Search

Background and Objectives: This study aims to contribute to the definition of the defensive medicine phenomenon between obstetricians and gynecologists, as well as to possible effects on the frequency of deliveries performed by cesarean sections (CS). Materials and Methods: a digital questionnaire was administered through a mail-list including 600 gynecological specialists (of these 168 doctors completed the test), both in public and private settings. It was made of twenty multiple choice questions, concerning their awareness about the practice of defensive medicine and the planning and execution of CS. All doctors involved received clear and complete information about the purpose of this study and about the organizations that received their answers. Analyses of variance and regression were performed to describe differences between groups and to estimate the relationships between variables. The value of p &lt, 0.5 was considered statistically relevant. Results: our analysis revealed that most respondents are confident with the defensive medicine definition and characteristics. This survey confirmed that gynecologists fear legal actions promoted by their patients and therefore modulate their choices by implementing professional behaviors of so-called “defensive medicine”. This relates to a greater number of medical liability judgements, which more often concern omission or delayed execution of cesarean section, rather than unskillful surgical procedures. Conclusions: there are few data to support a relation between the high rate of CS and defensive medicine. Numerous scientific studies associated this CS rate with the phenomenon of defensive medicine. This practice is constantly growing in all medical areas, especially in high-risk specialties such as obstetrics and gynecology. Our study highlights physicians’ awareness of adopting defensive medicine behaviors in their clinical practice, affecting the choice of the type of delivery to be performed.

Purpose To assess the impact of baseline liver tumour burden, alkaline phosphatase (ALP) elevation, and target lesion size on treatment outcomes with 177Lu-Dotatate. Methods In the phase 3 NETTER-1 trial, patients with advanced, progressive midgut neuroendocrine tumours (NET) were randomised to 177Lu-Dotatate (every 8 weeks, four cycles) plus octreotide long-acting release (LAR) or to octreotide LAR 60 mg. Primary endpoint was progression-free survival (PFS). Analyses of PFS by baseline factors, including liver tumour burden, ALP elevation, and target lesion size, were performed using Kaplan-Meier estimates; hazard ratios (HRs) with corresponding 95% CIs were estimated using Cox regression. Results Significantly prolonged median PFS occurred with 177Lu-Dotatate versus octreotide LAR 60 mg in patients with low ( 50%) liver tumour burden (HR 0.187, 0.216, 0.145), and normal or elevated ALP (HR 0.153, 0.177), and in the presence or absence of a large target lesion (diameter > 30 mm; HR, 0.213, 0.063). Within the 177Lu-Dotatate arm, no significant difference in PFS was observed amongst patients with low/moderate/high liver tumour burden (P = 0.7225) or with normal/elevated baseline ALP (P = 0.3532), but absence of a large target lesion was associated with improved PFS (P = 0.0222). Grade 3 and 4 liver function abnormalities were rare and did not appear to be associated with high baseline liver tumour burden. Conclusions 177Lu-Dotatate demonstrated significant prolongation in PFS versus high-dose octreotide LAR in patients with advanced, progressive midgut NET, regardless of baseline liver tumour burden, elevated ALP, or the presence of a large target lesion. Clinicaltrials.gov: NCT01578239, EudraCT: 2011-005049-11

Lo spunto per l’organizzazione della giornata di studio « Origines : percorsi di ricerca sulle identità etniche nell’Italia antica », tenutasi a Roma il 18 ottobre 2013 e di cui vengono qui presentati gli interventi, è stato fornito all’École Française de Rome e all’Istituto di studi sul Mediterraneo antico del Consiglio Nazionale delle Ricerche (ISMA) dalla pubblicazione del volume Le origini degli Etruschi : storia, archeologia, antropologia (Roma, L’Erma di Brestchneider, 2012). Quest’oper...

International audience

Rosi Braidotti, Transpositions: On Nomadic Ethics(Nadia Manzo) – Beïda Chikhi, Assia Djébar: histoires et fantaisies (Mena Marotta) – Juan Goytisolo, Contra las sagradas formas (Paola Chiara Santoro) – Lisa Hopkins, Screen Adaptations. Shakespeare’s The Tempest. The relationship between Text and Film (Maria Izzo) – Paul Skandera (ed.), Phraseology and Culture in English (Paola Attolino) – Yoko Tawada, Sprachpolizei und Spielpolyglotte (Daniela Allocca) Rosi Braidotti, Transpositions: On Nomadic Ethics(Nadia Manzo) – Beïda Chikhi, Assia Djébar: histoires et fantaisies (Mena Marotta) – Juan Goytisolo, Contra las sagradas formas (Paola Chiara Santoro) – Lisa Hopkins, Screen Adaptations. Shakespeare’s The Tempest. The relationship between Text and Film (Maria Izzo) – Paul Skandera (ed.), Phraseology and Culture in English (Paola Attolino) – Yoko Tawada, Sprachpolizei und Spielpolyglotte (Daniela Allocca)

