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1. Exploring the mycobacteriophage metaproteome: Phage genomics as an educational platform

Author

Hatfull, GF, Pedulla, ML, Jacobs-Sera, D, Cichon, PM, Foley, A, Ford, ME, Gonda, RM, Houtz, JM, Hryckowian, AJ, Kelchner, VA, Namburi, S, Pajcini, KV, Popovich, MG, Schleicher, DT, Simanek, BZ, Smith, AL, Zdanowicz, GM, Kumar, V, Peebles, CL, Jacobs, WR, Lawrence, JG, Hendrix, RW, Hatfull, GF, Pedulla, ML, Jacobs-Sera, D, Cichon, PM, Foley, A, Ford, ME, Gonda, RM, Houtz, JM, Hryckowian, AJ, Kelchner, VA, Namburi, S, Pajcini, KV, Popovich, MG, Schleicher, DT, Simanek, BZ, Smith, AL, Zdanowicz, GM, Kumar, V, Peebles, CL, Jacobs, WR, Lawrence, JG, and Hendrix, RW

Abstract

Bacteriophages are the most abundant forms of life in the biosphere and carry genomes characterized by high genetic diversity and mosaic architectures. The complete sequences of 30 mycobacteriophage genomes show them collectively to encode 101 tRNAs, three tmRNAs, and 3,357 proteins belonging to 1,536 "phamilies" of related sequences, and a statistical analysis predicts that these represent approximately 50% of the total number of phamilies in the mycobacteriophage population. These phamilies contain 2.19 proteins on average; more than half (774) of them contain just a single protein sequence. Only six phamilies have representatives in more than half of the 30 genomes, and only three - encoding tape-measure proteins, lysins, and minor tail proteins - are present in all 30 phages, although these phamilies are themselves highly modular, such that no single amino acid sequence element is present in all 30 mycobacteriophage genomes. Of the 1,536 phamilies, only 230 (15%) have amino acid sequence similarity to previously reported proteins, reflecting the enormous genetic diversity of the entire phage population. The abundance and diversity of phages, the simplicity of phage isolation, and the relatively small size of phage genomes support bacteriophage isolation and comparative genomic analysis as a highly suitable platform for discovery-based education. © 2006 Hatfull et al.

Published
2006

2. Exploring the mycobacteriophage metaproteome: phage genomics as an educational platform.

Author

Hatfull GF, Pedulla ML, Jacobs-Sera D, Cichon PM, Foley A, Ford ME, Gonda RM, Houtz JM, Hryckowian AJ, Kelchner VA, Namburi S, Pajcini KV, Popovich MG, Schleicher DT, Simanek BZ, Smith AL, Zdanowicz GM, Kumar V, Peebles CL, Jacobs WR Jr, Lawrence JG, and Hendrix RW

Subjects
DNA, Viral genetics, Genes, Viral, Genome, Viral, Genomics, Molecular Sequence Data, RNA, Messenger genetics, RNA, Transfer genetics, RNA, Viral genetics, Viral Proteins genetics, Mycobacteriophages genetics, Proteome, Virology education
Abstract

Bacteriophages are the most abundant forms of life in the biosphere and carry genomes characterized by high genetic diversity and mosaic architectures. The complete sequences of 30 mycobacteriophage genomes show them collectively to encode 101 tRNAs, three tmRNAs, and 3,357 proteins belonging to 1,536 "phamilies" of related sequences, and a statistical analysis predicts that these represent approximately 50% of the total number of phamilies in the mycobacteriophage population. These phamilies contain 2.19 proteins on average; more than half (774) of them contain just a single protein sequence. Only six phamilies have representatives in more than half of the 30 genomes, and only three-encoding tape-measure proteins, lysins, and minor tail proteins-are present in all 30 phages, although these phamilies are themselves highly modular, such that no single amino acid sequence element is present in all 30 mycobacteriophage genomes. Of the 1,536 phamilies, only 230 (15%) have amino acid sequence similarity to previously reported proteins, reflecting the enormous genetic diversity of the entire phage population. The abundance and diversity of phages, the simplicity of phage isolation, and the relatively small size of phage genomes support bacteriophage isolation and comparative genomic analysis as a highly suitable platform for discovery-based education., Competing Interests: Competing interests. The authors have declared that no competing interests exist.

Published
2006
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