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285 results on '"Samai, Mohamed"'

1. An intra-covid-19 assessment of hand hygiene facility, policy and staff compliance in two hospitals in Sierra Leone: Is there a difference between regional and capital city hospitals?

Author

Lakoh, Sulaiman, Firima, Emmanuel, Williams, Christine Ellen Elleanor, Conteh, Sarah K, Jalloh, Mohamed Boie, Sheku, Mohamed Gbeshay, Adekanmbi, Olukemi, Sevalie, Stephen, Kamara, Sylvia Adama, Kamara, Mohamed Akmed Salim, Barrie, Umu, Kamara, Gladys Nanilla, Yi, Le, Guo, Xuejun, Haffner, Chukwuemeka, Kamara, Matilda N, Jiba, Darlinda F, Namanaga, Enanga Sonia, Maruta, Anna, Kallon, Christiana, Kanu, Joseph Sam, Deen, Gibrilla F, Samai, Mohamed, Okeibunor, Joseph Chukwudi, and Russell, James BW

Published
2021

3. Coverage of intermittent preventive treatment of malaria in infants after four years of implementation in Sierra Leone

Author

Fombah, Augustin E., Chen, Haily, Owusu-Kyei, Kwabena, Quinto, Llorenç, Gonzalez, Raquel, Williams, Julian, Berne, Mireia LLach, Wassenaar, Myrte, Jalloh, Abubakarr, Sunders, Joe-Henry C., Ramirez, Maximo, Bertran-Cobo, Cesc, Saute, Francisco, Ekouevi, Didier K., Briand, Valérie, Kamara, Anitta R. Y., Sesay, Tom, Samai, Mohamed, and Menendez, Clara

Published
2023
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4. Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in infants: a phase 2, randomised, double-blind, active-controlled trial in Guinea and Sierra Leone

Author

Mooney, T, Conteh, L, Bangura, MS, Bangura, MA, Jalloh, H, Kamara, I, Kamara, M, Koroma, S, Sesay, M, Sesay, MT, Deen, AT, Kamara, A, Kamara, EL, Kamara, SLM, Koroma, AH, Mansaray, IS, Massaquoi, MJ, Nabie, A, Kowuor, D, Njie, Y, Odeny, L, Sheku, M, Jalloh, AB, Sow, A, Swaray, E, Mansaray, F, Sessie, T, Sunders, J-HC, Turay, SI-S, Weekes, J, Pessima, M, Wurie, A, Conteh, M, Jalloh, MI, Kamara, PBD, Kanneh, DP, Kanneh, M, Komeh, I, Koroma, M, Kuyateh, M, Mansaray, FF, Leigh, B, Watson-Jones, D, Samai, M, Deen, GF, Sesay, T, Piot, P, Greenwood, B, Lees, S, Larson, H, Afolabi, M, Ishola, D, Baiden, F, Faye, F, Tindanbil, D, Kamara, MM, Swaray, IB, Bangura, A, Kamara, AB, Morovia, FE, Kallon, JA, Murray, M, Sesay, F, Suma, F, Sesay, IG, Choi, EM, Manno, D, Foster, J, Rwezaula, R, Akhigbe, I, Adetola, H, Kamara, B, Lowe, B, Lawal, B, Kohn, B, Tuda, GO, Koroma, F, Bangura, G, Kroma, MT, Fofanah, L, Pessima, A, Rogers, M, Sheriff, O, Fangawa, J, Foday, S, Jabbie, I, Mansaray, HA, Sesay, K, Jakema, HB, Sheku, MF, Jalloh, KFN, Kabba, M, Kanjie, F, Kanu, AP, Kassa-Koroma, G, Jusu, M, Koroma, B, Borboh, P, Kallon, A, van Roey, K, Conteh, P, Samura, M, Gandie, V, Marrah, M, Kalokoh, J, Bangura, MI, Connor, N, Saidu, S, Turay, AS, Lahai, A, Johnson, CL, Kogba, DB, Vincent, W, Bangura, M, Tengbeh, A, Bangura, K, Kabia, R, Nyakoi, AM, Lee, S, Nyaberi, D, Ndingi, S, Nyallay, L, Bangura, AR, Idriss, B, Sillah, M, Mackay, W, Murray, T, Edem-Hotah, J, Fatorma, T, Bangura, S, Bonnie, E, Sannoh, M, Malcolm, S, Brown, J, Snowden, E, Howard, K, Ojugo, A, Massin-Shepherd, C, BEAVOGUI, AH, KEITA, CM, CAMARA, OK, GUILAVOGUI, JPY, BAH, H, SAMOURA, MA, MUAMBA, D, SEMAKUBA, B, CAMARA, AK, KABA, AS, BERERD-CAMARA, M, YARADOUNO, M, DECHENAUD, M, CAMARA, MT, TAMBALOU, J, HABA, M, DIALLO, SD, THEA, A, DOUMBOUYA, N, FOFANA, ML, BEAVOGUI, M, CAMARA, AA, BEAVOGUI, JT, DIOUF, W, AUGIER, A, BARTE DE SAINTE FARE, E, SIVAHERA MUYISA, B, SANI, S, VATRINET, R, HAMZE, B, LACARRA, B, D’ORTENZIO, E, ALE, B, BETARD, C, RICHERT, L, OULAI, D, KANTE, M, SOUTTHIPHONG, A-A, SCHWIMMER, C, THIÉBAUT, R, OTTAVI, A, COUFFIN-CADIERGUES, S, ESPEROU, H, Chai, SP, Buth, W, Offergeld, K, Menten, A, Hammoud, N, De Ridder, S, Sellecchia, R, in ’t Veld, R, Fogap, N, Anumendem, D, Stapleton, H, Reijns, T, Haydon, J, Roza, L, Sawyer, B, Hoda, S, Yee, J, De Cnodder, T, Hubin, E, Telen, L, Desai, J, Bennet, M, Pawlowski, M, van Gils, N, Boeykens, N, Kwasniak, A, Ligthart, M, Van Roey, G, Fernandez, E, Gaddah, A, van Dijck, W, Jingshuang, S, Randrasana, S, Artis, C, Akinbinu, A, Poretti, A, Van Ballaert, S, Harris, M, Van Looveren, M, Brandt, P, Robinson, C, Bockstal, V, McLean, C, Versteege, I, Ferrault, C, Kaminski, A, Vergauwen, H, Kerama, CI, Forcheh, CA, DiMondi, CV, Stewart, L, Meurer, J, Beounitis, A, Peeters, J, Su, C, Keshinro, B, Delport, C, Sharkie, E, Zhang, J, Du, C, Hu, K, Strydom, A, Bezem-Aviv, I, Wachnicka, A, Kumar, P, Cheng, S, Kang, K, Choi, Edward Man-Lik, Lacarra, Boris, Afolabi, Muhammed O, Ale, Boni Maxime, Baiden, Frank, Bétard, Christine, Foster, Julie, Hamzé, Benjamin, Schwimmer, Christine, Manno, Daniela, D’Ortenzio, Eric, Ishola, David, Keita, Cheick Mohamed, Keshinro, Babajide, Njie, Yusupha, van Dijck, Wim, Gaddah, Auguste, Anumendem, Dickson, Lowe, Brett, Vatrinet, Renaud, Lawal, Bolarinde Joseph, Otieno, Godfrey T, Samai, Mohamed, Deen, Gibrilla Fadlu, Swaray, Ibrahim Bob, Kamara, Abu Bakarr, Kamara, Michael Morlai, Diagne, Mame Aminata, Kowuor, Dickens, McLean, Chelsea, Leigh, Bailah, Beavogui, Abdoul Habib, Leyssen, Maarten, Luhn, Kerstin, Robinson, Cynthia, Douoguih, Macaya, Greenwood, Brian, Thiébaut, Rodolphe, and Watson-Jones, Deborah

Published
2023
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6. Prevalence of immunoglobulin G and M to SARS-CoV-2 and other human coronaviruses in The Democratic Republic of Congo, Sierra Leone, and Uganda: A longitudinal study

