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Your search keyword '"Terada, Yuriko"' showing total 153 results
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153 results on '"Terada, Yuriko"'

1. Targeting immune–fibroblast cell communication in heart failure

Author

Amrute, Junedh M., Luo, Xin, Penna, Vinay, Yang, Steven, Yamawaki, Tracy, Hayat, Sikander, Bredemeyer, Andrea, Jung, In-Hyuk, Kadyrov, Farid F., Heo, Gyu Seong, Venkatesan, Rajiu, Shi, Sally Yu, Parvathaneni, Alekhya, Koenig, Andrew L., Kuppe, Christoph, Baker, Candice, Luehmann, Hannah, Jones, Cameran, Kopecky, Benjamin, Zeng, Xue, Bleckwehl, Tore, Ma, Pan, Lee, Paul, Terada, Yuriko, Fu, Angela, Furtado, Milena, Kreisel, Daniel, Kovacs, Atilla, Stitziel, Nathan O., Jackson, Simon, Li, Chi-Ming, Liu, Yongjian, Rosenthal, Nadia A., Kramann, Rafael, Ason, Brandon, and Lavine, Kory J.

Published
2024
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2. Abstract 4140393: Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis

Author

Amrute, Junedh, Luo, Xin, Penna, Vinay, Yang, Steven, Yamawaki, Tracy, Hayat, Sikander, Bredemeyer, Andrea, Jung, In-hyuk, Kadyrov, Farid, Heo, Gyu Seong, VENKATESAN, RAJIU, Shi, Sally, Parvathaneni, Alekhya, Koenig, Andrew, Kuppe, Christoph, Baker, Candice, Luehmann, Hannah, Jones, Cameran, Kopecky, Benjamin, Zeng, Xue, Blekwehl, Tore, Ma, Pan, Lee, Paul, Terada, Yuriko, Fu, Angela, Furtado, Milena, KREISEL, DANIEL, Kovacs, Attila, Stitziel, Nathan, Jackson, Simon, Li, Chi-Ming, Liu, Yongjian, Rosenthal, Nadia, Kramann, Rafael, Ason, Brandon, and Lavine, Kory

Published
2024
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5. Smoking exposure-induced bronchus-associated lymphoid tissue in donor lungs does not prevent tolerance induction after transplantation

Author

Terada, Yuriko, Li, Wenjun, Shepherd, Hailey M., Takahashi, Tsuyoshi, Yokoyama, Yuhei, Bery, Amit I., Mineura, Katsutaka, Bai, Yun Zhu, Ritter, Jon H., Hachem, Ramsey R., Bharat, Ankit, Lavine, Kory J., Nava, Ruben G., Puri, Varun, Krupnick, Alexander S., Gelman, Andrew E., Reed, Hasina Outtz, Wong, Brian W., and Kreisel, Daniel

Published
2024
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6. B cells mediate lung ischemia/reperfusion injury by recruiting classical monocytes via synergistic B cell receptor/TLR4 signaling

Author

Farahnak, Khashayar, Bai, Yun Zhu, Yokoyama, Yuhei, Morkan, Deniz B., Liu, Zhiyi, Amrute, Junedh M., De Filippis Falcon, Alejandro, Terada, Yuriko, Liao, Fuyi, Li, Wenjun, Shepherd, Hailey M., Hachem, Ramsey R., Puri, Varun, Lavine, Kory J., Gelman, Andrew E., Bharat, Ankit, Kreisel, Daniel, and Nava, Ruben G.

Subjects
Thermo Fisher Scientific Inc., Transplantation of organs, tissues, etc., Medical research, Medicine, Experimental, Scientific equipment and supplies industry, Lung diseases, Immune response, B cells, Health care industry, Washington University. School of Medicine
Abstract

