1. Effect of Maternal Obesity and Preconceptional Weight Loss on Male and Female Offspring Metabolism and Olfactory Performance in Mice
- Author
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Marion Lemaire, Delphine Rousseau-Ralliard, Sofiane Safi-Stibler, Christophe Breton, Karine Badonnel, Marie-Annick Persuy, Sarah Voisin, Mélanie Jouin, Didier Durieux, Luc Jouneau, Marie-Christine Lacroix, Simon Lecoutre, Christine Baly, Hélène Jammes, Nicolas Meunier, Anne Gabory, Polina Panchenko, Claudine Junien, Biologie du développement et reproduction (BDR), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Université Paris Saclay (COmUE), Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), Institut National de la Recherche Agronomique (INRA), Équipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, Université de Lille, Fondation Cœur et Artères (FCA 13T1), Prix de Projet de Recherche Institut Benjamin Delessert, Biologie du Développement et Reproduction (BDR), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), Neurobiologie de l'olfaction (NBO), Panchenko, Polina, Lacroix, Marie-Christine, Gabory, Anne, and École nationale vétérinaire - Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)
- Subjects
Male ,obesity ,croissance fœtale ,Physiology ,Disease ,preconceptional weight loss ,Mice ,0302 clinical medicine ,Pregnancy ,Weight loss ,[SDV.BDD]Life Sciences [q-bio]/Development Biology ,2. Zero hunger ,Nutrition and Dietetics ,DOHaD ,Biologie du développement ,programmation nutritionnelle ,[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism ,Development Biology ,Smell ,obésité ,medicine.anatomical_structure ,Alimentation et Nutrition ,Endocrinologie et métabolisme ,Female ,medicine.symptom ,lcsh:Nutrition. Foods and food supply ,olfaction ,Offspring ,Mothers ,030209 endocrinology & metabolism ,Context (language use) ,lcsh:TX341-641 ,Olfaction ,Diet, High-Fat ,programming ,Article ,03 medical and health sciences ,Placenta ,Weight Loss ,medicine ,Food and Nutrition ,Animals ,Weaning ,métabolisme ,Endocrinology and metabolism ,perte de poids préconceptionelle ,business.industry ,medicine.disease ,Obesity ,Mice, Inbred C57BL ,Fertilization ,Energy Metabolism ,business ,metabolism ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,030217 neurology & neurosurgery ,Food Science ,Perte de poids préconceptionelle - Abstract
According to the &ldquo, developmental origins of health and disease&rdquo, (DOHaD) concept, maternal obesity predisposes the offspring to non-communicable diseases in adulthood. While a preconceptional weight loss (WL) is recommended for obese women, its benefits on the offspring have been poorly addressed. We evaluated whether preconceptional WL was able to reverse the adverse effects of maternal obesity in a mouse model, exhibiting a modification of foetal growth and of the expression of genes encoding epigenetic modifiers in liver and placenta. We tracked metabolic and olfactory behavioural trajectories of offspring born to control, obese or WL mothers. After weaning, the offspring were either put on a control diet (CD) or a high-fat (HFD). After only few weeks of HFD, the offspring developed obesity, metabolic alterations and olfactory impairments, independently of maternal context. However, male offspring born to obese mother gained even more weight under HFD than their counterparts born to lean mothers. Preconceptional WL normalized the offspring metabolic phenotypes but had unexpected effects on olfactory performance: a reduction in olfactory sensitivity, along with a lack of fasting-induced, olfactory-based motivation. Our results confirm the benefits of maternal preconceptional WL for male offspring metabolic health but highlight some possible adverse outcomes on olfactory-based behaviours.
- Published
- 2019
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