Search

Your search keyword '"Struffert, Tobias"' showing total 383 results
Start Over Author "Struffert, Tobias" Publication Year Range Last 50 years
383 results on '"Struffert, Tobias"'

3. Outcome of whole brain irradiation with a dose-escalated simultaneous-integrated boost in patients with multiple large and/or diffuse brain metastases: real live data and review of the literature.

Author

Agolli, Linda, Nicosia, Luca, Hilger, Thomas, Iancu, Gheorghe, Exeli, Ann-Katrin, Eul, Bastian, Struffert, Tobias, Acker, Till, and Habermehl, Daniel

Subjects
LITERATURE reviews, BRAIN tumors, BREAST cancer, HISTOLOGY, MELANOMA
Abstract

Background: We retrospectively investigate feasibility and safety of whole brain radiotherapy (WBRT) including a simultaneous-integrated boost technique (WBRT-SIB) in a cohort of patients with a very poor prognosis suffering from multiple and/or large brain metastases, unfavorable primary histology, poor performance status and/or symptomatic BMs. Materials and Methods: Thirty-five patients with high brain tumor burden, extracranial metastases and low life-expectancy were treated with WBRT-SIB mostly with 35-42 Gy/14 fractions. All metastases were boosted in patients with up to 12 BMs. In patients with > 12 BM, large and/or small metastases in critical brain regions were boosted up to a maximum of 12 SIB volumes. Results: The median number of BM was 8 (range 2–45) and the median BM diameter was 12 mm (range 4–90 mm). Fifteen (43%) patients had ≥ 10 BMs and 25 patients presented with a Karnofski index ≤ 80%. Primary tumor histology was NSCLC (n = 13), SCLC (n = 11), breast cancer (n = 7), melanoma (n = 2), other (n = 2). The median iPFS was not reached, and 12- and 18-months iPFS were 75% and 50%, respectively. Overall, seven patients had intracranial progression: two patients within the SIB and WBRT area, one patient only within the SIB region and four patients had new BMs in the WBRT volume alone. The median iPFS for non-SCLC patients was 17 months and the 12- and 18-month iPFS were 56.8% and 28.4%, respectively. There was no significant OS difference between SCLC-group and non-SCLC patients (p = 0.38). Overall, median OS was 8.7 months and 1-year OS was 25%. The treatment was generally well-tolerated with no observed cases of radionecrosis. Conclusion: Our WBRT-SIB approach involves a combination of whole brain radiotherapy and a simultaneous integrated boost to specific tumor volumes, and its effectiveness is compared with other treatment modalities in the literature. Further research, including prospective studies with larger patient cohorts, is necessary to validate and refine the findings. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

7. Comparison of vascular risk profile and clinical outcomes among patients with central (branch) retinal artery occlusion versus amaurosis fugax.

Author

Diel, Norma J., Gerner, Stefan T., Doeppner, Thorsten R., Juenemann, Martin, Maxhuni, Toska, Frühwald, Tobias, Worm, Andre, Alhaj Omar, Omar, Lytvynchuk, Lyubomyr, Struffert, Tobias, Bauer, Pascal, and Huttner, Hagen B.

Subjects
RETINAL artery, RETINAL artery occlusion, BLINDNESS, ISCHEMIC stroke, TREATMENT effectiveness, MONOCULAR vision
Abstract

Background: Retinal artery occlusions lead to sudden, painless vision loss, affecting millions globally. Despite their significance, treatment strategies remain unestablished, contrasting with acute ischemic stroke (AIS), where IVT has proven efficacy. Similar to AIS, retinal artery occlusions demand urgent evaluation and treatment, reflecting the principle "time is retina". Even for patients with transient monocular vision loss, also known as amaurosis fugax (AF), pertinent guidelines meanwhile recommend immediate emergency assessment in a specialized facility. However, data on the clinical benefit and comparability with persistent occlusions are missing. This study aimed to compare the results of a comprehensive stroke-workup among patients with persistent retinal artery occlusions (RAO), including both central retinal (CRAO) and branch retinal artery occlusion (BRAO) and those with AF. Methods: Conducted at the University Hospital Giessen, Germany, this exploratory cross-sectional study enrolled patients with transient or permanent unilateral vision loss of non-arteritic origin. The primary outcome were differences between the two groups RAO and AF with regard to cardiovascular risk profiles and comorbidities, vascular and pharmacological interventions and clinical neurological and ophthalmological outcomes. Secondary outcome was a sub-group analysis of patients receiving IVT. Results: Out of 166 patients assessed, 76 with RAO and 40 with AF met the inclusion criteria. Both groups exhibited comparable age, gender distribution, and cardiovascular risk profiles. Notably, RAO patients did not show significantly more severe vascular comorbidities than AF patients. However, AF patients received vascular interventions more frequently. Pharmacological intervention rates were similar across groups. RAO patients had slightly worse neurological outcomes, and IVT did not yield favorable ophthalmological outcomes within any observed patients. Conclusion: The study found similar vascular burden and risk factors in patients with RAO and AF, with implications for clinical workflows. IVT for RAO may only be effective in very early treatment windows. This emphasizes the need for public awareness and collaborative protocols between ophthalmologists and neurologists to improve outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