Author

Lawal, Bolarinde J., Gallagher, Katherine E., Kitonsa, Jonathan, Tindanbil, Daniel, Kasonia, Kambale, Drammeh, Abdoulie, Lowe, Brett, Mukadi-Bamuleka, Daniel, Patterson, Catriona, Greenwood, Brian, Samai, Mohamed, Leigh, Bailah, Tetteh, Kevin K.A., Ruzagira, Eugene, Watson-Jones, Deborah, and Kavunga-Membo, Hugo

Published
2023
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7. Immune response of a two-dose heterologous Ebola vaccine regimen: summary of three African clinical trials using a single validated Filovirus Animal Nonclinical Group enzyme-linked immunosorbent assay in a single accredited laboratory

Author

McLean, Chelsea, Barry, Houreratou, Kieh, Mark, Anywaine, Zacchaeus, Tapima Rogers, Baimba, Doumbia, Seydou, Sirima, Sodiomon B., Serry-Bangura, Alimamy, Habib Beavogui, Abdoul, Gaddah, Auguste, Katwere, Michael, Hendriks, Jenny, Keshinro, Babajide, Eholie, Serge, Kibuuka, Hannah, Kennedy, Stephen B., Anzala, Omu, Samai, Mohamed, D'Ortenzio, Eric, Leigh, Bailah, Sow, Samba, Thiébaut, Rodolphe, Greenwood, Brian, Watson-Jones, Deborah, Douoguih, Macaya, Luhn, Kerstin, and Robinson, Cynthia

Published
2023
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8. Safety and immunogenicity of an Ad26.ZEBOV booster dose in children previously vaccinated with the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen: an open-label, non-randomised, phase 2 trial

Author

Manno, Daniela, Bangura, Agnes, Baiden, Frank, Kamara, Abu Bakarr, Ayieko, Philip, Kallon, Joseph, Foster, Julie, Conteh, Musa, Connor, Nicholas Edward, Koroma, Bockarie, Njie, Yusupha, Borboh, Paul, Keshinro, Babajide, Lawal, Bolarinde Joseph, Kroma, Mattu Tehtor, Otieno, Godfrey Tuda, Deen, Abdul Tejan, Choi, Edward Man-Lik, Balami, Ahmed Dahiru, Gaddah, Auguste, McLean, Chelsea, Luhn, Kerstin, Adetola, Hammed Hassan, Deen, Gibrilla Fadlu, Samai, Mohamed, Lowe, Brett, Robinson, Cynthia, Leigh, Bailah, Greenwood, Brian, and Watson-Jones, Deborah

Published
2023
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9. Incidence and risk factors of surgical site infections and related antibiotic resistance in Freetown, Sierra Leone: a prospective cohort study

Author

Lakoh, Sulaiman, Yi, Le, Sevalie, Stephen, Guo, Xuejun, Adekanmbi, Olukemi, Smalle, Isaac O., Williams, Nathaniel, Barrie, Umu, Koroma, Celesis, Zhao, Yongkun, Kamara, Matilda N., Cummings-John, Constance, Jiba, Darlinda F., Namanaga, Enanga Sonia, Deen, Betsy, Zhang, Juling, Maruta, Anna, Kallon, Christiana, Liu, Peng, Wurie, Haja Ramatulai, Kanu, Joseph Sam, Deen, Gibrilla F., Samai, Mohamed, Sahr, Foday, and Firima, Emmanuel

Published
2022
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11. Impact of oral azithromycin and intermittent preventive treatment with sulfadoxine-pyrimethamine regimen on child mortality in Sierra Leone: trial protocol for a randomised, two-arm, double-blinded, placebo-controlled clinical trial (ICARIA).

Author

Owusu-kyei, Kwabena, Chen, Haily, Chileshe, Maureen, Quintó, Llorenç, Sibley, Maya, Figueroa-Romero, Antía, Llach, Mireia, Ramírez, Máximo, Bofill, Andreu, Samai, Mohamed, and Menéndez, Clara

Subjects
CLINICAL trials, CHILD mortality, MORTALITY, COMMUNICABLE diseases, DRUG resistance in microorganisms
Abstract

Background: Azithromycin has been shown to be beneficial in preventing infectious diseases, including malaria, infectious diarrhoea and pneumonia. A cluster randomised control trial on azithromycin MDA in children in Niger, Malawi and Tanzania found a reduction in all-cause under-five (U5) mortality in communities who received azithromycin compared to placebo. However, the reduction was largest and statistically significant only in Niger. The purpose of this trial is to evaluate the impact of azithromycin plus intermittent preventive treatment in infants (IPTi), recently renamed by the World Health Organisation as perennial malaria chemoprevention (PMC), with sulfadoxine-pyrimethamine (SP) on all-cause mortality up to 18 months of age in children living in areas of high mortality burden through the Expanded Program on Immunisation (EPI) in Sierra Leone. Methods: The Improving Care through Azithromycin Research for Infants in Africa (ICARIA) trial is a phase III two-arm, individually randomised, double-blinded, placebo-controlled trial administering oral AZI (20 mg/kg bodyweight) at three time points to children attending EPI visits in Sierra Leone. A total of 20,560 infants attending the first EPI contact at around 6 weeks of age are recruited and randomised to AZI or placebo in a 1:1 ratio. The second and third AZI/placebo doses are given at 9 and 15 months of age. The primary outcome of the trial is all-cause mortality rate at 18 months of age assessed through mortality surveillance. Other trial outcomes include the impact on antimicrobial resistance, and on the immune response to certain key routine EPI immunisations, the safety of the intervention, the prevalence of SP resistance markers and the feasibility, and acceptability of adding AZI to the EPI programme. Discussion: The trial will provide the evidence needed to inform policy regarding the adoption and large-scale implementation of AZI in areas of high-mortality burden in sub-Saharan Africa. Trial registration: ClinicalTrials.gov NCT04235816. Registered on 22 January 2020. Pan-African Clinical Trials Registry PACTR202004540256535. Registered on 14 April 2020. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in children in Sierra Leone: a randomised, double-blind, controlled trial

