changes in schizophrenia reported by the ENIGMA consortium. Further, we revealed leftward asymmetry for thalamus, lateral ventricle, caudate and putamen volumes, and rightward asymmetry for amygdala and hippocampal volumes in both controls and patients with schizophrenia. Also, we demonstrated a schizophrenia-specific leftward asymmetry for pallidum volume. These findings suggest the possibility of aberrant laterality in neural pathways and connectivity patterns related to the pallidum in schizophrenia.
- Published
- 2016
20. Temporal evolution of pressure profiles for laser-induced cavitation bubble on the metal surface.
- Author
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Hironaka, Y., Shigemori, K., Ozaki, N., Kurita, T., and Kodama, R.
- Subjects
METALLIC surfaces ,PLASMA confinement ,CAVITATION ,LASER ablation ,PLASMA interactions ,MICROBUBBLE diagnosis - Abstract
When a laser is focused on an underwater object, it experiences a large amount of pressure owing to the plasma confinement effect of water. A hemispherical bubble is generated on the surface of the object, and large pressure is generated when the bubble collapses. In this study, we conducted experiments using different laser energies to analyze the pressure–time histories associated with bubble contraction. The maximum pressure was 10%–40% of the laser ablation pressure, whereas the pressure pulse width was 5–10 times longer than the laser pulse width. Furthermore, the bubble motion could be adiabatically explained, except for the plasma interaction region. The results indicate that the pressure at which the bubble collapses does not depend on the maximum size of the generated bubble but depends on the energy of water vapor within the bubble. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
21. Melting of iron close to Earth's inner core boundary conditions and beyond
- Author
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Harmand, M., Ravasio, A., Mazevet, S., Bouchet, J., Denoeud, A., Dorchies, F., Feng, Y., Fourment, C., Galtier, E ., Gaudin, J., Guyot, F., Kodama, R., Koenig, M., Lee, H. J., Miyanishi, K., Morard, G., Musella, R., Nagler, B., Nakatsutsumi, M., Ozaki, N., Recoules, V., Toleikis, S., Vinci, T., Zastrau, U., Zhu, D., and Benuzzi-Mounaix, A.
- Subjects
Physics - Geophysics ,Condensed Matter - Materials Science - Abstract
Several important geophysical features such as heat flux at the Core-Mantle Boundary or geodynamo production are intimately related with the temperature profile in the Earth's core. However, measuring the melting curve of iron at conditions corresponding to the Earth inner core boundary under pressure of 330 GPa has eluded scientists for several decades. Significant discrepancies in previously reported iron melting temperatures at high pressure have called into question the validity of dynamic measurements. We report measurements made with a novel approach using X-ray absorption spectroscopy using an X-ray free electron laser source coupled to a laser shock experiment. We determine the state of iron along the shock Hugoniot up to 420 GPa (+/- 50) and 10800 K (+/- 1390) and find an upper boundary for the melting curve of iron by detecting solid iron at 130 GPa and molten at 260, 380 and 420 GPa along the shock Hugoniot. Our result establishes unambiguous agreement between dynamic measurement and recent extrapolations from static data thus resolving the long-standing controversy over the reliability of using dynamic compression to study the melting of iron at conditions close to the Earth's inner core boundary and beyond., Comment: 9 pages 3 figures
- Published
- 2014
22. Mode Transition from Fast-Gas Ionization Wave to Laser-Supported Detonation Wave
- Author
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Shimamura, K., Ozaki, N., Matsui, K., Komurasaki, K., Sasoh, Akihiro, editor, Aoki, Toshiyuki, editor, and Katayama, Masahide, editor
- Published
- 2019
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- View/download PDF
23. Observation of ultra-high energy density state with x-ray free electron laser SACLA
- Author
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Maeda, Y., Hironaka, Y., Iwasaki, T., Kawasaki, K., Sakawa, Y., Izumi, T., Ota, M., Egashira, S., Nakagawa, Y., Higashi, N., Sentoku, Y., Kodama, R., Ozaki, N., Matsuoka, T., Somekawa, T., Yabuuchi, T., Inubushi, Y., Togashi, T., Kon, A., Sueda, K., Miyanishi, K., Shingubara, S., Shimizu, T., Okumura, A., and Shigemori, K.
