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2. Loss of CASK Accelerates Heart Failure Development

Author

Mustroph, Julian, Sag, Can M, Bähr, Felix, Schmidtmann, Anna-Lena, Gupta, Shamindra N, Dietz, Alexander, Islam, MM Towhidul, Lücht, Charlotte, Beuthner, Bo Eric, Pabel, Steffen, Baier, Maria J, El-Armouche, Ali, Sossalla, Samuel, Anderson, Mark E, Möllmann, Julia, Lehrke, Michael, Marx, Nikolaus, Mohler, Peter J, Bers, Donald M, Unsöld, Bernhard, He, Tao, Dewenter, Matthias, Backs, Johannes, Maier, Lars S, and Wagner, Stefan

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Animals, Calcium, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Cells, Cultured, Glucagon-Like Peptide-1 Receptor, Guanylate Kinases, Heart Failure, Heart Rate, Humans, Male, Mice, Mice, Inbred C57BL, Myocardial Contraction, Myocytes, Cardiac, calmodulin, heart failure, myocardium, neurons, sarcoplasmic reticulum, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

[Figure: see text].

Published
2021

3. Reduction of radiation exposure during transcatheter edge‐to‐edge mitral valve repair

Author

Paulus, Michael G., Meindl, Christine, Hamerle, Michael, Schach, Christian, Maier, Lars S., Debl, Kurt, Birner, Christoph, and Unsöld, Bernhard

Subjects
Heart Valve Prosthesis Implantation, ddc:610, Cardiac Catheterization, 610 Medizin, Mitral Valve Insufficiency, General Medicine, Radiation Exposure, fluoroscopy, mitral regurgitation, radiation dosage, Treatment Outcome, Humans, Mitral Valve, Radiology, Nuclear Medicine and imaging, Cardiac Surgical Procedures, Cardiology and Cardiovascular Medicine
Abstract

Background Transcatheter mitral valve repair is an increasingly used therapy for mitral regurgitation which requires fluoroscopic guidance. Limiting radiation exposure during lengthy procedures is important for both patient and operator safety. This study aimed to investigate radiation dose during contemporary use of MitraClip implantation and the effects of a dose reduction program. Methods A total of 115 patients who underwent MitraClip implantation were prospectively enrolled in a single-center observational study. During the inclusion period, our institution adopted a radiation dose reduction program, comprising lowering of fluoroscopy pulse rate and image target dose. The first 58 patients were treated with conventional fluoroscopy settings, while the following 57 patients underwent the procedure with the newly implemented low dose protocol. Results Radiation dose area product significantly decreased after introduction of the low dose protocol (693 [366–1231] vs. 2265 [1517–3914] cGy·cm2, p < 0.001). After correcting for fluoroscopy time, gender and body mass index, the low dose protocol emerged as a strong negative predictor of radiation dose (p < 0.001), reducing dose area product by 64% (95% confidence interval [57–70]). Device time, device success, and procedural safety did not differ between the normal dose and low dose group. Furthermore, the low dose protocol was not associated with an increased incidence of a combined endpoint consisting of death, repeat intervention, or heart surgery during 12 months follow-up. Conclusion Reduction of radiation exposure during transcatheter mitral valve repair by 64% is feasible without affecting procedural success or safety.

Published
2022

7. Transapical mitral valve implantation for treatment of symptomatic mitral valve disease: a real-world multicentre experience

Author

Wild, Mirjam G, Kreidel, Felix, Hell, Michaela M, Praz, Fabien, Mach, Markus, Adam, Matti, Reineke, David, Ruge, Hendrik, Ludwig, Sebastian, Conradi, Lenard, Rudolph, Tanja K, Bleiziffer, Sabine, Kellermair, Jörg, Zierer, Andreas, Nickenig, Georg, Weber, Marcel, Petronio, Anna Sonia, Giannini, Cristina, Dahle, Gry, Rein, Kjell A, Coisne, Augustin, Vincentelli, André, Dubois, Christophe, Duncan, Alison, Quarto, Cesare, Unbehaun, Axel, Amat-Santos, Ignacio, Cobiella, Javier, Dumonteil, Nicolas, Estevez-Loureiro, Rodrigo, Fumero, Andrea, Geisler, Tobias, Lurz, Philipp, Mangieri, Antonio, Monivas, Vanessa, Noack, Thilo, Franco, Luis Nombela, Pinon, Miguel A, Stolz, Lukas, Tchétché, Didier, Walter, Thomas, Unsöld, Bernhard, Baldus, Stephan, Andreas, Martin, Hausleiter, Jörg, and von Bardeleben, Ralph S

