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403 results on '"Panizo, Carlos"'

1. Polatuzumab vedotin plus rituximab and lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma: a cohort of a multicentre, single-arm, phase 1b/2 study

Author

Abrisqueta, Pau, González-Barca, Eva, Panizo, Carlos, Pérez, José María Arguiñano, Miall, Fiona, Bastos-Oreiro, Mariana, Triguero, Ana, Banerjee, Lalita, McMillan, Andrew, Seymour, Erlene, Hirata, Jamie, de Guzman, Jayson, Sharma, Sunil, Jin, Hyun Yong, Musick, Lisa, and Diefenbach, Catherine

Published
2024
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2. Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma

Author

Larrayoz, Marta, Garcia-Barchino, Maria J., Celay, Jon, Etxebeste, Amaia, Jimenez, Maddalen, Perez, Cristina, Ordoñez, Raquel, Cobaleda, Cesar, Botta, Cirino, Fresquet, Vicente, Roa, Sergio, Goicoechea, Ibai, Maia, Catarina, Lasaga, Miren, Chesi, Marta, Bergsagel, P. Leif, Larrayoz, Maria J., Calasanz, Maria J., Campos-Sanchez, Elena, Martinez-Cano, Jorge, Panizo, Carlos, Rodriguez-Otero, Paula, Vicent, Silvestre, Roncador, Giovanna, Gonzalez, Patricia, Takahashi, Satoru, Katz, Samuel G., Walensky, Loren D., Ruppert, Shannon M., Lasater, Elisabeth A., Amann, Maria, Lozano, Teresa, Llopiz, Diana, Sarobe, Pablo, Lasarte, Juan J., Planell, Nuria, Gomez-Cabrero, David, Kudryashova, Olga, Kurilovich, Anna, Revuelta, Maria V., Cerchietti, Leandro, Agirre, Xabier, San Miguel, Jesus, Paiva, Bruno, Prosper, Felipe, and Martinez-Climent, Jose A.

Published
2023
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3. Mosunetuzumab monotherapy is active and tolerable in patients with relapsed/refractory diffuse large B-cell lymphoma

Author

Bartlett, Nancy L., Assouline, Sarit, Giri, Pratyush, Schuster, Stephen J., Cheah, Chan Y., Matasar, Matthew, Gregory, Gareth P., Yoon, Dok Hyun, Shadman, Mazyar, Fay, Keith, Yoon, Sung-Soo, Panizo, Carlos, Flinn, Ian, Johnston, Anna, Bosch, Francesc, Sehn, Laurie H., Wei, Michael C., Yin, Shen, To, Iris, Li, Chi-Chung, Huang, Huang, Kwan, Antonia, Penuel, Elicia, and Budde, Lihua E.

Published
2023
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4. Final results and overall survival data from a phase II study of acalabrutinib monotherapy in patients with relapsed/refractory mantle cell lymphoma, including those with poor prognostic factors

Author

Le Gouill, Steven, Długosz-Danecka, Monika, Rule, Simon, Zinzani, Pier Luigi, Goy, Andre, Smith, Stephen D., Doorduijn, Jeanette K., Panizo, Carlos, Shah, Bijal D., Davies, Andrew J., Eek, Richard, Jacobsen, Eric, Kater, Arnon P., Robak, Tadeusz, Jain, Preetesh, Calvo, Roser, Tao, Lin, Wang, Michael, Le Gouill, Steven, Długosz-Danecka, Monika, Rule, Simon, Zinzani, Pier Luigi, Goy, Andre, Smith, Stephen D., Doorduijn, Jeanette K., Panizo, Carlos, Shah, Bijal D., Davies, Andrew J., Eek, Richard, Jacobsen, Eric, Kater, Arnon P., Robak, Tadeusz, Jain, Preetesh, Calvo, Roser, Tao, Lin, and Wang, Michael

Published
2024

5. Immune dysfunction prior to and during vaccination in multiple myeloma: a case study based on COVID-19.

Author

Martín-Sánchez, Esperanza, Tamariz-Amador, Luis-Esteban, Guerrero, Camila, Zherniakova, Anastasiia, Zabaleta, Aintzane, Maia, Catarina, Blanco, Laura, Alignani, Diego, Fortuño, Maria-Antonia, Grande, Carlos, Manubens, Andrea, Arguiñano, Jose-Maria, Gomez, Clara, Perez-Persona, Ernesto, Olazabal, Iñigo, Oiartzabal, Itziar, Panizo, Carlos, Prosper, Felipe, San-Miguel, Jesus F., and Rodriguez-Otero, Paula

Subjects
MULTIPLE myeloma, VACCINE immunogenicity, B cells, T cells, HUMORAL immunity, CD38 antigen
Abstract

Infection is the leading cause of death in multiple myeloma (MM). However, the cellular composition associated with immune dysfunction is not defined. We analyzed immune profiles in the peripheral blood of patients with MM (n = 28) and B-cell chronic lymphoproliferative disorders (n = 53) vs. health care practitioners (n = 96), using multidimensional and computational flow cytometry. MM patients displayed altered distribution of most cell types (41/56, 73%), particularly within the B-cell (17/17) and T-cell (20/30) compartments. Using COVID-19 as a case study, we compared the immune response to vaccination based on 64,304 data points generated from the analysis of 1099 longitudinal samples. MM patients showed limited B-cell expansion linked to lower anti-RBD and anti-S antibody titers after the first two doses and booster. The percentages of B cells and CD4+ T cells in the blood, as well as the absolute counts of B cells and dendritic cells, predicted vaccine immunogenicity at different time points. In contrast with the humoral response, the percentage and antigen-dependent differentiation of SARS-CoV-2-specific CD8+ T cells was not altered in MM patients. Taken together, this study defined the cellular composition associated with immune dysfunction in MM and provided biomarkers such as the B-cell percentage and absolute count to individualize vaccination calendars. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Immune biomarkers to predict SARS-CoV-2 vaccine effectiveness in patients with hematological malignancies

Author

Tamariz-Amador, Luis-Esteban, Battaglia, Anna Martina, Maia, Catarina, Zherniakova, Anastasiia, Guerrero, Camila, Zabaleta, Aintzane, Burgos, Leire, Botta, Cirino, Fortuño, Maria-Antonia, Grande, Carlos, Manubens, Andrea, Arguiñano, Jose-Maria, Gomez, Clara, Perez-Persona, Ernesto, Olazabal, Iñigo, Oiartzabal, Itziar, Panizo, Carlos, Prosper, Felipe, San-Miguel, Jesus F., Rodriguez-Otero, Paula, Martín-Sánchez, Esperanza, and Paiva, Bruno