Ischemia/reperfusion injury-mediated (IRI-mediated) primary graft dysfunction (PGD) adversely affects both short- and long-term outcomes after lung transplantation, a procedure that remains the only treatment option for patients suffering from end-stage respiratory failure. While B cells are known to regulate adaptive immune responses, their role in lung IRI is not well understood. Here, we demonstrated by intravital imaging that B cells are rapidly recruited to injured lungs, where they extravasate into the parenchyma. Using hilar clamping and transplant models, we observed that lung-infiltrating B cells produce the monocyte chemokine CCL7 in a TLR4-TRIF-dependent fashion, a critical step contributing to classical monocyte (CM) recruitment and subsequent neutrophil extravasation, resulting in worse lung function. We found that synergistic BCR-TLR4 activation on B cells is required for the recruitment of CMs to the injured lung. Finally, we corroborated our findings in reperfused human lungs, in which we observed a correlation between B cell infiltration and CM recruitment after transplantation. This study describes a role for B cells as critical orchestrators of lung IRI. As B cells can be depleted with currently available agents, our study provides a rationale for clinical trials investigating B cell-targeting therapies., Introduction Primary graft dysfunction (PGD) is a common early complication after lung transplantation that adversely affects both shortand long-term outcomes. This includes both early morbidity and mortality as well as [...]

Published
2024
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8. Necroptosis triggers spatially restricted neutrophil-mediated vascular damage during lung ischemia reperfusion injury

Author

Li, Wenjun, Terada, Yuriko, Tyurina, Yulia Y., Tyurin, Vladimir A., Bery, Amit I., Gauthier, Jason M., Higashikubo, Ryuji, Tong, Alice Y., Zhou, Dequan, Nunez-Santana, Felix, Lecuona, Emilia, Hassan, Adil, Hashimoto, Kohei, Scozzi, Davide, Puri, Varun, Nava, Ruben G., Krupnick, Alexander S., Lavine, Kory J., Gelman, Andrew E., Miller, Mark J., Kagan, Valerian E., Bharat, Ankit, and Kreisel, Daniel

Published
2022

22. Lymphatic drainage from bronchus-associated lymphoid tissue in tolerant lung allografts promotes peripheral tolerance

Author

Li, Wenjun, Gauthier, Jason M., Tong, Alice Y., Terada, Yuriko, Higashikubo, Ryuji, Frye, Christian C., Harrison, Margaret S., Hashimoto, Kohei, Bery, Amit I., Ritter, Jon H., Nava, Ruben G., Puri, Varun, Wong, Brian W., Lavine, Kory J., Bharat, Ankit, Krupnick, Alexander S., Gelman, Andrew E., and Kreisel, Daniel

Subjects
Immune response -- Genetic aspects, Transcription factors -- Health aspects, Lymph nodes -- Medical examination, Health care industry
Abstract

Tertiary lymphoid organs are aggregates of immune and stromal cells including high endothelial venules and lymphatic vessels that resemble secondary lymphoid organs and can be induced at nonlymphoid sites during inflammation. The function of lymphatic vessels within tertiary lymphoid organs remains poorly understood. During lung transplant tolerance, [Foxp3.sup.+] cells accumulate in tertiary lymphoid organs that are induced within the pulmonary grafts and are critical for the local downregulation of alloimmune responses. Here, we showed that tolerant lung allografts could induce and maintain tolerance of heterotopic donor-matched hearts through pathways that were dependent on the continued presence of the transplanted lung. Using lung retransplantation, we showed that [Foxp3.sup.+] cells egressed from tolerant lung allografts via lymphatics and were recruited into donor-matched heart allografts. Indeed, survival of the heart allografts was dependent on lymphatic drainage from the tolerant lung allograft to the periphery. Thus, our work indicates that cellular trafficking from tertiary lymphoid organs regulates immune responses in the periphery. We propose that these findings have important implications for a variety of disease processes that are associated with the induction of tertiary lymphoid organs., Introduction Tertiary lymphoid organs can be induced in nonlymphoid tissues during states of chronic inflammation or antigen exposure and are structurally similar to secondary lymphoid organs. One such example is [...]

Published
2020
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24. Smoking exposure-induced bronchus-associated lymphoid tissue in donor lungs does not prevent tolerance induction after transplantation

Author

Terada, Yuriko, primary, Li, Wenjun, additional, Shepherd, Hailey M., additional, Takahashi, Tsuyoshi, additional, Yokoyama, Yuhei, additional, Bery, Amit I., additional, Mineura, Katsutaka, additional, Bai, Yun Zhu, additional, Ritter, Jon H., additional, Hachem, Ramsey R., additional, Bharat, Ankit, additional, Lavine, Kory J., additional, Nava, Ruben G., additional, Puri, Varun, additional, Krupnick, Alexander S., additional, Gelman, Andrew E., additional, Reed, Hasina Outtz, additional, Wong, Brian W., additional, and Kreisel, Daniel, additional