- Published
- 2020
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24. Micron-scale phenomena observed in a turbulent laser-produced plasma
- Author
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Rigon, G., Albertazzi, B., Pikuz, T., Mabey, P., Bouffetier, V., Ozaki, N., Vinci, T., Barbato, F., Falize, E., Inubushi, Y., Kamimura, N., Katagiri, K., Makarov, S., Manuel, M. J.-E., Miyanishi, K., Pikuz, S., Poujade, O., Sueda, K., Togashi, T., Umeda, Y., Yabashi, M., Yabuuchi, T., Gregori, G., Kodama, R., Casner, A., and Koenig, M.
- Published
- 2021
- Full Text
- View/download PDF
25. Laser-shock compression experiment on magnesium hydride
- Author
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Morioka, S., Ozaki, N., Hosomi, M., Katagiri, K., Matsuoka, T., Miyanishi, K., Okuchi, T., Sano, T., Umeda, Y., and Kodama, R.
- Published
- 2019
- Full Text
- View/download PDF
26. In Situ Characterization of XFEL Beam Intensity Distribution and Focusability by High-Resolution LiF Crystal Detector
- Author
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Pikuz, T. A., Faenov, A. Ya., Matsuoka, T., Albertazzi, B., Ozaki, N., Hartely, N., Muray Ricardo Arturo, O., Yabuuchi, T., Habara, H., Matsuyama, S., Yamauchi, K., Inubushi, Y., Togashi, T., Yumoto, H., Tange, Y., Tono, K., Sato, Y., Yabashi, M., Nishikino, M., Kawachi, T., Mitrofanov, A., Pikuz, S. A., Bleiner, D., Grum-Grzhimailo, A., Rosanov, N. N., Vysotina, N. V., Harmand, M., Koenig, M., Tanaka, K. A., Ishikawa, T., Kodama, R., Kawachi, Tetsuya, editor, Bulanov, Sergei V., editor, Daido, Hiroyuki, editor, and Kato, Yoshiaki, editor
- Published
- 2018
- Full Text
- View/download PDF
27. Ultrafast anisotropic disordering in graphite driven by intense hard X-ray pulses
- Author
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Hartley, N.J., Grenzer, J., Lu, W., Huang, L.G., Inubushi, Y., Kamimura, N., Katagiri, K., Kodama, R., Kon, A., Lipp, V., Makita, M., Matsuoka, T., Medvedev, N., Nakajima, S., Ozaki, N., Pikuz, T., Rode, A.V., Rohatsch, K., Sagae, D., Schuster, A.K., Tono, K., Vorberger, J., Yabuuchi, T., and Kraus, D.
- Published
- 2019
- Full Text
- View/download PDF
28. Laser-Shock Compression and Hugoniot Measurements of Liquid Hydrogen to 55 GPa
- Author
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Sano, T., Ozaki, N., Sakaiya, T., Shigemori, K., Ikoma, M., Kimura, T., Miyanishi, K., Endo, T., Shiroshita, A., Takahashi, H., Jitsui, T., Hori, Y., Hironaka, Y., Iwamoto, A., Kadono, T., Nakai, M., Okuchi, T., Otani, K., Shimizu, K., Kondo, T., Kodama, R., and Mima, K.
- Subjects
Condensed Matter - Materials Science ,Astrophysics - Earth and Planetary Astrophysics - Abstract
The principal Hugoniot for liquid hydrogen was obtained up to 55 GPa under laser-driven shock loading. Pressure and density of compressed hydrogen were determined by impedance-matching to a quartz standard. The shock temperature was independently measured from the brightness of the shock front. Hugoniot data of hydrogen provide a good benchmark to modern theories of condensed matter. The initial number density of liquid hydrogen is lower than that for liquid deuterium, and this results in shock compressed hydrogen having a higher compression and higher temperature than deuterium at the same shock pressure., Comment: 8 pages, 7 figures, 2 tables, accepted for publication in Physical Review B
- Published
- 2011
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- View/download PDF
29. Effects of hydrogen concentration in ablator material on stimulated Raman scattering, two-plasmon decay, and hot electrons for direct-drive inertial confinement fusion
- Author
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Kawasaki, K., primary, Cristoforetti, G., additional, Idesaka, T., additional, Hironaka, Y., additional, Tanaka, D., additional, Batani, D., additional, Fujioka, S., additional, Gizzi, L. A., additional, Hata, M., additional, Johzaki, T., additional, Katagiri, K., additional, Kodama, R., additional, Matsuo, S., additional, Nagatomo, H., additional, Nicolai, Ph., additional, Ozaki, N., additional, Sentoku, Y., additional, Takizawa, R., additional, Yogo, A., additional, Yamada, H., additional, and Shigemori, K., additional
- Published
- 2023
- Full Text
- View/download PDF
30. Phosphorus Recovery from Sewage in a Pilot-Scale UASB-DHS System
- Author