Subjects
Male, Cardiac Catheterization, Cardiac & Cardiovascular Systems, FEASIBILITY, Heart Valve Diseases, 610 Medicine & health, REGURGITATION, PROSTHESIS, Tendyne, Humans, Mitral regurgitation, Aged, Retrospective Studies, REPAIR, Aged, 80 and over, Heart Failure, Heart Valve Prosthesis Implantation, OUTCOMES, Science & Technology, Mitral Valve Insufficiency, REPLACEMENT, Treatment Outcome, Mitral valve disease, Heart Valve Prosthesis, Cardiovascular System & Cardiology, Mitral Valve, Female, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, Transcatheter mitral valve implantation
Abstract

AIMS: Transcatheter mitral valve implantation (TMVI) is a new treatment option for patients with symptomatic mitral valve (MV) disease. Real-world data have not yet been reported. This study aimed to assess procedural and 30-day outcomes of TMVI in a real-world patient cohort. METHOD AND RESULTS: All consecutive patients undergoing implantation of a transapically delivered self-expanding valve at 26 European centres from January 2020 to April 2021 were included in this retrospective observational registry. Among 108 surgical high-risk patients included (43% female, mean age 75 ± 7 years, mean STS-PROM 7.2 ± 5.3%), 25% was treated for an off-label indication (e.g. previous MV intervention or surgery, mitral stenosis, mitral annular calcification). Patients were highly symptomatic (New York Heart Association [NYHA] functional class III/IV in 86%) and mitral regurgitation (MR) was graded 3+/4+ in 95% (38% primary, 37% secondary, and 25% mixed aetiology). Technical success rate was 96%, and MR reduction to ≤1+ was achieved in all patients with successful implantation. There were two procedural deaths and 30-day all-cause mortality was 12%. At early clinical follow-up, MR reduction was sustained and there were significant reductions of pulmonary pressure (systolic pulmonary artery pressure 52 vs. 42 mmHg, p

Published
2022

8. Impact of transcatheter edge-to-edge mitral valve repair on central sleep apnoea

Author

Paulus, Michael G., Liedtke, Tobias, Hamerle, Michael, Schach, Christian, Maier, Lars S., Stadler, Stefan, Birner, Christoph, Debl, Kurt, Arzt, Michael, Unsöld, Bernhard, and Meindl, Christine

Subjects
ddc:610, Sleep apnoea · Sleep-disordered breathing · Cheyne–Stokes respiration · Mitral regurgitation · Transcatheter mitral valve repair · Edge-to-edge mitral valve repair, 610 Medizin, General Medicine, Cardiology and Cardiovascular Medicine
Abstract

Aims Sleep-disordered breathing (SDB) and its subtype central sleep apnoea (CSA) are highly prevalent in patients with heart failure and associated with worse prognosis. Whereas pharmacological therapy of heart failure has been shown to ameliorate CSA, results from previous studies on the effect of mitral regurgitation therapy on SDB are contradicting. The aim of this study was to assess the impact of transcatheter edge-to-edge mitral valve repair (TEER) on prevalence and severity of CSA. Methods and results We enrolled 47 patients undergoing TEER for symptomatic mitral regurgitation in a prospective study. Secondary mitral regurgitation and left ventricular ejection fraction p = 0.007; 6 [0–34] vs. 0 [0–8] %, p = 0.008). Median relative reduction of central apnoea index was 75% (p = 0.023), while obstructive apnoea index did not change significantly. Increase in stroke volume after TEER and high systolic pulmonary artery pressure at baseline predicted a > 50% reduction of both Apnoea-hypopnoea index and Cheyne-Stokes respiration. Conclusion TEER is associated with a significant short-term reduction of CSA and Cheyne-Stokes respiration in high-risk patients, strengthening its value as an effective treatment option for advanced heart failure. Graphical abstract

Published
2022
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10. Transapical mitral valve implantation for treatment of symptomatic mitral valve disease: a real2̆010world multicentre experience