Author

Kargbo, M, Bockarie, E, James, N L, Kabbah, A, Kamara, A, Koroma, K H, Langley, S O, William, N, Kessebeh, R, Mooney, T, Conteh, L, Smout, E, Allieu, K, Bangura, K, Bangura, M S, Bangura, M A, Jalloh, H, Jalloh, A B, Kamara, I, Kamara, M, Konteh, A, Koroma, S, Marrah, C, Sesay, M, Sesay, M T, Deen, A T, Jalloh, A, Kaimbay, R M, Kain, D, Kamara, E L, Kamara, M P, Kamara, O J, Kamara, S L M, Kanneh, M, Koroma, A H, Lahai, D, Mansaray, I S, Marah, W S, Massaquoi, M J, Nabie, A, Saidu, N S, Samai, I, Tengheh, J N, Turay, A S, Fornah, A, Sesay, F, Sow, A, Swaray, E, Mansaray, F, Ade-Cole, T, Bangura, L M, Conteh, M L, Koroma, A M, Koroma, M, Sam, A, Scott, T, Sessie, T, Sunders, J-H C, Turay, S I-S, Weekes, J, Sheku, M, Gibson, L, Kowuor, D, Ahamed, I, Allieu, W, Kabba, D U, Kamara, F J, Kebbie, M S, Pessima, M, Wurie, A, Bah, F, Bangura, A I, Bangura, R A S, Blango, L, Boima, S, Conteh, M, Conteh, Y, Daramy, M L, Fofanah, O, George, E, Hanson, T F, Jalloh, M I, Kalawa, M, Kamara, A M, Kamara, F E, Kamara, G M, Kamara, H M, Kamara, P B D, Kamara, R T, Kamara, R, Kanneh, D P, Komeh, I, Kuyateh, M, Mansaray, F F, Mansaray, M M, Sillah, A B, Tarawally, M A, Turya, O S, Yawmah, J B, Leigh, B, Watson-Jones, D, Greenwood, B, Samai, M H, Deen, G F, Marke, D, Sesay, T, Piot, P, Smith, P, Edmunds, J, Lees, S, Larson, H, Weiss, H, Wilson, P, Phillips, R, Maxwell, C, Ishola, D, Afolabi, M, Baiden, F, Akoo, P, Owusu-Kyei, K, Tindanbil, D, Bower, H, Stuart, J, Bah, O M, Rogers, B T, Serry-Bangura, A, Swaray, I B, Bangura, A, David, I J, Davies, D G M, Kallon, J A, Kamara, A B, Kamara, I F, Kamara, M M, Morovia, F E, Suma, F B, Thompson, F, Murray, M, Kakay, O, Suma, F, Sesay, I, Foster, J, Manno, D, Gallagher, K, Cox, S, Howard, N, Cesay, M, Torrani, P, Sharma, S, Snowden, E, Banks, T, Harber, T, Brown, J, Howard, K, Melton, N, Malcolm, S, Welsh, S, Eggo, R, Jendrossek, M, Pearson, C, Offergeld, K, Ferrault, C, Van Alst, M, Mahajan, N, Van Looveren, M, Van Ballaert, S, De Cnodder, T, Grobler, N, Roza, L, Liberi, T, Armishaw, L, Verkleij, C, Henrick, T, Banaszkiewicz, A, Lowe, B, Awuondo, K, Hafezi, H, Hancox, E, Kohn, B, Tuda, G O, Bangura, G, Kroma, M T, Fofanah, L, Pessima, A, Rogers, M, Sheriff, O, Ajala, T W, Fangawa, J, Foday Jr, S, Koroma, I S F, Mansaray, B, Mansaray, H A, Sesay, K, Charles, M K, Heroe, P C, Lamin Karbo, M, Yansaneh, I S, Gogo Egoeh, S, Trye, A, Amponsah, M, Donelson, L, Sylvester, T, Owira, V, Onyuka, G, Nambuchi, L, Oburu, A, Apollo, D, Vandi, L, Alghali, N D, Bah, A, Bangura, I J, Cole, A C, Fofanah, S, Jalloh, H U, Jalloh, K F N, Jalloh, N, Kabba, H U, Kabba, J N, Kabba, M, Kamara, J S, Kanjie, F, Kanu, A P, Kargbo, I, Kassa-Koroma, G, Koroma, S B, Sankoh, A, Sankoh, T, Sesay, O D, Wilhem, H, Williams, C T, Bangura, I, Ben-Rogers, Y, Jamboria, F J, Kamara, N, Kanawah, I, Kargbo, A T, Swaray, I, Amara, L, Bundu, I, Jakema, H B, Kamara, K, Sheku, M F, Adeleye, Q, Akhigbe, I, Bakalemwa, R, Chami, N P, Altmann, L, Kamara, B, van Roey, K, Conteh, P, Samura, M, Gandie, V, Marrah, M, Moinina, E, Kalokoh, J, Bosompem, S, Hilton, T, Jusu, M O, Borboh, P, Brima, A S, Caulker, A F Y, Kallon, A, Koroma, B, Macauley, R C, Saquee, T M D, Williams, H I, Bangura, A R, Fornah, J, Idriss, B, Sillah, M, Mackay, W, Aleghen, B, Murray, T, Edem-Hotah, J, Fatorma, T, Amara, F, Bangura, S, Bonnie, E, Sannoh, M, Donaldson, A, Ndingi, S, Nyaberi, D, Pereira, M, Rothwell, A, Vy, V, Nyallay, L, Fombah, A, Saidu, S, Dambo, T P, Fakaba, P J, Fatorma, M M E, Freeman, R H, Johnson, C L, Kogba, D B, Lahai, A, Vincent, W, Yambasu, N, Bangura, M, Tengbeh, A, Kabia, R, Nyakoi, A M, Callaghan, M, Enria, L, Lee, S, Afolabi, Muhammed O, Ishola, David, Manno, Daniela, Keshinro, Babajide, Bockstal, Viki, Rogers, Baimba, Owusu-Kyei, Kwabena, Serry-Bangura, Alimamy, Swaray, Ibrahim, Lowe, Brett, Kowuor, Dickens, Baiden, Frank, Mooney, Thomas, Smout, Elizabeth, Köhn, Brian, Otieno, Godfrey T, Jusu, Morrison, Foster, Julie, Samai, Mohamed, Deen, Gibrilla Fadlu, Larson, Heidi, Lees, Shelley, Goldstein, Neil, Gallagher, Katherine E, Gaddah, Auguste, Heerwegh, Dirk, Callendret, Benoit, Luhn, Kerstin, Robinson, Cynthia, Greenwood, Brian, Leyssen, Maarten, Douoguih, Macaya, Leigh, Bailah, and Watson-Jones, Deborah

Published
2022
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13. Safety and long-term immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in adults in Sierra Leone: a combined open-label, non-randomised stage 1, and a randomised, double-blind, controlled stage 2 trial

