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36 results on '"Triolo, Daniela"'

10. When Functionalization of PLA Surfaces Meets Thiol−Yne Photochemistry: Case Study with Antibacterial PolyaspartamideDerivatives

Author

SARDO, Carla, TRIOLO, Daniela, GIAMMONA, Gaetano, CAVALLARO, Gennara, Nottelet, B, Flaud, V, Garric, X, Lavigne,JP, Coudane, Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli studi di Palermo - University of Palermo, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Istituto di BioFisica [Palermo] (IBF), Consiglio Nazionale delle Ricerche (CNR), Virulence bactérienne et maladies infectieuses (VBMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Fondazione Cariplo (Project 2010-0454), MIUR (PRIN 2010-2011, 20109P1MH2_003), Sardo, C, Nottelet, B, Triolo, D, Giammona, G, Flaud, V, Garric, X, Lavigne,JP, Cavallaro, G, and Coudane

Subjects
Polymers and Plastics, Polyaspartamide copolymer, Photochemistry, Surface Properties, Polyesters, PLA surfaces, Bioengineering, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Cell Line, Biomaterials, Mice, Materials Chemistry, Copolymer, Organic chemistry, Animals, Sulfhydryl Compounds, Polyaspartamide copolymers, chemistry.chemical_classification, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Biofilm, 021001 nanoscience & nanotechnology, Grafting, Fluorescence, Combinatorial chemistry, In vitro, 0104 chemical sciences, Anti-Bacterial Agents, chemistry, Covalent bond, Settore CHIM/09 - Farmaceutico Tecnologico Applicativo, Thiol, Surface modification, 0210 nano-technology, Peptides
Abstract

International audience; In this work we wish to report on the covalent functionalization of polylactide (PLA) surfaces by photoradical thiol–yne to yield antibacterial surfaces. At first, hydrophilic and hydrophobic thiol fluorescent probes are synthesized and used to study and optimize the conditions of ligation on alkyne-PLA surfaces. In a second part, a new antibacterial polyaspartamide copolymer is covalently grafted. The covalent surface modification and the density of surface functionalization are evaluated by SEC and XPS analyses. No degradation of PLA chains is observed, whereas covalent grafting is confirmed by the presence of S2p and N1s signals. Antiadherence and antibiofilm activities are assessed against four bacterial strains, including Gram-negative and Gram-positive bacteria. A strong activity is observed with adherence reduction factors superior to 99.98% and biofilm formation decreased by 80%. Finally, in vitro cytocompatibility tests of the antibacterial surfaces are performed with L929 murine fibroblasts and show cell viability without promoting proliferation.

Published
2014

14. New amphiphilic copolymers based on a poly(hydroxyethylaspartamide): coating of Au nanostars to obtain antimicrobial photothermal/delivering systems activated by NIR irradiation

Author

CAVALLARO, Gennara, TRIOLO, Daniela, GIAMMONA, Gaetano, Pallavicini, P, Donà, A, Cabrini, E., Cavallaro, G, Triolo, D, Giammona, G, Pallavicini, P, Donà, A, and Cabrini, E

Subjects
PHEA, gold nanostars, antimicrobial system, photothermal/delivering systems, NIR irradiation, Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
Published
2012

15. RHEOLOGICAL AND RELEASE PROPERTIES OF FUNCTIONALIZED INULIN HYDROGELS

Author

PITARRESI, Giovanna, TRIOLO, Daniela, GIAMMONA, Gaetano, Giacomazza, D, San Biagio, PL, Pitarresi, G, Giacomazza, D, Triolo, D, Giammona, G, and San Biagio, PL

Subjects
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo, inulin, hydrogel, drug delivery system
Published
2012

17. Inulin-Based Hydrogel for Oral Delivery of Flutamide: Preparation, Characterization, and in vivo Release Studies

Author

PITARRESI, Giovanna, TRIOLO, Daniela, FIORICA, Calogero, CALASCIBETTA, Filippo, GIAMMONA, Gaetano, Giorgi, M, Pitarresi, G, Triolo, D, Giorgi, M, Fiorica, C, Calascibetta, F, and Giammona, G

Subjects
inulin, hydrogel, oral drug delivery, flutamide, Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
Abstract

The ability of a hydrogel obtained by crosslinking INUDV and PEGBa to facilitate sustained release of flutamide is examined. The hydrogel is prepared in pH 7.4 PBS and no toxic solvents or catalysts are used. It is recovered in microparticulate form and its size distribution is determined. Mucoadhesive properties are evaluated in vitro by reproducing gastrointestinal conditions. Flutamide is loaded into the hydrogel using a post-fabrication encapsulation procedure that allows a drug loading comparable to that of market tablets. Drug-loaded microparticles are orally administered to cross-bred dogs and the in vivo study demonstrates their ability to prolong the half-life of the principal active metabolite approximately threefold and to significantly increase its bioavailability.