Published
2021
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8. RELINF: prospective epidemiological registry of lymphoid neoplasms in Spain. A project from the GELTAMO group

Author

Bastos-Oreiro, Mariana, Muntañola, Ana, Panizo, Carlos, Gonzalez-Barca, Eva, de Villambrosia, Sonia González, Córdoba, Raúl, López, Jose Luís Bello, González-Sierra, Pedro, Terol, María José, Gutierrez, Antonio, Grande, Carlos, Ramirez, María José, Iserte, Laura, Perez, Elena, Navarro, Belén, Gomez, Pilar, Salar, Antonio, Luzardo, Hugo, López, Andrés, Del Campo, Raquel, García-Belmonte, Daniel, Vida, María Jesús, Infante, María, Queizan-Hernandez, Jose Antonio, Novelli, Silvana, Moreno, Miriam, Penarrubia, Miriam, Gómez, Joaquín, Domingo, Abel, Donato, Eva, Viguria, María Cruz, López, Francisca, Rodriguez, María José, Pardal, Emilia, Noriega, Victor, Andreu, Rafael, Peñalver, Javier, Martín, Alejandro, Caballero, Dolores, and López-Guillermo, Armando

Published
2020
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9. Durable response with single-agent acalabrutinib in patients with relapsed or refractory mantle cell lymphoma

Author

Wang, Michael, Rule, Simon, Zinzani, Pier Luigi, Goy, Andre, Casasnovas, Olivier, Smith, Stephen D., Damaj, Gandhi, Doorduijn, Jeanette K., Lamy, Thierry, Morschhauser, Franck, Panizo, Carlos, Shah, Bijal, Davies, Andrew, Eek, Richard, Dupuis, Jehan, Jacobsen, Eric, Kater, Arnon P., Le Gouill, Steven, Oberic, Lucie, Robak, Tadeusz, Jain, Preetesh, Frigault, Melanie M., Izumi, Raquel, Nguyen, Dorothy, Patel, Priti, Yin, Ming, and Długosz-Danecka, Monika

Published
2019
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10. P1552: AN IMMUNE ATLAS OF THE DYSFUNCTIONAL CELLULAR AND ANTIBODY RESPONSE TO COVID-19 VACCINATION IN HEMATOLOGICAL PATIENTS WITH A MATURE B-CELL NEOPLASM

Author

Martín-Sánchez, Esperanza, primary, Guerrero, Camila, additional, Tamariz-Amador, Luis-Esteban, additional, Zherniakova, Anastasiia, additional, Zabaleta, Aintzane, additional, Maia, Catarina, additional, Blanco, Laura, additional, Fortuño, Maria-Antonia, additional, Grande, Carlos, additional, Manubens, Andrea, additional, Arguiñano, Jose-Maria, additional, Perez, Clara Gomez, additional, Persona, Ernesto Perez, additional, Eizaguirre, Iñigo Olazabal, additional, Oiartzabal, Itziar, additional, Panizo, Carlos, additional, Prosper, Felipe, additional, Miguel, Jesús San, additional, Rodríguez-Otero, Paula, additional, and Paiva, Bruno, additional

Published
2023
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11. Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial

Author

Wang, Michael, Rule, Simon, Zinzani, Pier Luigi, Goy, Andre, Casasnovas, Olivier, Smith, Stephen D, Damaj, Gandhi, Doorduijn, Jeanette, Lamy, Thierry, Morschhauser, Franck, Panizo, Carlos, Shah, Bijal, Davies, Andrew, Eek, Richard, Dupuis, Jehan, Jacobsen, Eric, Kater, Arnon P, Le Gouill, Steven, Oberic, Lucie, Robak, Taduesz, Covey, Todd, Dua, Richa, Hamdy, Ahmed, Huang, Xin, Izumi, Raquel, Patel, Priti, Rothbaum, Wayne, Slatter, J Greg, and Jurczak, Wojciech

Published
2018
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12. Final results and overall survival data from a phase II study of acalabrutinib monotherapy in patients with relapsed/refractory mantle cell lymphoma, including those with poor prognostic factors

Author

Le Gouill, Steven, primary, Długosz-Danecka, Monika, additional, Rule, Simon, additional, Zinzani, Pier Luigi, additional, Goy, Andre, additional, Smith, Stephen D., additional, Doorduijn, Jeanette K., additional, Panizo, Carlos, additional, Shah, Bijal D., additional, Davies, Andrew J., additional, Eek, Richard, additional, Jacobsen, Eric, additional, Kater, Arnon P., additional, Robak, Tadeusz, additional, Jain, Preetesh, additional, Calvo, Roser, additional, Tao, Lin, additional, and Wang, Michael, additional

Published
2023
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13. Supplementary Data from Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death

Author

Fresquet, Vicente, primary, Garcia-Barchino, Maria J., primary, Larrayoz, Marta, primary, Celay, Jon, primary, Vicente, Carmen, primary, Fernandez-Galilea, Marta, primary, Larrayoz, Maria J., primary, Calasanz, Maria J., primary, Panizo, Carlos, primary, Junza, Alexandra, primary, Han, Jiahuai, primary, Prior, Celia, primary, Fortes, Puri, primary, Pio, Ruben, primary, Oyarzabal, Julen, primary, Martinez-Baztan, Alvaro, primary, Paiva, Bruno, primary, Moreno-Aliaga, Maria J., primary, Odero, Maria D., primary, Agirre, Xabier, primary, Yanes, Oscar, primary, Prosper, Felipe, primary, and Martinez-Climent, Jose A., primary

Published
2023
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14. Supplementary Figures S1-S7 from Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death

Author

Fresquet, Vicente, primary, Garcia-Barchino, Maria J., primary, Larrayoz, Marta, primary, Celay, Jon, primary, Vicente, Carmen, primary, Fernandez-Galilea, Marta, primary, Larrayoz, Maria J., primary, Calasanz, Maria J., primary, Panizo, Carlos, primary, Junza, Alexandra, primary, Han, Jiahuai, primary, Prior, Celia, primary, Fortes, Puri, primary, Pio, Ruben, primary, Oyarzabal, Julen, primary, Martinez-Baztan, Alvaro, primary, Paiva, Bruno, primary, Moreno-Aliaga, Maria J., primary, Odero, Maria D., primary, Agirre, Xabier, primary, Yanes, Oscar, primary, Prosper, Felipe, primary, and Martinez-Climent, Jose A., primary

Published
2023
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15. Data from Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death