Author

Kargbo, M, Bockarie, E, James, N L, Kabbah, A, Kamara, A, Koroma, K H, Langley, S O, William, N, Kessebeh, R, Mooney, T, Conteh, L, Smout, E, Allieu, K, Bangura, K, Bangura, M S, Bangura, M A, Jalloh, H, Jalloh, A B, Kamara, I, Kamara, M, Konteh, A, Koroma, S, Marrah, C, Sesay, M, Sesay, M T, Deen, A T, Jalloh, A, Kaimbay, R M, Kain, D, Kamara, E L, Kamara, M P, Kamara, O J, Kamara, S L M, Kanneh, M, Koroma, A H, Lahai, D, Mansaray, I S, Marah, W S, Massaquoi, M J, Nabie, A, Saidu, N S, Samai, I, Tengheh, J N, Turay, A S, Fornah, A, Sesay, F, Sow, A, Swaray, E, Mansaray, F, Ade-Cole, T, Bangura, L M, Conteh, M L, Koroma, A M, Koroma, M, Sam, A, Scott, T, Sessie, T, Sunders, J-H C, Turay, S I-S, Weekes, J, Sheku, M, Gibson, L, Kowuor, D, Ahamed, I, Allieu, W, Kabba, D U, Kamara, F J, Kebbie, M S, Pessima, M, Wurie, A, Bah, F, Bangura, A I, Bangura, R A S, Blango, L, Boima, S, Conteh, M, Conteh, Y, Daramy, M L, Fofanah, O, George, E, Hanson, T F, Jalloh, M I, Kalawa, M, Kamara, A M, Kamara, F E, Kamara, G M, Kamara, H M, Kamara, P B D, Kamara, R T, Kamara, R, Kanneh, D P, Komeh, I, Kuyateh, M, Mansaray, F F, Mansaray, M M, Sillah, A B, Tarawally, M A, Turya, O S, Yawmah, J B, Leigh, B, Watson-Jones, D, Greenwood, B, Samai, M H, Deen, G F, Marke, D, Piot, P, Smith, P, Edmunds, J, Lees, S, Larson, H, Weiss, H, Wilson, P, Maxwell, C, Ishola, D, Afolabi, M, Baiden, F, Akoo, P, Owusu-Kyei, K, Tindanbil, D, Bower, H, Stuart, J, Bah, O M, Rogers, B T, Serry-Bangura, A, Swaray, I B, Bangura, A, David, I J, Davies, D G M, Kallon, J A, Kamara, A B, Kamara, I F, Kamara, M M, Morovia, F E, Suma, F B, Thompson, F, Murray, M, Sesay, I, Kakay, O, Suma, F, Foster, J, Philips, R, Manno, D, Gallager, K, Cox, S, Howard, N, Cesay, M, Torrani, P, Sharma, S, Snowden, E, Banks, T, Harber, T, Brown, J, Howard, K, Melton, N, Malcolm, S, Welsh, S, Eggo, R, Jendrossek, M, Pearson, C, Van Hoof, J, Douoguih, M, Offergelt, K, Robinson, C, Keshinro, B, Van Alst, M, Mahajan, N, Bockstal, V, Goldstein, N, Gaddah, A, Heerwegh, D, Luhn, K, Leyssen, M, Lowe, B, Awuondo, K, Hafezi, H, Hancox, E, Kohn, B, Tuda, G O, Koroma, F, Bangura, G, Kroma, M T, Fofanah, L, Pessima, A, Rogers, M, Sheriff, O, Ajala, T W, Fangawa, J, Foday Jr, S, Jabbie, I, Mansaray, B, Mansaray, H A, Sesay, K, Charles, M K, Heroe, P C, Karbo, M L, Yansaneh, IS, Egoeh, S G, Trye, A, Amponsah, M, Alghali, N D, Bah, A, Bangura, IJ, Cole, A C, Fofanah, K, Fofanah, S, Jalloh, H U, Jalloh, K F N, Jalloh, N, Kabba, H U, Kabba, J N, Kabba, M, Kamara, J S, Kanjie, F, Kanu, A P, Kargbo, I, Kassa-Koroma, G, Koroma, S B, Sankoh, A, Sankoh, T, Sesay, O D, Wilhem, H, Williams, C T, Bangura, I, Ben-Rogers, Y, Jamboria, F J, Kamara, N, Kanawah, I, Kargbo, A T, Swaray, I, Amara, L, Bundu, I, Jakema, H B, Kamara, K, Sheku, M F, Adeleye, Q, Akhigbe, I, Bakalemwa, R, Chami, N P, Sylvester, T, Altmann, L, Kamara, B, van Roey, K, Conteh, P, Samura, M, Gandie, V, Marrah, M, Moinina, E, Kalokoh, J, Bangura, M I, Bosompem, S, Hilton, T, Jusu, M O, Borboh, P, Brima, A S, Caulker, A F Y, Kallon, A, Koroma, B, Macauley, RC, Saquee, T M D, Williams, H I, Bangura, A R, Fornah, J, Idriss, B, Sillah, M, Mackay, W, Aleghen, B, Murray, T, Edem-Hotah, J, Fatorma, T, Amara, F, Bangura, S, Bonnie, E, Sannoh, M, Donaldson, A, Ndingi, S, Nyaberi, D, Pereira, M, Rothwell, A, Vy, V, Nyallay, L, Fombah, A, Saidu, S, Connor, N, Dambo, T P, Fakaba, P J, Fatorma, M M E, Johnson, C L, Kogba, D B, Lahai, A, Vincent, W, Yambasu, N, Bangura, M, Tengbeh, A, Kabia, R, Nyakoi, AM, Callaghan, M, Enria, L, Lee, S, Ishola, David, Manno, Daniela, Afolabi, Muhammed O, Keshinro, Babajide, Bockstal, Viki, Rogers, Baimba, Owusu-Kyei, Kwabena, Serry-Bangura, Alimamy, Swaray, Ibrahim, Lowe, Brett, Kowuor, Dickens, Baiden, Frank, Mooney, Thomas, Smout, Elizabeth, Köhn, Brian, Otieno, Godfrey T, Jusu, Morrison, Foster, Julie, Samai, Mohamed, Deen, Gibrilla Fadlu, Larson, Heidi, Lees, Shelley, Goldstein, Neil, Gallagher, Katherine E, Gaddah, Auguste, Heerwegh, Dirk, Callendret, Benoit, Luhn, Kerstin, Robinson, Cynthia, Leyssen, Maarten, Greenwood, Brian, Douoguih, Macaya, Leigh, Bailah, and Watson-Jones, Deborah

Published
2022
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14. An Assessment of Medication Errors Among Pediatric Patients in Three Hospitals in Freetown Sierra Leone: Findings and Implications for a Low-Income Country

Author

Abiri, Onome, primary, Ninka, Alex, additional, Coker, Joshua, additional, Thomas, Fawzi, additional, Smalle, Isaac, additional, Lakoh, Sulaiman, additional, Turay, Foday, additional, Komeh, James, additional, Sesay, Mohamed, additional, Kanu, Joseph, additional, Mustapha, Ayeshatu, additional, Bell, Nellie, additional, Conteh, Thomas, additional, Conteh, Sarah, additional, Jalloh, Alhaji, additional, Russell, James, additional, Sesay, Noah, additional, Bawoh, Mohamed, additional, Samai, Mohamed, additional, and Lahai, Michael, additional

Published
2024
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16. Immunisation coverage and factors associated with incomplete immunisation in children under two during the COVID-19 pandemic in Sierra Leone

Author

Wassenaar, Myrte, Fombah, Augustin E., Chen, Haily, Owusu-Kyei, Kwabena, Williams, Julian, Sunders, Joe Henry C., Llach, Mireia, Quinto, Llorenç, Sesay, Tom, Samai, Mohamed, Menéndez, Clara, González, Raquel, Wassenaar, Myrte, Fombah, Augustin E., Chen, Haily, Owusu-Kyei, Kwabena, Williams, Julian, Sunders, Joe Henry C., Llach, Mireia, Quinto, Llorenç, Sesay, Tom, Samai, Mohamed, Menéndez, Clara, and González, Raquel

Published
2024

17. An Assessment of Medication Errors Among Pediatric Patients in Three Hospitals in Freetown Sierra Leone: Findings and Implications for a Low-Income Country

Author

Abiri,Onome, Ninka,Alex, Coker,Joshua, Thomas,Fawzi, Smalle,Isaac, Lakoh,Sulaiman, Turay,Foday, Komeh,James, Sesay,Mohamed, Kanu,Joseph, Mustapha,Ayeshatu, Bell,Nellie, Conteh,Thomas, Conteh,Sarah, Jalloh,Alhaji, Russell,James, Sesay,Noah, Bawoh,Mohamed, Samai,Mohamed, Lahai,Michael, Abiri,Onome, Ninka,Alex, Coker,Joshua, Thomas,Fawzi, Smalle,Isaac, Lakoh,Sulaiman, Turay,Foday, Komeh,James, Sesay,Mohamed, Kanu,Joseph, Mustapha,Ayeshatu, Bell,Nellie, Conteh,Thomas, Conteh,Sarah, Jalloh,Alhaji, Russell,James, Sesay,Noah, Bawoh,Mohamed, Samai,Mohamed, and Lahai,Michael

Abstract

Onome T Abiri,1,2 Alex Ninka,3 Joshua Coker,4 Fawzi Thomas,2,5 Isaac O Smalle,6 Sulaiman Lakoh,4 Foday Umaro Turay,7 James Komeh,2,3 Mohamed Sesay,2,7 Joseph Sam Kanu,8 Ayeshatu M Mustapha,9 Nellie VT Bell,9 Thomas Ansumus Conteh,2,5 Sarah Kadijatu Conteh,10 Alhaji Alusine Jalloh,10 James BW Russell,4 Noah Sesay,3 Mohamed Bawoh,1 Mohamed Samai,1 Michael Lahai7 1Department of Pharmacology and Therapeutics, College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone; 2Department of Pharmacovigilance and Clinical Trials, Pharmacy Board of Sierra Leone, Freetown, Sierra Leone; 3Department of Clinical Pharmacy and Therapeutics, College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone; 4Department of Internal Medicine, College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone; 5Department of Pharmaceutics, College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone; 6Department of Surgery, College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone; 7Department of Pharmaceutical Chemistry, College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone; 8Department of Community Medicine, College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone; 9Department of Pediatrics, Ola During Children Hospital, Freetown, Sierra Leone; 10Department of Pediatrics, King Harman Road Maternity and Children Hospital, Freetown, Sierra LeoneCorrespondence: Onome T Abiri, Department of Pharmacology and Therapeutics, College of Medicine and Allied Health Sciences, University of Sierra Leone Freetown, Sierra Leone/Department of Pharmacovigilance and Clinical Trials, Pharmacy Board of Sierra Leone, Freetown, Sierra Leone, Tel +23276370315, Email berylonome@gmail.comBackground: Pediatric patients are prone to medicine-relat

