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2. A consensus protocol for functional connectivity analysis in the rat brain

Author

Grandjean, Joanes, Desrosiers-Gregoire, Gabriel, Anckaerts, Cynthia, Angeles-Valdez, Diego, Ayad, Fadi, Barrière, David A., Blockx, Ines, Bortel, Aleksandra, Broadwater, Margaret, Cardoso, Beatriz M., Célestine, Marina, Chavez-Negrete, Jorge E., Choi, Sangcheon, Christiaen, Emma, Clavijo, Perrin, Colon-Perez, Luis, Cramer, Samuel, Daniele, Tolomeo, Dempsey, Elaine, Diao, Yujian, Doelemeyer, Arno, Dopfel, David, Dvořáková, Lenka, Falfán-Melgoza, Claudia, Fernandes, Francisca F., Fowler, Caitlin F., Fuentes-Ibañez, Antonio, Garin, Clément M., Gelderman, Eveline, Golden, Carla E. M., Guo, Chao C. G., Henckens, Marloes J. A. G., Hennessy, Lauren A., Herman, Peter, Hofwijks, Nita, Horien, Corey, Ionescu, Tudor M., Jones, Jolyon, Kaesser, Johannes, Kim, Eugene, Lambers, Henriette, Lazari, Alberto, Lee, Sung-Ho, Lillywhite, Amanda, Liu, Yikang, Liu, Yanyan Y., López -Castro, Alejandra, López-Gil, Xavier, Ma, Zilu, MacNicol, Eilidh, Madularu, Dan, Mandino, Francesca, Marciano, Sabina, McAuslan, Matthew J., McCunn, Patrick, McIntosh, Alison, Meng, Xianzong, Meyer-Baese, Lisa, Missault, Stephan, Moro, Federico, Naessens, Daphne M. P., Nava-Gomez, Laura J., Nonaka, Hiroi, Ortiz, Juan J., Paasonen, Jaakko, Peeters, Lore M., Pereira, Mickaël, Perez, Pablo D., Pompilus, Marjory, Prior, Malcolm, Rakhmatullin, Rustam, Reimann, Henning M., Reinwald, Jonathan, Del Rio, Rodrigo Triana, Rivera-Olvera, Alejandro, Ruiz-Pérez, Daniel, Russo, Gabriele, Rutten, Tobias J., Ryoke, Rie, Sack, Markus, Salvan, Piergiorgio, Sanganahalli, Basavaraju G., Schroeter, Aileen, Seewoo, Bhedita J., Selingue, Erwan, Seuwen, Aline, Shi, Bowen, Sirmpilatze, Nikoloz, Smith, Joanna A. B., Smith, Corrie, Sobczak, Filip, Stenroos, Petteri J., Straathof, Milou, Strobelt, Sandra, Sumiyoshi, Akira, Takahashi, Kengo, Torres-García, Maria E., Tudela, Raul, van den Berg, Monica, van der Marel, Kajo, van Hout, Aran T. B., Vertullo, Roberta, Vidal, Benjamin, Vrooman, Roël M., Wang, Victora X., Wank, Isabel, Watson, David J. G., Yin, Ting, Zhang, Yongzhi, Zurbruegg, Stefan, Achard, Sophie, Alcauter, Sarael, Auer, Dorothee P., Barbier, Emmanuel L., Baudewig, Jürgen, Beckmann, Christian F., Beckmann, Nicolau, Becq, Guillaume J. P. C., Blezer, Erwin L. A., Bolbos, Radu, Boretius, Susann, Bouvard, Sandrine, Budinger, Eike, Buxbaum, Joseph D., Cash, Diana, Chapman, Victoria, Chuang, Kai-Hsiang, Ciobanu, Luisa, Coolen, Bram F., Dalley, Jeffrey W., Dhenain, Marc, Dijkhuizen, Rick M., Esteban, Oscar, Faber, Cornelius, Febo, Marcelo, Feindel, Kirk W., Forloni, Gianluigi, Fouquet, Jérémie, Garza-Villarreal, Eduardo A., Gass, Natalia, Glennon, Jeffrey C., Gozzi, Alessandro, Gröhn, Olli, Harkin, Andrew, Heerschap, Arend, Helluy, Xavier, Herfert, Kristina, Heuser, Arnd, Homberg, Judith R., Houwing, Danielle J., Hyder, Fahmeed, Ielacqua, Giovanna Diletta, Jelescu, Ileana O., Johansen-Berg, Heidi, Kaneko, Gen, Kawashima, Ryuta, Keilholz, Shella D., Keliris, Georgios A., Kelly, Clare, Kerskens, Christian, Khokhar, Jibran Y., Kind, Peter C., Langlois, Jean-Baptiste, Lerch, Jason P., López-Hidalgo, Monica A., Manahan-Vaughan, Denise, Marchand, Fabien, Mars, Rogier B., Marsella, Gerardo, Micotti, Edoardo, Muñoz-Moreno, Emma, Near, Jamie, Niendorf, Thoralf, Otte, Willem M., Pais-Roldán, Patricia, Pan, Wen-Ju, Prado-Alcalá, Roberto A., Quirarte, Gina L., Rodger, Jennifer, Rosenow, Tim, Sampaio-Baptista, Cassandra, Sartorius, Alexander, Sawiak, Stephen J., Scheenen, Tom W. J., Shemesh, Noam, Shih, Yen-Yu Ian, Shmuel, Amir, Soria, Guadalupe, Stoop, Ron, Thompson, Garth J., Till, Sally M., Todd, Nick, Van Der Linden, Annemie, van der Toorn, Annette, van Tilborg, Geralda A. F., Vanhove, Christian, Veltien, Andor, Verhoye, Marleen, Wachsmuth, Lydia, Weber-Fahr, Wolfgang, Wenk, Patricia, Yu, Xin, Zerbi, Valerio, Zhang, Nanyin, Zhang, Baogui B., Zimmer, Luc, Devenyi, Gabriel A., Chakravarty, M. Mallar, and Hess, Andreas