23. Clinical Evaluation of an Innovative Metal-Artifact-Reduction Algorithm in FD-CT Angiography in Cerebral Aneurysms Treated by Endovascular Coiling or Surgical Clipping

Author

Eisenhut, Felix, primary, Schmidt, Manuel Alexander, additional, Kalik, Alexander, additional, Struffert, Tobias, additional, Feulner, Julian, additional, Schlaffer, Sven-Martin, additional, Manhart, Michael, additional, Doerfler, Arnd, additional, and Lang, Stefan, additional

Published
2022
Full Text
View/download PDF

26. Imaging modalities using magnetic nanoparticles – overview of the developments in recent years

Author

Schwarz Marc, Dörfler Arnd, Engelhorn Tobias, Struffert Tobias, Tietze Rainer, Janko Christina, Tripal Philipp, Cicha Iwona, Dürr Stephan, Alexiou Christoph, and Lyer Stefan

Subjects
magnetic particle imaging, magnetorelaxometry, multifunctional nanoparticles, nanoparticles, Technology, Chemical technology, TP1-1185, Physical and theoretical chemistry, QD450-801
Abstract

The use of nanoparticles in tumor imaging, molecular imaging, and drug delivery has significantly expanded in the last few years. The relatively new field of “theranostics” combines their capacity for drug delivery with their potential as contrast agents. Depending on the imaging modality used, several types of nanoparticles are available, such as gold for optical imaging or superparamagnetic iron oxide for magnetic resonance imaging. This review will give a short overview of the different types of nanoparticles as well as their development and potential application in recent years. Furthermore, it describes the research on classic imaging modalities as well as on new techniques to image nanoparticles in vivo and focuses on magnetic-based imaging modalities.

Published
2013
Full Text
View/download PDF

29. Evaluation After Cochlear Implant Surgery

Author

Stock, Annika, Bozzato, Victoria, Kloska, Stephan P., Bozzato, Alessandro, Hoppe, Ulrich, Hornung, Joachim, Dörfler, Arnd, and Struffert, Tobias

Subjects
Cochlear implantation, Dyna-CT, Misplaced cochlear implant electrode array, Rehabilitation, otorhinolaryngologic diseases, Original Article, ddc:610, sense organs, Deafness, psychological phenomena and processes
Abstract

Purpose Assessment of the cochlear implant (CI) electrode array position using flat-detector computed tomography (FDCT) to test dependence of postoperative outcome on intracochlear electrode position. Methods A total of 102 patients implanted with 107 CIs underwent FDCT. Electrode position was rated as 1) scala tympani, 2) scala vestibuli, 3) scalar dislocation and 4) no deconvolution. Two independent neuroradiologists rated all image data sets twice and the scalar position was verified by a third neuroradiologist. Presurgical and postsurgical speech audiometry by the Freiburg monosyllabic test was used to evaluate auditory outcome after 6 months of speech rehabilitation. Results Electrode array position was assessed by FDCT in 107 CIs. Of the electrodes 60 were detected in the scala tympani, 21 in the scala vestibuli, 24 electrode arrays showed scalar dislocation and 2 electrodes were not placed in an intracochlear position. There was no significant difference in rehabilitation outcomes between scala tympani and scala vestibuli inserted patients. Rehabilitation was also possible in patients with dislocated electrodes. Conclusion The use of FDCT is a reliable diagnostic method to determine the position of the electrode array. In our study cohort, the electrode position had no significant impact on postoperative outcome except for non-deconvoluted electrode arrays.

Published
2020

30. Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome

Author

Braun, Tobias, Viard, Maxime, Juenemann, Martin, Struffert, Tobias, Schwarm, Frank, Huttner, Hagen B., and Roessler, Florian C.

