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Clinical metrics of baseline health in sentinel seabird species can offer insight into marine ecosystem dynamics, individual and population health, and assist in wildlife rehabilitation and conservation efforts. Protein electrophoresis is useful for detecting changes in acute phase proteins and immunoglobulin levels that may indicate subtle inflammatory responses and/or infectious disease. Serum biochemistry can highlight nutritional status, metabolic derangements, and organ injury and function. However, baseline values for such health parameters are largely unknown for many seabird species. Therefore, the objective of this study is to establish baseline clinical health reference intervals for serum protein electrophoresis, acute phase proteins including serum amyloid A and haptoglobin, and biochemistry parameters in the rhinoceros auklet (Cerorhinca monocerata), a key sentinel species in the North Pacific. From 2013 to 2019, 178 wild, apparently healthy breeding adult rhinoceros auklets were captured across four breeding colonies in British Columbia, Canada (Lucy Island, Pine Island, Triangle Islands, and SGang Gwaay) and from one colony in Washington, United States (Protection Island). Reference intervals were calculated for protein electrophoresis fractions and acute phase proteins (n = 163), and serum biochemistry (n = 35) following established guidelines by the American Society of Veterinary Clinical Pathology. Animals were also assessed for the presence of antibodies to the influenza A virus. Approximately 48% (70/147) of sampled birds were seropositive for influenza A virus, with a prevalence of 50% (6/12) in 2013, 75% (47/63) in 2014, and 24% (17/72) in 2019. This work provides clinical baseline health metrics of a key North Pacific sentinel species to help inform marine ecosystem monitoring, recovery, and rehabilitation efforts in the Pacific Northwest. [ABSTRACT FROM AUTHOR]

Error is a neglected epistemological category in the history of science. This neglect has been driven by the commonsense idea that its elimination is a general good, which often renders it invisible or at least not worth noticing. At the end of the sixteenth century across Europe, medicine increasingly focused on "popular errors," a genre where learned doctors addressed potential patients to disperse false belief about treatments. By the mid-seventeenth century, investigations into popular error informed the working methodology of natural philosophers, rather than just physicians. In 1646, Thomas Browne published Pseudodoxia Epidemica, a large volume on popular error. Despite Browne's formal training as a physician, this work examined only a few medical errors and instead aspired to be an encyclopedia of error. Pseudodoxia Epidemica was highly popular, running to six editions, and was known by the Fellows of the Royal Society. Influenced by Browne, alongside Bacon's theory of the idols, natural philosophic practice in the late sixteenth and seventeenth century developed a focus on error that revised traditional attention to the discovery of knowledge. Fellows such as Robert Boyle and Robert Hooke proposed new ways to secure truth under the far-reaching influence of Bacon's refutations of "natural human reason" distorted by false idols, of syllogistic logic, and of "theories," his label for traditional philosophical systems that bias thought toward falsity. In three parts, this article traces the progression in early modern scientific approaches to handling error, and especially medical error – from physicians' efforts to identify and eradicate it through collaborative effort, to the striking tension in Browne's work between seeking to eliminate error while also showing a marked tolerance for it, to the Royal Society's Baconian objective of instrumentalizing error to find truth. Error emerges as its own epistemic category that serves as a driving force toward knowledge production. [ABSTRACT FROM AUTHOR]

Background: Equine recurrent uveitis (ERU) is the leading cause of blindness for horses; previous research implicated the leopard complex spotting allele (LP) as a genetic risk factor for insidious uveitis in the Appaloosa. There is limited information about risk in the Knabstrupper. Objective: To evaluate clinical manifestations, disease frequency and potential risk factors for ERU in Knabstrupper horses. Study design: Cross‐sectional study. Methods: Ocular examinations were performed on 116 horses, and based on identified anomalies, horses were classified as suspect, ERU‐affected or having no clinical signs. Microagglutination testing (MAT) of serum assessed exposure to Leptospira spp. Clinical signs, age, sex, base colour, coat pattern, LP and PATN1 genotypes, percent white at birth, progressive roaning and Leptospira were assessed as risk factors using multivariable exact logistic regression, accounting for clustering at the barn level. Additionally, a pedigree analysis was performed (n = 20 cases and 21 controls), and coefficients of coancestry (CC) and inbreeding were calculated. Results: Prevalence of insidious uveitis in this sample of Knabstruppers was 20.7%. Similar to findings for Appaloosas, LP homozygotes had higher odds of uveitis compared with true solid (N/N) horses (LP/LP OR = 7.64, 95% CI [0.8 to +INF], p = 0.04) and age was also identified as a risk factor. After accounting for LP, the 16–20 age group had higher odds compared with the youngest group (OR = 13.36, 95% CI [1.4–213.4], p = 0.009). The distributions of average CC were significantly different between cases and controls (p = 0.01). Main limitations: A relatively small sample size decreased the power for detecting additional associations. The progressive nature of insidious uveitis may have prevented identification of younger affected horses. Conclusions: Our data support genotyping for LP to assess risk of ERU in Knabstruppers. Additional studies are necessary to develop more robust risk models across LP breeds for earlier detection and improved clinical management. [ABSTRACT FROM AUTHOR]