Published
2023
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8. Author Correction: A consensus protocol for functional connectivity analysis in the rat brain

Author

Grandjean, Joanes, primary, Desrosiers-Gregoire, Gabriel, additional, Anckaerts, Cynthia, additional, Angeles-Valdez, Diego, additional, Ayad, Fadi, additional, Barrière, David A., additional, Blockx, Ines, additional, Bortel, Aleksandra, additional, Broadwater, Margaret, additional, Cardoso, Beatriz M., additional, Célestine, Marina, additional, Chavez-Negrete, Jorge E., additional, Choi, Sangcheon, additional, Christiaen, Emma, additional, Clavijo, Perrin, additional, Colon-Perez, Luis, additional, Cramer, Samuel, additional, Daniele, Tolomeo, additional, Dempsey, Elaine, additional, Diao, Yujian, additional, Doelemeyer, Arno, additional, Dopfel, David, additional, Dvořáková, Lenka, additional, Falfán-Melgoza, Claudia, additional, Fernandes, Francisca F., additional, Fowler, Caitlin F., additional, Fuentes-Ibañez, Antonio, additional, Garin, Clément M., additional, Gelderman, Eveline, additional, Golden, Carla E. M., additional, Guo, Chao C. G., additional, Henckens, Marloes J. A. G., additional, Hennessy, Lauren A., additional, Herman, Peter, additional, Hofwijks, Nita, additional, Horien, Corey, additional, Ionescu, Tudor M., additional, Jones, Jolyon, additional, Kaesser, Johannes, additional, Kim, Eugene, additional, Lambers, Henriette, additional, Lazari, Alberto, additional, Lee, Sung-Ho, additional, Lillywhite, Amanda, additional, Liu, Yikang, additional, Liu, Yanyan Y., additional, López -Castro, Alejandra, additional, López-Gil, Xavier, additional, Ma, Zilu, additional, MacNicol, Eilidh, additional, Madularu, Dan, additional, Mandino, Francesca, additional, Marciano, Sabina, additional, McAuslan, Matthew J., additional, McCunn, Patrick, additional, McIntosh, Alison, additional, Meng, Xianzong, additional, Meyer-Baese, Lisa, additional, Missault, Stephan, additional, Moro, Federico, additional, Naessens, Daphne M. P., additional, Nava-Gomez, Laura J., additional, Nonaka, Hiroi, additional, Ortiz, Juan J., additional, Paasonen, Jaakko, additional, Peeters, Lore M., additional, Pereira, Mickaël, additional, Perez, Pablo D., additional, Pompilus, Marjory, additional, Prior, Malcolm, additional, Rakhmatullin, Rustam, additional, Reimann, Henning M., additional, Reinwald, Jonathan, additional, Del Rio, Rodrigo Triana, additional, Rivera-Olvera, Alejandro, additional, Ruiz-Pérez, Daniel, additional, Russo, Gabriele, additional, Rutten, Tobias J., additional, Ryoke, Rie, additional, Sack, Markus, additional, Salvan, Piergiorgio, additional, Sanganahalli, Basavaraju G., additional, Schroeter, Aileen, additional, Seewoo, Bhedita J., additional, Selingue, Erwan, additional, Seuwen, Aline, additional, Shi, Bowen, additional, Sirmpilatze, Nikoloz, additional, Smith, Joanna A. B., additional, Smith, Corrie, additional, Sobczak, Filip, additional, Stenroos, Petteri J., additional, Straathof, Milou, additional, Strobelt, Sandra, additional, Sumiyoshi, Akira, additional, Takahashi, Kengo, additional, Torres-García, Maria E., additional, Tudela, Raul, additional, van den Berg, Monica, additional, van der Marel, Kajo, additional, van Hout, Aran