28 results on '"Santucci, M.B."'
Search Results
2. Lysophosphatidic acid enhances antimycobacterial activity both in vitro and ex vivo
- Author
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Garg, S.K., primary, Valente, E., additional, Greco, E., additional, Santucci, M.B., additional, De Spirito, M., additional, Papi, M., additional, Bocchino, M., additional, Saltini, C., additional, and Fraziano, M., additional
- Published
- 2006
- Full Text
- View/download PDF
3. Expansion of CCR5+ CD4+ T-lymphocytes in the course of active pulmonary tuberculosis
- Author
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Santucci, M.B., primary
- Published
- 2004
- Full Text
- View/download PDF
4. Batimastat reduces Mycobacterium tuberculosis-induced apoptosis in macrophages
- Author
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Santucci, M.B., primary, Ciaramella, A., additional, Mattei, M., additional, Sumerska, T., additional, and Fraziano, M., additional
- Published
- 2003
- Full Text
- View/download PDF
5. T Cell Responses during Human Immunodeficiency Virus/ Mycobacterium tuberculosis Coinfection.
- Author
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Bohórquez, José Alejandro, Jagannath, Chinnaswamy, Xu, Huanbin, Wang, Xiaolei, and Yi, Guohua
- Subjects
HIV infections ,T cells ,HIV ,MYCOBACTERIUM tuberculosis ,PUBLIC health - Abstract
Coinfection with Mycobacterium tuberculosis (Mtb) and the human immunodeficiency virus (HIV) is a significant public health concern. Individuals infected with Mtb who acquire HIV are approximately 16 times more likely to develop active tuberculosis. T cells play an important role as both targets for HIV infection and mediators of the immune response against both pathogens. This review aims to synthesize the current literature and provide insights into the effects of HIV/Mtb coinfection on T cell populations and their contributions to immunity. Evidence from multiple in vitro and in vivo studies demonstrates that T helper responses are severely compromised during coinfection, leading to impaired cytotoxic responses. Moreover, HIV's targeting of Mtb-specific cells, including those within granulomas, offers an explanation for the severe progression of the disease. Herein, we discuss the patterns of differentiation, exhaustion, and transcriptomic changes in T cells during coinfection, as well as the metabolic adaptations that are necessary for T cell maintenance and functionality. This review highlights the interconnectedness of the immune response and the pathogenesis of HIV/Mtb coinfection. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
6. Live Attenuated Vaccines against Tuberculosis: Targeting the Disruption of Genes Encoding the Secretory Proteins of Mycobacteria.
- Author
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Veerapandian, Raja, Gadad, Shrikanth S., Jagannath, Chinnaswamy, and Dhandayuthapani, Subramanian
- Subjects
TUBERCULOSIS vaccines ,GENE targeting ,MYCOBACTERIUM tuberculosis ,BCG vaccines ,MYCOBACTERIA ,VIRAL vaccines - Abstract
Tuberculosis (TB), a chronic infectious disease affecting humans, causes over 1.3 million deaths per year throughout the world. The current preventive vaccine BCG provides protection against childhood TB, but it fails to protect against pulmonary TB. Multiple candidates have been evaluated to either replace or boost the efficacy of the BCG vaccine, including subunit protein, DNA, virus vector-based vaccines, etc., most of which provide only short-term immunity. Several live attenuated vaccines derived from Mycobacterium tuberculosis (Mtb) and BCG have also been developed to induce long-term immunity. Since Mtb mediates its virulence through multiple secreted proteins, these proteins have been targeted to produce attenuated but immunogenic vaccines. In this review, we discuss the characteristics and prospects of live attenuated vaccines generated by targeting the disruption of the genes encoding secretory mycobacterial proteins. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
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7. Asymmetric Lipid Vesicles: Techniques, Applications, and Future Perspectives as an Innovative Drug Delivery System.
- Author
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Gardea-Gutiérrez, Denisse, Núñez-García, Eduardo, Oseguera-Guerra, Berenice E., Román-Aguirre, Manuel, and Montes-Fonseca, Silvia L.