Purpose: To describe the complications of conjunctival graft surgery occurring in cases at a referral ophthalmic service and evaluate factors that lead to occurrence of complications in canine cases. Methods: A retrospective case–control study was completed using data from the Veterinary Medical Center at the Western College of Veterinary Medicine, Saskatoon, Canada, between May 2015 and March 2020. Case records from dogs that underwent conjunctival pedicle graft surgery and subsequently either did or did not develop a conjunctival graft complication were reviewed. Results: One hundred and six dogs undergoing conjunctival graft surgeries were identified. Sixteen conjunctival graft complications occurred, of which, eight led to negative outcomes. Univariable analysis comparing canine eyes that developed complications to control eyes revealed potential (p ≤.05) differences between the groups in post‐operative fluoroquinolone use, Streptococcus canis isolation, intraoperative intravenous cefazolin use, corneal stromal white cell infiltrate, and mean ulcer diameter. The use of intraoperative cefazolin could not be effectively evaluated with available data; however, no dogs (n = 22) receiving intraoperative cefazolin developed complications. Multivariable analysis revealed that dogs that were treated with a second‐generation fluoroquinolone and that had S. canis isolated had higher odds of experiencing complications than dogs that were not treated with a second‐generation fluoroquinolone and that were S. canis negative (Odds ratio = 64.7 [95% CI 6.3–669], p <.0001). Conclusions: Streptococcus species played a role in conjunctival graft complications in our study. Empiric selection of second‐generation fluoroquinolone monotherapy may need reconsideration given the frequent isolation of Streptococcus spp. from canine ulcers. The use of intraoperative cefazolin may be associated with a lower complication rate. [ABSTRACT FROM AUTHOR]

Reconstruction of past changes in monsoon climate from speleothem oxygen isotope (δ[sup 18]O) records is complex because δ[sup 18]O signals can be influenced by multiple factors including changes in precipitation, precipitation recycling over land, temperature at the moisture source and changes in the moisture source region and transport pathway. Here, we analyse > 150 speleothem records from version 2 of the Speleothem Isotopes Synthesis and Analysis (SISAL) database to produce composite regional trends in δ[sup 18]O in monsoon regions; compositing minimises the influence of site-specific karst and cave processes that can influence individual site records. We compare speleothem δ[sup 18]O observations with isotope-enabled climate model simulations to investigate the specific climatic factors causing these regional trends. We focus on differences in δ[sup 18]O signals between interglacial (mid-Holocene and Last Interglacial) and glacial (Last Glacial Maximum) states, and on δ[sup 18]O evolution through the Holocene. Differences in speleothem δ[sup 18]O between the mid-Holocene and Last Interglacial in the East Asian and Indian monsoons are small, despite the larger summer insolation values during the Last Interglacial. Last Glacial Maximum δ[sup 18]O values are significantly less negative than interglacial values. Comparison with simulated glacial-interglacial δ[sup 18]O shows that changes are principally driven by global shifts in temperature and regional precipitation. Holocene speleothem δ[sup 18]O records show distinct and coherent regional trends. Trends are similar to summer insolation in India, China and southwestern South America, but different in the Indonesian-Australian region. Redundancy analysis shows that 37 % of Holocene variability can be accounted for by latitude and longitude, supporting the differentiation of records into individual monsoon regions. Regression analysis of simulated precipitation δ[sup 18]O and climate variables show that global Holocene monsoon δ[sup 18]O trends are driven by changes in precipitation, atmospheric circulation and (to a lesser extent) source area temperature, whilst precipitation recycling is non-significant. However, there are differences in regional scale mechanisms; there are clear relationships between changes in precipitation and in δ[sup 18]O for India, southwestern South America and the Indonesian-Australian regions, but not for the East Asian monsoon. Changes in atmospheric circulation contributes to δ[sup 18]O trends in the East Asian, Indian and Indonesian-Australian monsoons, and a weak source area temperature effect is observed over southern and central America and Asia. Precipitation recycling is influential in southwestern South America and southern Africa. Overall, our analyses show that it is possible to differentiate the impacts of specific climatic mechanisms influencing precipitation δ[sup 18]O and use this analysis to interpret changes in speleothem δ[sup 18]O. [ABSTRACT FROM AUTHOR]

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