34 results on '"Tabo, Mitsuyasu"'
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2. Rapid in vitro assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4+ T cell interleukin-2 secretion
3. Involvement of the Autonomic Nervous System in Diurnal Variation of Corrected QT Intervals in Common Marmosets
4. Electrophysiological Characterization of Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells
5. In Vivo Imaging With Two-Photon Microscope For Assessing Tumor Selective Binding Of Anti-CD137 Switch Antibody
6. Rapid in vitro assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4+ T cell interleukin-2 secretion.
7. Sensitivity of common marmosets to detect drug-induced QT interval prolongation: Moxifloxacin case study
8. Application of probabilistic analysis for precisely correcting the QT interval for heart rate in telemetered common marmosets
9. Prediction of Human Pharmacokinetics Profile of Monoclonal Antibody Using hFcRn Transgenic Mouse Model
10. Monophasic action potential in anaesthetized guinea pigs as a biomarker for prediction of liability for drug-induced delayed ventricular repolarization
11. QT PRODACT: Evaluation of the Potential of Compounds to Cause QT Interval Prolongation by Action Potential Assays Using Guinea-Pig Papillary Muscles
12. QT PRODACT: A Multi-site Study of In Vitro Action Potential Assays on 21 Compounds in Isolated Guinea-Pig Papillary Muscles
13. Cardiac safety assessment with motion field imaging analysis of human iPS cell-derived cardiomyocytes is improved by an integrated evaluation with cardiac ion channel profiling
14. In vitro human helper T-cell assay to screen antibody drug candidates for immunogenicity
15. Different players generate positive responses in two in vitro cytokine assay formats with aqueous and immobilized TGN1412 analog
16. Conduction and contraction properties of human iPS cell-derived cardiomyocytes: analysis by motion field imaging compared with the guinea-pig isolated heart model
17. Rapid in vitroassessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4+T cell interleukin-2 secretion
18. The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors
19. Is an in vitro whole blood cytokine assay useful to detect the potential risk of severe infusion reaction of monoclonal antibody pharmaceuticals?
20. Studies of in vivo drug-induced QT interval prolongation in early-stage drug development
21. Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning
22. Estimating the clinical risk of hypertension from VEGF signal inhibitors by a non-clinical approach using telemetered rats
23. Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties
24. Application of a probabilistic analytical method to detect drug-induced qt prolongation in telemetered common marmosets: Effects of moxifloxacin
25. Accurate detection of drug-induced delayed ventricular repolarization with a suitable correction formula in Langendorff guinea pig heart
26. Prediction of drug-induced QT interval prolongation in telemetered common marmosets
27. Cardiovascular safety profile of MA-2029, a novel motilin receptor antagonist
28. HEMODYNAMIC AND ELECTROPHYSIOLOGICAL EFFECTS OF MITEMCINAL (GM-611), A NOVEL PROKINETIC AGENT DERIVED FROM ERYTHROMYCIN IN A HALOTHANE-ANESTHETIZED CANINE MODEL
29. PRECLINICAL ELECTROPHYSIOLOGY ASSAYS OF MITEMCINAL (GM-611), A NOVEL PROKINETIC AGENT DERIVED FROM ERYTHROMYCIN
30. QT-RR RELATIONSHIPS AND SUITABLE QT CORRECTION FORMULAS FOR HALOTHANE-ANESTHETIZED DOGS
31. EFFECTS OF K^+ ON Ca^<2+> INFLUX AFTER DEPLETION OF INTRACELLULAR Ca^<2+> STORES IN ILEAL SMOOTH MUSCLE OF THE RAT
32. Effects of external K+ on depletion-induced Ca2+ entry in rat ileal smooth muscle
33. Studies of in vivo drug-induced OT interval prolongation in early-stage drug development.
34. Rapid in vitro assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4 + T cell interleukin-2 secretion.
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