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Your search keyword '"Tarkkanen, Jussi"' showing total 286 results
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286 results on '"Tarkkanen, Jussi"'

26. Adenoidectomy and nasopharyngeal carriage of Streptococcus pneumoniae in young children

Author

Mattila, Petri S., Hammaren-Malmi, Sari, Saxen, Harri, Kaijalainen, Tarja, Kayhty, Helena, and Tarkkanen, Jussi

Subjects
Microbial colonies -- Research, Otitis media -- Risk factors, Otitis media -- Demographic aspects, Otitis media -- Research, Adenoidectomy -- Complications and side effects, Adenoidectomy -- Research, Streptococcus pneumoniae -- Risk factors, Streptococcus pneumoniae -- Demographic aspects, Streptococcus pneumoniae -- Research
Published
2010

28. Adenoidectomy does not significantly reduce the incidence of otitis media in conjunction with the insertion of tympanostomy tubes in children who are younger than 4 years: a randomized trial

Author

Hammaren-Malmi, Sari, Saxen, Harri, Tarkkanen, Jussi, and Mattila, Petri S.

Subjects
Otitis media -- Causes of, Otitis media -- Care and treatment, Otitis media -- Drug therapy, Adenoidectomy -- Health aspects
Abstract

Objective. To evaluate the efficacy of adenoidectomy in reducing the incidence of otitis media among children who are younger than 4 years and receive tympanostomy tubes. Methods. A randomized trial was conducted at a tertiary center clinic. A total of 217 children who were aged 12 to 48 months and had recurrent acute otitis media (>3 episodes during the past 6 months) or chronic otitis media with effusion, no obstructive symptoms as a result of adenoid enlargement, and no previous surgical intervention were enrolled in the study. Adenoidectomy in conjunction with the insertion of tympanostomy tubes or insertion of tympanostomy tubes without adenoidectomy was studied. The number of otitis media episodes during the follow-up period of 12 months was measured. Results. During the follow-up, the mean number of otitis media episodes was 1.7 among children who underwent adenoidectomy with concurrent insertion of tympanostomy tubes and 1.4 among children who received tympanostomy tubes only. The risk for recurrent otitis media ([greater than or equal to] 3 episodes) could not be reduced by adenoidectomy (odds ratio: 1.66; 95% confidence interval: 0.80-3.46). Conclusion. Adenoidectomy does not significantly reduce the incidence of acute otitis media in otitis prone children who are younger than 4 years and receive tympanostomy tubes. Pediatrics 2005;116:185-189; otitis media, otitis media with effusion, adenoidectomy. ABBREVIATIONS. RAOM, recurrent acute otitis media; COME, chronic otitis media with effusion; CI, confidence interval., Otitis media is one of the most common disorders of childhood. (1,2) It is frequently followed by recurrent acute otitis media (RAOM) infections, and it may also lead to chronic [...]

Published
2005

45. In situ hybridization for high-risk HPV E6/E7 mRNA is a superior method for detecting transcriptionally active HPV in oropharyngeal cancer

Author

Randén-Brady, Reija, primary, Carpén, Timo, additional, Jouhi, Lauri, additional, Syrjänen, Stina, additional, Haglund, Caj, additional, Tarkkanen, Jussi, additional, Remes, Satu, additional, Mäkitie, Antti, additional, Mattila, Petri S, additional, Silén, Suvi, additional, and Hagström, Jaana, additional

Published
2019
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47. Pariisin luokitus - uusi virtsan sytologian luokitusjärjestelmä

Author

Kholová, Ivana, Laurila, Marita, Aho, Heikki, Ikonen, Essi, Krogerus, Leena, Kujala, Paula, Mäkelä, Anu, Rauramaa, Tuomas, Tarkkanen, Jussi, Medicum, Patologian osasto, Clinicum, HUSLAB, and HUS Pää- ja kaulakeskus

Subjects
3111 Biolääketieteet
Abstract

Virtsan sytologiseen irtosolunäytetutkimukseen on tullut uusi luokitusjärjestelmä TPS eli Pariisin luokitus. Uusi luokitus jakaa solumuutokset pahanlaatuisuudeltaan korkea-asteiseen uroteelikarsinomaan viittaaviin muutoksiin sekä lievempiin, matala-asteisiin muutoksiin. Uuden järjestelmän avulla pyritään parantamaan tiedonkulkua näytteen tutkijan ja kliinikon välillä.

Published
2017

49. WRAP53 beta, survivin and p16(INK4a) expression as potential predictors of radiotherapy/chemoradiotherapy response in T2N0-T3N0 glottic laryngeal cancer

Author

Tiefenböck Hansson, Katharina, Haapaniemi, Aaro, Farnebo, Lovisa, Palmgren, Bjorn, Tarkkanen, Jussi, Farnebo, Marianne, Munck-Wikland, Eva, Makitie, Antti, Garvin, Stina, Roberg, Karin, Tiefenböck Hansson, Katharina, Haapaniemi, Aaro, Farnebo, Lovisa, Palmgren, Bjorn, Tarkkanen, Jussi, Farnebo, Marianne, Munck-Wikland, Eva, Makitie, Antti, Garvin, Stina, and Roberg, Karin

Abstract

The current treatment recommendation for T2-3N0M0 glottic squamous cell carcinoma (SCC) in the Nordic countries comprises of radiotherapy (RT) and chemoradiotherapy (CRT). Tumor radiosensitivity varies and another option is primary surgical treatment, which underlines the need for predictive markers in this patient population. The aim of the present study was to investigate the relation of the proteins WRAP53 beta, survivin and p16INK4a to RT/CRT response and ultimate outcome of patients with T2-T3N0 glottic SCC. Protein expression was determined using immunohistochemistry on tumors from 149 patients consecutively treated with RT or CRT at Helsinki University Hospital, Karolinska University Hospital, and Linkping University Hospital during 1999-2010. Our results demonstrate a significantly better 5-year relapse-free survival, disease-free survival (DFS), disease-specific survival and overall survival of patients with T3N0 tumors treated with CRT compared with RT alone. Patients with tumors showing a cytoplasmic staining of WRAP53 beta revealed significantly worse DFS compared with those with nuclear staining. For survivin, we observed a trend towards better 5-year DFS in patients with strong nuclear survivin expression compared with those with weak nuclear survivin expression (p=0.091). Eleven (7%) tumors showed p16 positivity, with predilection to younger patients, and this age group of patients with p16-positive SCC had a significantly better DFS compared with patients with p16-negative SCC. Taken together, our results highlight WRAP53 beta as a potential biomarker for predicting RT/CRT response in T2-T3N0 glottic SCC. p16 may identify a small but distinct group of glottic SCC with favorable outcome. Furthermore, for T3N0 patients better outcome was observed following CRT compared to RT alone., Funding Agencies|Swedish Cancer Society [2010/545]; County Council of Ostergotland; Research Funds of Linkoping University Hospital; Finnish Cancer Society; Finnish Medical Foundation; Finnish-Norwegian Medical Foundation; Helsinki University Hospital Research Funds [TYH2015204]

Published
2017
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