- Subjects
DRUG delivery systems ,BILAYER lipid membranes ,TRANSDERMAL medication ,POLYMERSOMES ,ASYMMETRIC synthesis ,LIPIDS - Abstract
Novel lipid-based nanosystems have been of interest in improving conventional drug release methods. Liposomes are the most studied nanostructures, consisting of lipid bilayers ideal for drug delivery, thanks to their resemblance to the cell plasma membrane. Asymmetric liposomes are vesicles with different lipids in their inner and outer layers; because of this, they can be configured to be compatible with the therapeutic drug while achieving biocompatibility and stability. Throughout this review, topics such as the applications, advantages, and synthesis techniques of asymmetric liposomes will be discussed. Further, an in silico analysis by computational tools will be examined as a helpful tool for designing and understanding asymmetric liposome mechanisms in pharmaceutical applications. The dual-engineered design of asymmetric liposomes makes them an ideal alternative for transdermal drug delivery because of the improved protection of pharmaceuticals without lowering adsorption rates and system biocompatibility. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
8. A Current Perspective on the Potential of Nanomedicine for Anti-Tuberculosis Therapy.
- Author
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Borah Slater, Khushboo, Kim, Daniel, Chand, Pooja, Xu, Ye, Shaikh, Hanif, and Undale, Vaishali
- Published
- 2023
- Full Text
- View/download PDF
9. Mycobacterium tuberculosis-Induced Apoptosis in Monocytes/Macrophages: Early Membrane Modifications and Intracellular Mycobacterial Viability.
- Author
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Santucci, M.B., Amicosante, M., Cicconi, R., Montesano, C., Casarini, M., Giosue, S., Bisetti, A., Colizzi, V., and Fraziano, M.
- Subjects
- *
MYCOBACTERIUM tuberculosis , *MONOCYTES - Abstract
Examines the intracellular mycobacterial viability of mycobacterium tuberculosis (MTB)-induced apoptosis in monocytes. Association of MTB- induces apoptosis with CD14 expression; Correlation between MTB high doses and parasite survival; Role of monocytes on cytokines and chemokines release.
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- 2000
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10. Insights into Asymmetric Liposomes as a Potential Intervention for Drug Delivery Including Pulmonary Nanotherapeutics.
- Author
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Al Badri, Yaqeen Nadheer, Chaw, Cheng Shu, and Elkordy, Amal Ali
- Subjects
AMIKACIN ,NANOMEDICINE ,BIOLOGICAL membranes ,POLYMERSOMES ,NEUROENDOCRINE cells ,LIPOSOMES ,DISTRIBUTION (Probability theory) ,DRUG delivery systems ,MYCOBACTERIUM avium - Abstract
Liposome-based drug delivery systems are nanosized spherical lipid bilayer carriers that can encapsulate a broad range of small drug molecules (hydrophilic and hydrophobic drugs) and large drug molecules (peptides, proteins, and nucleic acids). They have unique characteristics, such as a self-assembling bilayer vesicular structure. There are several FDA-approved liposomal-based medicines for treatment of cancer, bacterial, and viral infections. Most of the FDA-approved liposomal-based therapies are in the form of conventional "symmetric" liposomes and they are administered mainly by injection. Arikace
® is the first and only FDA-approved liposomal-based inhalable therapy (amikacin liposome inhalation suspension) to treat only adults with difficult-to-treat Mycobacterium avium complex (MAC) lung disease as a combinational antibacterial treatment. To date, no "asymmetric liposomes" are yet to be approved, although asymmetric liposomes have many advantages due to the asymmetric distribution of lipids through the liposome's membrane (which is similar to the biological membranes). There are many challenges for the formulation and stability of asymmetric liposomes. This review will focus on asymmetric liposomes in contrast to conventional liposomes as a potential clinical intervention drug delivery system as well as the formulation techniques available for symmetric and asymmetric liposomes. The review aims to renew the research in liposomal nanovesicle delivery systems with particular emphasis on asymmetric liposomes as future potential carriers for enhancing drug delivery including pulmonary nanotherapeutics. [ABSTRACT FROM AUTHOR]- Published
- 2023
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11. Smart Insole Based on Flexi Force and Flex Sensor for Monitoring Different Body Postures.