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Nurmiyanto, A., Kodera, H., Kindaichi, T., Ozaki, N., Ohashi, A., di Prisco, Marco, Series editor, Chen, Sheng-Hong, Series editor, Solari, Giovanni, Series editor, Vayas, Ioannis, Series editor, and Mannina, Giorgio, editor
- Published
- 2017
- Full Text
- View/download PDF
31. Comparison of quality of life and psychological distress in patients with tongue cancer undergoing a total/subtotal glossectomy or extended hemiglossectomy and free flap transfer: a prospective evaluation
- Author
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Suzuki, K., primary, Nishio, N., additional, Kimura, H., additional, Tokura, T., additional, Kishi, S., additional, Ozaki, N., additional, Fujimoto, Y., additional, and Sone, M., additional
- Published
- 2023
- Full Text
- View/download PDF
32. Indirect evidence for elemental hydrogen in laser-compressed hydrocarbons
- Author
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Kraus, D., primary, Vorberger, J., additional, Hartley, N. J., additional, Lütgert, J., additional, Rödel, M., additional, Chekrygina, D., additional, Döppner, T., additional, van Driel, T., additional, Falcone, R. W., additional, Fletcher, L. B., additional, Frydrych, S., additional, Galtier, E., additional, Gericke, D. O., additional, Glenzer, S. H., additional, Granados, E., additional, Inubushi, Y., additional, Kamimura, N., additional, Katagiri, K., additional, MacDonald, M. J., additional, MacKinnon, A. J., additional, Matsuoka, T., additional, Miyanishi, K., additional, McBride, E. E., additional, Nam, I., additional, Neumayer, P., additional, Ozaki, N., additional, Pak, A., additional, Ravasio, A., additional, Saunders, A. M., additional, Schuster, A. K., additional, Stevenson, M. G., additional, Sueda, K., additional, Sun, P., additional, Togashi, T., additional, Voigt, K., additional, Yabashi, M., additional, and Yabuuchi, T., additional
- Published
- 2023
- Full Text
- View/download PDF
33. Optical characterization of lithium fluoride thin-film imaging detectors for monochromatic hard X-rays
- Author
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Vincenti, M.A., primary, Montereali, R.M., additional, Nichelatti, E., additional, Nigro, V., additional, Piccinini, M., additional, Koenig, M., additional, Mabey, P., additional, Rigon, G., additional, Dabrowski, H.J., additional, Benkadoum, Y., additional, Mercere, P., additional, Da Silva, P., additional, Pikuz, T., additional, Ozaki, N., additional, Makarov, S., additional, Pikuz, S., additional, and Albertazzi, B., additional
- Published
- 2023
- Full Text
- View/download PDF
34. Shock-Induced Melting and Recrystallization of MoO3Studied by Dynamic X-Ray Diffraction
- Author
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Kishimura, H., Kawai, N., Miyanishi, K., Sueda, K., Yabuuchi, T., Nakamura, H., Amouretti, A., Ozaki, N., Aimi, A., and Ichiyanagi, K.
- Abstract
Molybdenum(VI) oxide (MoO3) is a promising semiconductor material that can be used in several functional applications. Understanding the structural response of MoO3under high-pressure and high-temperature conditions is important for designing a material used in device applications. An X-ray free electron laser (XFEL) enables the structural response under extreme conditions to be probed at the nanosecond timescale. We describe laser-driven shock compression experiments on MoO3using an XFEL to directly observe the structural evolution of MoO3. When a laser-driven shock wave arrives at a pressure of 61 GPa, MoO3melts immediately and remains in the molten state for a few nanoseconds. Rapid recrystallization to the α-MoO3phase and a high-pressure phase MoO3-II is also observed on nanosecond timescales during pressure release. Our results provide insights into the kinetic and phase transition under shock compression and represent the advancement toward the understanding structural response of MoO3under high-pressure, high-temperature conditions, which has not been studied.
- Published
- 2024
- Full Text
- View/download PDF
35. Ultrahigh-energy density state in nanowire arrays irradiated with picosecond kilojoule-class ultra-intense laser.
- Author
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Tanaka, D., Maeda, Y., Hironaka, Y., Kawasaki, K., Higashi, N., Iwata, N., Sentoku, Y., Kodama, R., Ozaki, N., Somekawa, T., Shinguubara, S., Shimizu, T., Sawada, H., and Shigemori, K.
