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1. Early pregnancy disorders

Author

Painter, Rebecca C., van Mello, Norah M., Goddijn, Mariëtte, van den Berg, Merel M. J., Lok, Christianne, van Trommel, Nienke, van der Post, Joris A. M., Steegers, Eric A.P., editor, de Groot, Christianne J.M., editor, Hilders, Carina G.J.M., editor, Hoek, Annemieke, editor, Jaddoe, Vincent W.V., editor, Schoenmakers, Sam, editor, and Zweemer, Ronald P., editor

Published
2024
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2. Future perspectives part V

Author

de Groot, Christianne, van der Post, Joris A. M., Steegers, Eric A.P., editor, de Groot, Christianne J.M., editor, Hilders, Carina G.J.M., editor, Hoek, Annemieke, editor, Jaddoe, Vincent W.V., editor, Schoenmakers, Sam, editor, and Zweemer, Ronald P., editor

Published
2024
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5. Levothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

Author

van Dijk, Myrthe M, Vissenberg, Rosa, Fliers, Eric, van der Post, Joris A M, van der Hoorn, Marie-Louise P, de Weerd, Sabina, Kuchenbecker, Walter K, Hoek, Annemieke, Sikkema, J Marko, Verhoeve, Harold R, Broeze, Kimiko A, de Koning, Corry H, Verpoest, Willem, Christiansen, Ole B, Koks, Carolien, de Bruin, Jan P, Papatsonis, Dimitri N M, Torrance, Helen, van Wely, Madelon, Bisschop, Peter H, and Goddijn, Mariëtte

Published
2022
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6. Early pregnancy disorders

Author

Painter, Rebecca C., van Mello, Norah M., Goddijn, Mariëtte, van den Berg, Merel M. J., Lok, Christianne, van Trommel, Nienke, van der Post, Joris A. M., Steegers, Eric A.P., editor, Fauser, Bart C.J.M., editor, Hilders, Carina G.J.M., editor, Jaddoe, Vincent W.V., editor, Massuger, Leon F.A.G., editor, van der Post, Joris A.M., editor, and Schoenmakers, Sam, editor

Published
2019
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7. Life course approach in obstetrics and gynaecology for patient care, education and research

Author

Schoenmakers, Sam, Fauser, Bart C. J. M., Dankbaar, Mary E. W., Hilders, Carina G. J. M., Jaddoe, Vincent W. V., Massuger, Leon F. A. G., van der Post, Joris A. M., Steegers, Eric A. P., Steegers, Eric A.P., editor, Fauser, Bart C.J.M., editor, Hilders, Carina G.J.M., editor, Jaddoe, Vincent W.V., editor, Massuger, Leon F.A.G., editor, van der Post, Joris A.M., editor, and Schoenmakers, Sam, editor

Published
2019
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9. Determinants of disease course and severity in hyperemesis gravidarum

Author

Koot, Marjette H., Grooten, Iris J., van der Post, Joris A.M., Bais, Joke M.J., Ris-Stalpers, Carrie, Leeflang, Mariska M.G., Bremer, Henk A., van der Ham, David P., Heidema, Wieteke M., Huisjes, Anjoke, Kleiverda, Gunilla, Kuppens, Simone M., van Laar, Judith O.E.H., Langenveld, Josje, van der Made, Flip, van Pampus, Mariëlle G., Papatsonis, Dimitri, Pelinck, Marie-José, Pernet, Paula J., van Rheenen-Flach, Leonie, Rijnders, Robbert J., Scheepers, Hubertina C.J., Vogelvang, Tatjana E., Mol, Ben W., Roseboom, Tessa J., and Painter, Rebecca C.