- Author
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Lakho, Rafique Ahmed, Abro, Zamir Ahmed, Chen, Jun, and Min, Rui
- Subjects
POSTURE ,INTELLIGENT sensors ,POLYVINYL chloride ,ERROR rates ,DETECTORS - Abstract
This study aims to fabricate smart insoles using wireless Flexi force and bend sensing technology. Polyvinyl chloride (PVC) film was chosen as the substrate to hold all the sensors. The developed smart insole has a three-layer structure (insole-PVC layer-fabric layer) and is calibrated in an isolation laboratory to evaluate its measurement performance. One male volunteer subject exhibited four different body postures, namely tree pose, forward-leaning, squatting, and forward folding pose. Changes in pressure distribution were considered to be similar for the forward, squat, and forward-folded positions. When subjects performed a full squat, the flex sensor exhibited maximum flexion during the squat position, and the flex sensor response against the squat pose was found to be higher by about 18.18% than in the forward lean, respectively. The tree pose has the highest error rate at the first metatarsal, about 18.6%, of which the maximum absolute relative error of the sensor is less than 5%. Plantar pressure distribution and body posture measurements were successfully validated using Flexi force and flex sensors embedded in the smart insole. The smart insole proposed in this research work has broader prospects for clinical application. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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12. Mycobacterium abscessus : It's Complex.
- Author
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Abdelaal, Hazem F. M., Chan, Edward D., Young, Lisa, Baldwin, Susan L., and Coler, Rhea N.
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MYCOBACTERIUM ,LUNG infections ,CYSTIC fibrosis ,LUNG diseases ,MYCOBACTERIA ,LABORATORY animals - Abstract
Mycobacterium abscessus (M. abscessus) is an opportunistic pathogen usually colonizing abnormal lung airways and is often seen in patients with cystic fibrosis. Currently, there is no vaccine available for M. abscessus in clinical development. The treatment of M. abscessus-related pulmonary diseases is peculiar due to intrinsic resistance to several commonly used antibiotics. The development of either prophylactic or therapeutic interventions for M. abscessus pulmonary infections is hindered by the absence of an adequate experimental animal model. In this review, we outline the critical elements related to M. abscessus virulence mechanisms, host–pathogen interactions, and treatment challenges associated with M. abscessus pulmonary infections. The challenges of effectively combating this pathogen include developing appropriate preclinical animal models of infection, developing proper diagnostics, and designing novel strategies for treating drug-resistant M. abscessus. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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13. Liposomes Bearing Non-Bilayer Phospholipid Arrangements Induce Specific IgG Anti-Lipid Antibodies by Activating NK1.1 + , CD4 + T Cells in Mice.
- Author
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Landa-Saldívar, Carla, Reséndiz-Mora, Albany, Sánchez-Barbosa, Sandra, Sotelo-Rodríguez, Anahi, Barrera-Aveleida, Giovanna, Nevárez-Lechuga, Irene, Galarce-Sosa, Iván, Taniguchi-Ponciano, Keiko, Cruz-Guzmán, Oriana del Rocío, Wong-Baeza, Isabel, Escobar-Gutiérrez, Alejandro, Baeza, Isabel, and Wong-Baeza, Carlos
- Published
- 2022
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14. Liposomes as Adjuvants and Vaccine Delivery Systems.
- Author
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Tretiakova, D. S. and Vodovozova, E. L.
