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DNA methylation is a crucial epigenetic marker used in various clocks to predict epigenetic age. However, many existing clocks fail to account for crucial information about CpG sites and their interrelationships, such as co-methylation patterns. We present a novel approach to represent methylation data as a graph, using methylation values and relevant information about CpG sites as nodes, and relationships like co-methylation, same gene, and same chromosome as edges. We then use a Graph Neural Network (GNN) to predict age. Thus our model, GraphAge, leverages both structural and positional information for prediction as well as better interpretation. Although we had to train in a constrained compute setting, GraphAge still showed competitive performance with a Mean Absolute Error (MAE) of 3.207 and a Mean Squared Error (MSE) of 25.277, slightly outperforming the current state of the art. Perhaps more importantly, we utilized GNN explainer for interpretation purposes and were able to unearth interesting insights (e.g., key CpG sites, pathways, and their relationships through Methylation Regulated Networks in the context of aging), which were not possible to 'decode' without leveraging the unique capability of GraphAge to 'encode' various structural relationships. GraphAge has the potential to consume and utilize all relevant information (if available) about an individual that relates to the complex process of aging. So, in that sense, it is one of its kind and can be seen as the first benchmark for a multimodal model that can incorporate all this information in order to close the gap in our understanding of the true nature of aging.

This report outlines our approach in the IEEE SPS VIP Cup 2023: Ophthalmic Biomarker Detection competition. Our primary objective in this competition was to identify biomarkers from Optical Coherence Tomography (OCT) images obtained from a diverse range of patients. Using robust augmentations and 5-fold cross-validation, we trained two vision transformer-based models: MaxViT and EVA-02, and ensembled them at inference time. We find MaxViT's use of convolution layers followed by strided attention to be better suited for the detection of local features while EVA-02's use of normal attention mechanism and knowledge distillation is better for detecting global features. Ours was the best-performing solution in the competition, achieving a patient-wise F1 score of 0.814 in the first phase and 0.8527 in the second and final phase of VIP Cup 2023, scoring 3.8% higher than the next-best solution.

In this work, we have presented a way to increase the contrast of an image. Our target is to find a transformation that will be image specific. We have used a fuzzy system as our transformation function. To tune the system according to an image, we have used Genetic Algorithm and Hill Climbing in multiple ways to evolve the fuzzy system and conducted several experiments. Different variants of the method are tested on several images and two variants that are superior to others in terms of fitness are selected. We have also conducted a survey to assess the visual improvement of the enhancements made by the two variants. The survey indicates that one of the methods can enhance the contrast of the images visually., Comment: 14 pages, 7 figures, Image Processing, Computer Vision, Evolutionary Computation

Raman spectroscopy provides a vibrational profile of the molecules and thus can be used to uniquely identify different kind of materials. This sort of fingerprinting molecules has thus led to widespread application of Raman spectrum in various fields like medical dignostics, forensics, mineralogy, bacteriology and virology etc. Despite the recent rise in Raman spectra data volume, there has not been any significant effort in developing generalized machine learning methods for Raman spectra analysis. We examine, experiment and evaluate existing methods and conjecture that neither current sequential models nor traditional machine learning models are satisfactorily sufficient to analyze Raman spectra. Both has their perks and pitfalls, therefore we attempt to mix the best of both worlds and propose a novel network architecture RamanNet. RamanNet is immune to invariance property in CNN and at the same time better than traditional machine learning models for the inclusion of sparse connectivity. Our experiments on 4 public datasets demonstrate superior performance over the much complex state-of-the-art methods and thus RamanNet has the potential to become the defacto standard in Raman spectra data analysis

Data transformation (DT) is a process that transfers the original data into a form which supports a particular classification algorithm and helps to analyze the data for a special purpose. To improve the prediction performance we investigated various data transform methods. This study is conducted in a customer churn prediction (CCP) context in the telecommunication industry (TCI), where customer attrition is a common phenomenon. We have proposed a novel approach of combining data transformation methods with the machine learning models for the CCP problem. We conducted our experiments on publicly available TCI datasets and assessed the performance in terms of the widely used evaluation measures (e.g. AUC, precision, recall, and F-measure). In this study, we presented comprehensive comparisons to affirm the effect of the transformation methods. The comparison results and statistical test proved that most of the proposed data transformation based optimized models improve the performance of CCP significantly. Overall, an efficient and optimized CCP model for the telecommunication industry has been presented through this manuscript., Comment: 24 pages