The authors present a detailed description of the project of the virtual reunification and recontextualisation of the grave goods found in a tomb of the Sabine necropolis of Colle del Forno, which held a princely burial: archaeological research, technical analyses, restoration, 3D reconstruction of the cart found inside the tomb and of its bronze decoration, and virtual reconstitution of the grave goods – constituted both by local products and objects imported from the Orient, as well as by two wheeled vehicles: a cart and a chariot) – in the framework of their original archaeological and cultural context. Besides a DVD, which shows a video at the Ny Carlsberg Glyptotek in the room containing the exhibition of the cart and other objects from the tomb, a web site has been created (http://www.principisabini.it/): the web visitors can reconstruct the history of the discovery, walk through this 7th-6th century BC tomb, see the structural and functional mechanisms of the cart in action, and enjoy this Italic masterpiece.

The article presents some aspects of the research project which has been carried out in the middle Tiber Valley (Sabina Tiberina), to analyse the distribution of archaeological sites in the territory, based on new field surveys and the study of archive documents ('Progetto Galantina'). The research takes advantage of the positive experiment conducted by the Istituto di Studi sulle Civiltà Italiche e del Mediterraneo Antico (ISCIMA) of the Italian CNR to set up and integrate within a Geographical Information System a new model of archiving, managing and querying archaeological information, focused on the analysis of excavation diaries and their SGML and XML encoding. The implemented system gives rise to a many-sided repeatable digital model, easily exportable in various situations. The integration between the DTD established to formally describe archaeological data and the elements of the TEI Lite and Dublin Core standards makes it possible to record and query data coming from both published excavation reports and archive documents dating from the nineteenth century, which deal with the description of archaeological itineraries around Rome. The example presented in this paper refers to the manuscript by Ercole Nardi 'Ruderi delle Ville Romano-Sabine nei dintorni di Poggio Mirteto' (1885) and is aimed at preserving archaeological information through digital supports, electronic exchange formats and especially reliability of the information integrity. Moreover, it makes an attempt to experiment and develop new forms of knowledge diffusion which are more suitable for interactive web consultation than passive reading.

The group of bronze sheets with repoussé decoration, kept in the Ny Carlsberg Glyptotek and coming from the princely burial in Tomb XI at the Colle del Forno necropolis, has been identified as the decoration of a chariot and the magnificent upholstery from horse trappings. This group represents a collection of extraordinary interest regarding figurative culture in the Tiber river area in the Late Orientalizing Period, an identification proven by a second group of objects kept in the same museum. The decorative repertory represents one of the most refined expressions of the artistic style called “Orientalizzante fiorito”, which is best known from the decoration of bucchero pottery, carved ivories and ostrich eggs. Computer graphic techniques have been used for the documentation and study of this repertory, using as a base the excellent photographic documentation provided by the Glyptotek. This methodology, experimented through the use of a graphical workstation at the Istituto per l’Archeologia Etrusco-Italica, provides the opportunity to create a graphical documentation very close to the original technical and graphical cipher and qualifies itself as a very important tool for reading elements regarding the incision technique. However, close collaboration between the specialist and the archaeologist is essential in order to validate this as a useful scientific method of documentation.

In general, a territory can be considered as the centre which contains all information related to different historical ages. The study of a portion of a given territory characterised by the presence of archaeological sites must be aimed at the complete and accurate acquisition of environmental data (e.g. topography, geo-morphology, litho-stratigraphy, land use, etc.), which will be used for an overall study of the site, the reconstruction of the man-environment interaction, and the evaluation of possible applications of geophysical prospecting methods. By interpreting different sets of remote-sensing data, studying existing geological and geo-morphological information and through systematic field work (e.g. archaeological survey, geophysical investigations, etc.), a wide spectrum of environmental data can be collected. The methodology of a complete analysis of the territory can be summarised as follows: analysis of remote-sensing data sets and their geo-referencing; DTM of the selected study area; morphological and geological definition of the selected study area; identification, location and geo-referencing of all archaeological sites in the territory; high-resolution integrated geophysical prospecting methods, to delineate the extension of the site and to locate the archaeological structures; a complete description of the site in its environmental context; definition of an integrated analysis method, based on the spatial correlation of the different data sets; study and design of a GIS for the management of all data sets which have been collected, elaborated and interpreted; definition of a model for the knowledge and protection of the historical and environmental aspects of the territory.

Breve sintesi su parte dei materiali provenienti dalla tomba XI di Colle del Forno

Serie di brevi articoli dedicati alla necropoli di Colle del Forno e al contenuto della tomba XI