Published
2020
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10. 28 Oral antihyperglycemic agent strategy versus insulin for gestational diabetes mellitus – a randomized controlled trial

Author

Rademaker, Doortje, primary, de Wit, Leon, additional, Duijnhoven, Ruben G., additional, Voormolen-van Münster, Daphne N., additional, van der Post, Joris, additional, Bosmans, Judith E., additional, de Valk, Harold W., additional, Evers, Inge M., additional, Mol, Ben Willem W., additional, Franx, Arie, additional, de Vries, Hans, additional, Painter, Rebecca, additional, and van Rijn, Bas, additional

Published
2024
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18. Usability and Usefulness of a Mobile Health App for Pregnancy-Related Work Advice: Mixed-Methods Approach

Author

van Beukering, Monique, Velu, Adeline, van den Berg, Liesbeth, Kok, Marjolein, Mol, Ben Willem, Frings-Dresen, Monique, de Leeuw, Robert, van der Post, Joris, and Peute, Linda

Subjects
Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270
Abstract

BackgroundPregnant women are often unaware of the potential risks that working conditions can cause to them and their unborn child. A mobile health (mHealth) app, the Pregnancy and Work (P and W) app, developed by a multidisciplinary team and based on an evidence-based guideline for occupational physicians, aims to provide advice on work adjustment during pregnancy. ObjectiveThis study evaluates the usability of the mHealth P and W app and the perceived usefulness of the work advice, the main goal of the app, by potential end users. MethodsA total of 12 working pregnant women participated in think aloud usability sessions and performed 9 tasks. All think aloud sessions were recorded, transcribed, and coanalyzed. The usability problems were rated for their severity in accordance with Nielsen severity scale. The completion rates and time taken for completion of tasks were registered. In addition, participants were questioned on demographics and user characteristics and were asked to evaluate the value of the app by filling in the Intrinsic Motivation Inventory (IMI) score and the System Usability Scale (SUS) questionnaire. ResultsIn total, 82 usability problems with a severity ≥1 were identified, of which 40 had severity ≥3. The main usability problems concerned the interpretation of terminology used in the app’s questionnaires and difficulties in finding and understanding the work advice. Furthermore, 10 out of 12 participants were able to open the work advice page in the app. Only 7 out of these 10 participants understood and intended to follow the work advice. The overall mean IMI score was relatively high (5 out of 7), indicating that the participants did indeed value the use of the app. This IMI score corresponded to the overall mean SUS score (68 out of 100) and the mean grade given to the P and W app (7 out of 10). ConclusionsThis think aloud usability study showed that the information provided in the P and W app was considered valuable by the end users, working pregnant women, and it meets their needs; however, usability issues severely impacted the perceived usefulness of the work advice given in the app.

Published
2019
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19. Nifedipine versus atosiban for threatened preterm birth (APOSTEL III): a multicentre, randomised controlled trial

Author

van Vliet, Elvira O G, Nijman, Tobias A J, Schuit, Ewoud, Heida, Karst Y, Opmeer, Brent C, Kok, Marjolein, Gyselaers, Wilfried, Porath, Martina M, Woiski, Mallory, Bax, Caroline J, Bloemenkamp, Kitty W M, Scheepers, Hubertina C J, Jacquemyn, Yves, Beek, Erik van, Duvekot, Johannes J, Franssen, Maureen T M, Papatsonis, Dimitri N, Kok, Joke H, van der Post, Joris A M, Franx, Arie, Mol, Ben W, and Oudijk, Martijn A

Published
2016
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20. Extending the scope of pooled analyses of individual patient biomarker data from heterogeneous laboratory platforms and cohorts using merging algorithms

Author

Burke, Órlaith, Benton, Samantha, Szafranski, Pawel, von Dadelszen, Peter, Buhimschi, S. Catalin, Cetin, Irene, Chappell, Lucy, Figueras, Francesc, Galindo, Alberto, Herraiz, Ignacio, Holzman, Claudia, Hubel, Carl, Knudsen, Ulla, Kronborg, Camilla, Laivuori, Hannele, Lapaire, Olav, McElrath, Thomas, Moertl, Manfred, Myers, Jenny, Ness, Roberta B., Oliveira, Leandro, Olson, Gayle, Poston, Lucilla, Ris-Stalpers, Carrie, Roberts, James M., Schalekamp-Timmermans, Sarah, Schlembach, Dietmar, Steegers, Eric, Stepan, Holger, Tsatsaris, Vassilis, van der Post, Joris A., Verlohren, Stefan, Villa, Pia M., Williams, David, Zeisler, Harald, Redman, Christopher W.G., and Staff, Anne Cathrine

Published
2016
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21. Ethnic differences in the impact of male fetal gender on the risk of spontaneous preterm birth

Author

Peelen, Myrthe J. C. S., Kazemier, Brenda M., Ravelli, Anita C. J., de Groot, Christianne J. M., van der Post, Joris A. M., Mol, Ben W. J., Kok, Marjolein, and Hajenius, Petra J.