Lung cancer is one of the deadliest cancers, and in part its effective diagnosis and treatment depend on the accurate delineation of the tumor. Human-centered segmentation, which is currently the most common approach, is subject to inter-observer variability, and is also time-consuming, considering the fact that only experts are capable of providing annotations. Automatic and semi-automatic tumor segmentation methods have recently shown promising results. However, as different researchers have validated their algorithms using various datasets and performance metrics, reliably evaluating these methods is still an open challenge. The goal of the Lung-Originated Tumor Segmentation from Computed Tomography Scan (LOTUS) Benchmark created through 2018 IEEE Video and Image Processing (VIP) Cup competition, is to provide a unique dataset and pre-defined metrics, so that different researchers can develop and evaluate their methods in a unified fashion. The 2018 VIP Cup started with a global engagement from 42 countries to access the competition data. At the registration stage, there were 129 members clustered into 28 teams from 10 countries, out of which 9 teams made it to the final stage and 6 teams successfully completed all the required tasks. In a nutshell, all the algorithms proposed during the competition, are based on deep learning models combined with a false positive reduction technique. Methods developed by the three finalists show promising results in tumor segmentation, however, more effort should be put into reducing the false positive rate. This competition manuscript presents an overview of the VIP-Cup challenge, along with the proposed algorithms and results.

Lung cancer is a leading cause of death in most countries of the world. Since prompt diagnosis of tumors can allow oncologists to discern their nature, type and the mode of treatment, tumor detection and segmentation from CT Scan images is a crucial field of study worldwide. This paper approaches lung tumor segmentation by applying two-dimensional discrete wavelet transform (DWT) on the LOTUS dataset for more meticulous texture analysis whilst integrating information from neighboring CT slices before feeding them to a Deeply Supervised MultiResUNet model. Variations in learning rates, decay and optimization algorithms while training the network have led to different dice co-efficients, the detailed statistics of which have been included in this paper. We also discuss the challenges in this dataset and how we opted to overcome them. In essence, this study aims to maximize the success rate of predicting tumor regions from two dimensional CT Scan slices by experimenting with a number of adequate networks, resulting in a dice co-efficient of 0.8472.

Cardiovascular diseases are the most common causes of death around the world. To detect and treat heart-related diseases, continuous Blood Pressure (BP) monitoring along with many other parameters are required. Several invasive and non-invasive methods have been developed for this purpose. Most existing methods used in the hospitals for continuous monitoring of BP are invasive. On the contrary, cuff-based BP monitoring methods, which can predict Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP), cannot be used for continuous monitoring. Several studies attempted to predict BP from non-invasively collectible signals such as Photoplethysmogram (PPG) and Electrocardiogram (ECG), which can be used for continuous monitoring. In this study, we explored the applicability of autoencoders in predicting BP from PPG and ECG signals. The investigation was carried out on 12,000 instances of 942 patients of the MIMIC-II dataset and it was found that a very shallow, one-dimensional autoencoder can extract the relevant features to predict the SBP and DBP with the state-of-the-art performance on a very large dataset. Independent test set from a portion of the MIMIC-II dataset provides an MAE of 2.333 and 0.713 for SBP and DBP, respectively. On an external dataset of forty subjects, the model trained on the MIMIC-II dataset, provides an MAE of 2.728 and 1.166 for SBP and DBP, respectively. For both the cases, the results met British Hypertension Society (BHS) Grade A and surpassed the studies from the current literature., Comment: 22 pages, Figure 8, Table 13

In this note, we consider the problem of counting and verifying abelian border arrays of binary words. We show that the number of valid abelian border arrays of length \(n\) is \(2^{n-1}\). We also show that verifying whether a given array is the abelian border array of some binary word reduces to computing the abelian border array of a specific binary word. Thus, assuming the word-RAM model, we present an \(O\left(\frac{n^2}{\log^2n}\right)\) time algorithm for the abelian border array verification problem.