Author

Fresquet, Vicente, primary, Garcia-Barchino, Maria J., primary, Larrayoz, Marta, primary, Celay, Jon, primary, Vicente, Carmen, primary, Fernandez-Galilea, Marta, primary, Larrayoz, Maria J., primary, Calasanz, Maria J., primary, Panizo, Carlos, primary, Junza, Alexandra, primary, Han, Jiahuai, primary, Prior, Celia, primary, Fortes, Puri, primary, Pio, Ruben, primary, Oyarzabal, Julen, primary, Martinez-Baztan, Alvaro, primary, Paiva, Bruno, primary, Moreno-Aliaga, Maria J., primary, Odero, Maria D., primary, Agirre, Xabier, primary, Yanes, Oscar, primary, Prosper, Felipe, primary, and Martinez-Climent, Jose A., primary

Published
2023
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16. Supplementary Figure 3 from The Mechanism of Action of the Anti-CD38 Monoclonal Antibody Isatuximab in Multiple Myeloma

Author

Moreno, Laura, primary, Perez, Cristina, primary, Zabaleta, Aintzane, primary, Manrique, Irene, primary, Alignani, Diego, primary, Ajona, Daniel, primary, Blanco, Laura, primary, Lasa, Marta, primary, Maiso, Patricia, primary, Rodriguez, Idoia, primary, Garate, Sonia, primary, Jelinek, Tomas, primary, Segura, Victor, primary, Moreno, Cristina, primary, Merino, Juana, primary, Rodriguez-Otero, Paula, primary, Panizo, Carlos, primary, Prosper, Felipe, primary, San-Miguel, Jesus F., primary, and Paiva, Bruno, primary

Published
2023
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17. Supplementary Figure 4 from The Mechanism of Action of the Anti-CD38 Monoclonal Antibody Isatuximab in Multiple Myeloma

Author

Moreno, Laura, primary, Perez, Cristina, primary, Zabaleta, Aintzane, primary, Manrique, Irene, primary, Alignani, Diego, primary, Ajona, Daniel, primary, Blanco, Laura, primary, Lasa, Marta, primary, Maiso, Patricia, primary, Rodriguez, Idoia, primary, Garate, Sonia, primary, Jelinek, Tomas, primary, Segura, Victor, primary, Moreno, Cristina, primary, Merino, Juana, primary, Rodriguez-Otero, Paula, primary, Panizo, Carlos, primary, Prosper, Felipe, primary, San-Miguel, Jesus F., primary, and Paiva, Bruno, primary

Published
2023
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18. Supplementary Figure 5 from The Mechanism of Action of the Anti-CD38 Monoclonal Antibody Isatuximab in Multiple Myeloma

Author

Moreno, Laura, primary, Perez, Cristina, primary, Zabaleta, Aintzane, primary, Manrique, Irene, primary, Alignani, Diego, primary, Ajona, Daniel, primary, Blanco, Laura, primary, Lasa, Marta, primary, Maiso, Patricia, primary, Rodriguez, Idoia, primary, Garate, Sonia, primary, Jelinek, Tomas, primary, Segura, Victor, primary, Moreno, Cristina, primary, Merino, Juana, primary, Rodriguez-Otero, Paula, primary, Panizo, Carlos, primary, Prosper, Felipe, primary, San-Miguel, Jesus F., primary, and Paiva, Bruno, primary

Published
2023
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19. Supplementary Figure 1 from The Mechanism of Action of the Anti-CD38 Monoclonal Antibody Isatuximab in Multiple Myeloma

Author

Moreno, Laura, primary, Perez, Cristina, primary, Zabaleta, Aintzane, primary, Manrique, Irene, primary, Alignani, Diego, primary, Ajona, Daniel, primary, Blanco, Laura, primary, Lasa, Marta, primary, Maiso, Patricia, primary, Rodriguez, Idoia, primary, Garate, Sonia, primary, Jelinek, Tomas, primary, Segura, Victor, primary, Moreno, Cristina, primary, Merino, Juana, primary, Rodriguez-Otero, Paula, primary, Panizo, Carlos, primary, Prosper, Felipe, primary, San-Miguel, Jesus F., primary, and Paiva, Bruno, primary

Published
2023
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20. Supplementary Figure 2 from The Mechanism of Action of the Anti-CD38 Monoclonal Antibody Isatuximab in Multiple Myeloma

Author

Moreno, Laura, primary, Perez, Cristina, primary, Zabaleta, Aintzane, primary, Manrique, Irene, primary, Alignani, Diego, primary, Ajona, Daniel, primary, Blanco, Laura, primary, Lasa, Marta, primary, Maiso, Patricia, primary, Rodriguez, Idoia, primary, Garate, Sonia, primary, Jelinek, Tomas, primary, Segura, Victor, primary, Moreno, Cristina, primary, Merino, Juana, primary, Rodriguez-Otero, Paula, primary, Panizo, Carlos, primary, Prosper, Felipe, primary, San-Miguel, Jesus F., primary, and Paiva, Bruno, primary

Published
2023
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21. Venetoclax improves CD20 immunotherapy in a mouse model of MYC/BCL2 double-expressor diffuse large B-cell lymphoma

Author

Melchor, Javier, primary, Garcia-Lacarte, Marcos, additional, Grijalba, Sara C., additional, Arnaiz-Leché, Adrián, additional, Pascual, Marién, additional, Panizo, Carlos, additional, Blanco, Oscar, additional, Segura, Victor, additional, Novo, Francisco J., additional, Valero, Juan Garcia, additional, Pérez-Galán, Patricia, additional, Martinez-Climent, Jose A., additional, and Roa, Sergio, additional

Published
2023
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22. Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study