Abstract

Objective: To study the impact of fetal gender on the risk of spontaneous preterm birth in various ethnicities. Study design: National cohort study in which all singleton live births from 25+0weeks onwards without congenital anomalies were included of African, Asian, and Mediterranean women (1999–2010). Our primary outcome measure was preterm birth before 37 weeks. Per ethnic group, male and female neonates were compared. Result: In each ethnic group, male fetuses were at increased risk of preterm birth (adjusted odds ratio (aOR) 1.63 for African, aOR 1.71 for Asian, and aOR 1.84 for Mediterranean males). The population-attributable risk of male gender on spontaneous preterm birth is lower in African women (3.9%) than in Asian (10.3%) and Mediterranean women (9.0%). Conclusion: Male fetal gender is associated with spontaneous preterm birth in African, Asian, and Mediterranean women, but the total impact of ethnicity on spontaneous preterm birth rate is different.

Published
2024
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24. Induction of labour at 41 weeks or expectant management until 42 weeks: A systematic review and an individual participant data meta-analysis of randomised trials

Author

Alkmark, Mårten, Keulen, Judit K. J., Kortekaas, Joep C., Bergh, Christina, van Dillen, Jeroen, Duijnhoven, Ruben G., Hagberg, Henrik, Mol, Ben Willem, Molin, Mattias, van der Post, Joris A. M., Saltvedt, Sissel, Wikström, Anna-Karin, Wennerholm, Ulla-Britt, and de Miranda, Esteriek

Subjects
Pregnancy, Protracted -- Patient outcomes, Labor, Induced (Obstetrics) -- Usage -- Patient outcomes, Biological sciences
Abstract

Background The risk of perinatal death and severe neonatal morbidity increases gradually after 41 weeks of pregnancy. Several randomised controlled trials (RCTs) have assessed if induction of labour (IOL) in uncomplicated pregnancies at 41 weeks will improve perinatal outcomes. We performed an individual participant data meta-analysis (IPD-MA) on this subject. Methods and findings We searched PubMed, Excerpta Medica dataBASE (Embase), The Cochrane Library, Cumulative Index of Nursing and Allied Health Literature (CINAHL), and PsycINFO on February 21, 2020 for RCTs comparing IOL at 41 weeks with expectant management until 42 weeks in women with uncomplicated pregnancies. Individual participant data (IPD) were sought from eligible RCTs. Primary outcome was a composite of severe adverse perinatal outcomes: mortality and severe neonatal morbidity. Additional outcomes included neonatal admission, mode of delivery, perineal lacerations, and postpartum haemorrhage. Prespecified subgroup analyses were conducted for parity (nulliparous/multiparous), maternal age ( From 89 full-text articles, we identified three eligible RCTs (n = 5,161), and two contributed with IPD (n = 4,561). Baseline characteristics were similar between the groups regarding age, parity, BMI, and higher level of education. IOL resulted overall in a decrease of severe adverse perinatal outcome (0.4% [10/2,281] versus 1.0% [23/2,280]; relative risk [RR] 0.43 [95% confidence interval [CI] 0.21 to 0.91], p-value 0.027, risk difference [RD] -57/10,000 [95% CI -106/10,000 to -8/10,000], I.sup.2 0%). The number needed to treat (NNT) was 175 (95% CI 94 to 1,267). Perinatal deaths occurred in one ( Prespecified subgroup analyses for the primary outcome showed a significant difference in the treatment effect (p = 0.01 for interaction) for parity, but not for maternal age or BMI. The risk of severe adverse perinatal outcome was decreased for nulliparous women in the IOL group (0.3% [4/1,219] versus 1.6% [20/1,264]; RR 0.20 [95% CI 0.07 to 0.60], p-value 0.004, RD -127/10,000, [95% CI -204/10,000 to -50/10,000], I.sup.2 0%, NNT 79 [95% CI 49 to 201]) but not for multiparous women (0.6% [6/1,219] versus 0.3% [3/1,264]; RR 1.59 [95% CI 0.15 to 17.30], p-value 0.35, RD 27/10,000, [95% CI -29/10,000 to 84/10,000], I.sup.2 55%). A limitation of this IPD-MA was the risk of overestimation of the effect on perinatal mortality due to early stopping of the largest included trial for safety reasons after the advice of the Data and Safety Monitoring Board. Furthermore, only two RCTs were eligible for the IPD-MA; thus, the possibility to assess severe adverse neonatal outcomes with few events was limited. Conclusions In this study, we found that, overall, IOL at 41 weeks improved perinatal outcome compared with expectant management until 42 weeks without increasing the cesarean delivery rate. This benefit is shown only in nulliparous women, whereas for multiparous women, the incidence of mortality and morbidity was too low to demonstrate any effect. The magnitude of risk reduction of perinatal mortality remains uncertain. Women with pregnancies approaching 41 weeks should be informed on the risk differences according to parity so that they are able to make an informed choice for IOL at 41 weeks or expectant management until 42 weeks. Study Registration: PROSPERO CRD42020163174, Author(s): Mårten Alkmark 1,2,*, Judit K. J. Keulen 3, Joep C. Kortekaas 4, Christina Bergh 5,6, Jeroen van Dillen 4, Ruben G. Duijnhoven 3, Henrik Hagberg 1,2, Ben Willem Mol [...]

