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Elena Milanesi,1,* Maria Dobre,1,* Cătălina Anca Cucos,1 Ana I Rojo,2– 5 José Jiménez-Villegas,2,3 Estibaliz Capetillo-Zarate,5– 7 Carlos Matute,6,7 Gerard Piñol-Ripoll,8 Gina Manda,1 Antonio Cuadrado1– 5 1“Victor Babes” National Institute of Pathology, Bucharest, 050096, Romania; 2Department of Endocrine Physiology and Nervous System, Instituto de Investigaciones Biomédicas “Alberto Sols” UAM-CSIC, Madrid, 28029, Spain; 3Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid, Madrid, 28049, Spain; 4Neuroscience Section, Instituto de Investigación Sanitaria La Paz (IDIPAZ), Madrid, 28046, Spain; 5Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), ISCIII, Madrid, 28031, Spain; 6IKERBASQUE, Basque Foundation for Science, Bilbao, 48009, Spain; 7Department of Neuroscience, University of the Basque Country UPV/EHU, Achucarro Basque Center for Neuroscience, Leioa, Spain; 8Unitat Trastons Cognitius, Hospital Universitari Santa Maria-IRB Leida, Lleida, 25198, Spain*These authors contributed equally to this workCorrespondence: Antonio CuadradoInstituto de Investigaciones Biomédicas “Alberto Sols” UAM-CSIC, C/ Arturo Duperier 4, Madrid, 28029, SpainEmail antonio.cuadrado@uam.esGina Manda“Victor Babes” National Institute of Pathology, 99-101 Splaiul Independentei, Bucharest, 050096, RomaniaEmail gina.manda@gmail.comBackground: Although Alzheimer’s disease (AD) is associated with alterations of the central nervous system, this disease has an echo in blood that might represent a valuable source of biomarkers for improved diagnosis, prognosis and for monitoring drug response.Methods: We performed a targeted transcriptomics study on 38 mild Alzheimer’s disease (AD) patients and 38 matched controls for evaluating the expression levels of 136 inflammation and 84 redox genes in whole blood. Patients were diagnosed as mild AD based on altere

Elena Milanesi,1 Gina Manda,1 Maria Dobre,1 Elena Codrici,1 Ionela Victoria Neagoe,1 Bogdan Ovidiu Popescu,1– 3 Ovidiu Alexandru Bajenaru2,4 †, Luiza Spiru,2,5 Catalina Tudose,2,6 Gabriel-Ioan Prada,2,7 Eugenia Irene Davidescu,2,3 Gerard Piñol-Ripoll,8 Antonio Cuadrado1,9– 12 1“Victor Babes” National Institute of Pathology, Bucharest, 050096, Romania; 2Clinical Neurosciences, Geriatrics and Gerontology Departments, “Carol Davila” University of Medicine and Pharmacy, Bucharest, 020021, Romania; 3Neurology Department, Clinical Hospital Colentina, Bucharest, 020125, Romania; 4Neurology Department, University Emergency Hospital, Bucharest, 050098, Romania; 5The Excellence Memory Center and Longevity Medicine, “Ana Aslan” International Foundation,, Bucharest, 050064, Romania; 6Section II, “Prof. Dr. Al. Obregia” Psychiatry Clinical Hospital & the Memory Center of the Romanian Alzheimer Society, Bucharest, 041914, Romania; 7Section IV, “Ana Aslan” National Institute of Gerontology and Geriatrics, Bucharest, 011241, Romania; 8Unitat Trastons Cognitius, Hospital Universitari Santa Maria-IRBLLeida, Lleida, 25198, Spain; 9Department of Endocrine Physiology and Nervous System, Instituto de Investigaciones Biomédicas “Alberto Sols” UAM-CSIC, Madrid, 28029, Spain; 10Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid, Madrid, 28049, Spain; 11Neuroscience Section, Instituto de Investigación Sanitaria La Paz (IdiPaz), Madrid, 28046, Spain; 12Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), ISCIII, Madrid, 28031, Spain†Prof. Ovidiu A. Bajenaru passed away on 03.09.2020Correspondence: Gina Manda“Victor Babes” National Institute of Pathology, 99-101 Splaiul Independentei, B