Contemporary works on abstractive text summarization have focused primarily on high-resource languages like English, mostly due to the limited availability of datasets for low/mid-resource ones. In this work, we present XL-Sum, a comprehensive and diverse dataset comprising 1 million professionally annotated article-summary pairs from BBC, extracted using a set of carefully designed heuristics. The dataset covers 44 languages ranging from low to high-resource, for many of which no public dataset is currently available. XL-Sum is highly abstractive, concise, and of high quality, as indicated by human and intrinsic evaluation. We fine-tune mT5, a state-of-the-art pretrained multilingual model, with XL-Sum and experiment on multilingual and low-resource summarization tasks. XL-Sum induces competitive results compared to the ones obtained using similar monolingual datasets: we show higher than 11 ROUGE-2 scores on 10 languages we benchmark on, with some of them exceeding 15, as obtained by multilingual training. Additionally, training on low-resource languages individually also provides competitive performance. To the best of our knowledge, XL-Sum is the largest abstractive summarization dataset in terms of the number of samples collected from a single source and the number of languages covered. We are releasing our dataset and models to encourage future research on multilingual abstractive summarization. The resources can be found at \url{https://github.com/csebuetnlp/xl-sum}., Comment: Findings of the Association for Computational Linguistics, ACL 2021 (camera-ready)

In recent years, physiological signal based authentication has shown great promises,for its inherent robustness against forgery. Electrocardiogram (ECG) signal, being the most widely studied biosignal, has also received the highest level of attention in this regard. It has been proven with numerous studies that by analyzing ECG signals from different persons, it is possible to identify them, with acceptable accuracy. In this work, we present, EDITH, a deep learning-based framework for ECG biometrics authentication system. Moreover, we hypothesize and demonstrate that Siamese architectures can be used over typical distance metrics for improved performance. We have evaluated EDITH using 4 commonly used datasets and outperformed the prior works using less number of beats. EDITH performs competitively using just a single heartbeat (96-99.75% accuracy) and can be further enhanced by fusing multiple beats (100% accuracy from 3 to 6 beats). Furthermore, the proposed Siamese architecture manages to reduce the identity verification Equal Error Rate (EER) to 1.29%. A limited case study of EDITH with real-world experimental data also suggests its potential as a practical authentication system., Comment: Preprint

In this work, we introduce BanglaBERT, a BERT-based Natural Language Understanding (NLU) model pretrained in Bangla, a widely spoken yet low-resource language in the NLP literature. To pretrain BanglaBERT, we collect 27.5 GB of Bangla pretraining data (dubbed `Bangla2B+') by crawling 110 popular Bangla sites. We introduce two downstream task datasets on natural language inference and question answering and benchmark on four diverse NLU tasks covering text classification, sequence labeling, and span prediction. In the process, we bring them under the first-ever Bangla Language Understanding Benchmark (BLUB). BanglaBERT achieves state-of-the-art results outperforming multilingual and monolingual models. We are making the models, datasets, and a leaderboard publicly available at https://github.com/csebuetnlp/banglabert to advance Bangla NLP., Comment: Findings of North American Chapter of the Association for Computational Linguistics, NAACL 2022 (camera-ready)

Background: The inception of next generations sequencing technologies have exponentially increased the volume of biological sequence data. Protein sequences, being quoted as the `language of life', has been analyzed for a multitude of applications and inferences. Motivation: Owing to the rapid development of deep learning, in recent years there have been a number of breakthroughs in the domain of Natural Language Processing. Since these methods are capable of performing different tasks when trained with a sufficient amount of data, off-the-shelf models are used to perform various biological applications. In this study, we investigated the applicability of the popular Skip-gram model for protein sequence analysis and made an attempt to incorporate some biological insights into it. Results: We propose a novel $k$-mer embedding scheme, Align-gram, which is capable of mapping the similar $k$-mers close to each other in a vector space. Furthermore, we experiment with other sequence-based protein representations and observe that the embeddings derived from Align-gram aids modeling and training deep learning models better. Our experiments with a simple baseline LSTM model and a much complex CNN model of DeepGoPlus shows the potential of Align-gram in performing different types of deep learning applications for protein sequence analysis.