Published
2024

18. Immunisation coverage and factors associated with incomplete immunisation in children under two during the COVID-19 pandemic in Sierra Leone

Author

Wassenaar, Myrte, primary, Fombah, Augustin E., additional, Chen, Haily, additional, Owusu-Kyei, Kwabena, additional, Williams, Julian, additional, Sunders, Joe-Henry C., additional, Llach, Mireia, additional, Quinto, Llorenç, additional, Sesay, Tom, additional, Samai, Mohamed, additional, Menéndez, Clara, additional, and González, Raquel, additional

Published
2024
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19. PA-605 Acceptability and feasibility of perennial malaria chemoprevention for children under two years: a mixed method pre-implementation assessment in Togo (MULTIPLY project)

Author

Dzoka, Koku, primary, Revollon, Natacha, additional, Gbeasor-Komlanvi, Diane Fifonsi, additional, Sadio, Arnold, additional, Arikawa, Shino, additional, Konu, Rodion, additional, Battha, Bandana, additional, Enguita-Fernandez, Cristina, additional, Tchankoni, Martin, additional, Atchrimi, Bernard Tossou, additional, Saute, Francisco, additional, Briand, Valérie, additional, Samai, Mohamed, additional, Ekouevi, Didier K, additional, Menendez, Clara, additional, and Orne-Gliemann, Joanna, additional

Published
2023
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20. PA-566 Acceptability and feasibility of a pilot malaria prevention strategy for children under two years in Sierra Leone: a mixed methods study among health care workers

Author

Bakarr, Jalloh Abu, primary, Bhatta, Bandana, additional, Fombah, Augustin, additional, Alonso, Yara, additional, Saute, Francisco, additional, Ekouevi, Didier K, additional, Briand, Valérie, additional, Samai, Mohamed, additional, Menéndez, Clara, additional, and Orne-Gliemann, Joanna, additional

Published
2023
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21. PA-466 Factors associated with coverage of three doses of intermittent preventive treatment of malaria in infants with Sulfadoxine-pyrimethamine: a cross-sectional community-based survey in Sierra Leone

Author

Fombah, Augustin E, primary, Chen, Haily, additional, Owusu-Kyei, Kwabena, additional, Quinto, Llorenç, additional, Gonzalez, Raquel, additional, Williams, Julian, additional, Berne, Mireia LLach, additional, Wassenaar, Myrte, additional, Jalloh, Abubakarr, additional, Sunders, Joe-Henry C, additional, Ramirez, Maximo, additional, Bertran-Cobo, Cesc, additional, Saute, Francisco, additional, Ekouevi, Didier K, additional, Briand, Valérie, additional, Kamara, Anitta RY, additional, Sesay, Tom, additional, Samai, Mohamed, additional, and Menendez, Clara, additional

Published
2023
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22. PA-574 Prevalence and factors associated with malaria infection in children aged 10 to 23 months in Togo in 2022

Author

Tchankoni, Martin Kouame, primary, Arikawa, Shino, additional, Gbeasor-Komlanvi, Fifonsi Adjidossi, additional, Sadio, Arnold Junior, additional, Figueroa-Romero, Antia, additional, Berne, Mireia LLach, additional, González, Raquel, additional, Bertran-Cobo, Cesc, additional, Saute, Francisco, additional, Ekouevi, Didier Koumavi, additional, Briand, Valérie, additional, Samai, Mohamed, additional, and Menendez, Clara, additional

Published
2023
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23. Pregnancy Outcomes among Women Receiving rVSV[DELTA]-ZEBOV-GP Ebola Vaccine during the Sierra Leone Trial to Introduce a Vaccine against Ebola

Author

Legardy-Williams, Jennifer K., Carter, Rosalind J., Goldstein, Susan T., Jarrett, Olamide D., Szefer, Elena, Fombah, Augustin E., Tinker, Sarah C., Samai, Mohamed, and Mahon, Barbara E.

Subjects
Ebola hemorrhagic fever -- Prevention, Pregnancy complications -- Risk factors, Medical research, Ebola vaccines -- Complications and side effects, Vaccines, Virus diseases, Genetic disorders, Infants, Clinical trials, Pregnant women, Vaccination, Viremia, Health
Abstract

The 2014-2016 West Africa Ebola virus disease outbreak was unprecedented in magnitude and complexity, resulting in >28,000 cases and >11,000 deaths in the 3 highly affected countries (Sierra Leone, Guinea, [...]

Published
2020
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24. Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in infants: a phase 2, randomised, double-blind, active-controlled trial in Guinea and Sierra Leone

