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2. Qualitative study to explore the perspectives and mental health experiences of first episode psychosis patients and their caregivers in North India

Author

Sood, Mamta, Chadda, Rakesh K., Chawla, Nishtha, Shukla, Tulika, Patil, Vaibhav, Ratra, Dhriti, Rajhans, Pallavi, Padmavati, R., Thara, Rangaswamy, Raghavan, Vijaya, Mohan, Mohapradeep, Iyer, Srividya, Shah, Jai, Madan, Jason, Birchwood, Max, Meyer, Caroline, Lilford, RJ, Furtado, Vivek, Currie, Graeme, and Singh, Swaran P.

Published
2024
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3. Protocol-based assessment and management of first episode psychosis: Comparison of short and medium-term outcomes in psychopathology, quality of life, functioning and family burden across two sites in India

Author

Chadda, Rakesh K., Sood, Mamta, Chawla, Nishtha, Padmavati, R., Thara, Rangaswamy, Raghavan, Vijaya, Shukla, Tulika, Patil, Vaibhav, Sen, Mahadev Singh, Mohan, Mohapradeep, Iyer, Srividya, Shah, Jai, Madan, Jason, Birchwood, Max, Meyer, Caroline, Lilford, R.J., Furtado, Vivek, Currie, Graeme, and Singh, Swaran P.

Published
2024
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4. Effectiveness of a mental health literacy module on stigma related mental health knowledge and behaviour among youth in two educational settings in Chennai, South India: A quasi-experimental study

Author

Raghavan, Vijaya, Chandrasekaran, Sangeetha, Paul, Vimala, Pattabiraman, Ramakrishnan, Mohan, Greeshma, Durairaj, Jothilakshmi, Currie, Graeme, Lilford, Richard, Furtado, Vivek, Madan, Jason, Birchwood, Maximilian, Meyer, Caroline, Sood, Mamta, Chadda, Rakesh, Mohan, Mohapradeep, Shah, Jai, John, Sujit, Padmavati, R., Iyer, Srividya, Thara, R., and Singh, Swaran

Published
2024
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5. Designing and implementing a physical exercise intervention for people with first episode psychosis using experience-based co-design: A pilot study from Chennai, India

Author

Vijayalakshmi, U., Padmavati, R., Raghavan, Vijaya, Chandrasekaran, Sangeetha, Mohan, Greeshma, Durairaj, Jothilakshmi, Currie, Graeme, Lilford, Richard, Furtado, Vivek, Madan, Jason, Birchwood, Maximilian, Meyer, Caroline, Sood, Mamta, Chadda, Rakesh, Mohan, Mohapradeep, Shah, Jai, John, Sujit, Iyer, Srividya N., Thara, R., and Singh, Swaran

Published
2024
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23. Childhood Onset Schizophrenia: Clinical Features, Course and Outcome

Author

Sood, Mamta and Kattimani, Shivanand

Abstract

Schizophrenia in children is diagnosed by using adult criteria. Based on the age of onset, patients with childhood onset schizophrenia (COS) are subdivided into those with very early onset (before age 12-14 years) and those with early onset (between 14-17 years). The prevalence of COS is reported to be 1 in 10,000 before the age of 12 years; however, there is a significant increase around puberty and early adolescence and by 18 years of age, 20% of the patients with schizophrenia will have the illness. Simple delusions and hallucinations revolving around childhood themes, language and communication deficits and flat affect have been reported in COS. Follow-up studies suggest that the outcome is generally poor to fair. Predictors of poor outcome are age of onset (less than 12 years), insidious onset and marked premorbid abnormalities. (Contains 1 table.)

Published
2008

32. Genetic Landscape of Major Depressive Disorder: Assessment of Potential Diagnostic and Antidepressant Response Markers.

Author

Singh, Priyanka, Srivastava, Ankit, Guin, Debleena, Thakran, Sarita, Yadav, Jyoti, Chandna, Puneet, Sood, Mamta, Chadda, Rakesh Kumar, and Kukreti, Ritushree

Subjects
MENTAL depression, ANTIDEPRESSANTS, GENOME-wide association studies, DIAGNOSIS
Abstract

Background The clinical heterogeneity in major depressive disorder (MDD), variable treatment response, and conflicting findings limit the ability of genomics toward the discovery of evidence-based diagnosis and treatment regimen. This study attempts to curate all genetic association findings to evaluate potential variants for clinical translation. Methods We systematically reviewed all candidates and genome-wide association studies for both MDD susceptibility and antidepressant response, independently, using MEDLINE, particularly to identify replicated findings. These variants were evaluated for functional consequences using different in silico tools and further estimated their diagnostic predictability by calculating positive predictive values. Results A total of 217 significantly associated studies comprising 1200 variants across 545 genes and 128 studies including 921 variants across 412 genes were included with MDD susceptibility and antidepressant response, respectively. Although the majority of associations were confirmed by a single study, we identified 31 and 18 replicated variants (in at least 2 studies) for MDD and antidepressant response. Functional annotation of these 31 variants predicted 20% coding variants as deleterious/damaging and 80.6% variants with regulatory effect. Similarly, the response-related 18 variants revealed 25% coding variant as damaging and 88.2% with substantial regulatory potential. Finally, we could calculate the diagnostic predictability of 19 and 5 variants whose positive predictive values ranges from 0.49 to 0.66 for MDD and 0.36 to 0.66 for response. Conclusions The replicated variants presented in our data are promising for disease diagnosis and improved response outcomes. Although these quantitative assessment measures are solely directive of available observational evidence, robust homogenous validation studies are required to strengthen these variants for molecular diagnostic application. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Transforming access to care for serious mental disorders in slums (the TRANSFORM Project): rationale, design and protocol