Despite being the seventh most widely spoken language in the world, Bengali has received much less attention in machine translation literature due to being low in resources. Most publicly available parallel corpora for Bengali are not large enough; and have rather poor quality, mostly because of incorrect sentence alignments resulting from erroneous sentence segmentation, and also because of a high volume of noise present in them. In this work, we build a customized sentence segmenter for Bengali and propose two novel methods for parallel corpus creation on low-resource setups: aligner ensembling and batch filtering. With the segmenter and the two methods combined, we compile a high-quality Bengali-English parallel corpus comprising of 2.75 million sentence pairs, more than 2 million of which were not available before. Training on neural models, we achieve an improvement of more than 9 BLEU score over previous approaches to Bengali-English machine translation. We also evaluate on a new test set of 1000 pairs made with extensive quality control. We release the segmenter, parallel corpus, and the evaluation set, thus elevating Bengali from its low-resource status. To the best of our knowledge, this is the first ever large scale study on Bengali-English machine translation. We believe our study will pave the way for future research on Bengali-English machine translation as well as other low-resource languages. Our data and code are available at https://github.com/csebuetnlp/banglanmt., Comment: EMNLP 2020

We are presenting COVID-19Base, a knowledgebase highlighting the biomedical entities related to COVID-19 disease based on literature mining. To develop COVID-19Base, we mine the information from publicly available scientific literature and related public resources. We considered seven topic-specific dictionaries, including human genes, human miRNAs, human lncRNAs, diseases, Protein Databank, drugs, and drug side effects, are integrated to mine all scientific evidence related to COVID-19. We have employed an automated literature mining and labeling system through a novel approach to measure the effectiveness of drugs against diseases based on natural language processing, sentiment analysis, and deep learning. To the best of our knowledge, this is the first knowledgebase dedicated to COVID-19, which integrates such large variety of related biomedical entities through literature mining. Proper investigation of the mined biomedical entities along with the identified interactions among those, reported in COVID-19Base, would help the research community to discover possible ways for the therapeutic treatment of COVID-19., Comment: 10 pages, 3 figures

Cardiovascular diseases are one of the most severe causes of mortality, taking a heavy toll of lives annually throughout the world. The continuous monitoring of blood pressure seems to be the most viable option, but this demands an invasive process, bringing about several layers of complexities. This motivates us to develop a method to predict the continuous arterial blood pressure (ABP) waveform through a non-invasive approach using photoplethysmogram (PPG) signals. In addition we explore the advantage of deep learning as it would free us from sticking to ideally shaped PPG signals only, by making handcrafted feature computation irrelevant, which is a shortcoming of the existing approaches. Thus, we present, PPG2ABP, a deep learning based method, that manages to predict the continuous ABP waveform from the input PPG signal, with a mean absolute error of 4.604 mmHg, preserving the shape, magnitude and phase in unison. However, the more astounding success of PPG2ABP turns out to be that the computed values of DBP, MAP and SBP from the predicted ABP waveform outperforms the existing works under several metrics, despite that PPG2ABP is not explicitly trained to do so.

Class imbalance problem is commonly faced while developing machine learning models for real-life issues. Due to this problem, the fitted model tends to be biased towards the majority class data, which leads to lower precision, recall, AUC, F1, G-mean score. Several researches have been done to tackle this problem, most of which employed resampling, i.e. oversampling and undersampling techniques to bring the required balance in the data. In this paper, we propose neural network based algorithms for undersampling. Then we resampled several class imbalanced data using our algorithms and also some other popular resampling techniques. Afterwards we classified these undersampled data using some common classifier. We found out that our resampling approaches outperform most other resampling techniques in terms of both AUC, F1 and G-mean score., Comment: 8 pages in IEEE format

Malaria is a female anopheles mosquito-bite inflicted life-threatening disease which is considered endemic in many parts of the world. This article focuses on improving malaria detection from patches segmented from microscopic images of red blood cell smears by introducing a deep convolutional neural network. Compared to the traditional methods that use tedious hand engineering feature extraction, the proposed method uses deep learning in an end-to-end arrangement that performs both feature extraction and classification directly from the raw segmented patches of the red blood smears. The dataset used in this study was taken from National Institute of Health named NIH Malaria Dataset. The evaluation metric accuracy and loss along with 5-fold cross validation was used to compare and select the best performing architecture. To maximize the performance, existing standard pre-processing techniques from the literature has also been experimented. In addition, several other complex architectures have been implemented and tested to pick the best performing model. A holdout test has also been conducted to verify how well the proposed model generalizes on unseen data. Our best model achieves an accuracy of almost 97.77%., Comment: Application of deep learning in biological science for the early detection of disease