- Subjects
NANOWIRES ,ULTRASHORT laser pulses ,DENSITY of states ,INERTIAL confinement fusion ,HOT carriers ,FEMTOSECOND lasers ,LASERS - Abstract
Ultrahigh-energy density (UHED) states greater than 1 Gbar pressure are typically observed under extreme conditions, such as in the core of an inertial confinement fusion implosion. A novel alternative approach for generating volumetric UHED states is to use nanowire arrays irradiated with a femtosecond ultrahigh-intensity laser. In this paper, we present an experimental investigation on laser absorption and energy transport in nanowire arrays irradiated with a picosecond kilojoule petawatt laser. The laser–target interactions were studied by measuring the x-ray emission and escaping hot electrons from a bare Cu foil and a foil with a nanowire array grown on its surface. The measured Cu-Kα and He-α emissions from the nanowire array were higher than those from the flat foil. In addition, hot electrons observed from the front surface of the nanowire array were enhanced. On the other hand, despite the stronger Kα emission from the nanowire array and the enhancement of hot electrons escaping from the front surface of the nanowire array, the number of hot electrons observed from the rear side of the flat foil target was slightly lower than that of the flat foil. A comparison of the experimental results with the results of a two-dimensional particle-in-cell simulation code suggested that the magnetic fields generated around the periodic nanowire array trap hot electrons, improving the electron-to-target energy coupling and efficiently producing UHED states. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
36. Corrigendum to ultrafast anisotropic disordering in graphite driven by intense hard X-ray pulses
- Author
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Hartley, N.J., primary, Grenzer, J., additional, Lu, W., additional, Huang, L.G., additional, Inubushi, Y., additional, Kamimura, N., additional, Katagiri, K., additional, Kodama, R., additional, Kon, A., additional, Lipp, V., additional, Makita, M., additional, Matsuoka, T., additional, Medvedev, N., additional, Nakajima, S., additional, Ozaki, N., additional, Pikuz, T., additional, Rode, A.V., additional, Sagae, D., additional, Schuster, A.K., additional, Tono, K., additional, Voigt, K., additional, Vorberger, J., additional, Yabuuchi, T., additional, and Kraus, D., additional
- Published
- 2023
- Full Text
- View/download PDF
37. Evaluation of driving performance in schizophrenic patients
- Author
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Konishi, Y., primary, Kitagawa, S., additional, Iwamoto, K., additional, Yamaguchi, A., additional, Yoshimura, R., additional, and Ozaki, N., additional
- Published
- 2023
- Full Text
- View/download PDF
38. Multibeam laser–plasma interaction at the Gekko XII laser facility in conditions relevant for direct-drive inertial confinement fusion
- Author
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Cristoforetti, G., primary, Koester, P., additional, Atzeni, S., additional, Batani, D., additional, Fujioka, S., additional, Hironaka, Y., additional, Hüller, S., additional, Idesaka, T., additional, Katagiri, K., additional, Kawasaki, K., additional, Kodama, R., additional, Mancelli, D., additional, Nicolai, Ph., additional, Ozaki, N., additional, Schiavi, A., additional, Shigemori, K., additional, Takizawa, R., additional, Tamagawa, T., additional, Tanaka, D., additional, Tentori, A., additional, Umeda, Y., additional, Yogo, A., additional, and Gizzi, L. A., additional
- Published
- 2023
- Full Text
- View/download PDF
39. Effect of brief hypoxic exposure on growth rate in peripheral rats
- Author
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Ozaki, N, Pederico, CL, Waffam, F, and Cooper, DM
- Subjects
Paediatrics and Reproductive Medicine ,Pediatrics - Published
- 1999
40. Laser-driven shock compression of “synthetic planetary mixtures” of water, ethanol, and ammonia
- Author
-
Guarguaglini, M., Hernandez, J.-A., Okuchi, T., Barroso, P., Benuzzi-Mounaix, A., Bethkenhagen, M., Bolis, R., Brambrink, E., French, M., Fujimoto, Y., Kodama, R., Koenig, M., Lefevre, F., Miyanishi, K., Ozaki, N., Redmer, R., Sano, T., Umeda, Y., Vinci, T., and Ravasio, A.