Published
2020
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26. Vaginal bacterium Prevotella timonensis turns protective Langerhans cells into HIV ‐1 reservoirs for virus dissemination

Author

van Teijlingen, Nienke H, primary, Helgers, Leanne C, additional, Sarrami‐Forooshani, Ramin, additional, Zijlstra‐Willems, Esther M, additional, van Hamme, John L, additional, Segui‐Perez, Celia, additional, van Smoorenburg, Marleen Y, additional, Borgdorff, Hanneke, additional, van de Wijgert, Janneke HHM, additional, van Leeuwen, Elisabeth, additional, van der Post, Joris AM, additional, Strijbis, Karin, additional, Ribeiro, Carla MS, additional, and Geijtenbeek, Teunis BH, additional

Published
2022
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30. Risk factors for spontaneous preterm birth among healthy nulliparous pregnant women in the Netherlands, a prospective cohort study

Author

Schuster, Heleen J., primary, Peelen, Myrthe J. C. S., additional, Hajenius, Petra J., additional, van Beukering, Monique D. M., additional, van Eekelen, Rik, additional, Schonewille, Marit, additional, Playfair, Henna, additional, van der Post, Joris A. M., additional, Kok, Marjolein, additional, and Painter, Rebecca C., additional

Published
2022
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31. Vaginal bacterium Prevotella timonensis turns protective Langerhans cells into HIV-1 reservoirs for virus dissemination

Author

Infectiebiologie, van Teijlingen, Nienke H, Helgers, Leanne C, Sarrami-Forooshani, Ramin, Zijlstra-Willems, Esther M, van Hamme, John L, Segui-Perez, Celia, van Smoorenburg, Marleen Y, Borgdorff, Hanneke, van de Wijgert, Janneke Hhm, van Leeuwen, Elisabeth, van der Post, Joris Am, Strijbis, Karin, Ribeiro, Carla Ms, Geijtenbeek, Teunis Bh, Infectiebiologie, van Teijlingen, Nienke H, Helgers, Leanne C, Sarrami-Forooshani, Ramin, Zijlstra-Willems, Esther M, van Hamme, John L, Segui-Perez, Celia, van Smoorenburg, Marleen Y, Borgdorff, Hanneke, van de Wijgert, Janneke Hhm, van Leeuwen, Elisabeth, van der Post, Joris Am, Strijbis, Karin, Ribeiro, Carla Ms, and Geijtenbeek, Teunis Bh