Author

Wild, Mirjam G., Kreidel, Felix, Hell, Michaela M., Praz, Fabien, Mach, Markus, Adam, Matti, Reineke, David, Ruge, Hendrik, Ludwig, Sebastian, Conradi, Lenard, Rudolph, Tanja K., Bleiziffer, Sabine, Kellermair, Jörg, Zierer, Andreas, Nickenig, Georg, Weber, Marcel, Petronio, Anna Sonia, Giannini, Cristina, Dahle, Gry, Rein, Kjell A., Coisne, Augustin, Vincentelli, André, Dubois, Christophe, Duncan, Alison, Quarto, Cesare, Unbehaun, Axel, Amat2̆010Santos, Ignacio, Cobiella, Javier, Dumonteil, Nicolas, Estevez\0̆10Loureiro, Rodrigo, Fumero, Andrea, Geisler, Tobias, Lurz, Philipp, Mangieri, Antonio, Monivas, Vanessa, Noack, Thilo, Franco, Luis Nombela, Pinon, Miguel A., Stolz, Lukas, Tchétché, Didier, Walter, Thomas, Unsöld, Bernhard, Baldus, Stephan, Andreas, Martin, Hausleiter, Jörg, and von Bardeleben, Ralph S.

Subjects
Research article, TRANSCATHETER TREATMENT OF MR, Mitral valve disease, Mitral regurgitation, Transcatheter mitral valve implantation, Tendyne, ddc
Published
2021

17. Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction

Author

Unsöld, Bernhard, Kaul, Axel, Sbroggiò, Mauro, Schubert, Carola, Regitz-Zagrosek, Vera, Brancaccio, Mara, Damilano, Federico, Hirsch, Emilio, Van Bilsen, Marc, Munts, Chantal, Sipido, Karin, Bito, Virginie, Detre, Elke, Wagner, Nana Maria, Schäfer, Katrin, Seidler, Tim, Vogt, Johannes, Neef, Stefan, Bleckmann, Annalen, Maier, Lars S., Balligand, Jean Luc, Bouzin, Caroline, Ventura-Clapier, Renée, Garnier, Anne, Eschenhagen, Thomas, El-Armouche, Ali, Knöll, Ralph, Tarone, Guido, and Hasenfu, Gerd

Published
2014
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18. The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry

Author

Meindl, Christine, Hochadel, Matthias, Frankenstein, Lutz, Bruder, Oliver, Pauschinger, Matthias, Hambrecht, Rainer, von Scheidt, Wolfgang, Pfister, Otmar, Hartmann, Andreas, Maier, Lars S., Senges, Jochen, and Unsöld, Bernhard

Subjects
Cardiomyopathy, Dilated, Male, Medical Implants, Endocrine Disorders, Death Rates, Science, Cardiology, 610 Medizin, Bioengineering, Vascular Medicine, Endocrinology, Population Metrics, Medicine and Health Sciences, Diabetes Mellitus, Humans, Coronary Heart Disease, Registries, ddc:610, cardiovascular diseases, Aged, Heart Failure, Population Biology, Biology and Life Sciences, Middle Aged, Diabetes Mellitus, Type 2, Diabetes mellitus, Heart failure, Coronary heart disease, ejection fraction, Death rates, Cardiomyopathies, Medical devices and equipment, Medical implants, Metabolic Disorders, Engineering and Technology, Medicine, Female, Medical Devices and Equipment, Cardiomyopathies, Follow-Up Studies, Research Article, Ejection Fraction, Biotechnology
Abstract

BackgroundType 2 diabetes is a major risk factor for cardiovascular diseases, e.g. coronary artery disease (CAD). But it has also been shown that diabetes can cause heart failure independently of ischemic heart disease (IHD) by causing diabetic cardiomyopathy. In contrast to diabetes and IHD, limited data exist regarding patients with diabetes and dilated cardiomyopathy (DCM).MethodsEVIdence based TreAtment in Heart Failure (EVITA-HF) comprises web-based case report data on demography, diagnostic measures, adverse events and 1-year follow-up of patients hospitalized for chronic heart failure and an ejection fraction ≤40%. In the present study we focused on the results of patients with diabetes and heart failure.ResultsBetween February 2009 and November 2015, 4101 patients with chronic heart failure were included in 16 tertiary care centers in Germany. The mortality in patients with diabetes and DCM (n = 323) was more than double (15.2%) than that of DCM patients without diabetes (6.5%, pConclusionThe influence of diabetes on the mortality rate is only significant in patients with DCM not in patients with CAD. Therefore, the underlying mechanisms of this effect should be studied in greater detail to improve patient care and outcome.

