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Improvised explosive devices (IEDs) are effective weapons for insurgents targeting conventional military and security forces. Real-time information gathering about likely use of such weapons is one approach to reduce the effectiveness of IEDs. Unmanned aerial system (UASs) may provide the information gathering capability commanders need to interdict IEDs. Currently, UASs are not systematically utilized in that capacity. This research develops a routing tool that uses column-generation techniques and a greedy algorithm to route UASs through suspected IED locations for the purpose of IED interdiction as it transit to and from command directed missions. In empirical studies of data sets with up to 125 IED locations and missions, the routing tool provides optimal or near-optimal solutions in all instances tested. The tool produces de-conflicted routes for up to three UASs within five minutes of computing time. http://archive.org/details/aheuristiclgorit109454001 Outstanding Thesis US Army (USA) author. Approved for public release; distribution is unlimited.