Author

García-Sancho, Alejandro Martín, Bellei, Monica, López-Parra, Miriam, Gritti, Giuseppe, Cortés, María, Novelli, Silvana, Panizo, Carlos, Petrucci, Luigi, Gutiérrez, Antonio, Dlouhy, Ivan, Bastos, Mariana, Sancho, Juan M., Ramírez, María J., Moraleda, José M., Carrillo, Estrella, Jiménez-Ubieto, Ana I., Jarque, Isidro, Orsucci, Lorella, García-Torres, Estefanía, Montalbán, Carlos, Dodero, Anna, Arranz, Reyes, De las Heras, Natalia, Pascual, María J., López-Jiménez, Javier, Spina, Michelle, Re, Alessandro, de Villambrosia, Sonia González, Bobillo, Sabela, Federico, Massimo, Caballero, Dolores, Universitat Autònoma de Barcelona, Institut Català de la Salut, [García-Sancho AM, López-Parra M] Department of Hematology, Hospital Universitario de Salamanca, IBSAL, CIBERONC, Salamanca, Spain. [Bellei M] Fondazione Italiana Linfomi (FIL) Onlus, Modena, Italy. [Gritti G] Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy. [Cortés M] Department of Statistics, Hospital Universitario de Salamanca / IBSAL, Salamanca, Spain. [Novelli S] Hematology Department, Hospital de la Santa Creu i Sant Pau, José Carreras Leukemia Research Institute and IIB Sant Pau, Barcelona, Spain. [Bobillo S] Servei d’Hematologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
neoplasias::neoplasias por tipo histológico::linfoma::linfoma no Hodgkin::linfoma de células T::linfoma de células T periféricas [ENFERMEDADES], Cèl·lules mare hematopoètiques - Trasplantació, Hematopoietic Stem Cell Transplantation, Surgical Procedures, Operative::Transplantation::Transplantation, Autologous [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Lymphoma, T-Cell, Peripheral, Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores], Hematology, Other subheadings::Other subheadings::/drug therapy [Other subheadings], Transplantation, Autologous, Disease-Free Survival, Hodgkin, Malaltia de - Tractament, Antineoplastic Combined Chemotherapy Protocols, Humans, Therapeutics::Biological Therapy::Cell- and Tissue-Based Therapy::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Neoplasms::Neoplasms by Histologic Type::Lymphoma::Lymphoma, Non-Hodgkin::Lymphoma, T-Cell::Lymphoma, T-Cell, Peripheral [DISEASES], Prospective Studies, terapéutica::terapia biológica::tratamientos basados en células y tejidos::trasplante de células::trasplante de células madre::trasplante de células madre hematopoyéticas [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], intervenciones quirúrgicas::trasplante::trasplante autólogo [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Retrospective Studies
Abstract

Autologous stem-cell transplantation; Chemotherapy; T-cell lymphoma Trasplante autólogo de células madre; Quimioterapia; Linfoma de células T Trasplantament autòleg de cèl·lules mare; Quimioteràpia; Limfoma de cèl·lules T Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of rare lymphoid malignancies that mostly have poor prognoses with currently available treatments. Upfront consolidation with autologous stem cell transplantation (ASCT) is frequently carried out, but its efficacy has never been investigated in randomized trials. We designed a multicenter, international, retrospective study with the main objective of comparing progression-free survival and overall survival of patients with PTCL who underwent ASCT in complete remission (CR) after first-line chemotherapy with a control group who did not undergo ASCT. From the initial population of 286 registered patients, 174 patients with PTCL other than anaplastic large cell lymphoma, ALK-positive, deemed fit for ASCT at the time of diagnosis, and who were in CR or uncertain CR after induction therapy (CR1) were included in our analysis. one hundred and three patients underwent ASCT, whereas 71 did not, in most cases (n=53) because the physician decided against it. With a median follow-up of 65.5 months, progression-free survival was significantly better in the transplanted patients than in the non-transplanted group: 63% versus 48% at 5 years (P=0.042). Overall survival was significantly longer for ASCT patients in the subgroup with advanced stage at diagnosis (5-year overall survival: 70% vs. 50%, P=0.028). In the multivariate analysis, first-line ASCT was associated with significantly prolonged progression-free survival (HR=0.57, 95% CI: 0.35-0.93) and overall survival (HR=0.57, 95% CI: 0.33-0.99). In conclusion, our study supports the use of ASCT as a consolidation strategy for patients with PTCL in CR1. These results should be confirmed in a prospective randomized study.

Published
2022

23. Low‐risk HPLLs/ABC score patients with splenic marginal zone lymphoma can be safely managed without treatment: Results from a prospective Spanish study.

Author

Muntañola, Ana, Villalobos, María Teresa, González‐Villambrosia, Sonia, Rodríguez‐Salazar, María José, Jiménez‐Ubieto, Ana, Bastidas‐Mora, Gabriela, Córdoba, Raúl, Infante, María, Vidal, María Jesús, Díaz, Francisco Javier, Baile, Mónica, Bastos‐Oreiro, Mariana, Panizo, Carlos, Sancho, Juan Manuel, Navarro, Belén, García, Tomás, Escoda, Lourdes, Abrisqueta, Pau, Terol, María José, and de Campo, Raquel

Subjects
MUCOSA-associated lymphoid tissue lymphoma, LONGITUDINAL method, RITUXIMAB, OVERALL survival, PROGRESSION-free survival, SPLENIC rupture
Abstract

Summary: The aims of our study were to analyse compliance with the 2014 GELTAMO SMZL Guidelines, in patients with splenic marginal zone lymphoma (SMZL), and to evaluate the outcome according to the HPLLs/ABC‐adapted therapeutic strategy. Observational prospective multicenter study of 181 SMZL patients diagnosed between 2014 and 2020. Lymphoma‐specific survival (LSS), composite event‐free survival (CEFS) and response rates were assessed. 57% of the 168 patients included in the analysis followed the Guidelines. The overall response rate was higher in the rituximab chemotherapy and in the rituximab arms compared with the splenectomy arm (p < 0.001). The 5‐year overall survival was 77% and the 5‐year LSS of 93%. There were no differences in the 5‐year LSS according to the treatment received (p = 0.68). The 5‐year CEFS in the overall series was 45%, and there were significant differences between scores A and B (p = 0.036). There were no significant differences when comparing LSS and progression‐free survival in patients treated with rituximab or rituximab chemotherapy at diagnosis or after observation. Our data support HPLLs/ABC score as a practical tool for the management of SMZL, observation as the best approach for patients in group A and rituximab as the best treatment for group B. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Evaluation of Clinical and Biological Prognostic Factors in Relapsed or Refractory Diffuse Large B-Cell Lymphoma Patients After Previous Treatment With Rituximab and Chemotherapy: Results of the PRO-R-IPI Study

Author

Panizo, Carlos, Rodríguez, Anny Jaramillo, Gutiérrez, Gonzalo, Díaz, Francisco Javier, González-Barca, Eva, de Oña, Raquel, Grande, Carlos, Sancho, Juan Manuel, García-Álvarez, María Flor, Sánchez-González, Blanca, Peñalver, Francisco Javier, Cannata, Jimena, Espeso, Manuel, Requena, María José, Gardella, Santiago, Durán, Soledad, González, Ana Pilar, Alfonso, Ana, and Caballero, María Dolores

Published
2015
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26. Clinical Characterization, Prognosis and Therapeutic Management of 181 Patients with Splenic Marginal Zone Lymphoma (SMZL): Real World Experience of the Geltamo Group

