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Your search keyword '"Rao, Sudhaker Dhanwada"' showing total 9 results
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9 results on '"Rao, Sudhaker Dhanwada"'

4. Multi-Level Annotation of Germ Line MEN1 Variants of Synonymous, Non-Synonymous and Uncertain Significance in Indian Patients with Sporadic Primary Hyperparathyroidism

Author

Kaur, Gurjeet, primary, Bhadada, Sanjay K., additional, Santra, Mithun, additional, Pal, Rimesh, additional, Sarma, Phulen, additional, Sachdeva, Naresh, additional, Dhiman, Vandana, additional, Dahiya, Divya, additional, Saikia, Uma Nahar, additional, Chakraborty, Anuradha, additional, Sood, Ashwani, additional, Prakash, Mahesh, additional, Behera, Arunanshu, additional, and Rao, Sudhaker Dhanwada, additional

Published
2022
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7. Aberrant Epigenetic Alteration of PAX1 Expression Contributes to Parathyroid Tumorigenesis.

Author

Singh, Priyanka, Bhadada, Sanjay Kumar, Arya, Ashutosh Kumar, Saikia, Uma Nahar, Sachdeva, Naresh, Dahiya, Divya, Kaur, Jyotdeep, Brandi, Maria Luisa, and Rao, Sudhaker Dhanwada

Subjects
HYPERPARATHYROIDISM, PARATHYROID gland cancer, TRANSCRIPTION factors
Abstract

Context: Primary hyperparathyroidism (PHPT) results from the hypersecretion of parathyroid hormone from parathyroid tumors. A transcription factor, namely Paired box1 (PAX1), is active in parathyroid gland development. Objective: We aimed to study potential epigenetic-mediated mechanism of PAX1 gene in sporadic parathyroid adenomas. Methods: In parathyroid adenomas tissues, we analyzed the DNA methylation via bisulfite-specific polymerase chain reaction (BSP) and histone modifications via chromatin immunoprecipitation in regulating the differential expression of PAX1. Results: The results showed that mRNA and protein expression of PAX1 was significantly reduced in parathyroid adenomas. Bisulfite sequencing demonstrated hypermethylation in the promoter region of PAX1 (35%; 14/40) and lower levels of histone 3 lysine 9 acetylation (H3K9ac) were observed on the promoter region of PAX1 (6-fold; P < .004) in parathyroid adenomas. Furthermore, upon treatment with a pharmacologic inhibitor namely 5′aza-2 deoxycytidine, in rat parathyroid continuous cells, we found re-expression of PAX1 gene. Conclusion: Our study not only reveals expression of PAX1 is epigenetically deregulated but also paves a way for clinical and therapeutic implications in patients with PHPT. [ABSTRACT FROM AUTHOR]

Published
2022
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