Published
2020

19. Acquired von Willebrand syndrome and factor VIII in patients with moderate to severe mitral regurgitation undergoing transcatheter mitral valve repair

Author

Meindl, Christine, primary, Paulus, Michael, additional, Koller, Theresia, additional, Rogalski, Dominik, additional, Hamerle, Michael, additional, Schach, Christian, additional, Buchner, Stefan, additional, Zeman, Florian, additional, Maier, Lars S., additional, Debl, Kurt, additional, Unsöld, Bernhard, additional, and Birner, Christoph, additional

Published
2020
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21. Parthenogenetic stem cells for tissue-engineered heart repair

Author

Didié, Michael, Christalla, Peter, Rubart, Michael, Muppala, Vijayakumar, Döker, Stephan, Unsöld, Bernhard, El-Armouche, Ali, Rau, Thomas, Eschenhagen, Thomas, Schwoerer, Alexander P., Ehmke, Heimo, Schumacher, Udo, Fuchs, Sigrid, Lange, Claudia, Becker, Alexander, Tao, Wen, Scherschel, John A., Soonpaa, Mark H., Yang, Tao, Lin, Qiong, Zenke, Martin, Han, Dong-Wook, Schöler, Hans R., Rudolph, Cornelia, Steinemann, Doris, Schlegelberger, Brigitte, Kattman, Steve, Witty, Alec, Keller, Gordon, Field, Loren J., and Zimmermann, Wolfram-Hubertus

Published
2013
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25. The role of diabetes in cardiomyopathies of different etiologies—Characteristics and 1-year follow-up results of the EVITA-HF registry

Author

Meindl, Christine, primary, Hochadel, Matthias, additional, Frankenstein, Lutz, additional, Bruder, Oliver, additional, Pauschinger, Matthias, additional, Hambrecht, Rainer, additional, von Scheidt, Wolfgang, additional, Pfister, Otmar, additional, Hartmann, Andreas, additional, Maier, Lars S., additional, Senges, Jochen, additional, and Unsöld, Bernhard, additional

Published
2020
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30. Control of p21Cip by BRCA1-associated protein is critical for cardiomyocyte cell cycle progression and survival

Author

Volland, Cornelia, primary, Schott, Peter, primary, Didié, Michael, primary, Männer, Jörg, primary, Unsöld, Bernhard, primary, Toischer, Karl, primary, Schmidt, Carla, primary, Urlaub, Henning, primary, Nickels, Katrin, primary, Knöll, Ralph, primary, Schmidt, Albrecht, primary, Guan, Kaomei, primary, Hasenfuß, Gerd, primary, and Seidler, Tim, primary

Published
2019
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31. Exercise intolerance and systemic manifestations of pulmonary emphysema in a mouse model

Author

Hasenfuss Gerd, Unsöld Bernhard, Michels Hellmuth, Raupach Tobias, Lüthje Lars, Kögler Harald, and Andreas Stefan

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Systemic effects of chronic obstructive pulmonary disease (COPD) significantly contribute to severity and mortality of the disease. We aimed to develop a COPD/emphysema model exhibiting systemic manifestations of the disease. Methods Female NMRI mice were treated 5 times intratracheally with porcine pancreatic elastase (emphysema) or phosphate-buffered saline (control). Emphysema severity was quantified histologically by mean linear intercept, exercise tolerance by treadmill running distance, diaphragm dysfunction using isolated muscle strips, pulmonary hypertension by measuring right ventricular pressure, and neurohumoral activation by determining urinary norepinephrine concentration. Results Mean linear intercept was higher in emphysema (260.7 ± 26.8 μm) than in control lungs (24.7 ± 1.7 μm). Emphysema mice lost body weight, controls gained weight. Running distance was shorter in emphysema than in controls. Diaphragm muscle length was shorter in controls compared to emphysema. Fatigue tests of muscle strips revealed impaired relaxation in emphysema diaphragms. Maximum right ventricular pressure and norepinephrine were elevated in emphysema compared to controls. Linear correlations were observed between running distance changes and intercept, right ventricular weight, norepinephrine, and diaphragm length. Conclusion The elastase mouse model exhibited severe emphysema with consecutive exercise limitation, and neurohumoral activation. The model may deepen our understanding of systemic aspects of COPD.

Published
2009
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33. Control of p21Cip by BRCA1-associated protein is critical for cardiomyocyte cell cycle progression and survival.