T. B., additional, Vertullo, Roberta, additional, Vidal, Benjamin, additional, Vrooman, Roël M., additional, Wang, Victora X., additional, Wank, Isabel, additional, Watson, David J. G., additional, Yin, Ting, additional, Zhang, Yongzhi, additional, Zurbruegg, Stefan, additional, Achard, Sophie, additional, Alcauter, Sarael, additional, Auer, Dorothee P., additional, Barbier, Emmanuel L., additional, Baudewig, Jürgen, additional, Beckmann, Christian F., additional, Beckmann, Nicolau, additional, Becq, Guillaume J. P. C., additional, Blezer, Erwin L. A., additional, Bolbos, Radu, additional, Boretius, Susann, additional, Bouvard, Sandrine, additional, Budinger, Eike, additional, Buxbaum, Joseph D., additional, Cash, Diana, additional, Chapman, Victoria, additional, Chuang, Kai-Hsiang, additional, Ciobanu, Luisa, additional, Coolen, Bram F., additional, Dalley, Jeffrey W., additional, Dhenain, Marc, additional, Dijkhuizen, Rick M., additional, Esteban, Oscar, additional, Faber, Cornelius, additional, Febo, Marcelo, additional, Feindel, Kirk W., additional, Forloni, Gianluigi, additional, Fouquet, Jérémie, additional, Garza-Villarreal, Eduardo A., additional, Gass, Natalia, additional, Glennon, Jeffrey C., additional, Gozzi, Alessandro, additional, Gröhn, Olli, additional, Harkin, Andrew, additional, Heerschap, Arend, additional, Helluy, Xavier, additional, Herfert, Kristina, additional, Heuser, Arnd, additional, Homberg, Judith R., additional, Houwing, Danielle J., additional, Hyder, Fahmeed, additional, Ielacqua, Giovanna Diletta, additional, Jelescu, Ileana O., additional, Johansen-Berg, Heidi, additional, Kaneko, Gen, additional, Kawashima, Ryuta, additional, Keilholz, Shella D., additional, Keliris, Georgios A., additional, Kelly, Clare, additional, Kerskens, Christian, additional, Khokhar, Jibran Y., additional, Kind, Peter C., additional, Langlois, Jean-Baptiste, additional, Lerch, Jason P., additional, López-Hidalgo, Monica A., additional, Manahan-Vaughan, Denise, additional, Marchand, Fabien, additional, Mars, Rogier B., additional, Marsella, Gerardo, additional, Micotti, Edoardo, additional, Muñoz-Moreno, Emma, additional, Near, Jamie, additional, Niendorf, Thoralf, additional, Otte, Willem M., additional, Pais-Roldán, Patricia, additional, Pan, Wen-Ju, additional, Prado-Alcalá, Roberto A., additional, Quirarte, Gina L., additional, Rodger, Jennifer, additional, Rosenow, Tim, additional, Sampaio-Baptista, Cassandra, additional, Sartorius, Alexander, additional, Sawiak, Stephen J., additional, Scheenen, Tom W. J., additional, Shemesh, Noam, additional, Shih, Yen-Yu Ian, additional, Shmuel, Amir, additional, Soria, Guadalupe, additional, Stoop, Ron, additional, Thompson, Garth J., additional, Till, Sally M., additional, Todd, Nick, additional, Van Der Linden, Annemie, additional, van der Toorn, Annette, additional, van Tilborg, Geralda A. F., additional, Vanhove, Christian, additional, Veltien, Andor, additional, Verhoye, Marleen, additional, Wachsmuth, Lydia, additional, Weber-Fahr, Wolfgang, additional, Wenk, Patricia, additional, Yu, Xin, additional, Zerbi, Valerio, additional, Zhang, Nanyin, additional, Zhang, Baogui B., additional, Zimmer, Luc, additional, Devenyi, Gabriel A., additional, Chakravarty, M. Mallar, additional, and Hess, Andreas, additional