- Abstract
The review considers liposomes as systems of substantial interest as adjuvant carriers in vaccinology due to their versatility and maximal biocompatibility. Research and development on the use of liposomes and lipid nanoparticles to create subunit vaccines for the prevention and treatment of infectious diseases has been going on for several decades. In recent years, the area has seen serious progress due to the improvement of the technology of industrial production of various high-grade lipids suitable for parenteral administration and the emergence of new technologies and equipment for the production of liposomal preparations. When developing vaccines, it is necessary to take into account how the body's immune system (innate and adaptive immunity) functions. The review briefly describes some of the fundamental mechanisms underlying the mobilization of immunity when encountering an antigen, as well as the influence of liposome carriers on the processes of internalization of antigens by immunocompetent cells and ways of immune response induction. The results of the studies on the interactions of liposomes with antigen-presenting cells in function of the liposome size, charge, and phase state of the bilayer, which depends on the lipid composition, are often contradictory and should be verified in each specific case. The introduction of immunostimulant components into the composition of liposomal vaccine complexes—ligands of the pathogen-associated molecular pattern receptors—permits modulation of the strength and type of the immune response. The review briefly discusses liposome-based vaccines approved for use in the clinic for the treatment and prevention of infectious diseases, including mRNA-loaded lipid nanoparticles. Examples of liposomal vaccines that undergo various stages of clinical trials are presented. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
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15. The role of the innate immune system on pulmonary infections.
- Author
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Galeas-Pena, Michelle, McLaughlin, Nathaniel, and Pociask, Derek
- Subjects
IMMUNE system ,LUNG infections ,IMMUNE response ,T cells ,CYTOKINES ,MACROPHAGES ,NATURAL immunity - Abstract
Inhalation is required for respiration and life in all vertebrates. This process is not without risk, as it potentially exposes the host to environmental pathogens with every breath. This makes the upper respiratory tract one of the most common routes of infection and one of the leading causes of morbidity and mortality in the world. To combat this, the lung relies on the innate immune defenses. In contrast to the adaptive immune system, the innate immune system does not require sensitization, previous exposure or priming to attack foreign particles. In the lung, the innate immune response starts with the epithelial barrier and mucus production and is reinforced by phagocytic cells and T cells. These cells are vital for the production of cytokines, chemokines and anti-microbial peptides that are critical for clearance of infectious agents. In this review, we discuss all aspects of the innate immune response, with a special emphasis on ways to target aspects of the immune response to combat antibiotic resistant bacteria. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
16. Is Sphingosine-1-Phosphate a Regulator of Tumor Vascular Functionality?
- Author
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Karam, Manale, Ives, Annette, and Auclair, Christian
- Subjects
THERAPEUTIC use of antimetabolites ,THERAPEUTIC use of antineoplastic agents ,PANCREATIC tumors ,ADENOCARCINOMA ,XENOGRAFTS ,CANCER chemotherapy ,CANCER patients ,TUMOR markers ,SPHINGOSINE-1-phosphate ,HYPOXEMIA ,CHEMICAL inhibitors - Abstract
Simple Summary: Despite substantial theoretical and experimental support for using vascular normalization as cancer therapy, effectively achieving this strategy in the clinic remains complex. In the present paper, we propose a novel potential approach for the induction of tumor vascular normalization, reduction of hypoxia, and improvement of conventional treatment in cancer patients. This approach consists of the pharmacological modulation of a patient's plasma S1P levels which through a PDGF signaling can enhance tumor vasculature functionality and reduce hypoxia. This approach is proposed following a clinical observation in pancreatic adenocarcinoma patients and pre-clinical data in different in vivo tumor models, and is supported by a review of the literature describing the biological role of S1P in vascular functionality regulation. Increasing evidence indicates that tumor vasculature normalization could be an appropriate strategy to increase therapies' efficacy in solid tumors by decreasing hypoxia and improving drug delivery. We searched for a novel approach that reduces hypoxia and enhances chemotherapy efficacy in pancreatic adenocarcinoma which is characterized by disrupted blood vasculature associated with poor patient survival. Clinical significance of plasma levels of the angiogenic lipid sphingosine-1-phosphate (S1P) was assessed at baseline in 175 patients. High plasma S1P concentration was found to be a favorable prognostic/predictive marker in advanced/metastatic pancreatic adenocarcinoma patients treated by gemcitabine alone but not in patients receiving a combination gemcitabine and PDGFR-inhibitor. In pancreatic adenocarcinoma PDX models, oral administration of an S1P lyase inhibitor (LX2931) significantly increased plasma S1P levels, decreased tumor expression of the hypoxia marker (CA IX), and enhanced chemotherapy efficacy when combined with gemcitabine treatment. The direct effect of S1P on tumor oxygenation was assessed by administration of S1P onto tumor-grafted CAM model and measuring intra-tumoral pO2 using a tissue oxygen monitor. S1P increased pO2 in a tumor-CAM model. Thus, increasing plasma S1P is a promising strategy to decrease tumor hypoxia and enhance therapy efficacy in solid tumors. S1P may act as a tumor vasculature normalizer. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
