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2. Mechanical Disruption of the Inner Limiting Membrane In Vivo Enhances Targeting to the Inner Retina

Author

L., Jiun, Pedroarena-Leal, Nicole, Louie, Mikaela, Garcia, Paula Avila, Alnihmy, Adam, Patel, Amit, Weinreb, Robert N, Wahlin, Karl J, La Torre Vila, Anna, and Welsbie, Derek S

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Biotechnology, Genetics, Eye Disease and Disorders of Vision, Bioengineering, Stem Cell Research, Neurosciences, Transplantation, Gene Therapy, Stem Cell Research - Embryonic - Human, 5.2 Cellular and gene therapies, Eye, Animals, Humans, Rats, Retina, Retinal Ganglion Cells, Coculture Techniques, Dependovirus, Intravitreal Injections, inner limiting membrane, inner limiting membrane peel, adeno-associated virus, stem cells, retinal ganglion cells, retinal ganglion cell direct cell replacement, retinal ganglion cell integration, optic nerve regeneration, Biological Sciences, Medical and Health Sciences, Ophthalmology & Optometry, Ophthalmology and optometry
Abstract

PurposeTo evaluate the effects of mechanical disruption of the inner limiting membrane (ILM) on the ability to target interventions to the inner neurosensory retina in a rodent model. Our study used an animal model to gain insight into the normal physiology of the ILM and advances our understanding of the effects of mechanical ILM removal on the viral transduction of retinal ganglion cells and retinal ganglion cell transplantation.MethodsThe ILM in the in vivo rat eye was disrupted using mechanical forces applied to the vitreoretinal interface. Immunohistology and electron microscopy were used to verify the removal of the ILM in retina flatmounts and sections. To assess the degree to which ILM disruption enhanced transvitreal access to the retina, in vivo studies involving intravitreal injections of adeno-associated virus (AAV) to transduce retinal ganglion cells (RGCs) and ex vivo studies involving co-culture of human stem cell-derived RGCs (hRGCs) on retinal explants were performed. RGC transduction efficiency and transplanted hRGC integration with retinal explants were evaluated by immunohistology of the retinas.ResultsMechanical disruption of the ILM in the rodent eye was sufficient to remove the ILM from targeted retinal areas while preserving the underlying retinal nerve fiber layer and RGCs. Removal of the ILM enhanced the transduction efficiency of intravitreally delivered AAV threefold (1380.0 ± 290.1 vs. 442.0 ± 249.3 cells/mm2; N = 6; P = 0.034). Removal of the ILM was also sufficient to promote integration of transplanted RGCs within the inner retina.ConclusionsThe ILM is a barrier to transvitreally delivered agents including viral vectors and cells. Mechanical removal of the ILM is sufficient to enhance access to the inner retina, improve viral transduction efficiencies of RGCs, and enhance cellular integration of transplanted RGCs with the retina.