Author

Choi, Edward Man-Lik, primary, Lacarra, Boris, additional, Afolabi, Muhammed O, additional, Ale, Boni Maxime, additional, Baiden, Frank, additional, Bétard, Christine, additional, Foster, Julie, additional, Hamzé, Benjamin, additional, Schwimmer, Christine, additional, Manno, Daniela, additional, D’Ortenzio, Eric, additional, Ishola, David, additional, Keita, Cheick Mohamed, additional, Keshinro, Babajide, additional, Njie, Yusupha, additional, van Dijck, Wim, additional, Gaddah, Auguste, additional, Anumendem, Dickson, additional, Lowe, Brett, additional, Vatrinet, Renaud, additional, Lawal, Bolarinde Joseph, additional, Otieno, Godfrey T, additional, Samai, Mohamed, additional, Deen, Gibrilla Fadlu, additional, Swaray, Ibrahim Bob, additional, Kamara, Abu Bakarr, additional, Kamara, Michael Morlai, additional, Diagne, Mame Aminata, additional, Kowuor, Dickens, additional, McLean, Chelsea, additional, Leigh, Bailah, additional, Beavogui, Abdoul Habib, additional, Leyssen, Maarten, additional, Luhn, Kerstin, additional, Robinson, Cynthia, additional, Douoguih, Macaya, additional, Greenwood, Brian, additional, Thiébaut, Rodolphe, additional, Watson-Jones, Deborah, additional, Mooney, T, additional, Conteh, L, additional, Bangura, MS, additional, Bangura, MA, additional, Jalloh, H, additional, Kamara, I, additional, Kamara, M, additional, Koroma, S, additional, Sesay, M, additional, Sesay, MT, additional, Deen, AT, additional, Kamara, A, additional, Kamara, EL, additional, Kamara, SLM, additional, Koroma, AH, additional, Mansaray, IS, additional, Massaquoi, MJ, additional, Nabie, A, additional, Kowuor, D, additional, Njie, Y, additional, Odeny, L, additional, Sheku, M, additional, Jalloh, AB, additional, Sow, A, additional, Swaray, E, additional, Mansaray, F, additional, Sessie, T, additional, Sunders, J-HC, additional, Turay, SI-S, additional, Weekes, J, additional, Pessima, M, additional, Wurie, A, additional, Conteh, M, additional, Jalloh, MI, additional, Kamara, PBD, additional, Kanneh, DP, additional, Kanneh, M, additional, Komeh, I, additional, Koroma, M, additional, Kuyateh, M, additional, Mansaray, FF, additional, Leigh, B, additional, Watson-Jones, D, additional, Samai, M, additional, Deen, GF, additional, Sesay, T, additional, Piot, P, additional, Greenwood, B, additional, Lees, S, additional, Larson, H, additional, Afolabi, M, additional, Ishola, D, additional, Baiden, F, additional, Faye, F, additional, Tindanbil, D, additional, Kamara, MM, additional, Swaray, IB, additional, Bangura, A, additional, Kamara, AB, additional, Morovia, FE, additional, Kallon, JA, additional, Murray, M, additional, Sesay, F, additional, Suma, F, additional, Sesay, IG, additional, Choi, EM, additional, Manno, D, additional, Foster, J, additional, Rwezaula, R, additional, Akhigbe, I, additional, Adetola, H, additional, Kamara, B, additional, Lowe, B, additional, Lawal, B, additional, Kohn, B, additional, Tuda, GO, additional, Koroma, F, additional, Bangura, G, additional, Kroma, MT, additional, Fofanah, L, additional, Pessima, A, additional, Rogers, M, additional, Sheriff, O, additional, Fangawa, J, additional, Foday, S, additional, Jabbie, I, additional, Mansaray, HA, additional, Sesay, K, additional, Jakema, HB, additional, Sheku, MF, additional, Jalloh, KFN, additional, Kabba, M, additional, Kanjie, F, additional, Kanu, AP, additional, Kassa-Koroma, G, additional, Jusu, M, additional, Koroma, B, additional, Borboh, P, additional, Kallon, A, additional, van Roey, K, additional, Conteh, P, additional, Samura, M, additional, Gandie, V, additional, Marrah, M, additional, Kalokoh, J, additional, Bangura, MI, additional, Connor, N, additional, Saidu, S, additional, Turay, AS, additional, Lahai, A, additional, Johnson, CL, additional, Kogba, DB, additional, Vincent, W, additional, Bangura, M, additional, Tengbeh, A, additional, Bangura, K, additional, Kabia, R, additional, Nyakoi, AM, additional, Lee, S, additional, Nyaberi, D, additional, Ndingi, S, additional, Nyallay, L, additional, Bangura, AR, additional, Idriss, B, additional, Sillah, M, additional, Mackay, W, additional, Murray, T, additional, Edem-Hotah, J, additional, Fatorma, T, additional, Bangura, S, additional, Bonnie, E, additional, Sannoh, M, additional, Malcolm, S, additional, Brown, J, additional, Snowden, E, additional, Howard, K, additional, Ojugo, A, additional, Massin-Shepherd, C, additional, BEAVOGUI, AH, additional, KEITA, CM, additional, CAMARA, OK, additional, GUILAVOGUI, JPY, additional, BAH, H, additional, SAMOURA, MA, additional, MUAMBA, D, additional, SEMAKUBA, B, additional, CAMARA, AK, additional, KABA, AS, additional, BERERD-CAMARA, M, additional, YARADOUNO, M, additional, DECHENAUD, M, additional, CAMARA, MT, additional, TAMBALOU, J, additional, HABA, M, additional, DIALLO, SD, additional, THEA, A, additional, DOUMBOUYA, N, additional, FOFANA, ML, additional, BEAVOGUI, M, additional, CAMARA, AA, additional, BEAVOGUI, JT, additional, DIOUF, W, additional, AUGIER, A, additional, BARTE DE SAINTE FARE, E, additional, SIVAHERA MUYISA, B, additional, SANI, S, additional, VATRINET, R, additional, HAMZE, B, additional, LACARRA, B, additional, D’ORTENZIO, E, additional, ALE, B, additional, BETARD, C, additional, RICHERT, L, additional, OULAI, D, additional, KANTE, M, additional, SOUTTHIPHONG, A-A, additional, SCHWIMMER, C, additional, THIÉBAUT, R, additional, OTTAVI, A, additional, COUFFIN-CADIERGUES, S, additional, ESPEROU, H, additional, Chai, SP, additional, Buth, W, additional, Offergeld, K, additional, Menten, A, additional, Hammoud, N, additional, De Ridder, S, additional, Sellecchia, R, additional, in ’t Veld, R, additional, Fogap, N, additional, Anumendem, D, additional, Stapleton, H, additional, Reijns, T, additional, Haydon, J, additional, Roza, L, additional, Sawyer, B, additional, Hoda, S, additional, Yee, J, additional, De Cnodder, T, additional, Hubin, E, additional, Telen, L, additional, Desai, J, additional, Bennet, M, additional, Pawlowski, M, additional, van Gils, N, additional, Boeykens, N, additional, Kwasniak, A, additional, Ligthart, M, additional, Van Roey, G, additional, Fernandez, E, additional, Gaddah, A, additional, van Dijck, W, additional, Jingshuang, S, additional, Randrasana, S, additional, Artis, C, additional, Akinbinu, A, additional, Poretti, A, additional, Van Ballaert, S, additional, Harris, M, additional, Van Looveren, M, additional, Brandt, P, additional, Robinson, C, additional, Bockstal, V, additional, McLean, C, additional, Versteege, I, additional, Ferrault, C, additional, Kaminski, A, additional, Vergauwen, H, additional, Kerama, CI, additional, Forcheh, CA, additional, DiMondi, CV, additional, Stewart, L, additional, Meurer, J, additional, Beounitis, A, additional, Peeters, J, additional, Su, C, additional, Keshinro, B, additional, Delport, C, additional, Sharkie, E, additional, Zhang, J, additional, Du, C, additional, Hu, K, additional, Strydom, A, additional, Bezem-Aviv, I, additional, Wachnicka, A, additional, Kumar, P, additional, Cheng, S, additional, and Kang, K, additional

Published
2023
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25. The Sierra Leone Trial to Introduce a Vaccine Against Ebola : An Evaluation of rVSVΔG-ZEBOV-GP Vaccine Tolerability and Safety During the West Africa Ebola Outbreak

Author

STRIVE Study Team, Samai, Mohamed, Seward, Jane F., Goldstein, Susan T., Mahon, Barbara E., Lisk, Durodami Radcliffe, Widdowson, Marc-Alain, Jalloh, Mohamed I., Schrag, Stephanie J., Idriss, Ayesha, Carter, Rosalind J., Dawson, Peter, Kargbo, S. A. S., Leigh, Bailah, Bawoh, Mohamed, Legardy-Williams, Jennifer, Deen, Gibrilla, Carr, Wendy, Callis, Amy, Lindblad, Robert, Russell, James B. W., Petrie, Carey R., Fombah, Augustin E., Kargbo, Brima, McDonald, Wendi, Jarrett, Olamide D., Walker, Robert E., Gargiullo, Paul, Bash-Taqi, Donald, Gibson, Laura, Fofanah, Abu Bakarr, and Schuchat, Anne

Published
2018

27. Monitoring Serious Adverse Events in the Sierra Leone Trial to Introduce a Vaccine Against Ebola

Author

Jarrett, Olamide D., Seward, Jane F., Fombah, Augustin E., Lindblad, Robert, Jalloh, Mohamed I., El-Khorazaty, Jill, Dawson, Peter, Burton, Deron, Zucker, Jane, Carr, Wendy, Bah, Mohamed M., Deen, Gibrilla F., George, Peter M, James, Faustine, Lisk, Durodami R., Pratt, Dudley, Russell, James B. W., Sandy, Jibao D., Turay, Patrick, Hamel, Mary J., Schrag, Stephanie J., Walker, Robert E., Samai, Mohamed, and Goldstein, Susan T.

Published
2018

28. Health Conditions in an Adult Population in Sierra Leone : Data Reported From the Sierra Leone Trial to Introduce a Vaccine Against Ebola (STRIVE)

Author

Fombah, Augustin E., Goldstein, Susan T., Jarrett, Olamide D., Jalloh, Mohamed I., El-Khorazaty, Jill, Lisk, Durodami Radcliffe, Legardy-Williams, Jennifer, Pratt, Dudley A., George, Peter M., Russell, James B. W., Schrag, Stephanie J., Dawson, Peter, Deen, Gibrilla F., Carr, Wendy, Lindblad, Robert, James, Faustine, Bah, Mohamed M., Yillia, John F., Sandy, Jibao D., Turay, Patrick E., Conteh, Muhammad-Abbas, Slutsker, Laurence, Mahon, Barbara E., Samai, Mohamed, and Seward, Jane F.

Published
2018

30. Implementing a Multisite Clinical Trial in the Midst of an Ebola Outbreak : Lessons Learned From the Sierra Leone Trial to Introduce a Vaccine Against Ebola

Author

Carter, Rosalind J., Idriss, Ayesha, Widdowson, Marc-Alain, Samai, Mohamed, Schrag, Stephanie J., Legardy-Williams, Jennifer K., Estivariz, Concepcion F., Callis, Amy, Carr, Wendy, Webber, Winston, Fischer, Marc E., Hadler, Stephen, Sahr, Foday, Thompson, Melvina, Greby, Stacie M., Edem-Hotah, Joseph, Momoh, Roselyn M’baindu, McDonald, Wendi, Gee, Julianne M., Kallon, Ahamed Flagbata, Spencer-Walters, Dayo, Bresee, Joseph S., Cohn, Amanda, Hersey, Sara, Gibson, Laura, Schuchat, Anne, and Seward, Jane F.