At present, cryptocurrencies have become a global phenomenon in financial sectors as it is one of the most traded financial instruments worldwide. Cryptocurrency is not only one of the most complicated and abstruse fields among financial instruments, but it is also deemed as a perplexing problem in finance due to its high volatility. This paper makes an attempt to apply machine learning techniques on the index and constituents of cryptocurrency with a goal to predict and forecast prices thereof. In particular, the purpose of this paper is to predict and forecast the close (closing) price of the cryptocurrency index 30 and nine constituents of cryptocurrencies using machine learning algorithms and models so that, it becomes easier for people to trade these currencies. We have used several machine learning techniques and algorithms and compared the models with each other to get the best output. We believe that our work will help reduce the challenges and difficulties faced by people, who invest in cryptocurrencies. Moreover, the obtained results can play a major role in cryptocurrency portfolio management and in observing the fluctuations in the prices of constituents of cryptocurrency market. We have also compared our approach with similar state of the art works from the literature, where machine learning approaches are considered for predicting and forecasting the prices of these currencies. In the sequel, we have found that our best approach presents better and competitive results than the best works from the literature thereby advancing the state of the art. Using such prediction and forecasting methods, people can easily understand the trend and it would be even easier for them to trade in a difficult and challenging financial instrument like cryptocurrency., Comment: main article along with the supplement article at the end

The genome rearrangement problem computes the minimum number of operations that are required to sort all elements of a permutation. A block-interchange operation exchanges two blocks of a permutation which are not necessarily adjacent and in a prefix block-interchange, one block is always the prefix of that permutation. In this paper, we focus on applying prefix block-interchanges on binary and ternary strings. We present upper bounds to group and sort a given binary/ternary string. We also provide upper bounds for a different version of the block-interchange operation which we refer to as the `restricted prefix block-interchange'. We observe that our obtained upper bound for restricted prefix block-interchange operations on binary strings is better than that of other genome rearrangement operations to group fully normalized binary strings. Consequently, we provide a linear-time algorithm to solve the problem of grouping binary normalized strings by restricted prefix block-interchanges. We also provide a polynomial time algorithm to group normalized ternary strings by prefix block-interchange operations. Finally, we provide a classification for ternary strings based on the required number of prefix block-interchange operations.

In recent years Deep Learning has brought about a breakthrough in Medical Image Segmentation. U-Net is the most prominent deep network in this regard, which has been the most popular architecture in the medical imaging community. Despite outstanding overall performance in segmenting multimodal medical images, from extensive experimentations on challenging datasets, we found out that the classical U-Net architecture seems to be lacking in certain aspects. Therefore, we propose some modifications to improve upon the already state-of-the-art U-Net model. Hence, following the modifications we develop a novel architecture MultiResUNet as the potential successor to the successful U-Net architecture. We have compared our proposed architecture MultiResUNet with the classical U-Net on a vast repertoire of multimodal medical images. Albeit slight improvements in the cases of ideal images, a remarkable gain in performance has been attained for challenging images. We have evaluated our model on five different datasets, each with their own unique challenges, and have obtained a relative improvement in performance of 10.15%, 5.07%, 2.63%, 1.41%, and 0.62% respectively.

Facial image retrieval is a challenging task since faces have many similar features (areas), which makes it difficult for the retrieval systems to distinguish faces of different people. With the advent of deep learning, deep networks are often applied to extract powerful features that are used in many areas of computer vision. This paper investigates the application of different deep learning models for face image retrieval, namely, Alexlayer6, Alexlayer7, VGG16layer6, VGG16layer7, VGG19layer6, and VGG19layer7, with two types of dictionary learning techniques, namely $K$-means and $K$-SVD. We also investigate some coefficient learning techniques such as the Homotopy, Lasso, Elastic Net and SSF and their effect on the face retrieval system. The comparative results of the experiments conducted on three standard face image datasets show that the best performers for face image retrieval are Alexlayer7 with $K$-means and SSF, Alexlayer6 with $K$-SVD and SSF, and Alexlayer6 with $K$-means and SSF. The APR and ARR of these methods were further compared to some of the state of the art methods based on local descriptors. The experimental results show that deep learning outperforms most of those methods and therefore can be recommended for use in practice of face image retrieval

Updating and querying on a range is a classical algorithmic problem with a multitude of applications. The Segment Tree data structure is particularly notable in handling the range query and update operations. A Segment Tree divides the range into disjoint segments and merges them together to perform range queries and range updates elegantly. Although this data structure is remarkably potent for 1-dimensional problems, it falls short in higher dimensions. Lazy Propagation enables the operations to be computed in $O(logn)$ time in a single dimension. However, the concept of lazy propagation could not be translated to higher-dimensional cases, which imposes a time complexity of $O(n^{k-1} \; logn)$ for operations on $k$-dimensional data. In this work, we have made an attempt to emulate the idea of lazy propagation differently so that it can be applied for 2-dimensional cases. Moreover, the proposed modification should be capable of performing most general aggregate functions similar to the original Segment Tree, and can also be extended to even higher dimensions. Our proposed algorithm manages to perform range sum queries and updates in $O(\log^2 n)$ time for a 2-dimensional problem, which becomes $O(\log^d n)$ for a $d$-dimensional situation.