Published
2023
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10. Behavioral and functional assessment of mice inner ear after chronic exposure to an ultrahigh B0 field of 11.7 T or 17.2 T.

Author

Le Ster, Caroline, Selingue, Erwan, Poirier, Rosline, Edeline, Jean‐Marc, Mériaux, Sébastien, and Boulant, Nicolas

Subjects
INNER ear, VESTIBULAR apparatus, MICE, HAIR cells, MOTOR ability
Abstract

Purpose: Assess short‐term and long‐term effects of chronic exposure to an ultrahigh static magnetic (B0) field on mice inner ear in the context of MR safety of human scanning at 11.7 T. Methods: Mice were chronically exposed to a B0 field of 11.7 T or 17.2 T during ten 2‐h exposure sessions evenly distributed over a period of 5 weeks, resulting in a total of 20 h of exposure per mouse. During exposure sessions, mice were anesthetized and positioned either parallel or antiparallel to B0. Before, during, and 2 weeks after the magnetic‐field exposure period, mice performed behavioral tests (balance beam, rotarod, and swim tests) to evaluate their short‐term and long‐term motor coordination and balance. An auditory brainstem response (ABR) test was finally performed to assess the functional integrity of mice cochlea, 2 weeks after the last exposure. Results: After awaking from anesthesia following B0 exposures at 11.7 Tor 17.2 T, mice displayed a transient (<5 min) rotating behavior. The behavioral tests did not show any difference between the exposed and the control mice at any time point. Determination of ABR thresholds did not reveal an impairment of cochlea hair cells resulting from chronic B0 exposure. Conclusion: Despite the transient disturbance of mice vestibular system observed immediately after B0 exposure, no short‐term nor long‐term alteration was detected with behavioral and ABR tests. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Behavioral and functional assessment of mice inner ear after chronic exposure to an ultra-high B0 field of 11.7T or 17.2T

Author

Le Ster, Caroline, Selingue, Erwan, Poirier, Roseline, Edeline, Jean-Marc, Mériaux, Sébastien, Boulant, Nicolas, Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and European Union Award grand 885876

Subjects
[PHYS]Physics [physics], [SCCO]Cognitive science, ultrahigh field, vestibular system, auditory brainstem response, behavioral tests
Abstract

International audience; Assess short-term and long-term effects of chronic exposure to an ultrahigh static magnetic (B 0) field on mice inner ear in the context of MR safety of human scanning at 11.7 T. Methods: Mice were chronically exposed to a B 0 field of 11.7 T or 17.2 T during ten 2-h exposure sessions evenly distributed over a period of 5 weeks, resulting in a total of 20 h of exposure per mouse. During exposure sessions, mice were anesthetized and positioned either parallel or antiparallel to B 0. Before, during, and 2 weeks after the magnetic-field exposure period, mice performed behavioral tests (balance beam, rotarod, and swim tests) to evaluate their short-term and long-term motor coordination and balance. An auditory brainstem response (ABR) test was finally performed to assess the functional integrity of mice cochlea, 2 weeks after the last exposure. Results: After awaking from anesthesia following B 0 exposures at 11.7 Tor 17.2 T, mice displayed a transient (

Published
2023

12. Efficient PD-L1 imaging of murine glioblastoma with FUS-aided immunoPET by leveraging FcRn-antibody interaction

Author

Chevaleyre, Céline, primary, Novell, Anthony, additional, Tournier, Nicolas, additional, Dauba, Ambre, additional, Dubois, Steven, additional, Kereselidze, Dimitri, additional, Selingue, Erwan, additional, Jego, Benoit, additional, Maillère, Bernard, additional, Larrat, Benoit, additional, Nozach, Hervé, additional, and Truillet, Charles, additional