17. Internalization, phagolysosomal biogenesis and killing of mycobacteria in enucleated epithelial cells.
- Author
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de Souza Carvalho, Cristiane, Kasmapour, Bahram, Gronow, Achim, Rohde, Manfred, Rabinovitch, Michel, and Gutierrez, Maximiliano Gabriel
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MYCOBACTERIA ,EPITHELIAL cells ,INTRACELLULAR pathogens ,HOSTS (Biology) ,PHAGOSOMES ,LYSOSOMES ,ERYTHROCYTES - Abstract
Summary [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
18. Microreview Mycobacterium tuberculosis cell envelope lipids and the host immune response.
- Author
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Karakousis, Petros C., Bishai, William R., and Dorman, Susan E.
- Subjects
MYCOBACTERIUM tuberculosis ,DISEASE susceptibility ,DISEASE risk factors ,DISEASE complications ,ETIOLOGY of diseases ,DIAGNOSIS - Abstract
Discusses the characteristics of mycobacterium tuberculosis. Epidemiology of the disease; Pathology of the infection; Progression of the disease.
- Published
- 2004
- Full Text
- View/download PDF
19. Role of macrophage phospholipase D in natural and CpG-induced antimycobacterial activity.
- Author
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Auricchio, G., Garg, S. K., Martino, A., Volpe, E., Ciaramella, A., De Vito, P., Baldini, P. M., Colizzi, V., and Fraziano, M.
- Subjects
MACROPHAGES ,MYCOBACTERIUM tuberculosis ,KILLER cells ,GROWTH factors ,MICROBIOLOGY - Abstract
The present study addresses the differential ability of macrophages to control intracellular growth of non-pathogenic Mycobacterium smegmatis (Msm) and pathogenic M . tuberculosis (MTB). Results reported herein show that 3 h post infection, intracellular Msm , but not MTB, was significantly killed by macrophages. As the role of human macrophage phospholipase D (PLD) in the activation of antimicrobial mechanisms has been documented, we hypothesised the role of such enzyme in antimycobacterial mechanisms. To this aim, macrophage PLD activity was analysed at different times after exposure with either pathogenic MTB or non-pathogenic Msm. Results showed that, starting from 15 min after mycobacterial exposure, MTB did not induce macrophage PLD activity, whereas the environmental non-pathogenic Msm stably increased it. The direct contribution of PLD in intracellular mycobacterial killing was also analysed by inhibiting enzymatic activity with ethanol or calphostin C. Results show that PLD inhibition significantly increases intracellular Msm replication. In order to see whether the innate PLD-mediated antimicrobial mechanisms against MTB are also induced after CpG ODN stimulation, the role of PLD has been analysed in the course of CpG-mediated intracellular MTB killing. CpG DNA increased PLD activity in both uninfected and MTB-infected macrophages, and the inhibition of PLD activity resulted in a significant reduction of CpG-induced MTB killing. Taken together, our data suggest a relationship between host PLD activation and the macrophage ability to control intracellular mycobacterial growth. [ABSTRACT FROM AUTHOR]
- Published
- 2003
- Full Text
- View/download PDF
20. Phospholipases in Physiology and Pathology
- Author
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Sajal Chakraborti and Sajal Chakraborti
- Abstract
Phospholipases in Physiology and Pathology presents a comprehensive overview on the physiology and pathology of phospholipases. This seven-volume set considers the biochemical and molecular mechanisms of normal and abnormal cell function upon dysregulation of phospholipases in different diseases. Volumes cover signal transduction mechanisms, implications in cancer, infectious diseases, neural diseases, cardiovascular diseases and other diseases, implications in inflammation, apoptosis, gene expression and non-coding RNAs, the role of natural and synthetic compounds, and stem cell therapies, nanotechnology-based therapies, and more. Together, these volumes give researchers critical insight on the mechanistic and therapeutic aspects of phospholipases. - Discusses the biochemical and molecular mechanisms of normal and abnormal cell function in different disease processes - Covers a wide range of basic and translational research appropriate for scientists engaged in studying the regulation of phospholipases from interdisciplinary perspectives - Features state-of-the-art chapter contributions from international leaders in the field
- Published
- 2023
21. Functional Properties of Advanced Engineering Materials and Biomolecules
- Author
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Felipe A. La Porta, Carlton A. Taft, Felipe A. La Porta, and Carlton A. Taft
- Subjects
- Biomaterials, Materials
- Abstract
This book shows how a small toolbox of experimental techniques, physical chemistry concepts as well as quantum/classical mechanics and statistical methods can be used to understand, explain and even predict extraordinary applications of these advanced engineering materials and biomolecules. It highlights how improving the material foresight by design, including the fundamental understanding of their physical and chemical properties, can provide new technological levels in the future.