Published
2023
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26. Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis

Author

Lavine, Kory, primary, Amrute, Junedh, additional, Luo, Xin, additional, Penna, Vinay, additional, Bredemeyer, Andrea, additional, Yamawaki, Tracy, additional, Yang, Steven, additional, Kadyrov, Farid, additional, Heo, Gyu, additional, Shi, Sally, additional, Lee, Paul, additional, Koenig, Andrew, additional, Kuppe, Christoph, additional, Jones, Cameran, additional, Kopecky, Benjamin, additional, Hayat, Sikander, additional, Ma, Pan, additional, Terada, Yuriko, additional, Fu, Angela, additional, Furtado, Milena, additional, Kreisel, Daniel, additional, Stitziel, Nathan, additional, Li, Chi-Ming, additional, Kramann, Rafael, additional, Liu, Yongjian, additional, and Ason, Brandon, additional

Published
2023
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28. Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure

Author

Amrute, Junedh M., primary, Luo, Xin, additional, Penna, Vinay, additional, Bredemeyer, Andrea, additional, Yamawaki, Tracy, additional, Heo, Gyu Seong, additional, Shi, Sally, additional, Koenig, Andrew, additional, Yang, Steven, additional, Kadyrov, Farid, additional, Jones, Cameran, additional, Kuppe, Christoph, additional, Kopecky, Benjamin, additional, Hayat, Sikander, additional, Ma, Pan, additional, Feng, Guoshai, additional, Terada, Yuriko, additional, Fu, Angela, additional, Furtado, Milena, additional, Kreisel, Daniel, additional, Stitziel, Nathan O., additional, Li, Chi-Ming, additional, Kramann, Rafael, additional, Liu, Yongjian, additional, Ason, Brandon, additional, and Lavine, Kory J., additional

Published
2022
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29. Donor Macrophages Modulate Rejection After Heart Transplantation

Author

Kopecky, Benjamin J., primary, Dun, Hao, additional, Amrute, Junedh M., additional, Lin, Chieh-Yu, additional, Bredemeyer, Andrea L., additional, Terada, Yuriko, additional, Bayguinov, Peter O., additional, Koenig, Andrew L., additional, Frye, Christian C., additional, Fitzpatrick, James A.J., additional, Kreisel, Daniel, additional, and Lavine, Kory J., additional

Published
2022
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36. Donor management using a specialized donor care facility is associated with higher organ utilization from drug overdose donors

Author

Frye, Christian Corbin, primary, Gauthier, Jason M., additional, Bery, Amit, additional, Gerull, William D., additional, Morkan, Deniz B., additional, Liu, Jingxia, additional, Shea Harrison, M., additional, Terada, Yuriko, additional, Van Zanden, Judith E., additional, Marklin, Gary F., additional, Pasque, Michael K., additional, Nava, Ruben G., additional, Meyers, Bryan F., additional, Patterson, Alexander G., additional, Kozower, Benjamin D., additional, Hachem, Ramsey, additional, Byers, Derek, additional, Witt, Chad, additional, Kulkarni, Hrishikesh, additional, Kreisel, Daniel, additional, and Puri, Varun, additional

Published
2020
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37. Necroptosis triggers spatially restricted neutrophil-mediated vascular damage during lung ischemia reperfusion injury.

Author

Wenjun Li, Terada, Yuriko, Tyurina, Yulia Y., Tyurin, Vladimir A., Bery, Amit I., Gauthier, Jason M., Higashikubo, Ryuji, Tong, Alice Y., Zhou, Dequan, Nunez-Santana, Felix, Lecuon, Emilia, Hassan, Adil, Hashimoto, Kohei, Scozzi, Davide, Puri, Varun, Nava, Ruben G., Krupnick, Alexander S., Lavine, Kory J., Gelman, Andrew E., and Miller, Mark J.