Subjects
Neurology, Covid-19-vaccination, ChAdOx1 nCoV-19 vaccine, Case Report, cerebral venous thrombosis, Neurology (clinical), vaccine-induced thrombotic thrombocytopenia, Neurology. Diseases of the nervous system, RC346-429, thrombotic thrombocytopenia syndrome
Abstract

We present two cases of ChAdOx1 nCov-19 (AstraZeneca)-associated thrombotic thrombocytopenia syndrome (TTS) and cerebral venous sinus thrombosis (CVST). At the time of emergency room presentation due to persistent headache, blood serum levels revealed reduced platelet counts. Yet, 1 or 4 days after the onset of the symptom, the first MR-angiography provided no evidence of CVST. Follow-up imaging, performed upon headache refractory to nonsteroidal pain medication verified CVST 2–10 days after initial negative MRI. Both the patients received combined treatment with intravenous immunoglobulins and parenteral anticoagulation leading to an increase of platelet concentration in both the individuals and resolution of the occluded cerebral sinus in one patient.

Published
2021

35. MRT-Veränderungen nach Protonentherapie in Kombination mit Tumor Treating Fields bei Glioblastompatienten

Author

Goett, Hanna, Jensen, Alexandra, Struffert, Tobias, Uhl, Eberhard, and Stein, Marco

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Tumor treating fields (TTFields) are an approved treatment modality for glioblastoma (GBM) with significant improvement of progression free survival and overall survival. Growing evidence suggest, that proton therapy increase early magnetic resonance imaging (MRI) changes. The aim of this[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Published
2021
Full Text
View/download PDF

36. Stent-Assisted Coiling Using Leo+ Baby Stent

Author

Luecking, Hannes, Struffert, Tobias, Goelitz, Philipp, Engelhorn, Tobias, Brandner, Sebastian, Kuramatsu, Joji B., Lang, Stefan, Schmidt, Manuel, and Doerfler, Arnd

Subjects
ddc:610
Abstract

Background Stent-assisted coiling is well-established for treatment of cerebral aneurysms. The technique enables treatment of wide-neck, bifurcation and recurrent aneurysms with high packing rates. While described in extenso for laser cut stents, the results of patients treated with the Leo+ Baby (Balt, Montmorency, France) braided microstent are presented. Material and Methods Patients were included if treated with a Leo+ Baby and with digital subtraction angiography (DSA) follow-up available of at least 6 months. Data were evaluated for successful deployment, aneurysm occlusion according to the modified Raymond-Roy classification (MRRC), stent patency and procedure-related morbidity and mortality. Results A total of 81 patients were included and Leo+ Baby deployment was successful in all cases. Coils were used in 80 cases. In 1 case 2 stents were used stent-in-stent without additional coiling. Initial aneurysm occlusion rates were MRRCi1 51.9%, MRRCi2 11.1%, MRRCi3a 24.7% and MRRCi3b 12.3%. Occlusion rates after 6 months were MRRC6m1 78.9%, MRRC6m2 3.9%, MRRC6m3a 6.6% and MRRC6m3b 10.5%. Procedure-related morbidity was 1 case of acute stent thrombosis successfully treated with tirofiban and 1 case with transient hemiparesis due to stent thrombosis after 4 months. There was 1 case of coil-associated subarachnoid hemorrhage (SAH) which caused prolonged hospitalization. No procedure-related mortality was observed. Conclusion The results confirm that stent-assisted coiling with the Leo+ Baby stent is safe and efficient for treatment of wide neck or recurrent cerebral aneurysms. Spontaneous progressive aneurysm occlusion over 6 months supports the theory of considerable flow-modulating effects of Leo+ Baby.

Published
2021

38. Case Report: A Well-Hidden Cause for Myelopathy

Author

Braun, Tobias, Schulz, Eva, Viard, Maxime, AlhajOmar, Omar, Struffert, Tobias, Gattenlöhner, Stefan, Yenigün, Mesut, Juenemann, Martin, and Justus Liebig University Giessen

Subjects
spinal cord syndrome, ddc:610, neurosarcoidosis, myelopathy, bone marrow sarcoidosis, case report, Neurology. Diseases of the nervous system, RC346-429
Abstract

Introduction: Sarcoidosis is a rare, systemic inflammatory disease and can involve multiple organs, especially the lungs and lymph nodes. The nervous system is affected in

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results