Though the interfacial tractor beam experiment supports the increase of photon momentum (i.e., Minkowski momentum), it is still a matter of investigation whether, inside matter, the photon momentum always increases. Considering the inhomogeneous or heterogeneous background, we have demonstrated that if the background and the half-immersed object are both non-absorbing, the transferred photon momentum to the object can be considered as the one of Minkowski exactly at the interface. In contrast, the presence of loss inside matter, either in the half-immersed object (i.e., plasmonic or lossy dielectric) or in the background, changes the whole situation. For such cases, our several demonstrations and proposed thought experiments have strongly supported the decrease of photon momentum instead of the usual perception of its increase. Although almost all the major radiation pressure experiments have so far supported the linear increase of photon momentum, our proposed simple experimental set-ups may introduce a novel way to observe and verify the exactly opposite proposal: the Abraham momentum of photon. Finally, as an interesting sidewalk, based on several parameters, a machine learning based system has been developed to predict the transferred momentum of photon within a very short time avoiding time-consuming full simulation.

Ventricular Fibrillation (VF), one of the most dangerous arrhythmias, is responsible for sudden cardiac arrests. Thus, various algorithms have been developed to predict VF from Electrocardiogram (ECG), which is a binary classification problem. In the literature, we find a number of algorithms based on signal processing, where, after some robust mathematical operations the decision is given based on a predefined threshold over a single value. On the other hand, some machine learning based algorithms are also reported in the literature; however, these algorithms merely combine some parameters and make a prediction using those as features. Both the approaches have their perks and pitfalls; thus our motivation was to coalesce them to get the best out of the both worlds. Hence we have developed, VFPred that, in addition to employing a signal processing pipeline, namely, Empirical Mode Decomposition and Discrete Time Fourier Transform for useful feature extraction, uses a Support Vector Machine for efficient classification. VFPred turns out to be a robust algorithm as it is able to successfully segregate the two classes with equal confidence (Sensitivity = 99.99%, Specificity = 98.40%) even from a short signal of 5 seconds long, whereas existing works though requires longer signals, flourishes in one but fails in the other.

Prediction of new drug-target interactions is extremely important as it can lead the researchers to find new uses for old drugs and to realize the therapeutic profiles or side effects thereof. However, experimental prediction of drug-target interactions is expensive and time-consuming. As a result, computational methods for prediction of new drug-target interactions have gained much interest in recent times. We present iDTI-ESBoost, a prediction model for identification of drug-target interactions using evolutionary and structural features. Our proposed method uses a novel balancing technique and a boosting technique for the binary classification problem of drug-target interaction. On four benchmark datasets taken from a gold standard data, iDTI-ESBoost outperforms the state-of-the-art methods in terms of area under Receiver operating characteristic (auROC) curve. iDTI-ESBoost also outperforms the latest and the best-performing method in the literature to-date in terms of area under precision recall (auPR) curve. This is significant as auPR curves are argued to be more appropriate as a metric for comparison for imbalanced datasets, like the one studied in this research. In the sequel, our experiments establish the effectiveness of the classifier, balancing methods and the novel features incorporated in iDTI-ESBoost. iDTI-ESBoost is a novel prediction method that has for the first time exploited the structural features along with the evolutionary features to predict drug-protein interactions. We believe the excellent performance of iDTI-ESBoost both in terms of auROC and auPR would motivate the researchers and practitioners to use it to predict drug-target interactions. To facilitate that, iDTI-ESBoost is readily available for use at: http://farshidrayhan.pythonanywhere.com/iDTI-ESBoost/, Comment: pre-print

Protein tertiary structure defines its functions, classification and binding sites. Similar structural characteristics between two proteins often lead to the similar characteristics thereof. Determining structural similarity accurately in real time is a crucial research issue. In this paper, we present a novel and effective scoring scheme that is dependent on novel features extracted from protein alpha carbon distance matrices. Our scoring scheme is inspired from pattern recognition and computer vision. Our method is significantly better than the current state of the art methods in terms of family match of pairs of protein structures and other statistical measurements. The effectiveness of our method is tested on standard benchmark structures. A web service is available at http://research.buet.ac.bd:8080/Comograd/score.html where you can get the similarity measurement score between two protein structures based on our method.