Author

Singh, Swaran P., primary, Jilka, Sagar, additional, Abdulmalik, Jibril, additional, Bouliotis, Georgios, additional, Chadda, Rakesh, additional, Egbokhare, Olayinka, additional, Huque, Rumana, additional, Hundt, Gillian Lewando, additional, Iyer, Srividya, additional, Jegede, Obafemi, additional, Khera, Neeru, additional, Lilford, Richard, additional, Madan, Jason, additional, Omigbodun, Akinyinka, additional, Omigbodun, Olayinka, additional, Raja, Tasneem, additional, Read, Ursula M., additional, Siddiqi, Bulbul Ashraf, additional, Sood, Mamta, additional, Soron, Tanjir Rashid, additional, and Ahmed, Helal Uddin, additional

Published
2022
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40. Effectiveness of an integrated perinatal oral health assessment and promotion program on the knowledge in Indian pregnant women

Author

Bansal, Kalpana, Kharbanda, Om, Sharma, J., Sood, Mamta, Priya, Harsh, and Kriplani, Alka

Subjects
Oral health, Women's health, Pregnancy, Pregnant women, Education, Children, Health
Abstract

Byline: Kalpana. Bansal, Om. Kharbanda, J. Sharma, Mamta. Sood, Harsh. Priya, Alka. Kriplani Background: Oral health during pregnancy plays a crucial role in the overall health and well-being of pregnant [...]

Published
2019

43. Understanding needs of stakeholders and outcomes desired from a home-based intervention program for “difficult to treat” schizophrenia and related disorders: A qualitative study

Author

Sood, Mamta, primary, Chadda, RakeshKumar, additional, Chawla, Nishtha, additional, Sharma, MonaR, additional, Patel, Rekha, additional, Mohan, Mohapradeep, additional, Iyer, Srividya, additional, Padmavati, R, additional, Thara, Rangaswamy, additional, and Singh, SwaranP, additional

Published
2022
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45. Understanding needs of stakeholders and outcomes desired from a home-based intervention program for 'difficult to treat' schizophrenia and related disorders: A qualitative study

Author

Sood, Mamta, Chadda, Rakesh Kumar, Chawla, Nishtha, Sharma, Mona R., Patel, Rekha, Mohan, Mohapradeep, Iyer, Srividya, Padmavati, R., Thara, Rangaswamy, and Singh, Swaran P.

Subjects
Psychiatry and Mental health, R1, RC
Abstract

Background: \ud We aimed to understand the needs of service users – families and patients with schizophrenia and related disorders, and mental health professionals (MHPs) and expectations from a home-based psychosocial intervention program in Indian setting.\ud \ud Materials and Methods: \ud We conducted four focus group discussions (FGDs) with families, patients with schizophrenia and related disorders and MHPs. Two FGDs were conducted with families and one each with the patients and MHPs. Participants in families and MHP group were asked about their primary concerns in caring for the patients, perceived needs of patients and the areas that can be targeted through a home-based psychosocial intervention program. All FGDs were audio-recorded and verbatim transcribed. Content analysis of the data was done to obtain a final list of needs and expected outcomes from a psychosocial intervention supported by families.\ud \ud Results: \ud Six key priority needs were identified for intervention: medication adherence, activities of daily living, promoting physical health, engagement in meaningful work, building of social and support networks and information about all aspects of illness. Priority outcomes identified by MHPs were mostly clinical like symptom reduction, fewer rehospitalisation while families and patients focused more on psychosocial outcomes, such as improvement of wellbeing, having relationships, engagement in meaningful activities, better organization of the day, increased self-respect, reduced stress, lesser interference, and critical comments. All groups suggested that book or mobile app or video could be used.\ud \ud Conclusion: \ud This qualitative study shows that while both clinicians and service users consider recovery from schizophrenia and related disorders to be important, they differ on what they prioritise.\ud

Published
2021

47. Warwick-India-Canada (WIC) global mental health group: rationale, design and protocol

Author

Singh, Swaran P, primary, Mohan, Mohapradeep, additional, Iyer, Srividya N, additional, Meyer, Caroline, additional, Currie, Graeme, additional, Shah, Jai, additional, Madan, Jason, additional, Birchwood, Max, additional, Sood, Mamta, additional, Ramachandran, Padmavati, additional, Chadda, Rakesh K, additional, Lilford, Richard J, additional, Rangaswamy, Thara, additional, and Furtado, Vivek, additional

Published
2021
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