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5. German Pediatric Reference Data for Quantitative Transverse Transmission Ultrasound of Finger Phalanges

Author

Barkmann, R., Rohrschneider, W., Vierling, M., Troger, J., de Terlizzi, F., Cadossi, R., Heller, M., and Gluer, C.C.

Subjects
Fingers -- Physiological aspects, Fingers -- Research, Ultrasonic waves -- Usage, Bones -- Growth, Bones -- Research, Health
Abstract

Byline: R. Barkmann (1), W. Rohrschneider (2), M. Vierling (2), J. Troger (2), F. de Terlizzi (3), R. Cadossi (3), M. Heller (1), C.-C. Gluer (1) Keywords: Key words:Bone -- Children -- Growth -- Ultrasound Abstract: Quantitative ultrasound (QUS) of the finger phalanges is a useful tool in the assessment of disease- or age-related deterioration of bone. For studying the impact of juvenile diseases or growth disorders affecting the skeleton, a reference database for QUS parameters is needed. The aim of this study was to establish a calibrated reference database of parameters of transverse ultrasound transmission through juvenile finger phalanges. A total of 1328 children (650 females, 678 males ages 3--17 years) were measured in Heidelberg and Kiel in order to establish a German reference database. Highly significant gender-specific correlations (p&lt 0.0001) were found between the QUS parameters amplitude-dependent speed of sound (AD-SoS) and bone transmission time (BTT) versus age, body height and body mass index (BMI). For AD-SoS the correlation coefficients were R .sup.2= 0.64 against age in males and R .sup.2= 0.73 in females, R .sup.2= 0.60 against body height in males and R .sup.2= 0.68 in females, and R .sup.2= 0.19 against BMI in males and R .sup.2= 0.23 in females. For BTT the correlation coefficients were R .sup.2= 0.74 against age in males and R .sup.2= 0.79 in females, R .sup.2= 0.75 against body height in males and R .sup.2= 0.77 in females, and R .sup.2= 0.32 against BMI in males and R .sup.2= 0.35 in females. Age and height were the strongest determinants of QUS results. Gender-specific differences were observed in AD-SoS (significant for ages 11--14 years and for 150--170 cm body height) and in BTT (significant for ages 7 and 11--17 years and for 160--170 cm body height). Tables of QUS parameters versus age and height can serve as a basis for the evaluation of the impact of skeletal diseases or growth disorders on phalangeal QUS. Depending on the type of disease or growth disorder, measurement results can be compared with age- or height- specific reference data. In this way a simple and radiation-free assessment of juvenile skeletal disorders using quantitative ultrasound might be possible in the future. Author Affiliation: (1) Medizinische Physik, Klinik fur Diagnostische Radiologie, Universitatsklinikum Kiel, Kiel, DE (2) Padiatrische Klinik der Universitat Heidelberg, Heidelberg, Germany , DE (3) IGEA Biophysics Laboratory, Carpi, Italy, IT Article note: Received: 9 February 2001 / Accepted: 1 August 2001

Published
2002

14. Granin - Derived Peptides in the Eye

Author

Troger J

Subjects
endocrine system, secretoneurin, Chemistry, Granin, vasostatins, catestatin, Peptides, Cell biology
Abstract

The granins are the acidic proteins of secretory granules and there exist three main members of this family, in particular chromogranin A, chromogranin B and secretogranin II. These proteins are widely distributed throughout neuroendocrine tissues and are stored in large dense core vesicles in neuronal cells. Their functional role is not fully clear but it seems that they might play an important role in the formation of secretory granules. Furthermore, the primary amino acid sequence of the granins features many pairs of basic amino acids and these pairs together with monobasic residues are targets of enzymes which proteolytically process the proteins, in particular the prohormone convertases 1 and 2. Thus the granins might be precursors of smaller fragments and they are indeed cleaved. Processing of chromogranin A leads to the generation of catestatin, vasostatins, pancreastatin, serpinin, WE-14, chromacin, chromofungin, chromostatin, betagranin and parastatin, of chromogranin B to secretolytin and of secretogranin II to secretoneurin, manserin and EM66. These peptides are either biologically highly active and/or of pathophysiological significance and the peptides with the highest degree of biological activity are secretoneurin, catestatin, vasostatins and pancreastatin. For secretoneurin, outstanding effects have been described, in particular it promotes not only both angiogenesis and vasculogenesis but also therapeutic angiogenesis in the hindlimb ischemia and myocardial infarcation model. Others however seem to be functionally inert, especially the chromogranin A-derived peptide GE-25 and the chromogranin B-derived peptide PE-11.

Published
2018
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18. Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1

Author

Eckhardt, K, Troger, J, Reissmann, J, Katschinski, D M, Wagner, K F, Stengel, P, Paasch, U, Hunziker, P, Borter, E, Barth, S, Schlafli, P, Spielmann, P, Stiehl, D P, Camenisch, G, Wenger, R H, University of Zurich, and Wenger, R H

Subjects
570 Life sciences, biology, 610 Medicine & health, 10071 Functional Genomics Center Zurich, 1314 Physiology, U7 Systems Biology / Functional Genomics, 10052 Institute of Physiology
Published
2007

28. 400 mW uncooled MiniDIL pump modules

Author

Mohrdiek, S., primary, Pliska, T., additional, Bättig, R., additional, Matuschek, N., additional, Valk, B., additional, Troger, J., additional, Mauron, P., additional, Schmidt, B.E., additional, Jung, I.D., additional, Harder, C.S., additional, and Enochs, S., additional

Published
2003
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41. Molecular characterization of immunoreactivities of peptides derived from chromogranin a (GE-25) and from secretogranin II (secretoneurin) in human and bovine cerebrospinal fluid

Author

Kirchmair, R., primary, Benzer, A., additional, Troger, J., additional, Miller, C., additional, Marksteiner, J., additional, Saria, A., additional, Gasser, R.W., additional, Hogue-Angeletti, R., additional, Fischer-Colbrie, R., additional, and Winkler, H., additional

Published
1994
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47. Measurement systems for the investigation of soldering quality in high-power diode laser bars.

Author

Troger, J., Schwarz, M., and Jakubowicz, A.

Abstract

Thermal and spatial-spectral imaging methods are used to investigate the soldering quality in high-power laser-bar devices. The temperature distribution and the wavelength profile across a driven laser bar correlate with the local thermal resistance between laser and cooler and, thus, with the uniformity of the solder layers. Measurements with a properly soldered and a deficiently soldered laser bar are made for the illustration and comparison of the methods. [ABSTRACT FROM PUBLISHER]

Published
2005
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