Author

Volland, Cornelia, Schott, Peter, Didié, Michael, Männer, Jörg, Unsöld, Bernhard, Toischer, Karl, Schmidt, Carla, Urlaub, Henning, Nickels, Katrin, Knöll, Ralph, Schmidt, Albrecht, Guan, Kaomei, Hasenfuß, Gerd, and Seidler, Tim

Subjects
CELL cycle, CELL cycle regulation, CELL cycle proteins, DNA synthesis, HEART dilatation, CELL anatomy
Abstract

Aims Identifying the key components in cardiomyocyte cell cycle regulation is of relevance for the understanding of cardiac development and adaptive and maladaptive processes in the adult myocardium. BRCA1-associated protein (BRAP) has been suggested as a cytoplasmic retention factor for several proteins including Cyclin-dependent-kinase inhibitor p21Cip. We observed profound expressional changes of BRAP in early postnatal myocardium and investigated the impact of BRAP on cardiomyocyte cell cycle regulation. Methods and results General knockout of Brap in mice evoked embryonic lethality associated with reduced myocardial wall thickness and lethal cardiac congestion suggesting a prominent role for BRAP in cardiomyocyte proliferation. αMHC-Cre driven cardiomyocyte-specific knockout of Brap also evoked lethal cardiac failure shortly after birth. Likewise, conditional cardiomyocyte-specific Brap deletion using tamoxifen-induced knockout in adult mice resulted in marked ventricular dilatation and heart failure 3 weeks after induction. Several lines of evidence suggest that Brap deletion evoked marked inhibition of DNA synthesis and cell cycle progression. In cardiomyocytes with proliferative capacity, this causes developmental arrest, whereas in adult hearts loss of BRAP-induced apoptosis. This is explained by altered signalling through p21Cip which we identify as the link between BRAP and cell cycle/apoptosis. BRAP deletion enhanced p21Cip expression, while BRAP overexpression in cardiomyocyte-specific transgenic mice impeded p21Cip expression. That was paralleled by enhanced nuclear Ki-67 expression and DNA synthesis. Conclusion By controlling p21Cip activity BRAP expression controls cell cycle activity and prevents developmental arrest in developing cardiomyocytes and apoptosis in adult cardiomyocytes. [ABSTRACT FROM AUTHOR]

Published
2020
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36. Long term biventricular support with Berlin Heart Excor in a Septuagenarian with giant-cell myocarditis

Author

Bireta, Christian, Tirilomis, Theodor, Grossmann, Marius, Unsöld, Bernhard, Wachter, Rolf, Perl, Thorsten, Jebran, Ahmad Fawad, Schoendube, Friedrich Albert, and Popov, Aron Frederik

Subjects
Heart Failure, Male, Prosthesis-Related Infections, Prednisolone, Shock, Cardiogenic, Staphylococcal Infections, giant-cell myocarditis, Anti-Bacterial Agents, Myocarditis, Extracorporeal Membrane Oxygenation, Treatment Outcome, Cyclosporine, Humans, Surgery, Pseudomonas Infections, Heart-Assist Devices, Cardiology and Cardiovascular Medicine, Immunosuppressive Agents, Aged, Follow-Up Studies
Abstract

Giant-cell myocarditis (GCM) is known as a rare, rapidly progressive, and frequently fatal myocardial disease in young and middle-aged adults. We report about a 76 year old male patient who underwent implantation with a biventricular Berlin Heart Excor system at the age of 74 due to acute biventricular heart failure caused by giant-cell myocarditis. The implantation was without any surgical problems; however, a difficulty was the immunosuppressive therapy after implantation. Meanwhile the patient is 76 years old and lives with circulatory support for about 3 years without major adverse events. Also, in terms of mobility in old age there are no major limitations. It seems that in even selected elderly patients an implantation of a long term support with the biventricular Berlin Heart Excor is a useful therapeutic option with an acceptable outcome. Open-Access-Publikationsfonds 2015 peerReviewed

Published
2015

37. Enhanced cardiac TBC1D10C expression lowers heart rate and enhances exercise capacity and survival

Author

Volland, Cornelia, primary, Bremer, Sebastian, additional, Hellenkamp, Kristian, additional, Hartmann, Nico, additional, Dybkova, Nataliya, additional, Khadjeh, Sara, additional, Kutschenko, Anna, additional, Liebetanz, David, additional, Wagner, Stefan, additional, Unsöld, Bernhard, additional, Didié, Michael, additional, Toischer, Karl, additional, Sossalla, Samuel, additional, Hasenfuß, Gerd, additional, and Seidler, Tim, additional

Published
2016
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38. Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator

Author

Chang Liao, Mei-Ling, de Boer, Teun P, Mutoh, Hiroki, Raad, Nour, Richter, Claudia, Wagner, Eva, Downie, Bryan R, Unsöld, Bernhard, Arooj, Iqra, Streckfuss-Bömeke, Katrin, Döker, Stephan, Luther, Stefan, Guan, Kaomei, Wagner, Stefan, Lehnart, Stephan E, Maier, Lars S, Stühmer, Walter, Wettwer, Erich, van Veen, Toon, Morlock, Michael M, Knöpfel, Thomas, Zimmermann, Wolfram-Hubertus, Chang Liao, Mei-Ling, de Boer, Teun P, Mutoh, Hiroki, Raad, Nour, Richter, Claudia, Wagner, Eva, Downie, Bryan R, Unsöld, Bernhard, Arooj, Iqra, Streckfuss-Bömeke, Katrin, Döker, Stephan, Luther, Stefan, Guan, Kaomei, Wagner, Stefan, Lehnart, Stephan E, Maier, Lars S, Stühmer, Walter, Wettwer, Erich, van Veen, Toon, Morlock, Michael M, Knöpfel, Thomas, and Zimmermann, Wolfram-Hubertus

Published
2015

39. Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator

Author

Medische Fysiologie, Circulatory Health, Chang Liao, Mei-Ling, de Boer, Teun P, Mutoh, Hiroki, Raad, Nour, Richter, Claudia, Wagner, Eva, Downie, Bryan R, Unsöld, Bernhard, Arooj, Iqra, Streckfuss-Bömeke, Katrin, Döker, Stephan, Luther, Stefan, Guan, Kaomei, Wagner, Stefan, Lehnart, Stephan E, Maier, Lars S, Stühmer, Walter, Wettwer, Erich, van Veen, Toon, Morlock, Michael M, Knöpfel, Thomas, Zimmermann, Wolfram-Hubertus, Medische Fysiologie, Circulatory Health, Chang Liao, Mei-Ling, de Boer, Teun P, Mutoh, Hiroki, Raad, Nour, Richter, Claudia, Wagner, Eva, Downie, Bryan R, Unsöld, Bernhard, Arooj, Iqra, Streckfuss-Bömeke, Katrin, Döker, Stephan, Luther, Stefan, Guan, Kaomei, Wagner, Stefan, Lehnart, Stephan E, Maier, Lars S, Stühmer, Walter, Wettwer, Erich, van Veen, Toon, Morlock, Michael M, Knöpfel, Thomas, and Zimmermann, Wolfram-Hubertus

Published
2015

40. Pericardiectomy for Constrictive Pericarditis: An Institution's 21 Years Experience.

Author

Rupprecht, Leopold, Putz, Christina, Flörchinger, Bernhard, Zausig, York, Camboni, Daniele, Unsöld, Bernhard, and Schmid, Christof

Subjects
ARTIFICIAL blood circulation, MECHANICAL hearts, CARDIOPULMONARY bypass, PERICARDITIS, CRITICALLY ill, CARDIAC surgery
Abstract

Background The aim of this retrospective study was to evaluate our experience with the surgical pericardiectomy procedure for patients suffering from isolated severe constrictive pericarditis. Methods From 1995 to 2016, 39 patients underwent isolated pericardiectomy for constrictive pericarditis. Fifteen patients were excluded because of concomitant surgery. There were 31 male (79.5%) patients and 8 female (20.5%) patients, 28 to 76 years old (mean, 56.6±13.6 years). The underlying etiologies were idiopathic pericarditis (74.5%), infection (10%), rheumatic disorders (8%), status post cardiac surgery (2.5%), tuberculosis (2.5%), and status post mediastinal irradiation (2.5%). Results Pericardiectomy was performed through midline sternotomy in all cases. Sixteen patients (41%) underwent pericardiectomy electively employing cardiopulmonary bypass with the heart beating, and 23 patients (59%) had surgery without extracorporeal circulation (ECC). The overall 30-day mortality rate was 50% if cardiopulmonary bypass was used (13.8% since 2007). If surgery was performed without a heart-lung machine, mortality was 0%. On-pump patients had a significantly longer intensive care unit (ICU) stay (12±9 vs. 4±4 days, p=0.013). Likewise, the duration of mechanical ventilation was much longer (171±246 vs. 21±40 hours, p=0.04). The hospital stay was comparable with 28±10 and 24±18 days (p=0.21). Conclusion The present study demonstrates that pericardiectomy, without the use of cardiopulmonary bypass as treatment for constrictive pericarditis, is a safe procedure with an excellent outcome in critically ill patients. [ABSTRACT FROM AUTHOR]