Author

Villalobos, Teresa, primary, Muntañola Prat, Ana, additional, González de Villambrosia, Sonia, additional, Rodriguez-Salazar, Maria J., additional, Jiminez Ubieto, Ana Isabel, additional, Bastidas-Mora, Gabriela, additional, Cordoba, Raul, additional, Infante, Maria Stefania, additional, Vidal, Maria Jesus, additional, Diaz-Galvez, Francisco Javier, additional, Baile, Monica, additional, Bastos-Oreiro, Mariana, additional, Panizo, Carlos, additional, Sancho, Juan-Manuel, additional, Navarro Matilla, Belen, additional, García, Tomas, additional, Escoda, Lourdes, additional, Abrisqueta, Pau, additional, Terol, María José, additional, Del Campo, Raquel, additional, López-Guillermo, Armando, additional, Salar, Antonio, additional, and Montalban, Carlos, additional

Published
2022
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27. First-line response-adapted treatment with the combination of bendamustine and rituximab in patients with mucosa-associated lymphoid tissue lymphoma (MALT2008-01): a multicentre, single-arm, phase 2 trial

Author

Salar, Antonio, Domingo-Domenech, Eva, Panizo, Carlos, Nicolás, Concepción, Bargay, Joan, Muntañola, Ana, Canales, Miguel, Bello, José Luis, Sancho, Juan Manuel, Tomás, José Francisco, Rodríguez, María José, Peñalver, Francisco Javier, Grande, Carlos, Sánchez-Blanco, José Javier, Palomera, Luis, Arranz, Reyes, Conde, Eulogio, García, Mar, García, Juan Fernando, Caballero, Dolores, and Montalbán, Carlos

Published
2014
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30. Clinical experience of bendamustine treatment for non-Hodgkin lymphoma and chronic lymphocytic leukemia in Spain

Author

Sanchez-Gonzalez, Blanca, Peñalver, F. Javier, Medina, Angeles, Guillén, Helga, Calleja, Marta, Gironella, Mercedes, Arranz, Reyes, Sebastian, Elena, de Oña, Raquel, Cánovas, Araceli, de la Fuente, Ignacio, Grande, Carlos, Sancho, Juan Manuel, Perez, Ricardo, Domingo, Eva, Lopez-Lorenzo, José Luis, Prieto, Elena, Panizo, Carlos, Gorosquieta, Ana, Perez, Inmaculada, Cervera, Jose Manuel, Marin, Miguel, Mencha, Carmen, Ramila, Elena, and Salar, Antonio

Published
2012
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33. Preneoplastic somatic mutations including MYD88L²⁶⁵P in lymphoplasmacytic lymphoma

Author

Rodriguez, Sara, Celay, Jon, Goicoechea, Ibai, Jimenez, Cristina, Botta, Cirino, Garcia-Barchino, Maria-José, Garces, Juan-Jose, Larrayoz, Marta, Santos, Susana, Alignani, Diego, Vilas-Zornoza, Amaia, Perez, Cristina, Garate, Sonia, Sarvide, Sarai, Lopez, Aitziber, Reinhardt, Christian, Carrasco, Yolanda R., Sanchez-Garcia, Isidro, Larrayoz, Maria-Jose, Calasanz, Maria-Jose, Panizo, Carlos, Prosper, Felipe, Lamo-Espinosa, Jose-Maria, Motta, Marina, Tucci, Alessandra, Sacco, Antonio, Gentile, Massimo, Duarte, Sara, Vitoria, Helena, Geraldes, Catarina, Paiva, Artur, Puig, Noemi, Garcia-Sanz, Ramon, Roccaro, Aldo M., Fuerte, Gema, San Miguel, Jesus F., Martinez-Climent, Jose-Angel, and Paiva, Bruno

Subjects
hemic and lymphatic diseases, Medizin
Abstract

Normal cell counterparts of solid and myeloid tumors accumulate mutations years before disease onset; whether this occurs in B lymphocytes before lymphoma remains uncertain. We sequenced multiple stages of the B lineage in elderly individuals and patients with lymphoplasmacytic lymphoma, a singular disease for studying lymphomagenesis because of the high prevalence of mutated MYD88. We observed similar accumulation of random mutations in B lineages from both cohorts and unexpectedly found MYD88L²⁶⁵P in normal precursor and mature B lymphocytes from patients with lymphoma. We uncovered genetic and transcriptional pathways driving malignant transformation and leveraged these to model lymphoplasmacytic lymphoma in mice, based on mutated MYD88 in B cell precursors and BCL2 overexpression. Thus, MYD88L²⁶⁵P is a preneoplastic event, which challenges the current understanding of lymphomagenesis and may have implications for early detection of B cell lymphomas. CA extern

Published
2022

34. A randomized phase II study comparing consolidation with a single dose of Y-90 ibritumomab tiuxetan vs. maintenance with rituximab for two years in patients with newly diagnosed follicular lymphoma responding to R-CHOP. Long-term follow-up results

Author

Lopez-Guillermo, Armando, Canales, Miguel Angel, Dlouhy, Ivan, Mercadal, Santiago, Briones, Javier, Martin Garcia-Sancho, Alejandro, Sancho, Juan Manuel, Maria Moraleda, Jose, Terol, Maria Jose, Salar, Antonio, Palomera, Luis, Gardella, Santiago, Jarque, Isidro, Ferrer, Secundino, Bargay, Joan, Lopez, Andres, Panizo, Carlos, Muntañola, Anna, Montalban, Carlos, Conde, Eulogio, Hernandez, Miguel T., Soler, Alfons, Garcia Marco, Jose A., Deben, Guillermo, Marin, Julian, and Tomas, Jose Francisco

Subjects
90Y ibritumomab tiuxetan, 90Y ibritumomab tiuxetan, Follicular lymphoma, maintenance, Follicular lymphoma, maintenance
Abstract

This is a randomized phase-2 trial aimed to compare consolidation vs. maintenance in untreated patients with follicular lymphoma (FL) responding to induction. 146 patients were enrolled from 25 Spanish institutions (ZAR2007; ClinicalTrials.gov #NCT00662948). Patients in PR or CR/CR[u] after R-CHOP were randomized 1:1 to Y-90-ibritumomab-tiuxetan 0.4 mCi/kg (arm A) vs. rituximab 375 mg/m(2) every 8 weeks for 2 years (arm B). After a median follow-up of 10.55 years, 53 patients eventually progressed with a 10-year PFS of 50% vs. 56% for patients in arm A and B, respectively (HR = 1.42; p > 0.1). No significant differences were seen in OS (10-year OS 78% vs. 84.5%; HR = 1.39, p > .1). Patients receiving Y-90-ibritumomab-tiuxetan showed higher incidence of second neoplasms than those in arm B (10-year cumulative incidence 18.5 vs. 2%, respectively; p = .038). In conclusion, in FL patients responding to R-CHOP, no significant differences were found between consolidation and maintenance, although with higher late toxicity for consolidation.

