Search

Hereditary breast cancer is an inherited genetic condition, mainly caused by BRCA1 and BRCA2 gene mutations. These genetic changes can increase the risks of breast and ovarian cancers in women, while prostate and breast cancers in men. Especially, mutations in either BRCA1 or BRCA2 genes take important roles in early-onset breast cancer. The present study focused on a 47-year-old Vietnamese woman with breast cancer by applying targeted next-generation sequencing technique. A novel BRCA1 gene mutation, namely NM_007294.3 (BRCA1): c.4998insA (p. Tyr1666Terfs), was identified both in this patient and in some of the members in her family proved the fact that the mutated genes passed down through generations. This change may exponentially initiate breast cancer risks and become a valuable marker for exact clinical prognosis and treatment.

Đề tài thực hiện trong điều kiện nhà lưới nhằm đánh giá khả năng chịu mặn của cỏ lông tây, cỏ Paspalum và cỏ Setaria trồng bằng phương pháp thủy canh trong dung dịch dinh dưỡng Hoagland. Muối NaCl được bổ sung để có năm mức độ muối 0, 5, 10, 15 và 20‰, nồng độ mặn 5‰ được tăng dần mỗi tuần đến khi đạt mức 20‰. Thí nghiệm được bố trí hoàn toàn ngẫu nhiên với ba lần lặp lại cho mỗi nghiệm thức. Kết quả cho thấy nồng độ mặn 15 và 20‰ ảnh hưởng đáng kể đến sinh trưởng và phát triển của ba loài cây nghiên cứu, nhưng chưa ảnh hưởng đến tỷ lệ sống của lông tây và cỏ Setaria. Hàm lượng diệp lục tố trong lá (SPAD) của cỏ lông tây có dấu hiệu tăng khi độ mặn tăng, trong khi cỏ Paspalum có dấu hiệu giảm và cỏ Setaria thì không thay đổi khi nồng độ mặn tăng. Trong ba loài cây nghiên cứu, cỏ lông tây tích lũy proline cao nhất. Điều này cho thấy khả năng chịu mặn của cỏ Paspalum kém hơn lông tây và cỏ Setaria, do đó, hai loài cây này có tiềm năng được chọn trồng cho sản xuất cỏ làm thức ăn cho gia súc vùng ven biển hay vùng đất bị nhiễm mặn ở đồng bằng sông Cửu Long.

Phương pháp thí nghiệm dựa trên nguyên lý áp lực súng bắn Hopkinson được sử dụng phổ biến trên thế giới để nghiên cứu ứng xử cơ học của vật liệu ở tốc độ biến dạng rất cao. Để phát triển mô hình thí nghiệm này ở Việt Nam, rất cần có những nghiên cứu thiết kế hệ thống thí nghiệm và được kiểm nghiệm bằng các kết quả mô phỏng để có phương án thiết kế tối ưu. Trong nghiên cứu này, mô hình thí nghiệm nén hợp kim nhôm ở tốc độ rất cao dựa trên nguyên lý áp lực súng bắn Hopkinson được mô hình hóa và mô phỏng bằng phương pháp phần tử hữu hạn. Ảnh hưởng của kích thước mẫu thử được xem xét qua các kết quả biểu đồ sóng thu được từ mô phỏng. Các kết quả cho thấy, tín hiệu sóng tốt hơn, đạt được cân bằng giữa sóng tới với sóng truyền và sóng phản hồi khi đường kính mẫu thử chỉ bằng một nửa so với chiều dài. Đồng thời, trường hợp đường kính mẫu thử nhỏ cũng cho kết quả tín hiệu sóng ít nhiễu hơn.

Economic is the greatest and most dynamic sector of the particularly extensive strategic relationship between Vietnam and Japan. In this sector, commercial cooperation plays an important role. The paper focused on analyzing the fundament of the Vietnam -Japan trade cooperation relationship (2008-2020) to reconstruct the reality of the relationship in terms of scale and structure of goods exchanges during the research period. Based on this analysis, the paper has made comments and suggested solutions to develop trade relations between the two countries in the coming time.