Published
2018
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41. Sensing Cardiac Electrical Activity With a Cardiac Myocyte–Targeted Optogenetic Voltage Indicator

Author

Chang Liao, Mei-Ling, primary, de Boer, Teun P., additional, Mutoh, Hiroki, additional, Raad, Nour, additional, Richter, Claudia, additional, Wagner, Eva, additional, Downie, Bryan R., additional, Unsöld, Bernhard, additional, Arooj, Iqra, additional, Streckfuss-Bömeke, Katrin, additional, Döker, Stephan, additional, Luther, Stefan, additional, Guan, Kaomei, additional, Wagner, Stefan, additional, Lehnart, Stephan E., additional, Maier, Lars S., additional, Stühmer, Walter, additional, Wettwer, Erich, additional, van Veen, Toon, additional, Morlock, Michael M., additional, Knöpfel, Thomas, additional, and Zimmermann, Wolfram-Hubertus, additional

Published
2015
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43. Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction

Author

UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - (SLuc) Service de médecine interne générale, Unsöld, Bernhard, Kaul, Axel, Sbroggiò, Mauro, Schubert, Carola, Regitz-Zagrosek, Vera, Brancaccio, Mara, Damilano, Federico, Hirsch, Emilio, Van Bilsen, Marc, Munts, Chantal, Sipido, Karin, Bito, Virginie, Detre, Elke, Wagner, Nana Maria, Schäfer, Katrin, Seidler, Tim, Vogt, Johannes, Neef, Stefan, Bleckmann, Annalen, Maier, Lars S, Balligand, Jean-Luc, Bouzin, Caroline, Ventura-Clapier, Renée, Garnier, Anne, Eschenhagen, Thomas, El-Armouche, Ali, Knöll, Ralph, Tarone, Guido, Hasenfuß, Gerd, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - (SLuc) Service de médecine interne générale, Unsöld, Bernhard, Kaul, Axel, Sbroggiò, Mauro, Schubert, Carola, Regitz-Zagrosek, Vera, Brancaccio, Mara, Damilano, Federico, Hirsch, Emilio, Van Bilsen, Marc, Munts, Chantal, Sipido, Karin, Bito, Virginie, Detre, Elke, Wagner, Nana Maria, Schäfer, Katrin, Seidler, Tim, Vogt, Johannes, Neef, Stefan, Bleckmann, Annalen, Maier, Lars S, Balligand, Jean-Luc, Bouzin, Caroline, Ventura-Clapier, Renée, Garnier, Anne, Eschenhagen, Thomas, El-Armouche, Ali, Knöll, Ralph, Tarone, Guido, and Hasenfuß, Gerd

Abstract

AIMS: Melusin is a muscle-specific chaperone protein whose expression is required for a compensatory hypertrophy response to pressure overload. Here, we evaluated the consequences of melusin overexpression in the setting of myocardial infarction (MI) using a comprehensive multicentre approach. METHODS AND RESULTS: Mice overexpressing melusin in the heart (TG) and wild-type controls (WT) were subjected to permanent LAD ligation and both the acute response (Day 3) and subsequent remodelling (2 weeks) were examined. Mortality in wild-type mice was significant between Days 3 and 7, primarily due to cardiac rupture, but melusin's overexpression strongly reduced mortality (43.2% in wild-type vs. 27.3% in melusin-TG, P = 0.005). At Day 3 after MI, a time point preceding the mortality peak, TG hearts had increased heat shock protein 70 expression, increased ERK1/2 signalling, reduced cardiomyocyte hyper-contractility and inflammatory cell infiltrates, and increased matricellular protein expression in the infarcted area. At 2 weeks after MI, melusin overexpression conferred a favourable adaptive remodelling characterized by reduced left ventricle dilatation and better preserved contractility in the presence of a comparable degree of hypertrophy. Adaptive remodelling in melusin TG mice was characterized by reduced apoptosis and fibrosis as well as increased cardiomyocyte contractility. CONCLUSIONS: Consistent with its function as a chaperone protein, melusin overexpression exerts a dual protective action following MI reducing an array of maladaptive processes. In the early phase after MI, reduced inflammation and myocyte remodelling protect against cardiac rupture. Chronically, reduced myocyte loss and matrix remodelling, with preserved myocyte contractility, confer adaptive LV remodelling.