Subjects
*REPERFUSION injury, *VASCULAR endothelial cells, *REMANUFACTURING, *NADPH oxidase, *CELL death, *LUNGS, PLANNING techniques
Abstract

Ischemia reperfusion injury represents a common pathological condition that is triggered by the release of endogenous ligands. While neutrophils are known to play a critical role in its pathogenesis, the tissue-specific spatiotemporal regulation of ischemia-reperfusion injury is not understood. Here, using oxidative lipidomics and intra-vital imaging of transplanted mouse lungs that are subjected to severe ischemia reperfusion injury, we discovered that necroptosis, a nonapoptotic form of cell death, triggers the recruitment of neu- trophils. During the initial stages of inflammation, neutrophils traffic predominantly to subpleural vessels, where their aggregation is directed by chemoattractants produced by nonclassical monocytes that are spatially restricted in this vascular compartment. Subse- quent neutrophilic disruption of capillaries resulting in vascular leakage is associated with impaired graft function. We found that TLR4 signaling in vascular endothelial cells and downstream NADPH oxidase 4 expression mediate the arrest of neutrophils, a step upstream of their extravasation. Neutrophil extracellular traps formed in injured lungs and their disruption with DNase prevented vascular leakage and ameliorated primary graft dysfunction. Thus, we have uncovered mechanisms that regulate the initial recruitment of neutrophils to injured lungs, which result in selective damage to subpleural pulmonary vessels and primary graft dys function. Our findings could lead to the development of new therapeutics that protect lungs from ischemia reperfusion injury. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Donor management using a specialized donor care facility is associated with higher organ utilization from drug overdose donors.

Author

Frye, Christian Corbin, Gauthier, Jason M., Bery, Amit, Gerull, William D., Morkan, Deniz B., Liu, Jingxia, Shea Harrison, M., Terada, Yuriko, Van Zanden, Judith E., Marklin, Gary F., Pasque, Michael K., Nava, Ruben G., Meyers, Bryan F., Patterson, Alexander G., Kozower, Benjamin D., Hachem, Ramsey, Byers, Derek, Witt, Chad, Kulkarni, Hrishikesh, and Kreisel, Daniel

Subjects
DRUG overdose, DRUG utilization, VIRAL transmission, PROCUREMENT of organs, tissues, etc.
Abstract

Drug overdoses have tripled in the United States over the last two decades. With the increasing demand for donor organs, one potential consequence of the opioid epidemic may be an increase in suitable donor organs. Unfortunately, organs from donors dying of drug overdose have poorer utilization rates than other groups of brain‐dead donors, largely due to physician and recipient concerns about viral disease transmission. During the study period of 2011 to 2016, drug overdose donors (DODs) account for an increasingly greater proportion of the national donor pool. We show that a novel model of donor care, known as specialized donor care facility (SDCF), is associated with an increase in organ utilization from DODs compared to the conventional model of hospital‐based donor care. This is likely related to the close relationship of the SDCF with the transplant centers, leading to improved communication and highly efficient donor care. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Comparison of outcomes in lung and heart transplant recipients from the same multiorgan donor.

Author

Takahashi, Tsuyoshi, Terada, Yuriko, Pasque, Michael K., Itoh, Akinobu, Nava, Ruben G., Puri, Varun, Kreisel, Daniel, Patterson, Alexander G., and Hachem, Ramsey R.

Subjects
*LUNG transplantation, *HEART transplant recipients, *HEART transplantation, *LOGISTIC regression analysis, *REGRESSION analysis
Abstract

Background: Primary graft dysfunction (PGD) and acute cellular rejection (ACR) are important causes of early morbidity and mortality following lung and heart transplantation. While many studies have elucidated donor‐related risk factors of PGD and ACR, these complications often occur even with "ideal" donors. Therefore, we investigated potential associations of PGD and ACR between bilateral lung and heart transplant recipients from the same multiorgan donor, respectively. Methods: Between 2011 and 2017, 100 donors contributed 100 bilateral lung transplants and 100 heart transplants performed. Logistic regression analysis for PGD and Cox proportional hazards regression analysis for ACR were used to estimate the relationship of heart and lung transplants. Results: The incidence of PGD was 33% among lung and 17% among heart transplant recipients. Similarly, the incidence of ACR grade ≥ A2 for lung recipients was 38% (30/80), and the incidence of ACR grade ≥ 2R for heart recipients was 19% (15/80). There was no association between the development of PGD and ACR in lung and heart transplant recipients from the same donor, respectively. Conclusions: These findings suggest that inherent donor factors are not critical to the development of PGD and ACR after lung and heart transplantation. [ABSTRACT FROM AUTHOR]

Published
2020
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