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Background Socioeconomic status (SES) patterned health disparities have been related to differences in dietary intake, especially in the elderly. Still, it is not known to what extent these differences culminate in vitamin deficiencies, as most studies have assessed nutrient intake, instead of measuring nutritional biomarkers. Hence, we aimed to objectively assess nutritional status in elderly with low and high SES and to investigate whether potential differences therein were mediated by diet. Methods 1605 individuals (60-75 years) were selected from the LifeLines Cohort Study to create two gender-matched groups with different SES. Nutritional status was assessed by measuring folic acid, vitamin B6, B12, D, A, E and K in the collected samples. SES-groups were defined according to highest completed education as high and low, and dietary quality was assessed the Lifelines Diet Score. Multiple linear regression and logistic regression were first used for the association between SES and vitamin status; and mediation analysis was used to explore the relationship of SES, diet and vitamin status. Results The overall prevalence of vitamin deficiency ranged from 4.1% (vitamin B6) to 19.5% (folic acid). The low SES group had significantly poorer status (p ≤ 0.04) of most vitamins, including the B vitamins (i.e., folic acid, B12 and B6) as well as multivitamin deficiencies (p ≤ 0.02). Low SES was independently associated with decreased folic acid, vitamin B6, vitamin B12, and vitamin A serum concentrations (p ≤ 0.03 for all). Diet quality was found to partially mediate the association between SES, and folic acid (39.1%), vitamin B6 (37.1%) and vitamin B12 (37.2%)(P ≤ 0.03). Conclusions Low SES is a risk factor for suboptimal nutritional status. The association between SES and nutritional status can be partially explained by diet quality, suggesting that policy makers can mitigate socioeconomic inequality in nutritional status by improving diet quality among elderly. Key messages Revealed that low SES was a risk factor for a suboptimal nutritional status among the elderly and a possible self-reinforcing trap has formed which causes low SES and hidden hunger to persist. Highlighted the importance of diet quality in socioeconomically patterned health disparities and indicating the need for SES-tailored public health strategies.

Purpose The aims of this study are to investigate the course of work functioning, health status, and work-related factors among cancer patients during 18 months after return to work (RTW) and to examine the associations between these variables and work functioning over time. Methods Data were used from the 18-month longitudinal “Work Life after Cancer” (WOLICA) cohort, among 384 cancer patients who resumed work. Linear mixed models were performed to examine the different courses during 18-month follow-up. Linear regression analyses with generalized estimating equations (GEE) were used to examine the associations and interactions. Results Cancer patients reported an increase of work functioning and a decrease of fatigue and depressive symptoms in the first 12 months, followed by a stable course between 12 and 18 months. Cognitive symptoms were stable during the first 18 months. Working hours increased and social support decreased during the first 6 months; both remained stable between 6 and 18 months. Fatigue, depressive, and cognitive symptoms were negatively associated with work functioning over time; working hours and supervisor social support were positively associated. Conclusions Interventions to improve cancer patients’ work functioning over time might be promising if they are aimed at reducing fatigue, depressive symptoms, cognitive symptoms, and encouraging supervisor social support. Implications for Cancer Survivors It is important to monitor cancer patients not only in the period directly after RTW but up to 18 months after RTW, allowing for timely interventions when needed.