Published
2018

31. Clinical Surveillance and Evaluation of Suspected Ebola Cases in a Vaccine Trial During an Ebola Epidemic : The Sierra Leone Trial to Introduce a Vaccine Against Ebola

Author

Conteh, Muhammad-Abbas, Goldstein, Susan T., Wurie, Haja R., Gidudu, Jane, Lisk, Durodami Radcliffe, Carter, Rosalind J., Seward, Jane F., Hampton, Lee M., Wang, David, Andersen, Lauren E., Arvay, Melissa, Schrag, Stephanie J., Dawson, Peter, Fombah, Augustin E., Petrie, Carey R., Feikin, Daniel R., Russell, James B. W., Lindblad, Robert, Kargbo, S. A. S., Samai, Mohamed, and Mahon, Barbara E.

Published
2018

34. Novel superoxide dismutase mimetics for protection against paraquat nephrotoxicity

Author

Samai, Mohamed

Subjects
615.9
Abstract

Paraquat (PO), a broad-spectrum herbicide, is primarily eliminated from the body unchanged via the kidneys. Unfortunately, it is nephrotoxic; and the PO-induced nephrotoxicity involves severe renal damage caused by reactive oxygen species (ROS), specifically by increasing superoxide anion (0/-) generation in the kidney. While proven to be of benefit in animal models of organ injury involving O2.-, superoxide dismutase (SOD) and superoxide dismutase mimetics (SOOm) can suffer problems regarding their bioavailability and toxicity. Since ROS has been incriminated in the pathogenesis of several disease conditions, the search for ideal SOOm therefore continues unabated. Thus, the current study was undertaken with the overall objective of investigating and comparing the therapeutic potentials of Mn (II) and Cu (II) complexes of ethylenebis (oxyethylenenitrilo) tetraacetic acid (EGTA) and ethylenebis hydroxyphenylglycine (EHPG), novel SOOm, against PO-induced nephrotoxicity using in vitro and in vivo models. The reno-cytotoxic effects of PO on confluent NRK-52E renal cell line in the absence and presence of SOOm were assessed using biochemical assays of cellular viability and cell death. The mode of injury produced by PO in vitro was evaluated using Hoechst-Propidium iodide staining. The ability of PO to increase ROS generation, specifically O2.- and hydroxyl radicals (OW) was investigated using nitroblue tetrazolium reduction/hydroxyethidium fluorescence and deoxyribose assay respectively. ROS-mediated cell damage was assessed via determination of lipid peroxidation, inhibition of DNA and protein synthesis, DNA single strand breaks and poly- (AOP-ribose) polymerase (PARP) activation using the thiobarbituric acid reactive substance assa¥., cellular incorporation of [3H]-thymidine and [3H]-leucine, a DNA precipitation and [ H]-NAO incorporation assays respectively. In addition, the effects of PO on the renal activities and expression of SOD, catalase (CAT) and glutathione peroxidase (GSH-Px) in confluent NRK-52E renal cells in culture were also evaluated. The reno-cytotoxic effects of paraquat were mediated in part by oxidative stress injury secondary to increase generation of ROS; specifically 0/- and OW. This was accompanied by a reduction in the activity and expression of SOD, a reduction in the activity with no significant change in the expression of CAT and an increased in the activity of GSH-Px. Oxidative stress injury was further confirmed by increased lipid peroxidation, inhibition of DNA and protein synthesis, and increased DNA single strand breaks with a subsequent increased in PARP activation. The doses of paraquat examined predominantly produced necrotic cell death. EUK-134 (30-300 IJM), tempol (0.1-1.0 mM) and Mn (II) and Cu (II) complexes of EGTA (10100 IJM) and EHPG (10-100 IJM) were able to improve cellular viability and reduce PO-mediated cell death in vitro via dismutation and/or scavenging of O2.- and reduced OH· generation. Mn (II) complexes displayed greater efficacy than Cu (II) complexes and at equivalent concentrations, Mn (II)-EHPG provided greatest protection. Thus, the hypothesis that, these novel SOOm, particularly Mn (II) complexes of EHPG and EGTA, could provide similar beneficial effect in vivo was tested in rodent model of paraquat-induced nephrotoxicity. Administration of a single intraperitoneal dose of PO (10-100 mg/kg) to male wistar rats (weighing 200-250 g) produced acute renal failure (ARF) within 24-48 hours as evidenced by a significant increase in serum creatinine levels and fractional excretion of sodium (FENa) and a concomitant reduction in creatinine clearance. Unlike Mn (II)-EGTA (2 mg/kg), Mn (II)-EHPG (4 mg/kg) was able to significantly attenuate the PO-induced ARF. In contrast to SOD and/or conventional SOOm which can display pro-oxidant actions at higher concentrations these complexes were not toxic at the doses examined. Since the clinical toxicity profiles of EGTA and EHPG are already known, these novel SOOm particularly Mn (II)-EHPG could be beneficial in attenuating disease conditions involving ROS generation.

Published
2008

35. The Effect of Previous Exposure to Malaria Infection and Clinical Malaria Episodes on the Immune Response to the Two-Dose Ad26.ZEBOV, MVA-BN-Filo Ebola Vaccine Regimen

Author

Manno, Daniela, primary, Patterson, Catriona, additional, Drammeh, Abdoulie, additional, Tetteh, Kevin, additional, Kroma, Mattu Tehtor, additional, Otieno, Godfrey Tuda, additional, Lawal, Bolarinde Joseph, additional, Soremekun, Seyi, additional, Ayieko, Philip, additional, Gaddah, Auguste, additional, Kamara, Abu Bakarr, additional, Baiden, Frank, additional, Afolabi, Muhammed Olanrewaju, additional, Tindanbil, Daniel, additional, Owusu-Kyei, Kwabena, additional, Ishola, David, additional, Deen, Gibrilla Fadlu, additional, Keshinro, Babajide, additional, Njie, Yusupha, additional, Samai, Mohamed, additional, Lowe, Brett, additional, Robinson, Cynthia, additional, Leigh, Bailah, additional, Drakeley, Chris, additional, Greenwood, Brian, additional, and Watson-Jones, Deborah, additional

Published
2023
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36. African Medicines Agency: How it will change the landscape of medicines in Africa

Author

Ogbodum, Molly Unoh, primary, Shomuyiwa, Deborah Oluwaseun, additional, Lucero‐Prisno, Don Eliseo, additional, Gutu, Comfort Tanaka, additional, Bouali, Hajar, additional, Bangura, Buya Nabie, additional, Fofana, Moussa, additional, Musa, Mohamed Babiker, additional, Daoud, Hassan Ali, additional, Owusu‐Mensah, Priscilla, additional, Fiagan, David Do Céu, additional, Danquah, Cynthia Amaning, additional, and Samai, Mohamed, additional

Published
2023
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40. Top 10 public health challenges to track in 2023: Shifting focus beyond a global pandemic

Author

Lucero‐Prisno, Don Eliseo, primary, Shomuyiwa, Deborah Oluwaseun, additional, Kouwenhoven, M. B. N., additional, Dorji, Thinley, additional, Odey, Goodness Ogeyi, additional, Miranda, Adriana Viola, additional, Ogunkola, Isaac Olushola, additional, Adebisi, Yusuff Adebayo, additional, Huang, Junjie, additional, Xu, Lin, additional, Obnial, Joseph Christian, additional, Huda, Aminath, additional, Thepanondh, Sarawut, additional, Dayrit, Manuel Millar, additional, Evardone, Salvador B., additional, Lamawansa, M. D., additional, Solomon Ethiopia, Samrawit, additional, Aziato, Lydia, additional, Adongo, Philip Baba, additional, Samai, Mohamed Hindolo, additional, Garcia, Fernando B., additional, Villaruz, Joselito F., additional, Karunathilake, Indika Mahesh, additional, Li, Hao, additional, Azanza, Patrick Alain, additional, Findlay, Ian, additional, and Wong, Martin C. S., additional