Published
2022

35. Cardiac Damage Biomarkers and Heart Rate Variability Following a 118-Km Mountain Race: Relationship with Performance and Recovery

Author

Ignacio Martínez-Navarro, Juan M. Sánchez-Gómez, Eladio J. Collado-Boira, Barbara Hernando, Nayara Panizo, Carlos Hernando

Subjects
lcsh:Sports, recovery, lcsh:GV557-1198.995, ultratrail, cardiac damage, lcsh:Sports medicine, heart rate complexity, lcsh:RC1200-1245, Heart rate variability, performance
Abstract

This study aimed to assess the release of cardiac damage biomarkers jointly with cardiac autonomic modulation after a mountain ultramarathon. Such knowledge and the possible relationship of these markers with race time is of primary interest to establish possible recommendations upon athletes’ recovery and return to training following these competitions. Forty six athletes enrolled in the Penyagolosa Trails CSP115 race (118 km and a total positive elevation of 5439 m) took part in the study. N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitive cardiac troponin T (hs-TNT) concentrations as well as linear and nonlinear heart rate variability (HRV) were evaluated before and after the race. NT-proBNP and hs-TNT significantly increased post-race; fifty percent of the finishers surpassed the Upper Reference Limit (URL) for hs-TNT while 87% exceeded the URL for NT-proBNP. Overall and vagally-mediated HRV were diminished and cardiac autonomic modulation became less complex and more predictable following the race. More pronounced vagal modulation decreases were associated with higher levels of postexertional NT-proBNP. Moreover, rise in hs-TNT and NT-proBNP was greater among faster runners, while pre-race overall and vagally-mediated HRV were correlated with finishing time. Participation in a 118-km ultratrail induces an acute release of cardiac damage biomarkers and a large alteration of cardiac autonomic modulation. Furthermore, faster runners were those who exhibited a greater rise in those cardiac damage biomarkers. In light of these findings, an appropriate recovery period after ultraendurance races appears prudent and particularly important among better performing athletes. At the same time, HRV analysis is shown as a promising tool to assess athletes’ readiness to perform at their maximum level in an ultraendurance race.

Published
2019

36. Preneoplastic somatic mutations including MYD88 L265P in lymphoplasmacytic lymphoma

Author

Rodriguez, Sara, primary, Celay, Jon, additional, Goicoechea, Ibai, additional, Jimenez, Cristina, additional, Botta, Cirino, additional, Garcia-Barchino, Maria-José, additional, Garces, Juan-Jose, additional, Larrayoz, Marta, additional, Santos, Susana, additional, Alignani, Diego, additional, Vilas-Zornoza, Amaia, additional, Perez, Cristina, additional, Garate, Sonia, additional, Sarvide, Sarai, additional, Lopez, Aitziber, additional, Reinhardt, Hans-Christian, additional, Carrasco, Yolanda R., additional, Sanchez-Garcia, Isidro, additional, Larrayoz, Maria-Jose, additional, Calasanz, Maria-Jose, additional, Panizo, Carlos, additional, Prosper, Felipe, additional, Lamo-Espinosa, Jose-Maria, additional, Motta, Marina, additional, Tucci, Alessandra, additional, Sacco, Antonio, additional, Gentile, Massimo, additional, Duarte, Sara, additional, Vitoria, Helena, additional, Geraldes, Catarina, additional, Paiva, Artur, additional, Puig, Noemi, additional, Garcia-Sanz, Ramon, additional, Roccaro, Aldo M., additional, Fuerte, Gema, additional, San Miguel, Jesus F., additional, Martinez-Climent, Jose-Angel, additional, and Paiva, Bruno, additional

Published
2022
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37. Phase 1/2 study of intratumoral G100 (TLR4 agonist) with or without pembrolizumab in follicular lymphoma

Author

Halwani, Ahmad S., primary, Panizo, Carlos, additional, Isufi, Iris, additional, Herrera, Alex F., additional, Okada, Craig Y., additional, Cull, Elizabeth H., additional, Kis, Bela, additional, Chaves, Jorge M., additional, Bartlett, Nancy L., additional, Ai, Weiyun, additional, de la Cruz-Merino, Luis, additional, Bryan, Locke J., additional, Houot, Roch, additional, Linton, Kim, additional, Briones, Javier, additional, Chau, Ian, additional, von Keudell, Gottfried R., additional, Lu, Hailing, additional, Yakovich, Adam, additional, Chen, Michael, additional, Meulen JH, ter, additional, Yurasov, Sergey, additional, Hsu, Frank J., additional, and Flowers, Christopher R., additional

Published
2021
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39. Optimization of a Universal Allogeneic CAR-T Cells Combining CRISPR and Transposon-Based Technologies for Treatment of Acute Myeloid Leukemia

Author

Ceballos Bolaños, Candela, Calviño, Cristina, Pierola, Ana Alfonso, Jauregui, Patricia, Calleja-Cervantes, Maria Erendira, San-Martin, Patxi, Rodríguez Márquez, Paula, Martin Mallo, Ángel, Iglesias, Elena, Abizanda, Gloria, Rodríguez Diaz, Saray, Martínez Turrillas, Rebeca, Illarramendi Esteban, Jorge, Redondo, Ana Margarita, Viguria-Alegría, MC, Panizo, Carlos, Rifon, Jose J., Villar, Sara, Lasarte, Juan J, Inogés, Susana, López-Díaz De Cerio, Ascensión, Hernaez, Mikel, Prosper, Felipe, and Rodriguez-Madoz, Juan Roberto

Published
2023
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40. Bispecific T-Cell Engagers for B-Cell NON-Hodgkin Lymphoma Patients before Allogeneic Stem Cell Transplantation. a Study on Behalf Od Geth-TC

Author

Peña, Marta, Mariotti, Jacopo, Bramanti, Stefania, Fabbri, Nicole, Serna, Angel, Serroukh, Yasmina, van der Poel, Marjolein, Hsu, Ya-Ting, Jimenez Ubieto, Ana, Rius-Sansalvador, Blanca, Kwon, Mi, Panizo, Carlos, Sanchez Pina, Jose Maria, Solano, Carlos, Lopez Corral, Lucia, Saldaña, Raquel, Albo Lopez, Carmen, Sanchez Salinas, Andres, Perez-Simon, Jose A., Sanz, Jaime, Valcarcel Ferreiras, David, Rovira, Montserrat, Bento De Miguel, Leyre, Mussetti, Alberto, and Sureda Balari, Anna Maria