Published
2023
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13. Refining the delivery and therapeutic efficacy of cetuximab using focused ultrasound in a mouse model of glioblastoma: An 89Zr-cetuximab immunoPET study

Author

Porret, Estelle, primary, Kereselidze, Dimitri, additional, Dauba, Ambre, additional, Schweitzer-Chaput, Arnaud, additional, Jegot, Benoit, additional, Selingue, Erwan, additional, Tournier, Nicolas, additional, Larrat, Benoît, additional, Novell, Anthony, additional, and Truillet, Charles, additional

Published
2023
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16. StandardRat: A multi-center consensus protocol to enhance functional connectivity specificity in the rat brain

Author

Grandjean, Joanes, primary, Desrosiers-Gregoire, Gabriel, additional, Anckaerts, Cynthia, additional, Angeles-Valdez, Diego, additional, Ayad, Fadi, additional, Barrière, David A, additional, Blockx, Ines, additional, Bortel, Aleksandra B, additional, Broadwater, Margaret, additional, Cardoso, Beatriz M, additional, Célestine, Marina, additional, Chavez-Negrete, Jorge E, additional, Choi, Sangcheon, additional, Christiaen, Emma, additional, Clavijo, Perrin, additional, Colon-Perez, Luis, additional, Cramer, Samuel, additional, Daniele, Tolomeo, additional, Dempsey, Elaine, additional, Diao, Yujian, additional, Doelemeyer, Arno, additional, Dopfel, David, additional, Dvořáková, Lenka, additional, Falfán-Melgoza, Claudia, additional, Fernandes, Francisca F, additional, Fowler, Caitlin F, additional, Fuentes-Ibañez, Antonio, additional, Garin, Clément, additional, Gelderman, Eveline, additional, Golden, Carla EM, additional, Guo, Chao CG, additional, Henckens, Marloes JAG, additional, Hennessy, Lauren A, additional, Herman, Peter, additional, Hofwijks, Nita, additional, Horien, Corey, additional, Ionescu, Tudor M, additional, Jones, Jolyon, additional, Kaesser, Johannes, additional, Kim, Eugene, additional, Lambers, Henriette, additional, Lazari, Alberto, additional, Lee, Sung-Ho, additional, Lillywhite, Amanda, additional, Liu, Yikang, additional, Liu, Yanyan Y, additional, López-Castro, Alejandra, additional, López-Gil, Xavier, additional, Ma, Zilu, additional, MacNicol, Eilidh, additional, Madularu, Dan, additional, Mandino, Francesca, additional, Marciano, Sabina, additional, McAuslan, Matthew J, additional, McCunn, Patrick, additional, McIntosh, Alison, additional, Meng, Xianzong, additional, Meyer-Baese, Lisa, additional, Missault, Stephan, additional, Moro, Federico, additional, Naessens, Daphne, additional, Nava-Gomez, Laura J, additional, Nonaka, Hiroi, additional, Ortiz, Juan J, additional, Paasonen, Jaakko, additional, Peeters, Lore M, additional, Pereira, Mickaël, additional, Perez, Pablo D, additional, Pompilus, Marjory, additional, Prior, Malcolm, additional, Rakhmatullin, Rustam, additional, Reimann, Henning M, additional, Reinwald, Jonathan, additional, de Rio, Rodrigo Triana, additional, Rivera-Olvera, Alejandro, additional, Ruiz-Pérez, Daniel, additional, Russo, Gabriele, additional, Rutten, Tobias J, additional, Ryoke, Rie, additional, Sack, Markus, additional, Salvan, Piergiorgio, additional, Sanganahalli, Basavaraju G, additional, Schroeter, Aileen, additional, Seewoo, Bhedita J, additional, Selingue, Erwan, additional, Seuwen, Aline, additional, Shi, Bowen, additional, Sirmpilatze, Nikoloz, additional, Smith, Joanna AB, additional, Smith, Corrie, additional, Sobczak, Filip, additional, Stenroos, Petteri J, additional, Straathof, Milou, additional, Strobelt, Sandra, additional, Sumiyoshi, Akira, additional, Takahashi, Kengo, additional, Torres-García, Maria E, additional, Tudela, Raul, additional, van den Berg, Monica, additional, van der Marel, Kajo, additional, van Hout, Aran TB, additional, Vertullo, Roberta, additional, Vidal, Benjamin, additional, Vrooman, Roel M, additional, Wang, Victora X, additional, Wank, Isabel, additional, Watson, David