Published
2023
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41. Prevalence of IgG and IgM to SARS-CoV-2 and other human coronaviruses in The Democratic Republic of Congo, Sierra Leone and Uganda: A Longitudinal Study

Author

Gallagher, Katherine E., primary, Lawal, Bolarinde J., additional, Kitonsa, Jonathan, additional, Tindanbil, Daniel, additional, Kasonia, Kambale, additional, Drammeh, Abdoulie, additional, Lowe, Brett, additional, Mukadi-Bamuleka, Daniel, additional, Patterson, Catriona, additional, Greenwood, Brian, additional, Samai, Mohamed, additional, Leigh, Bailah, additional, Tetteh, Kevin A., additional, Ruzagira, Eugene, additional, Watson-Jones, Deborah, additional, and Kavunga-Membo, Hugo, additional

Published
2023
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42. Additional file 2 of Coverage of intermittent preventive treatment of malaria in infants after four years of implementation in Sierra Leone

Author

Fombah, Augustin E., Chen, Haily, Owusu-Kyei, Kwabena, Quinto, Llorenç, Gonzalez, Raquel, Williams, Julian, Berne, Mireia LLach, Wassenaar, Myrte, Jalloh, Abubakarr, Sunders, Joe-Henry C., Ramirez, Maximo, Bertran-Cobo, Cesc, Saute, Francisco, Ekouevi, Didier K., Briand, Valérie, Kamara, Anitta R. Y., Sesay, Tom, Samai, Mohamed, and Menendez, Clara

Abstract

Additional file 2. Malaria prevalence.

Published
2023
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43. Additional file 1 of Coverage of intermittent preventive treatment of malaria in infants after four years of implementation in Sierra Leone

Author

Fombah, Augustin E., Chen, Haily, Owusu-Kyei, Kwabena, Quinto, Llorenç, Gonzalez, Raquel, Williams, Julian, Berne, Mireia LLach, Wassenaar, Myrte, Jalloh, Abubakarr, Sunders, Joe-Henry C., Ramirez, Maximo, Bertran-Cobo, Cesc, Saute, Francisco, Ekouevi, Didier K., Briand, Valérie, Kamara, Anitta R. Y., Sesay, Tom, Samai, Mohamed, and Menendez, Clara

Abstract

Additional file 1. MULTIPLY community-based household survey standard operating procedure.

Published
2023
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44. Randomized Trial of Vaccines for Zaire Ebola Virus Disease

Author

Kieh, Mark, Richert, Laura, Beavogui, Abdoul H., Grund, Birgit, Leigh, Bailah, D’ortenzio, Eric, Doumbia, Seydou, Lhomme, Edouard, Sow, Samba, Vatrinet, Renaud, Roy, Céline, Kennedy, Stephen B., Faye, Sylvain, Lees, Shelley, Millimouno, Niouma P., Camara, Alseny M., Samai, Mohamed, Deen, Gibrilla F., Doumbia, Moussa, Espérou, Hélène, Pierson, Jerome, Watson-Jones, Deborah, Diallo, Alpha, Wentworth, Deborah, Mclean, Chelsea, Simon, Jakub, Wiedemann, Aurélie, Dighero-Kemp, Bonnie, Hensley, Lisa, Lane, Clifford, Levy, Yves, Piot, Peter, Greenwood, Brian, Chêne, Geneviève, Neaton, James, Yazdanpanah, Yazdan, CHU de Bordeaux Pellegrin [Bordeaux], Statistics In System biology and Translational Medicine (SISTM), Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)- Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV]Life Sciences [q-bio], General Medicine
Abstract

Questions remain concerning the rapidity of immune responses and the durability and safety of vaccines used to prevent Zaire Ebola virus disease.We conducted two randomized, placebo-controlled trials - one involving adults and one involving children - to evaluate the safety and immune responses of three vaccine regimens against Zaire Ebola virus disease: Ad26.ZEBOV followed by MVA-BN-Filo 56 days later (the Ad26-MVA group), rVSVΔG-ZEBOV-GP followed by placebo 56 days later (the rVSV group), and rVSVΔG-ZEBOV-GP followed by rVSVΔG-ZEBOV-GP 56 days later (the rVSV-booster group). The primary end point was antibody response at 12 months, defined as having both a 12-month antibody concentration of at least 200 enzyme-linked immunosorbent assay units (EU) per milliliter and an increase from baseline in the antibody concentration by at least a factor of 4.A total of 1400 adults and 1401 children underwent randomization. Among both adults and children, the incidence of injection-site reactions and symptoms (e.g., feverishness and headache) was higher in the week after receipt of the primary and second or booster vaccinations than after receipt of placebo but not at later time points. These events were largely low-grade. At month 12, a total of 41% of adults (titer, 401 EU per milliliter) and 78% of children (titer, 828 EU per milliliter) had a response in the Ad26-MVA group; 76% (titer, 992 EU per milliliter) and 87% (titer, 1415 EU per milliliter), respectively, had a response in the rVSV group; 81% (titer, 1037 EU per milliliter) and 93% (titer, 1745 EU per milliliter), respectively, had a response in the rVSV-booster group; and 3% (titer, 93 EU per milliliter) and 4% (titer, 67 EU per milliliter), respectively, had a response in the placebo group (P0.001 for all comparisons of vaccine with placebo). In both adults and children, antibody responses with vaccine differed from those with placebo beginning on day 14.No safety concerns were identified in this trial. With all three vaccine regimens, immune responses were seen from day 14 through month 12. (Funded by the National Institutes of Health and others; PREVAC ClinicalTrials.gov number, NCT02876328; EudraCT numbers, 2017-001798-18 and 2017-001798-18/3rd; and Pan African Clinical Trials Registry number, PACTR201712002760250.).

Published
2022

46. The monkeypox virus: A public health challenge threatening Africa

Author

Manirambona, Emery, primary, Musa, Shuaibu Saidu, additional, Shomuyiwa, Deborah Oluwaseun, additional, Salam, Feruzi Abdu, additional, John, Okesanya Olalekan, additional, Dinyo, Daniel Garang Aluk, additional, Haruna, Usman Abubakar, additional, Sow, Alhaji Umar, additional, Lucero‐Prisno, Don Eliseo, additional, Ezie, Kengo Nathan, additional, Samai, Mohamed, additional, and Aziato, Lydia, additional

Published
2022
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49. Prevalence of malaria and helminth infections in rural communities in northern Sierra Leone, a baseline study to inform Ebola vaccine study protocols

Author

Baiden, Frank, primary, Fleck, Suzanne, additional, Leigh, Bailah, additional, Ayieko, Philip, additional, Tindanbil, Daniel, additional, Otieno, Tuda, additional, Lawal, Bolarinde, additional, Tehtor, Mattu, additional, Rogers, Maariam, additional, Odeny, Lazarus, additional, Hodges, Mary H., additional, Sonnie, Mustapha, additional, Samai, Mohamed, additional, Ishola, David, additional, Lowe, Brett, additional, Watson-Jones, Deborah, additional, and Greenwood, Brian, additional

Published
2022
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50. Hepatitis B Virus and Tuberculosis Are Associated with Increased Noncommunicable Disease Risk among Treatment-Naïve People with HIV: Opportunities for Prevention, Early Detection and Management of Comorbidities in Sierra Leone

Author

Yendewa, George A., primary, Lakoh, Sulaiman, additional, Jiba, Darlinda F., additional, Yendewa, Sahr A., additional, Barrie, Umu, additional, Deen, Gibrilla F., additional, Samai, Mohamed, additional, Jacobson, Jeffrey M., additional, Sahr, Foday, additional, and Salata, Robert A., additional

Published
2022
Full Text
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