Published
2023
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41. Deep Characterization of Immune Dysfunction in Patients with Multiple Myeloma (MM) and Identification of Cellular Biomarkers for Tailored Vaccination Strategies

Author

Martín-Sánchez, Esperanza, Guerrero, Camila, Tamariz-Amador, Luis-Esteban, Zherniakova, Anastasiia, Zabaleta, Aintzane, Maia, Catarina, Blanco, Laura, Fortuño, Maria-Antonia, Grande, Carlos, Manubens, Andrea, Arguiñano, Jose Maria, Gomez, Clara, Perez-Persona, Ernesto, Olazabal, Iñigo, Oiartzabal, Itziar, Panizo, Carlos, Prosper, Felipe, San Miguel, Jesús, Rodriguez Otero, Paula, Paiva, Bruno, and Asovasna, Basque-Navarre Association of Hematology and Hemotherapy

Published
2023
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43. Polatuzumab vedotin (Pola) + rituximab (R) + lenalidomide (Len) in patients (pts) with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL): Primary analysis of a phase 1b/2 trial.

Author

Magid Diefenbach, Catherine S., primary, Abrisqueta, Pau, additional, Gonzalez-Barca, Eva, additional, Panizo, Carlos, additional, Arguinano Perez, Jose Maria, additional, Miall, Fiona, additional, Bastos-Oreiro, Mariana, additional, Lopez-Guillermo, Armando, additional, Banerjee, Lalita, additional, McMillan, Andrew, additional, Hirata, Jamie, additional, Musick, Lisa, additional, Saha, Sourish, additional, Croft, Brandon, additional, and Seymour, Erlene Kuizon, additional

Published
2021
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44. Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death

Author

Universitat Rovira i Virgili, Fresquet, Vicente; Garcia-Barchino, Maria J.; Larrayoz, Marta; Celay, Jon; Vicente, Carmen; Fernandez-Galilea, Marta; Larrayoz, Maria J.; Calasanz, Maria J.; Panizo, Carlos; Junza, Alexandra; Han, Jiahuai; Prior, Celia; Fortes, Puri; Pio, Ruben; Oyarzabal, Julen; Martinez-Baztan, Alvaro; Paiva, Bruno; Moreno-Aliaga, Maria J.; Odero, Maria D.; Agirre, Xabier; Yanes, Oscar; Prosper, Felipe; Martinez-Climent, Jose A., Universitat Rovira i Virgili, and Fresquet, Vicente; Garcia-Barchino, Maria J.; Larrayoz, Marta; Celay, Jon; Vicente, Carmen; Fernandez-Galilea, Marta; Larrayoz, Maria J.; Calasanz, Maria J.; Panizo, Carlos; Junza, Alexandra; Han, Jiahuai; Prior, Celia; Fortes, Puri; Pio, Ruben; Oyarzabal, Julen; Martinez-Baztan, Alvaro; Paiva, Bruno; Moreno-Aliaga, Maria J.; Odero, Maria D.; Agirre, Xabier; Yanes, Oscar; Prosper, Felipe; Martinez-Climent, Jose A.

Abstract

For millions of years, endogenous retroelements have remained transcriptionally silent within mammalian genomes by epigenetic mechanisms. Modern anticancer therapies targeting the epigenetic machinery awaken retroelement expression, inducing antiviral responses that eliminate tumors through mechanisms not completely understood. Here, we find that massive binding of epigenetically activated retroelements by RIG-I and MDA5 viral sensors promotes ATP hydrolysis and depletes intracellular energy, driving tumor killing independently of immune signaling. Energy depletion boosts compensatory ATP production by switching glycolysis to mitochondrial oxidative phosphorylation, thereby reversing the Warburg effect. However, hyperfunctional succinate dehydrogenase in mitochondrial electron transport chain generates excessive oxidative stress that unleashes RIP1-mediated necroptosis. To maintain ATP generation, hyperactive mitochondrial membrane blocks intrinsic apoptosis by increasing BCL2 dependency. Accordingly, drugs targeting BCL2 family proteins and epigenetic inhibitors yield synergistic responses in multiple cancer types. Thus, epigenetic therapy kills cancer cells by rewiring mitochondrial metabolism upon retroelement activation, which primes mitochondria to apoptosis by BH3-mimetics. SIGNIFICANCE: The state of viral mimicry induced by epigenetic therapies in cancer cells remodels mitochondrial metabolism and drives caspase-independent tumor cell death, which sensitizes to BCL2 inhibitor drugs. This novel mechanism underlies clinical efficacy of hypomethylating agents and venetoclax in acute myeloid leukemia, suggesting similar combination therapies for other incurable cancers.

Published
2021

45. P-400 An immune atlas of the dysfunctional cellular and antibody response to COVID-19 vaccination in patients with multiple myeloma

Author

Martin-Sanchez, Esperanza, Guerrero, Camila, Tamariz-Amador, Luis-Esteban, Zherniakova, Anastasiia, Zabaleta, Aintzane, Maia, Catarina, Blanco, Laura, Fortuño, Maria-Antonia, Grande, Carlos, Manubens, Andrea, Arguiñano, Jose-Maria, Gomez, Clara, Perez-Persona, Ernesto, Olazabal, Iñigo, Oiartzabal, Itziar, Panizo, Carlos, Prosper, Felipe, San-Miguel, Jesús, Rodriguez-Otero, Paula, Paiva, Bruno, and (ASOVASNA), Asociación Vasco-Navarra de Hematología y Hemoterapia

Published
2023
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47. Avadomide monotherapy in relapsed/refractory DLBCL: safety, efficacy, and a predictive gene classifier.