Published
2022

32. Vaginal bacterium Prevotella timonensis turns protective Langerhans cells into HIV-1 reservoirs for virus dissemination

Author

Epi Infectieziekten Team 1b, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, van Teijlingen, Nienke H, Helgers, Leanne C, Sarrami-Forooshani, Ramin, Zijlstra-Willems, Esther M, van Hamme, John L, Segui-Perez, Celia, van Smoorenburg, Marleen Y, Borgdorff, Hanneke, van de Wijgert, Janneke Hhm, van Leeuwen, Elisabeth, van der Post, Joris Am, Strijbis, Karin, Ribeiro, Carla Ms, Geijtenbeek, Teunis Bh, Epi Infectieziekten Team 1b, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, van Teijlingen, Nienke H, Helgers, Leanne C, Sarrami-Forooshani, Ramin, Zijlstra-Willems, Esther M, van Hamme, John L, Segui-Perez, Celia, van Smoorenburg, Marleen Y, Borgdorff, Hanneke, van de Wijgert, Janneke Hhm, van Leeuwen, Elisabeth, van der Post, Joris Am, Strijbis, Karin, Ribeiro, Carla Ms, and Geijtenbeek, Teunis Bh

Published
2022

33. Nifedipine Versus Atosiban for Threatened Preterm Birth (APOSTEL III): A Multicentre, Randomized Controlled Trial

Author

van Vliet, Elvira O.G., Nijman, Tobias A.J., Schuit, Ewoud, Heida, Karst Y., Opmeer, Brent C., Kok, Marjolein, Gyselaers, Wilfried, Porath, Martina M., Woiski, Mallory, Bax, Caroline J., Bloemenkamp, Kitty W.M., Scheepers, Hubertina C.J., Jacquemyn, Yves, van Beek, Erik, Duvekot, Johannes J., Franssen, Maureen T.M., Papatsonis, Dimitri N., Kok, Joke H., van der Post, Joris A.M., Franx, Arie, Mol, Ben W., and Oudijk, Martijn A.

Published
2017
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34. Which Factors Contribute to False-Positive, False-Negative, and Invalid Results in Fetal Fibronectin Testing in Women with Symptoms of Preterm Labor?

Author

Bruijn, Merel M.C., Hermans, Frederik J.R., Vis, Jolande Y., Wilms, Femke F., Oudijk, Martijn A., Kwee, Anneke, Porath, Martina M., Oei, Guid, Scheepers, Hubertina C.J., Spaanderman, Marc E.A., Bloemenkamp, Kitty W.M., Haak, Monique C., Bolte, Antoinette C., Vandenbussche, Frank P.H.A., Woiski, Mallory D., Bax, Caroline J., Cornette, Jérôme M.J., Duvekot, Johannes J., Bijvank, Bas W.A.N.I.J., van Eyck, Jim, Franssen, Maureen T.M., Sollie, Krystyna M., van der Post, Joris A.M., Bossuyt, Patrick M.M., Kok, Marjolein, Mol, Ben W.J., and van Baaren, Gert-Jan

Published
2017
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36. Predicting seizures in pregnant women with epilepsy: Development and external validation of a prognostic model

Author

Allotey, John, Fernandez-Felix, Borja M., Zamora, Javier, Moss, Ngawai, Bagary, Manny, Kelso, Andrew, Khan, Rehan, van der Post, Joris A. M., Mol, Ben W., Pirie, Alexander M., McCorry, Dougall, Khan, Khalid S., and Thangaratinam, Shakila

Subjects
Maternal mortality -- Causes of, Epilepsy -- Patient outcomes -- Risk factors -- Care and treatment, Seizures (Medicine) -- Research, Pregnant women -- Health aspects, Death, Hospital admission and discharge, Decision making, Levetiracetam, Lamotrigine, Anticonvulsants, Biological sciences
Abstract