- Published
- 2019
- Full Text
- View/download PDF
41. Laboratory study of stationary accretion shock relevant to astrophysical systems
- Author
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Mabey, P., Albertazzi, B., Falize, E., Michel, Th., Rigon, G., Van Box Som, L., Pelka, A., Brack, F.-E., Kroll, F., Filippov, E., Gregori, G., Kuramitsu, Y., Lamb, D. Q., Li, C., Ozaki, N., Pikuz, S., Sakawa, Y., Tzeferacos, P., and Koenig, M.
- Published
- 2019
- Full Text
- View/download PDF
42. Advanced high resolution x-ray diagnostic for HEDP experiments
- Author
-
Faenov, A. Y., Pikuz, T. A., Mabey, P., Albertazzi, B., Michel, Th., Rigon, G., Pikuz, S. A., Buzmakov, A., Makarov, S., Ozaki, N., Matsuoka, T., Katagiri, K., Miyanishi, K., Takahashi, K., Tanaka, K. A., Inubushi, Y., Togashi, T., Yabuuchi, T., Yabashi, M., Casner, A., Kodama, R., and Koenig, M.
- Published
- 2018
- Full Text
- View/download PDF
43. Spectral and temporal photoluminescence behavior of colloidal PbS quantum dots
- Author
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Kitamura, S., Senshu, M., Tokushige, H., Katsuyama, T., Ozaki, N., Tanaka, I., and Sugimoto, Y.
- Published
- 2015
- Full Text
- View/download PDF
44. High-resolution copy number variation analysis of schizophrenia in Japan
- Author
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Kushima, I, Aleksic, B, Nakatochi, M, Shimamura, T, Shiino, T, Yoshimi, A, Kimura, H, Takasaki, Y, Wang, C, Xing, J, Ishizuka, K, Oya-Ito, T, Nakamura, Y, Arioka, Y, Maeda, T, Yamamoto, M, Yoshida, M, Noma, H, Hamada, S, Morikawa, M, Uno, Y, Okada, T, Iidaka, T, Iritani, S, Yamamoto, T, Miyashita, M, Kobori, A, Arai, M, Itokawa, M, Cheng, M -C, Chuang, Y -A, Chen, C -H, Suzuki, M, Takahashi, T, Hashimoto, R, Yamamori, H, Yasuda, Y, Watanabe, Y, Nunokawa, A, Someya, T, Ikeda, M, Toyota, T, Yoshikawa, T, Numata, S, Ohmori, T, Kunimoto, S, Mori, D, Iwata, N, and Ozaki, N
- Published
- 2017
- Full Text
- View/download PDF
45. High-power laser experiment on developing supercritical shock propagating in homogeneously magnetized plasma of ambient gas origin
- Author
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Matsukiyo, S., primary, Yamazaki, R., additional, Morita, T., additional, Tomita, K., additional, Kuramitsu, Y., additional, Sano, T., additional, Tanaka, S. J., additional, Takezaki, T., additional, Isayama, S., additional, Higuchi, T., additional, Murakami, H., additional, Horie, Y., additional, Katsuki, N., additional, Hatsuyama, R., additional, Edamoto, M., additional, Nishioka, H., additional, Takagi, M., additional, Kojima, T., additional, Tomita, S., additional, Ishizaka, N., additional, Kakuchi, S., additional, Sei, S., additional, Sugiyama, K., additional, Aihara, K., additional, Kambayashi, S., additional, Ota, M., additional, Egashira, S., additional, Izumi, T., additional, Minami, T., additional, Nakagawa, Y., additional, Sakai, K., additional, Iwamoto, M., additional, Ozaki, N., additional, and Sakawa, Y., additional
- Published
- 2022
- Full Text
- View/download PDF
46. Density Measurements of Shock Compressed Matter Using Short Pulse Laser Diagnostics
- Author
-
Koenig, M., Ravasio, A., Benuzzi-Mounaix, A., Loupias, B., Ozaki, N., Borghesi, M., Cecchetti, C., Batani, D., Dezulian, R., Lepape, S., Patel, P., Park, H. S., Hicks, D., Mckinnon, A., Boehly, T., Schiavi, A., Henry, E., Notley, M., Clark, R., Bandyopadhyay, S., and Lebedev, Sergey V., editor
- Published
- 2007
- Full Text
- View/download PDF
47. Plasma Jet Experiments Using LULI 2000 Laser Facility
- Author
-
Loupias, B., Koenig, M., Ozaki, N., Benuzzi-Mounaix, A., Rabec le Goahec, M., Falize, E., Bouquet, S., Michaut, C., Nazarov, W., Courtois, C., Aglitskiy, Y., Faenov, A. YA., Pikuz, T., and Lebedev, Sergey V., editor
- Published
- 2007
- Full Text
- View/download PDF
48. Radiative Shock Experiments at LULI
- Author