Author

UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/BCHM - Biochimie-Recherche métabolique, UCL - (SLuc) Service d'hématologie, Carpio, Cecilia, Bouabdallah, Reda, Ysebaert, Loïc, Sancho, Juan-Manuel, Salles, Gilles, Cordoba, Raul, Pinto, Antonio, Gharibo, Mecide, Rasco, Drew, Panizo, Carlos, Lopez-Martin, Jose A, Santoro, Armando, Salar, Antonio, Damian, Silvia, Martin, Alejandro, Verhoef, Gregor, Van Den Neste, Eric, Wang, Maria, Couto, Suzana, Carrancio, Soraya, Weng, Andrew, Wang, Xuehai, Schmitz, Frank, Wei, Xin, Hege, Kristen, Trotter, Matthew W B, Risueño, Alberto, Buchholz, Tonia J, Hagner, Patrick R, Gandhi, Anita K, Pourdehnad, Michael, Ribrag, Vincent, UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/BCHM - Biochimie-Recherche métabolique, UCL - (SLuc) Service d'hématologie, Carpio, Cecilia, Bouabdallah, Reda, Ysebaert, Loïc, Sancho, Juan-Manuel, Salles, Gilles, Cordoba, Raul, Pinto, Antonio, Gharibo, Mecide, Rasco, Drew, Panizo, Carlos, Lopez-Martin, Jose A, Santoro, Armando, Salar, Antonio, Damian, Silvia, Martin, Alejandro, Verhoef, Gregor, Van Den Neste, Eric, Wang, Maria, Couto, Suzana, Carrancio, Soraya, Weng, Andrew, Wang, Xuehai, Schmitz, Frank, Wei, Xin, Hege, Kristen, Trotter, Matthew W B, Risueño, Alberto, Buchholz, Tonia J, Hagner, Patrick R, Gandhi, Anita K, Pourdehnad, Michael, and Ribrag, Vincent

Abstract

Treatment options for relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) are limited, with no standard of care; prognosis is poor, with 4- to 6-month median survival. Avadomide (CC-122) is a cereblon-modulating agent with immunomodulatory and direct antitumor activities. This phase 1 dose-expansion study assessed safety and clinical activity of avadomide monotherapy in patients with de novo R/R DLBCL and transformed lymphoma. Additionally, a novel gene expression classifier, which identifies tumors with a high immune cell infiltration, was shown to enrich for response to avadomide in R/R DLBCL. Ninety-seven patients with R/R DLBCL, including 12 patients with transformed lymphoma, received 3 to 5 mg avadomide administered on continuous or intermittent schedules until unacceptable toxicity, disease progression, or withdrawal. Eighty-two patients (85%) experienced ≥1 grade 3/4 treatment-emergent adverse events (AEs), most commonly neutropenia (51%), infections (24%), anemia (12%), and febrile neutropenia (10%). Discontinuations because of AEs occurred in 10% of patients. Introduction of an intermittent 5/7-day schedule improved tolerability and reduced frequency and severity of neutropenia, febrile neutropenia, and infections. Among 84 patients with de novo R/R DLBCL, overall response rate (ORR) was 29%, including 11% complete response (CR). Responses were cell-of-origin independent. Classifier-positive DLBCL patients (de novo) had an ORR of 44%, median progression-free survival (mPFS) of 6 months, and 16% CR vs an ORR of 19%, mPFS of 1.5 months, and 5% CR in classifier-negative patients (P = .0096). Avadomide is being evaluated in combination with other antilymphoma agents. This trial was registered at www.clinicaltrials.gov as #NCT01421524.

Published
2020

48. Spanish Lymphoma Group (GELTAMO) guidelines for the diagnosis, staging, treatment, and follow-up of diffuse large B-cell lymphoma

Author

González Barca, Eva, Coronado, Mónica, Martin, Alejandro, Montalbán, Carlos, Montes Moreno, Santiago, Panizo, Carlos Manuel, Rodríguez, Guillermo, Sancho, Juan Manuel, López-Hernández, Andrés, and Spanish Lymphoma Group (GELTAMO)

Subjects
Limfomes, Pediatrics, medicine.medical_specialty, MEDLINE, Review, 03 medical and health sciences, 0302 clinical medicine, Diagnòstic, immune system diseases, hemic and lymphatic diseases, Diagnosis, medicine, guidelines, Grading (tumors), Risk assessment, treatment, business.industry, risk assessment, medicine.disease, Lymphoma, Oncology, DLBCL, 030220 oncology & carcinogenesis, Avaluació del risc, Lymphomas, business, Diffuse large B-cell lymphoma, DLBCL entities, 030215 immunology
Abstract

Diffuse large B-cell lymphoma (DLBCL) accounts for approximately 30% of non-Hodgkin lymphoma (NHL) cases in adult series. DLBCL is characterized by marked clinical and biological heterogeneity, encompassing up to 16 distinct clinicopathological entities. While current treatments are effective in 60% to 70% of patients, those who are resistant to treatment continue to die from this disease. An expert panel performed a systematic review of all data on the diagnosis, prognosis, and treatment of DLBCL published in PubMed, EMBASE and MEDLINE up to December 2017. Recommendations were classified in accordance with the Grading of Recommendations Assessment Development and Evaluation (GRADE) framework, and the proposed recommendations incorporated into practical algorithms. Initial discussions between experts began in March 2016, and a final consensus was reached in November 2017. The final document was reviewed by all authors in February 2018 and by the Scientific Committee of the Spanish Lymphoma Group GELTAMO.

Published
2018

49. Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death

Author

Fresquet, Vicente, primary, Garcia-Barchino, Maria J., additional, Larrayoz, Marta, additional, Celay, Jon, additional, Vicente, Carmen, additional, Fernandez-Galilea, Marta, additional, Larrayoz, Maria J., additional, Calasanz, Maria J., additional, Panizo, Carlos, additional, Junza, Alexandra, additional, Han, Jiahuai, additional, Prior, Celia, additional, Fortes, Puri, additional, Pio, Ruben, additional, Oyarzabal, Julen, additional, Martinez-Baztan, Alvaro, additional, Paiva, Bruno, additional, Moreno-Aliaga, Maria J., additional, Odero, Maria D., additional, Agirre, Xabier, additional, Yanes, Oscar, additional, Prosper, Felipe, additional, and Martinez-Climent, Jose A., additional

Published
2020
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50. Acalabrutinib Monotherapy in Patients with Relapsed/Refractory Mantle Cell Lymphoma: Long-Term Efficacy and Safety Results from a Phase 2 Study

Author

Wang, Michael, primary, Rule, Simon, additional, Zinzani, Pier Luigi, additional, Goy, Andre H., additional, Casasnovas, Rene-Olivier, additional, Smith, Stephen D., additional, Damaj, Gandhi Laurent, additional, Doorduijn, Jeanette K., additional, Lamy, Thierry, additional, Morschhauser, Franck, additional, Panizo, Carlos, additional, Shah, Bijal, additional, Davies, Andrew, additional, Eek, Richard, additional, Dupuis, Jehan, additional, Jacobsen, Eric, additional, Kater, Arnon P., additional, Le Gouill, Steven, additional, Oberic, Lucie, additional, Robak, Tadeusz, additional, Jain, Preetesh, additional, Brock, Graham, additional, Patel, Priti, additional, Tao, Lin, additional, and Dlugosz-Danecka, Monika, additional

Published
2020
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