1. Associations Between Muscle Weakness and Clinical Outcomes in Current and Former Smokers.
- Author
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Zou, Richard H, Nouraie, S Mehdi, Rossiter, Harry B, McDonald, Merry-Lynn, DeMeo, Dawn L, Mason, Stefanie, Washko, George R, Saha, Punam K, Make, Barry J, Casaburi, Richard, Regan, Elizabeth A, and Bon, Jessica
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Chronic Obstructive Pulmonary Disease ,Lung ,Respiratory ,Good Health and Well Being ,chronic obstructive pulmonary disease ,cigarette smoking ,COPDGene ,COPD outcomes ,musculoskeletal comorbidities ,COPDGene Investigators - Abstract
IntroductionSmokers with chronic obstructive pulmonary disease (COPD) are at increased risk of muscle weakness. There are limited data describing weakness in smokers with normal spirometry and preserved ratio-impaired spirometry (PRISm), 2 subgroups at risk of respiratory symptom burden and activity limitations. In this study, we evaluated the associations of 2 weakness measures, sit-to-stand (STS) and handgrip strength (HGS), with clinical outcomes in smokers with COPD, normal spirometry, and PRISm.MethodsWe evaluated 1972 current and former smokers from the COPD Genetic Epidemiology (COPDGene®) cohort with STS and HGS measurements at their 10-year study visit. Multivariable regression modeling was used to assess associations between weakness measures and the 6-minute walk distance (6MWD) test, the St George's Respiratory Questionnaire (SGRQ), the Short-Form-36 (SF-36), severe exacerbations, and prospective mortality, reported as standardized coefficients (β), odds ratios (ORs), or hazard ratios (HRs).ResultsCompared with HGS, STS was more strongly associated with the 6MWD (β=0.45, p
- Published
- 2023