From the ethyl acetate extract of the leaves of Amensiodendron chinense (Merr.) Hu (Sapindaceae), we isolated three known phenolic compounds: 4-hydroxy-3-methoxybenzaldehyde (1), methyl 3,4-dihydroxybenzoate (2), and 3,4-dihydroxybenzoic acid (3). We elucidated their chemical structures from the spectral data and compared them with those reported in the literature.

Carotenoid compounds are the popular natural antioxidants which are often isolated from plants. There have been more and more researches on carotenoid biosynthesis towards lowering product prices. In this study, in order to produce carotenoid, Rhodotorula mucilaginosa was grown on aqueous media composed of carbon source (glucose, glycerol), nitrogen source (yeast extract, (NH4)2SO4). The optimum nutrient concentration was 10g/L glucose, 10g/L glycerol, the ratio of yeast extract and (NH4)2SO4 (3:7). The fermentation time for obtaining the highest carotenoid yield was 10 days in our research condition. Additionally, some oxidative stress environment for Rhodotorula mucilaginosa was be studied. The result has shown that the low level of Cu2+ (4.5mM) or 1% H2O2 solution (% v/v) in the fermentation media could increase the carotenoid biosynthesis.

Microorganisms in petroleum product, including jet fuel, have been found by some English and American authors since the 20’s of the last century. In 1958, after Bakanaukas isolated many microorganisms in jet fuel JP4, this topic was especially concentrated. Most of microorganisms living in jet fuel are able to degrade hydrocarbon of the fuel to obtain energy and carbon source for their growth. The presence of microorganisms in jet fuel not only brings about the lost of fuel in store process, but also briefly changes the component and structure of jet fuel. Moreover, the products of their metabolism, such as organic acids, alcohols, H2S are corrosive. Hence, they cause many problems for fuel reservoirs and tanks, leak plugging pipelines. Besides, filter system and plugging pipeline can become obstructed because of microorganisms’ biomass. This influences the plane safety. Therefore, many countries in the world consider microorganisms criteria as an important standard to estimate the jet fuel quality. From 1985 to 1990, in our country, Vietnam, there were some science projects about microorganisms in TC1 fuel. At the present, as all country in Asia, Vietnam used to utilize and import hundred tons of jet A1. Tropical climate of Vietnam is the suitable condition for growing of microorganisms. With C8-C18 alkane chains, jet fuel is carbon source for a lot of microorganisms, especially bacteria and fungi, which harmfully affect plane safety. Therefore, we aimed Vietnam airlines company to control the number of microorganisms in jet fuel of all Vietnam airplanes, as well as study on the diversity of microorganisms in trace water in fuel samples, looking for the reason why filter is obstructed to contribute to the jet fuel storing and safety in Vietnam.

In the renovation cause initiated and guided by the Communist Party of Vietnam,along with economic though reform, the Party has gradually implemented socio-economic policies with the aim to boosting economic developing attached to social advancements and equality. The national social policy system has been completed and more people are offered these policies. The assistance levels have been increased and the State’s investment is also on the rise. Therefore, social areas have reached important achievements, particularly in poverty reduction, job creation and giving priorities to education and training sector and people who make contributions to the country’s revolutions. In this article, the writer focuses on clarifying the Party’s awareness process of social policies from the renovation time to date. Based on this, the writer mentions several gained achievements and also proposes solutions to raises quality and efficiencies of social policies in the current condition.

Over the past years, the State and Party have paid special attention to developing the social security system, considering this as a central factor in the development process of the country. During the 25-year development process, the social security system has been gradually finalised, making significant contribution to the national socio-economic stabilisation and development. However, the system still shows its weakness. In the article, the author focuses on analysing structure, function, tasks as well as compulsory institutions and operation principles of the social security system. This helps analyse the situation and assess strong points, weakness, causes and challenges for the process of building and completing the country’s social security. This also helps to promote some solutions to boost quality and operation effectiveness of the social security system in the industrilisation, modernisation and global integration process.