We first describe three algorithms for computing the Lyndon array that have been suggested in the literature, but for which no structured exposition has been given. Two of these algorithms execute in quadratic time in the worst case, the third achieves linear time, but at the expense of prior computation of both the suffix array and the inverse suffix array of x. We then go on to describe two variants of a new algorithm that avoids prior computation of global data structures and executes in worst-case n log n time. Experimental evidence suggests that all but one of these five algorithms require only linear execution time in practice, with the two new algorithms faster by a small factor. We conjecture that there exists a fast and worst-case linear-time algorithm to compute the Lyndon array that is also elementary (making no use of global data structures such as the suffix array).

$V$-order is a global order on strings related to Unique Maximal Factorization Families (UMFFs), which are themselves generalizations of Lyndon words. $V$-order has recently been proposed as an alternative to lexicographical order in the computation of suffix arrays and in the suffix-sorting induced by the Burrows-Wheeler transform. Efficient $V$-ordering of strings thus becomes a matter of considerable interest. In this paper we present new and surprising results on $V$-order in strings, then go on to explore the algorithmic consequences.

We consider the problem of finding repetitive structures and inherent patterns in a given string $\s{s}$ of length $n$ over a finite totally ordered alphabet. A border $\s{u}$ of a string $\s{s}$ is both a prefix and a suffix of $\s{s}$ such that $\s{u} \not= \s{s}$. The computation of the border array of a string $\s{s}$, namely the borders of each prefix of $\s{s}$, is strongly related to the string matching problem: given a string $\s{w}$, find all of its occurrences in $\s{s}$. A {\itshape Lyndon word} is a primitive word (i.e., it is not a power of another word) which is minimal for the lexicographical order of its conjugacy class (i.e., the set of words obtained by cyclic rotations of the letters). In this paper we combine these concepts to introduce the \emph{Lyndon Border Array} $\mathcal L \beta$ of $\s{s}$, whose $i$-th entry $\mathcal L \beta(\s{s})[i]$ is the length of the longest border of $\s{s}[1 \dd i]$ which is also a Lyndon word. We propose linear-time and linear-space algorithms for computing $\mathcal L \beta (\s{s})$. %in the case of both binary and bounded alphabets. Further, we introduce the \emph{Lyndon Suffix Array}, and by modifying the efficient suffix array technique of Ko and Aluru \cite{KA03} outline a linear time and space algorithm for its construction.

A \itbf{cover} of a string $x = x[1..n]$ is a proper substring $u$ of $x$ such that $x$ can be constructed from possibly overlapping instances of $u$. A recent paper \cite{FIKPPST13} relaxes this definition --- an \itbf{enhanced cover} $u$ of $x$ is a border of $x$ (that is, a proper prefix that is also a suffix) that covers a {\it maximum} number of positions in $x$ (not necessarily all) --- and proposes efficient algorithms for the computation of enhanced covers. These algorithms depend on the prior computation of the \itbf{border array} $\beta[1..n]$, where $\beta[i]$ is the length of the longest border of $x[1..i]$, $1 \le i \le n$. In this paper, we first show how to compute enhanced covers using instead the \itbf{prefix table}: an array $\pi[1..n]$ such that $\pi[i]$ is the length of the longest substring of $x$ beginning at position $i$ that matches a prefix of $x$. Unlike the border array, the prefix table is robust: its properties hold also for \itbf{indeterminate strings} --- that is, strings defined on {\it subsets} of the alphabet $\Sigma$ rather than individual elements of $\Sigma$. Thus, our algorithms, in addition to being faster in practice and more space-efficient than those of \cite{FIKPPST13}, allow us to easily extend the computation of enhanced covers to indeterminate strings. Both for regular and indeterminate strings, our algorithms execute in expected linear time. Along the way we establish an important theoretical result: that the expected maximum length of any border of any prefix of a regular string $x$ is approximately 1.64 for binary alphabets, less for larger ones.