Published
2014

45. Erythropoietin Responsive Cardiomyogenic Cells Contribute to Heart Repair Post Myocardial Infarction

Author

Zafiriou, Maria Patapia, primary, Noack, Claudia, additional, Unsöld, Bernhard, additional, Didie, Michael, additional, Pavlova, Elena, additional, Fischer, Henrike J., additional, Reichardt, Holger M., additional, Bergmann, Martin W., additional, El-Armouche, Ali, additional, Zimmermann, Wolfram-Hubertus, additional, and Zelarayan, Laura Cecilia, additional

Published
2014
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46. Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction

Author

Unsöld, Bernhard, primary, Kaul, Axel, primary, Sbroggiò, Mauro, primary, Schubert, Carola, primary, Regitz-Zagrosek, Vera, primary, Brancaccio, Mara, primary, Damilano, Federico, primary, Hirsch, Emilio, primary, Van Bilsen, Marc, primary, Munts, Chantal, primary, Sipido, Karin, primary, Bito, Virginie, primary, Detre, Elke, primary, Wagner, Nana Maria, primary, Schäfer, Katrin, primary, Seidler, Tim, primary, Vogt, Johannes, primary, Neef, Stefan, primary, Bleckmann, Annalen, primary, Maier, Lars S., primary, Balligand, Jean Luc, primary, Bouzin, Caroline, primary, Ventura-Clapier, Renée, primary, Garnier, Anne, primary, Eschenhagen, Thomas, primary, El-Armouche, Ali, primary, Knöll, Ralph, primary, Tarone, Guido, primary, and Hasenfuß, Gerd, primary

Published
2013
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48. Telethonin Deficiency Is Associated With Maladaptation to Biomechanical Stress in the Mammalian Heart

Author

Knöll, Ralph, primary, Linke, Wolfgang A., additional, Zou, Peijian, additional, Miočiċ, Snježana, additional, Kostin, Sawa, additional, Buyandelger, Byambajav, additional, Ku, Ching-Hsin, additional, Neef, Stefan, additional, Bug, Monika, additional, Schäfer, Katrin, additional, Knöll, Gudrun, additional, Felkin, Leanne E., additional, Wessels, Johannes, additional, Toischer, Karl, additional, Hagn, Franz, additional, Kessler, Horst, additional, Didié, Michael, additional, Quentin, Thomas, additional, Maier, Lars S., additional, Teucher, Nils, additional, Unsöld, Bernhard, additional, Schmidt, Albrecht, additional, Birks, Emma J., additional, Gunkel, Sylvia, additional, Lang, Patrick, additional, Granzier, Henk, additional, Zimmermann, Wolfram-Hubertus, additional, Field, Loren J., additional, Faulkner, Georgine, additional, Dobbelstein, Matthias, additional, Barton, Paul J.R., additional, Sattler, Michael, additional, Wilmanns, Matthias, additional, and Chien, Kenneth R., additional

Published
2011
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49. Response to Letter Regarding Article, “Differential Cardiac Remodeling in Preload Versus Afterload”

Author

Toischer, Karl, primary, Rokita, Adam G., additional, Unsöld, Bernhard, additional, Sossalla, Samuel, additional, Becker, Alexander, additional, Seidler, Tim, additional, Grebe, Cornelia, additional, Preuß, Lena, additional, Gupta, Shamindra N., additional, Schmidt, Kathie, additional, Lehnart, Stephan E., additional, Schäfer, Katrin, additional, Maier, Lars S., additional, Hasenfuss, Gerd, additional, Zhu, Wuqiang, additional, Reuter, Sean P., additional, Field, Loren J., additional, Kararigas, Georgios, additional, Regitz-Zagrosek, Vera, additional, Teucher, Nils, additional, Krüger, Martina, additional, Linke, Wolfgang A., additional, and Backs, Johannes, additional

Published
2011
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50. Differential Cardiac Remodeling in Preload Versus Afterload

Author

Toischer, Karl, primary, Rokita, Adam G., additional, Unsöld, Bernhard, additional, Zhu, Wuqiang, additional, Kararigas, Georgios, additional, Sossalla, Samuel, additional, Reuter, Sean P., additional, Becker, Alexander, additional, Teucher, Nils, additional, Seidler, Tim, additional, Grebe, Cornelia, additional, Preuß, Lena, additional, Gupta, Shamindra N., additional, Schmidt, Kathie, additional, Lehnart, Stephan E., additional, Krüger, Martina, additional, Linke, Wolfgang A., additional, Backs, Johannes, additional, Regitz-Zagrosek, Vera, additional, Schäfer, Katrin, additional, Field, Loren J., additional, Maier, Lars S., additional, and Hasenfuss, Gerd, additional

Published
2010
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