- Published
- 2021
22. Human Emerging and Re-emerging Infections
- Author
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Sunit Kumar Singh and Sunit Kumar Singh
- Subjects
- Human beings, Communicable diseases, Emerging infectious diseases
- Abstract
Emerging and re-emerging pathogens pose several challenges to diagnosis, treatment, and public health surveillance, primarily because pathogen identification is a difficult and time-consuming process due to the “novel” nature of the agent. Proper identification requires a wide array of techniques, but the significance of these diagnostics is anticipated to increase with advances in newer molecular and nanobiotechnological interventions and health information technology. Human Emerging and Re-emerging Infections covers the epidemiology, pathogenesis, diagnostics, clinical features, and public health risks posed by new viral and microbial infections. The book includes detailed coverage on the molecular mechanisms of pathogenesis, development of various diagnostic tools, diagnostic assays and their limitations, key research priorities, and new technologies in infection diagnostics. Volume 1 addresses viral and parasitic infections, while volume 2 delves into bacterial and mycotic infections. Human Emerging and Re-emerging Infections is an invaluable resource for researchers in parasitologists, microbiology, Immunology, neurology and virology, as well as clinicians and students interested in understanding the current knowledge and future directions of infectious diseases.
- Published
- 2016
23. Controlled Release Systems : Advances in Nanobottles and Active Nanoparticles
- Author
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Alex van Herk, Jacqueline Forcada, Giorgia Pastorin, Alex van Herk, Jacqueline Forcada, and Giorgia Pastorin
- Subjects
- Controlled release technology, Nanostructured materials
- Abstract
In the area of controlled release of active substances, such as drugs, a strong interest in nanoparticles as carriers of active ingredients has arisen. Some of the active components are extremely hydrophobic, without cellular permeability and susceptible to metabolic degradation. Owing to this, their use is limited. This kind of agent can be transp
- Published
- 2015
24. Mucosal Immunology
- Author
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Jiri Mestecky, Warren Strober, Michael W. Russell, Hilde Cheroutre, Bart N. Lambrecht, Brian L Kelsall, Jiri Mestecky, Warren Strober, Michael W. Russell, Hilde Cheroutre, Bart N. Lambrecht, and Brian L Kelsall
- Subjects
- Mucous membrane--Immunology
- Abstract
Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. Most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular importance in the field of immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective, and excellent organization. It covers immune system topics, such as inductive and effector tissues and cells, and development and physiology of the mucosal barrier; diseases in the digestive system, respiratory tract, and genitourinary tract; and immunodeficiency. - The most comprehensive text on mucosal immunology from internationally recognized experts in the field - Includes exceptional color illustrations, new research data, original theory and information on all mucosal diseases - Contains nine new chapters and an expanded appendix
- Published
- 2015
25. Bacterial Pathogenesis: Molecular and Cellular Mechanisms
- Author
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Camille Locht, Michel Simonet, Camille Locht, and Michel Simonet
- Subjects
- Bacterial diseases--Pathogenesis, Bacterial diseases--Microbiology, Molecular microbiology, Bacteria--pathogenicity, Virulence Factors, Virulence
- Abstract
One of the greatest public health achievements during the twentieth century was the dramatic reduction in the incidence of infectious diseases due to the development of improved hygiene, vaccines and antimicrobial agents. However, new infectious diseases are emerging and bacteria-induced illnesses, such as tuberculosis, whooping cough and typhoid fever, are still a major cause of global mortality. In recent decades the development of molecular biology and genetic tools has led to extensive studies on the molecular and cellular aspects of the virulence properties of pathogenic bacteria. In this book, a group of distinguished scientists from eight different countries and three continents, under the expert guidance of the editors Camille Locht and Michel Simonet, overview the molecular and cellular mechanisms of bacterial pathogenesis. The fifteen chapters are organized into five sections: approaches to the study of bacterial pathogenesis; bacterial adhesion to the cell surface and extracellular matrix of host tissues; poisoning the host by toxins; cellular invasion by bacterial pathogens; and bacterial evasion of host defences. The authors comprehensively describe the most relevant and up-to-date information on pathogenic features across the bacterial world. Aimed at the entire scientific community from students to senior scientists and physicians, the book is relevant to a broad range of people interested in the mechanisms of bacterial infectious diseases and is a recommended text for all microbiology laboratories.