JG, additional, Yin, Ting, additional, Zhang, Yongzhi, additional, Zurbruegg, Stefan, additional, Achard, Sophie, additional, Alcauter, Sarael, additional, Auer, Dorothee P, additional, Barbier, Emmanuel L, additional, Baudewig, Jürgen, additional, Beckmann, Christian F, additional, Beckmann, Nicolau, additional, Becq, Guillaume JPC, additional, Blezer, Erwin LA, additional, Bolbos, Radu, additional, Boretius, Susann, additional, Bouvard, Sandrine, additional, Budinger, Eike, additional, Buxbaum, Joseph D, additional, Cash, Diana, additional, Chapman, Victoria, additional, Chuang, Kai-Hsiang, additional, Ciobanu, Luisa, additional, Coolen, Bram, additional, Dalley, Jeffrey W, additional, Dhenain, Marc, additional, Dijkhuizen, Rick M, additional, Esteban, Oscar, additional, Faber, Cornelius, additional, Febo, Marcelo, additional, Feindel, Kirk W, additional, Forloni, Gianluigi, additional, Fouquet, Jérémie, additional, Garza-Villarreal, Eduardo A, additional, Gass, Natalia, additional, Glennon, Jeffrey C, additional, Gozzi, Alessandro, additional, Gröhn, Olli, additional, Harkin, Andrew, additional, Heerschap, Arend, additional, Helluy, Xavier, additional, Herfert, Kristina, additional, Heuser, Arnd, additional, Homberg, Judith R, additional, Houwing, Danielle J, additional, Hyder, Fahmeed, additional, Ielacqua, Giovanna Diletta, additional, Jelescu, Ileana O, additional, Johansen-Berg, Heidi, additional, Kaneko, Gen, additional, Kawashima, Ryuta, additional, Keilholz, Shella D, additional, Keliris, Georgios A, additional, Kelly, Clare, additional, Kerskens, Christian, additional, Khokhar, Jibran Y, additional, Kind, Peter C, additional, Langlois, Jean-Baptiste, additional, Lerch, Jason P, additional, López-Hidalgo, Monica A, additional, Manahan-Vaughan, Denise, additional, Marchand, Fabien, additional, Mars, Rogier B, additional, Marsella, Gerardo, additional, Micotti, Edoardo, additional, Muñoz-Moreno, Emma, additional, Near, Jamie, additional, Niendorf, Thoralf, additional, Otte, Willem M, additional, Pais, Patricia, additional, Pan, Wen-Ju, additional, Prado-Alcalá, Roberto A, additional, Quirarte, Gina L, additional, Rodger, Jennifer, additional, Rosenow, Tim, additional, Baptista, Cassandra Sampaio, additional, Sartorius, Alexander, additional, Sawiak, Stephen J, additional, Scheenen, Tom WJ, additional, Shemesh, Noam, additional, Shih, Yen-Yu Ian, additional, Shmuel, Amir, additional, Soria, Guadalupe, additional, Stoop, Ron, additional, Thompson, Garth J, additional, Till, Sally M, additional, Todd, Nick, additional, Van Der Linden, Annemie, additional, van der Toorn, Annette, additional, van Tilborg, Geralda AF, additional, Vanhove, Christian, additional, Veltien, Andor, additional, Verhoye, Marleen, additional, Wachsmuth, Lydia, additional, Weber-Fahr, Wolfgang, additional, Wenk, Patricia, additional, Yu, Xin, additional, Zerbi, Valerio, additional, Zhang, Nanyin, additional, Zhang, Baogui B, additional, Zimmer, Luc, additional, Devenyi, Gabriel A, additional, Chakravarty, M Mallar, additional, and Hess, Andreas, additional

Published
2022
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17. Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state

Author

Maté de Gérando, Anastasie, primary, d’Orange, Marie, additional, Augustin, Emma, additional, Joséphine, Charlène, additional, Aurégan, Gwénaelle, additional, Gaudin-Guérif, Mylène, additional, Guillermier, Martine, additional, Hérard, Anne-Sophie, additional, Stimmer, Lev, additional, Petit, Fanny, additional, Gipchtein, Pauline, additional, Jan, Caroline, additional, Escartin, Carole, additional, Selingue, Erwan, additional, Carvalho, Kévin, additional, Blum, David, additional, Brouillet, Emmanuel, additional, Hantraye, Philippe, additional, Gaillard, Marie-Claude, additional, Bonvento, Gilles, additional, Bemelmans, Alexis-Pierre, additional, and Cambon, Karine, additional

Published
2021
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20. Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state.