-
Koenig, M., Vinci, T., Benuzzi-Mounaix, A., Lepape, S., Ozaki, N., Bouquet, S., Boireau, L., Leygnac, S., Michaut, C., Stehle, C., Chièze, J.-P., Batani, D., Hall, T., Tanaka, K., Yoshida, M., and Kyrala, G.A., editor
- Published
- 2005
- Full Text
- View/download PDF
49. Assessment of antitumor activity and acute peripheral neuropathy of 1,2-diaminocyclohexane platinum (II)-incorporating micelles (NC-4016)
- Author
-
Ueno T, Endo K, Hori K, Ozaki N, Tsuji A, Kondo S, Wakisaka N, Murono S, Kataoka K, Kato Y, and Yoshizaki T
- Subjects
Medicine (General) ,R5-920 - Abstract
Takayoshi Ueno,1 Kazuhira Endo,1 Kiyomi Hori,2 Noriyuki Ozaki,2 Akira Tsuji,1 Satoru Kondo,1 Naohiro Wakisaka,1 Shigeyuki Murono,1 Kazunori Kataoka,3,4 Yasuki Kato,5 Tomokazu Yoshizaki11Division of Otolaryngology-Head and Neck Surgery, 2Department of Functional Anatomy, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan; 3Department of Materials Engineering, Graduate School of Engineering, 4Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 5Research Division, NanoCarrier Co., Ltd, Chiba, JapanAbstract: Oxaliplatin, a third-generation platinum compound incorporating oxalate and 1,2-diaminocyclohexane platinum, has been widely used in chemotherapy regimens for the treatment of metastatic colorectal cancer. Because of its wide spectrum of antitumor activity, oxaliplatin has been applied for the treatment of other carcinomas. However, the antitumor activity of single-agent oxaliplatin is insufficient. To increase its antitumor effects, polymeric micellar nanoparticles incorporating 1,2-diaminocyclohexane platinum (NC-4016) have been developed. The present study was designed to evaluate the efficacy of NC-4016 and its association with peripheral neuropathy, which is a primary dose-limiting factor in oxaliplatin therapy. The in vitro antitumor activity of NC-4016 was investigated using human carcinoma cell lines. To investigate the antitumor effects of NC-4016 in vivo, nude mice bearing the human carcinoma cell line KB were administered NC-4016 or oxaliplatin. The in vitro growth-inhibiting effect of NC-4016 was significantly weaker than that of oxaliplatin. However, the antitumor efficacy of NC-4016 was superior to that of oxaliplatin in vivo. Moreover, we compared the severity of peripheral neuropathy induced by oxaliplatin and NC-4016 in a rat model. Oxaliplatin, NC-4016, or 5% glucose (control) were administered by a single tail vein injection. In the oxaliplatin-treated rats, neither mechanical nor heat allodynia was observed during the experimental period, whereas cold hyperalgesia/allodynia was observed from day 1 to 7. Conversely, cold hyperalgesia/allodynia was not observed in the NC-4016-treated rats. The present study demonstrated that the antitumor efficacy of NC-4016 was superior to that of oxaliplatin in a mouse model of human carcinoma cell line KB. In addition, NC-4016-treated rats did not develop acute cold hypersensitivity, which is frequently experienced by patients after oxaliplatin administration.Keywords: oxaliplatin, carcinoma, chemotherapy, drug delivery system
- Published
- 2014
50. X-ray diffraction study of phase transformation dynamics of Fe and Fe-Si alloys along the shock Hugoniot using an x-ray free electron laser
- Author
-
Krygier, A., primary, Harmand, M., additional, Albertazzi, B., additional, McBride, E. E., additional, Miyanishi, K., additional, Antonangeli, D., additional, Inubushi, Y., additional, Kodama, R., additional, Koenig, M., additional, Matsuoka, T., additional, Mogni, G., additional, Pietrucci, F., additional, Saitta, A. M., additional, Togashi, T., additional, Umeda, Y., additional, Vinci, T., additional, Yabashi, M., additional, Yabuuchi, T., additional, Fiquet, G., additional, and Ozaki, N., additional
- Published
- 2022
- Full Text
- View/download PDF
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