- Published
- 2012
26. Bacterial Secreted Proteins: Secretory Mechanisms and Role in Pathogenesis
- Author
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Karl Wooldridge and Karl Wooldridge
- Subjects
- Proteins--Secretion, Pathogenic bacteria
- Abstract
Secreted proteins are particularly important in bacterial pathogenesis. These proteins have a range of biological functions ranging from host cell toxicity to more subtle alterations of the host cell for the benefit of the invader. The importance of protein secretion to bacterial pathogens is exemplified by the array of mechanisms that have evolved for this purpose. This extensive publication on bacterial secreted proteins, the secretory systems of bacteria and the vital role of secreted proteins in bacterial pathogenesis will be of immense value to all microbiologists, molecular biologists, public health scientists and researchers engaged in the study of pathogenesis, drug design and vaccine development. A skillful selection of topics and a panel of acknowledged experts as authors have ensured that this volume will become an important reference source for many years to come. The book is divided into two sections. The first section describes the various protein secretion systems including mechanisms for secretion across the cytoplasmic membrane of Gram-negative and Gram-positive bacteria, specialized mechanisms for secretion across the Gram-negative outer membrane, systems for transport across both membranes of Gram-negative bacteria, protein secretion systems in Gram-positive bacteria, the secretion of surface fimbrae/pili and a chapter on the less well defined pathways. Section 2 describes the protein secretion mechanisms and secreted proteins of a number of important human, veterinary and plant pathogens and their role in the pathogenicity of these organisms. The pathogens covered have been selected on the basis that there is active research on protein secretion by these pathogens and they employ a diverse array of secreted proteins and protein secretion systems. Each chapter of the book can be read in isolation, particularly the chapters in section 2. The book constitutes a broad and in-depth description of the current knowledge of bacterial protein secretion and its role in pathogenesis. A recommended reference volume for all microbiology libraries.
- Published
- 2009
27. Tuberculosis : The Microbe Host Interface
- Author
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Larry S. Schlesinger, Lucy DesJardin, Larry S. Schlesinger, and Lucy DesJardin
- Subjects
- Tuberculosis--Microbiology, Tuberculosis--Pathogenesis, Mycobacterium tuberculosis--pathogenicity, Tuberculosis--physiopathology
- Abstract
M. tuberculosis remains one of the most successful human pathogens known. The causative agent of tuberculosis, it also has a unique ability to persist for years in the infected, apparently healthy host. This dormant organism can be reactivated years, even decades later to cause tuberculosis. This book reviews the most important state-of-the-art approaches currently used to study microbe-host interactions and highlights emerging methodologies.
- Published
- 2004
28. Correlation between serum tumor necrosis factor alpha levels and clinical severity of tuberculosis
- Author
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Ramos de Andrade, Dahir, Jr., Santos, Sania Alves dos, de Castro, Isac, and de Andrade, Dahir Ramos
- Published
- 2008
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