Author

Gérando, Anastasie Maté de, d'Orange, Marie, Augustin, Emma, Joséphine, Charlène, Aurégan, Gwénaelle, Gaudin-Guérif, Mylène, Guillermier, Martine, Hérard, Anne-Sophie, Stimmer, Lev, Petit, Fanny, Gipchtein, Pauline, Jan, Caroline, Escartin, Carole, Selingue, Erwan, Carvalho, Kévin, Blum, David, Brouillet, Emmanuel, Hantraye, Philippe, Gaillard, Marie-Claude, and Bonvento, Gilles

Subjects
ASTROCYTES, TAU proteins, ADENO-associated virus, TRANSGENIC mice, GENETIC transformation, CHRONIC traumatic encephalopathy, FRONTOTEMPORAL lobar degeneration, PROTEIN metabolism, PROTEINS, RESEARCH, NERVE tissue proteins, HIPPOCAMPUS (Brain), NEURONS, ANIMAL experimentation, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, CELLS, NEURODEGENERATION, MICE
Abstract

Deposits of different abnormal forms of tau in neurons and astrocytes represent key anatomo-pathological features of tauopathies. Although tau protein is highly enriched in neurons and poorly expressed by astrocytes, the origin of astrocytic tau is still elusive. Here, we used innovative gene transfer tools to model tauopathies in adult mouse brains and to investigate the origin of astrocytic tau. We showed in our adeno-associated virus (AAV)-based models and in Thy-Tau22 transgenic mice that astrocytic tau pathology can emerge secondarily to neuronal pathology. By designing an in vivo reporter system, we further demonstrated bidirectional exchanges of tau species between neurons and astrocytes. We then determined the consequences of tau accumulation in astrocytes on their survival in models displaying various status of tau aggregation. Using stereological counting of astrocytes, we report that, as for neurons, soluble tau species are highly toxic to some subpopulations of astrocytes in the hippocampus, whereas the accumulation of tau aggregates does not affect their survival. Thus, astrocytes are not mere bystanders of neuronal pathology. Our results strongly suggest that tau pathology in astrocytes may significantly contribute to clinical symptoms. [ABSTRACT FROM AUTHOR]

Published
2021
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23. Abstract 2797: Liver cancer patient-derived xenografts to improve disease management in childhood and adolescence: perspectives and challenges of personalized medicine.

Author

Cairo, Stefano, primary, Gorse, Aurore, additional, Nicolle, Delphine, additional, Selingue, Erwan, additional, Gauthier, Frédéric, additional, Chardot, Christophe, additional, Fadel, Elie, additional, Elias, Dominique, additional, Orbach, Daniel, additional, Guettier, Catherine, additional, Beurdeley, Arnaud, additional, Yvonnet, Vanessa, additional, Deas, Olivier, additional, Fabre, Monique, additional, Brugières, Laurence, additional, Branchereau, Sophie, additional, and Judde, Jean-Gabriel, additional

Published
2013
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24. Behavioral and functional assessment of mice inner ear after chronic exposure to an ultrahigh B 0 field of 11.7 T or 17.2 T.

Author

Le Ster C, Selingue E, Poirier R, Edeline JM, Mériaux S, and Boulant N

Subjects
Mice, Humans, Animals, Auditory Threshold physiology, Evoked Potentials, Auditory, Brain Stem physiology, Ear, Inner diagnostic imaging
Abstract