Published
2012

18. SYNTHESIS AND CHARACTERIZATION OF NEW AMPHIPHILIC COPOLYMERS BASED ON A POLY(HYDROXYETHYL)-D,L-ASPARTAMIDE (PHEA) FOR THE COATING OF GOLD NANOPARTICLES TO BE USED AS ANTIMICROBIAL AGENTS ACTIVATED BY NIR IRRADIATION

Author

TRIOLO, Daniela, GIAMMONA, Gaetano, CAVALLARO, Gennara, DONA', A, CABRINI, E, PALLAVICINI, P, TRIOLO, D, DONA', A, GIAMMONA, G, CABRINI, E, PALLAVICINI, P, and CAVALLARO, G

Subjects
GOLD NANOPARTICLES, BIOCOMPATIBLE POLYMER, POLY(HYDROXYETHYL)-D,L-ASPARTAMIDE
Published
2012

19. Biomaterials for Biotechnological and Pharmaceutical application

Author

PITARRESI, Giovanna, PALUMBO, Fabio Salvatore, GIAMMONA, Gaetano, CALASCIBETTA, Filippo, FIORICA, Calogero, TRIOLO, Daniela, PITARRESI, G, PALUMBO, FS, GIAMMONA, G, CALASCIBETTA, F, FIORICA, C, and TRIOLO, D

Subjects
biocompatible polymer, biomedical applications
Published
2010

21. NEW IN SITU FORMING HYALURONIC ACID SCAFFOLDS WITH A FIBRILLAR STRUCTURE

Author

PITARRESI, Giovanna, PALUMBO, Fabio Salvatore, ALBANESE, Antonella, TRIOLO, Daniela, FIORICA, Calogero, GIAMMONA, Gaetano, PITARRESI, G, PALUMBO, FS, ALBANESE, A, TRIOLO, D, FIORICA, C, and GIAMMONA, G

Subjects
SCAFFOLD for Tissue Engeneering, Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
Published
2009

25. Jab1 regulates Schwann cell proliferation and axonal sorting through p27

Author

Porrello, Emanuela, primary, Rivellini, Cristina, additional, Dina, Giorgia, additional, Triolo, Daniela, additional, Del Carro, Ubaldo, additional, Ungaro, Daniela, additional, Panattoni, Martina, additional, Feltri, Maria Laura, additional, Wrabetz, Lawrence, additional, Pardi, Ruggero, additional, Quattrini, Angelo, additional, and Previtali, Stefano Carlo, additional

Published
2013
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30. Vimentin regulates peripheral nerve myelination

Author

Triolo, Daniela, primary, Dina, Giorgia, additional, Taveggia, Carla, additional, Vaccari, Ilaria, additional, Porrello, Emanuela, additional, Rivellini, Cristina, additional, Domi, Teuta, additional, La Marca, Rosa, additional, Cerri, Federica, additional, Bolino, Alessandra, additional, Quattrini, Angelo, additional, and Previtali, Stefano Carlo, additional

Published
2012
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34. Amphiphilic Copolymers Based on Poly[(hydroxyethyl)-d,l-aspartamide]: A Suitable Functional Coatingfor Biocompatible Gold Nanostars.

Author

Cavallaro, Gennara, Triolo, Daniela, Licciardi, Mariano, Giammona, Gaetano, Chirico, Giuseppe, Sironi, Laura, Dacarro, Giacomo, Donà, Alice, Milanese, Chiara, and Pallavicini, Piersandro

Subjects
*AMPHIPHILES, *ASPARTATES, *GOLD nanoparticles, *COPOLYMERIZATION, *LIPOIC acid, *BIOCOMPATIBILITY
Abstract