Background Seizures are the main cause of maternal death in women with epilepsy, but there are no tools for predicting seizures in pregnancy. We set out to develop and validate a prognostic model, using information collected during the antenatal booking visit, to predict seizure risk at any time in pregnancy and until 6 weeks postpartum in women with epilepsy on antiepileptic drugs. Methods and findings We used datasets of a prospective cohort study (EMPiRE) of 527 pregnant women with epilepsy on medication recruited from 50 hospitals in the UK (4 November 2011-17 August 2014). The model development cohort comprised 399 women whose antiepileptic drug doses were adjusted based on clinical features only; the validation cohort comprised 128 women whose drug dose adjustments were informed by serum drug levels. The outcome was epileptic (non-eclamptic) seizure captured using diary records. We fitted the model using LASSO (least absolute shrinkage and selection operator) regression, and reported the performance using C-statistic (scale 0-1, values > 0.5 show discrimination) and calibration slope (scale 0-1, values near 1 show accuracy) with 95% confidence intervals (CIs). We determined the net benefit (a weighted sum of true positive and false positive classifications) of using the model, with various probability thresholds, to aid clinicians in making individualised decisions regarding, for example, referral to tertiary care, frequency and intensity of monitoring, and changes in antiepileptic medication. Seizures occurred in 183 women (46%, 183/399) in the model development cohort and in 57 women (45%, 57/128) in the validation cohort. The model included age at first seizure, baseline seizure classification, history of mental health disorder or learning difficulty, occurrence of tonic-clonic and non-tonic-clonic seizures in the 3 months before pregnancy, previous admission to hospital for seizures during pregnancy, and baseline dose of lamotrigine and levetiracetam. The C-statistic was 0.79 (95% CI 0.75, 0.84). On external validation, the model showed good performance (C-statistic 0.76, 95% CI 0.66, 0.85; calibration slope 0.93, 95% CI 0.44, 1.41) but with imprecise estimates. The EMPiRE model showed the highest net proportional benefit for predicted probability thresholds between 12% and 99%. Limitations of this study include the varied gestational ages of women at recruitment, retrospective patient recall of seizure history, potential variations in seizure classification, the small number of events in the validation cohort, and the clinical utility restricted to decision-making thresholds above 12%. The model findings may not be generalisable to low- and middle-income countries, or when information on all predictors is not available. Conclusions The EMPiRE model showed good performance in predicting the risk of seizures in pregnant women with epilepsy who are prescribed antiepileptic drugs. Integration of the tool within the antenatal booking visit, deployed as a simple nomogram, can help to optimise care in women with epilepsy., Author(s): John Allotey 1,2, Borja M. Fernandez-Felix 3,4, Javier Zamora 1,3,4,*, Ngawai Moss 5, Manny Bagary 6, Andrew Kelso 7, Rehan Khan 8, Joris A. M. van der Post 9, [...]

Published
2019
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37. Maternal health-related quality of life after induction of labor or expectant monitoring in pregnancy complicated by intrauterine growth retardation beyond 36 weeks

Author

Bijlenga, Denise, Boers, Kim E., Birnie, Erwin, Mol, Ben-Willem J., Vijgen, Sylvia C. M., Van der Post, Joris A. M., De Groot, Christianne J., Rijnders, Robbert J. P., Pernet, Paula J., Roumen, Frans J., Stigter, Rob H., Delemarre, Friso M. C., Bremer, Henk A., Porath, Martina, Scherjon, Sicco A., and Bonsel, Gouke J.

Published
2011

38. Offspring education outcome at age 12 after induction of labour versus expectant management at term

Author

Burger, Renee J., Pajkrt, Eva, Mol, Bernardus W. J., Ganzevoort, Wessel W., Gordijn, Sanne, van der Post, Joris A. M., de Groot, Christianne J. M., Ravelli, Anita C. J., Amsterdam Reproduction & Development (AR&D), Public and occupational health, Graduate School, APH - Quality of Care, APH - Personalized Medicine, Obstetrics and Gynaecology, Medical Informatics, APH - Health Behaviors & Chronic Diseases, APH - Methodology, and APH - Digital Health