Purpose: Assess short-term and long-term effects of chronic exposure to an ultrahigh static magnetic (B 0 ) field on mice inner ear in the context of MR safety of human scanning at 11.7 T., Methods: Mice were chronically exposed to a B 0 field of 11.7 T or 17.2 T during ten 2-h exposure sessions evenly distributed over a period of 5 weeks, resulting in a total of 20 h of exposure per mouse. During exposure sessions, mice were anesthetized and positioned either parallel or antiparallel to B 0 . Before, during, and 2 weeks after the magnetic-field exposure period, mice performed behavioral tests (balance beam, rotarod, and swim tests) to evaluate their short-term and long-term motor coordination and balance. An auditory brainstem response (ABR) test was finally performed to assess the functional integrity of mice cochlea, 2 weeks after the last exposure., Results: After awaking from anesthesia following B 0 exposures at 11.7 Tor 17.2 T, mice displayed a transient (<5 min) rotating behavior. The behavioral tests did not show any difference between the exposed and the control mice at any time point. Determination of ABR thresholds did not reveal an impairment of cochlea hair cells resulting from chronic B 0 exposure., Conclusion: Despite the transient disturbance of mice vestibular system observed immediately after B 0 exposure, no short-term nor long-term alteration was detected with behavioral and ABR tests., (© 2023 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)

Published
2023
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25. Refining the delivery and therapeutic efficacy of cetuximab using focused ultrasound in a mouse model of glioblastoma: An 89 Zr-cetuximab immunoPET study.

Author

Porret E, Kereselidze D, Dauba A, Schweitzer-Chaput A, Jegot B, Selingue E, Tournier N, Larrat B, Novell A, and Truillet C

Subjects
Animals, Mice, Blood-Brain Barrier metabolism, Cell Line, Tumor, Cetuximab metabolism, Cetuximab therapeutic use, Positron-Emission Tomography, Brain Neoplasms diagnostic imaging, Brain Neoplasms drug therapy, Brain Neoplasms metabolism, Glioblastoma drug therapy, Glioblastoma metabolism
Abstract

Introduction: Glioblastoma (GBM) is the most common and deadly form of primary brain tumor. Between 30 % and 60 % of GBM are characterized by overexpression of the Epidermal Growth Factor Receptor (EGFR). The anti-EGFR antibody Cetuximab (CTX) showed a favorable effect for EGFR + colorectal cancer but failed to demonstrate efficacy for GBM. Insufficient CTX passage through the blood-brain barrier (BBB) and the blood-tumor barrier (BTB) is assumed to be the primary determinant of the limited efficacy of this immunotherapy., Objective: Using positron emission tomography (PET) imaging, we have previously demonstrated that focused ultrasound (FUS) combined with microbubbles (µB) allowed significant and persistent delivery of CTX across the BBB in healthy mice. In the current study, we investigated by PET imaging the combination impact of CTX and FUS on orthotopic GBM preclinical model., Methods: After radiolabeling CTX with the long half-life isotope 89 Zr, PET images have been acquired overtime in mice bearing U251 (EGFR + ) with or without FUS treatment. Autoradiography combined with immunofluorescence staining was used to corroborate CTX delivery with EGFR expression. A survival study was conducted simultaneously to evaluate the therapeutic benefit of repeated CTX monotherapy associated or not with FUS., Results: Ex vivo analysis confirmed that FUS enhanced and homogenized the delivery of CTX into all the FUS exposure area, including the tumor and the contralateral hemisphere at the early-time-point. Interestingly, FUS did not improve the long-term accumulation and retention of CTX in the tumor compared with the control group (no FUS). No significant difference in the CTX treatment efficacy, determined by the survival between FUS and non-FUS groups, has been either observed. This result is consistent with the absence of change in the CTX distribution through the GBM tumor after FUS. The neuroinflammation induced by FUS is not significant enough to explain the failure of the CTX delivery improvement., Conclusion: All together, these data suggest that the role of FUS combined with µB on the CTX distribution, even after multiple therapeutic sessions and glial cell activation is insufficient to improve survival of GBM mice compared with CTX treatment alone in this model., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)

Published
2023
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26. Tumor-targeted superfluorinated micellar probe for sensitive in vivo 19 F-MRI.

Author

Jamgotchian L, Vaillant S, Selingue E, Doerflinger A, Belime A, Vandamme M, Pinna G, Ling WL, Gravel E, Mériaux S, and Doris E

Subjects
Animals, Magnetic Resonance Imaging, Mice, Micelles, Fluorine-19 Magnetic Resonance Imaging, Neoplasms
Abstract

We describe herein the assembly and in vivo evaluation of a tailor-made micellar carrier system designed for the optimized encapsulation of a superfluorinated MRI probe and further targeting of solid tumors. The in vivo validation was carried out on MC38 tumor-bearing mice which allowed the confirmation of the efficient targeting properties of the nano-carrier, as monitored by 19F-MRI.

Published
2021
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