Novel amphiphilic copolymers havebeen synthesized based on a biocompatiblepoly(hydroxyethylaspartamide) (PHEA) backbone, bearing both anchoringgroups for gold nanoparticles, such as thiols and disulfide, and conjugablemoieties, such as amino groups, the latter as points suitable forappending further functional agents. The strategy was to functionalizeα,β-poly[(N-2-hydroxyethyl)-d,l-aspartamide] (PHEA) with PEG2000-NH2and with ethylenediamine (EDA) obtaining a partially pegylated copolymerwith a large number of pendant primary amino groups. A fraction ofthe latter was conjugated with molecules bearing terminal thiol moietiessuch as 12-mercaptododecanoic acid (MDA) and disulfide groups suchas lipoic acid (LA), obtaining the two amphiphilic derivatives PHEA–PEG2000–EDA–MDA (PPE–MDA) and PHEA–PEG2000–EDA–LA (PPE–LA), which also provedintrinsically able to self-assemble in polymeric micelles. The twocopolymers efficiently coated gold nanostars (GNSs, size ∼40nm), wrapping around the surface increasing only slightly the hydrodynamicdiameter (reaching ∼45 nm), imparting them stability and apH-switchable surface charge, due to the unreacted amino groups. Remarkably,the poor solvation and the huge steric hindrance experienced by theamino groups lowers the observed logarithmic protonation constantsto 5.6–5.7. In vitroexperiments demonstratedthat PPE–MDA and PPE–LA copolymers have an intrinsicexcellent biocompatibility in both the human brain neuroblastoma (SH-SY5Y)and human bronchial epithelial (16-HBE) cell lines. Interaction ofthe same cell lines with “nude” GNS and GNS coated withPPE–LA was also studied, disclosing a completely satisfactorybiocompatibility of the latter. [ABSTRACT FROM AUTHOR]

Published
2013
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35. Galactosylated Micelles for a Ribavirin Prodrug Targetingto Hepatocytes.

Author

Craparo, Emanuela F., Triolo, Daniela, Pitarresi, Giovanna, Giammona, Gaetano, and Cavallaro, Gennara

Subjects
*BIOPOLYMERS, *MICELLES, *RIBAVIRIN, *DRUG target, *PRODRUGS, *LIVER cells, *POLYLACTIC acid, *HEPATITIS C treatment
Abstract

Polymeric micelles potentially ableto carry to hepatocytes a ribavirin(RBV) prodrug, exploiting the presence of carbohydrate receptors,that is, ASGPR, were prepared starting from a galactosylated polylactide-polyaminoacidconjugate. This latter was obtained by chemical reaction of α,β-poly(N-2-hydroxyethyl) (2-aminoethylcarbamate)-dl-aspartamide(PHEA-EDA) with polylactic acid (PLA), and subsequent reaction withlactose, obtaining PHEA-EDA-PLA-GAL copolymer. To enhance the entrapmentinto obtained nanostructures, a hydrophobic RBV prodrug, that is,RBV tripalmitate, was synthesized and its capability to release RBVin the presence of an adequate enzymatic activity was demonstrated.Liver-targeted RBV tripalmitate-loaded micelles were obtained in aqueousmedia at low PHEA-EDA-PLA-GAL copolymer concentration value with nanometricsize. By in vitro experiments, the specificity of RBV tripalmitate-loadedPHEA-EDA-PLA-GAL micelles toward HepG2 was demonstrated by using acompetitive inhibition assay in the presence of free GAL. This findingraises hope in terms of future micelles-based liver-targeted drugdelivery strategy for the hepatitis C treatment. [ABSTRACT FROM AUTHOR]

Published
2013
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36. Jab1 regulates Schwann cell proliferation and axonal sorting through p27

Author

Porrello, Emanuela, Rivellini, Cristina, Dina, Giorgia, Triolo, Daniela, Del Carro, Ubaldo, Ungaro, Daniela, Panattoni, Martina, Feltri, Maria Laura, Wrabetz, Lawrence, Pardi, Ruggero, Quattrini, Angelo, and Previtali, Stefano Carlo

Abstract

Axonal sorting is a crucial event in nerve formation and requires proper Schwann cell proliferation, differentiation, and contact with axons. Any defect in axonal sorting results in dysmyelinating peripheral neuropathies. Evidence from mouse models shows that axonal sorting is regulated by laminin211– and, possibly, neuregulin 1 (Nrg1)–derived signals. However, how these signals are integrated in Schwann cells is largely unknown. We now report that the nuclear Jun activation domain–binding protein 1 (Jab1) may transduce laminin211 signals to regulate Schwann cell number and differentiation during axonal sorting. Mice with inactivation of Jab1 in Schwann cells develop a dysmyelinating neuropathy with axonal sorting defects. Loss of Jab1 increases p27 levels in Schwann cells, which causes defective cell cycle progression and aberrant differentiation. Genetic down-regulation of p27 levels in Jab1-null mice restores Schwann cell number, differentiation, and axonal sorting and rescues the dysmyelinating neuropathy. Thus, Jab1 constitutes a regulatory molecule that integrates laminin211 signals in Schwann cells to govern cell cycle, cell number, and differentiation. Finally, Jab1 may constitute a key molecule in the pathogenesis of dysmyelinating neuropathies.

Published
2014
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