Subjects
Obstertics
Abstract

OBJECTIVE: Induction of labour (IOL) from 37 weeks for various indications is associated with a reduction in perinatal deaths compared to expectant management, though absolute rates are small. The incidence of IOL has been rising. The effects of IOL from 37 weeks on childhood neurodevelopment however are not well studied. We aimed to study the influence of IOL for each week of 12 years. STUDY DESIGN: We performed a population-based study among liveborn singletons from 37+0-42+6 weeks of gestation in cephalic presentation born in 2003-2008 from uncomplicated pregnancies (no hypertensive disorders, diabetes or birthweight < p5). Children with congenital anomalies, of non-Western ethnicity and born after planned cesarean section were excluded. Birth records were linked with national data on standardized school achievement at age 11-12 (rates 501-550). We compared, using a fetus-at-risk approach and per week of gestation, school performance in those born after IOL to those born after expectant management, i.e. spontaneous onset of labour in the same week plus all those born at later gestations. Education scores were standardized to a mean of 0 and a S.D. of 1 and adjusted in the regression analyses. RESULTS: We included 226,684 children. At each week of gestation, IOL was associated with a decreased mean education score compared with expectant management (at 37 weeks -0.96, 95%CI -1.43 to -0.50; at 42 weeks -0.52, 95%CI -1.00 to -0.04; Table 1). Adjusted mean education z-score was -0.10 (-0.15 to -0.05) lower after IOL compared to expectant management at 37 weeks (Figure 1). At each gestational week between 38 and 42 weeks we found comparable differences in mean education z-score, favoring expectant management. CONCLUSION: Consistently, at every week of gestation from 37-42 weeks, IOL at term in uncomplicated pregnancies significantly reduces offspring school performance at age 12 compared to expectant management. Residual confounding may remain. These long-term effects should be incorporated in decisions around IOL.

Published
2022

43. Foley catheter versus vaginal prostaglandin E2 gel for induction of labour at term (PROBAAT trial): an open-label, randomised controlled trial

Author

Jozwiak, Marta, Rengerink, Katrien Oude, Benthem, Marjan, van Beek, Erik, Dijksterhuis, Marja GK, de Graaf, Irene M, van Huizen, Marloes E, Oudijk, Martijn A, Papatsonis, Dimitri NM, Perquin, Denise AM, Porath, Martina, van der Post, Joris AM, Rijnders, Robbert JP, Scheepers, Hubertina CJ, Spaanderman, Marc EA, van Pampus, Maria G, de Leeuw, Jan Willem, Mol, Ben WJ, and Bloemenkamp, Kitty WM

Published
2011
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49. Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial

Author

Koopmans, Corine M, Bijlenga, Denise, Groen, Henk, Vijgen, Sylvia MC, Aarnoudse, Jan G, Bekedam, Dick J, van den Berg, Paul P, de Boer, Karin, Burggraaff, Jan M, Bloemenkamp, Kitty WM, Drogtrop, Addy P, Franx, Arie, de Groot, Christianne JM, Huisjes, Anjoke JM, Kwee, Anneke, van Loon, Aren J, Lub, Annemiek, Papatsonis, Dimitri NM, van der Post, Joris AM, Roumen, Frans JME, Scheepers, Hubertina CJ, Willekes, Christine, Mol, Ben WJ, and van Pampus, Maria G

Published
2009
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50. Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34 weeks and not delivering within 7 days

Author

Hermans, Frederik J.R., Bruijn, Merel M.C., Vis, Jolande Y., Wilms, Femke F., Oudijk, Martijn A., Porath, Martina M., Scheepers, Hubertina C.J., Bloemenkamp, Kitty W.M., Bax, Caroline J., Cornette, Jérôme M.J., Nij Bijvanck, Bas W.A., Franssen, Maureen T.M., Vandenbussche, Frank P.H.A., Kok, Marjolein, Grobman, William A., Van Der Post, Joris A.M., Bossuyt, Patrick M.M., Opmeer, Brent C., Mol, Ben Willem J., Schuit, Ewoud, and Van Baaren, Gert-Jan

Published
2015
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