Published
2023

3. The International Linear Collider: Report to Snowmass 2021

Author

Aryshev, Alexander, Behnke, Ties, Berggren, Mikael, Brau, James, Craig, Nathaniel, Freitas, Ayres, Gaede, Frank, Gessner, Spencer, Gori, Stefania, Grojean, Christophe, Heinemeyer, Sven, Jeans, Daniel, Kruger, Katja, List, Benno, List, Jenny, Liu, Zhen, Michizono, Shinichiro, Miller, David W., Moult, Ian, Murayama, Hitoshi, Nakada, Tatsuya, Nanni, Emilio, Nojiri, Mihoko, Padamsee, Hasan, Perelstein, Maxim, Peskin, Michael E., Poeschl, Roman, Posen, Sam, Robson, Aidan, Strube, Jan, Suehara, Taikan, Tian, Junping, Titov, Maxim, Vos, Marcel, White, Andrew, Wilson, Graham, Yokoya, Kaoru, Zarnecki, Aleksander Filip, Adachi, Ichiro, Agashe, Kaustubh, Jovin, Tatjana Agatonovic, Aihara, Hiroaki, Altmannshofer, Wolfgang, Alves, Daniele, Anguiano, Justin, Aoki, Ken-Ichi, Aoki, Masato, Aoki, Toshihiro, Aoki, Yumi, Arai, Yasuo, Araki, Hayato, Asada, Haruka, Asai, Kento, Asai, Shoji, Attie, David, Baer, Howard, Bagger, Jonathan, Bai, Yang, Bailey, Ian, Barrue, Ricardo, Bartoldus, Rainer, Barzi, Emanuela, Basso, Matthew, Bauerdick, Lothar, Baum, Sebastian, Bellerive, Alain, Belomestnykh, Sergey, Antequera, Jorge Berenguer, Beyer, Jakob, Bhat, Pushpalatha, Bilki, Burak, Black, Kevin, Bloom, Kenneth, Bodwin, Geoffrey, Boisvert, Veronique, Boran, Fatma, Boudry, Vincent, Boughezal, Radja, Boveia, Antonio, Bozovic-Jelisavcic, Ivanka, Brient, Jean-Claude, Brodsky, Stanley, Brunetti, Laurent, Buesser, Karsten, Bulyak, Eugene, Burrows, Philip N., Burt, Graeme C., Cai, Yunhai, Cairo, Valentina, Canepa, Anadi, Celiberto, Francesco Giovanni, Cenni, Enrico, Chacko, Zackaria, Chaikovska, Iryna, Checchin, Mattia, Chen, Lisong, Chen, Thomas Y., Cheng, Hsin Chia, Cho, Gi-Chol, Choudhary, Brajesh, Clarke, Jim, Cline, James, Co, Raymond, Cohen, Timothy, Colas, Paul, Damerell, Chris, Das, Arindam, Dasu, Sridhara, Dawson, Sally, de Blas, Jorge, de Lima, Carlos Henrique, Deandrea, Aldo, Dehmelt, Klaus, Delayen, Jean, Demarteau, Marcel, Denisov, Dmitri, Dermisek, Radovan, Dieguez, Angel, Dohmae, Takeshi, Dopke, Jens, Dort, Katharina, Du, Yong, Dudar, Bohdan, Dutta, Bhaskar, Dutta, Juhi, Einhaus, Ulrich, Elsen, Eckhard, Endo, Motoi, Eremeev, Grigory, Eren, Engin, Erler, Jens, Esarey, Eric, Everett, Lisa, Golfe, Angeles Faus, Garcia, Marcos Fernandez, Foster, Brian, Fourches, Nicolas, Fouz, Mary-Cruz, Fujii, Keisuke, Fujimoto, Junpei, Torregrosa, Esteban Fullan, Furukawa, Kazuro, Fusayasu, Takahiro, Fuster, Juan, Ganjour, Serguei, Gao, Yuanning, Gaur, Naveen, Geng, Rongli, Georgi, Howard, Gherghetta, Tony, Goldstein, Joel, Goncalves, Dorival, Gonski, Julia, Gonzalo, Tomas, Goto, Takeyoshi, Goto, Toru, Graf, Norman, Grames, Joseph, Grannis, Paul, Gray, Lindsey, Grohsjean, Alexander, Gu, Jiayin, Guler, Yalcin, Gutierrez, Phillip, Haba, Junji, Haber, Howard, Hallford, John, Hamaguchi, Koichi, Han, Tao, Hara, Kazuhiko, Harada, Daisuke, Hashimoto, Koji, Hashino, Katsuya, Hayashi, Masahito, Heinrich, Gudrun, Hidaka, Keisho, Higuchi, Takeo, Hinode, Fujio, Hioki, Zenro, Hirose, Minoru, Hiroshima, Nagisa, Hisano, Junji, Hollik, Wolfgang, Homiller, Samuel, Hong, Sungwoo, Hook, Anson, Horii, Yasuyuki, Hoshina, Hiroki, Hristova, Ivana, Huitu, Katri, Hyakutake, Yoshifumi, Iijima, Toru, Ikematsu, Katsumasa, Ilderton, Anton, Inami, Kenji, Irles, Adrian, Ishikawa, Akimasa, Ishiwata, Koji, Ito, Hayato, Ivanov, Igor, Iwamoto, Sho, Iwamoto, Toshiyuki, Iwasaki, Masako, Iwashita, Yoshihisa, Jia, Haoyi, Morales, Fabricio Jimenez, Joshi, Prakash, Jung, Sunghoon, Kacarevic, Goran, Kagan, Michael, Kakizaki, Mitsuru, Kalinowski, Jan, Kaminski, Jochen, Kanaya, Kazuyuki, Kanemura, Shinya, Kanno, Hayato, Kano, Yuya, Kashiwagi, Shigeru, Kato, Yukihiro, Kawada, Nanami, Kawada, Shin-ichi, Kawagoe, Kiyotomo, Khoze, Valery, Kichimi, Hiromichi, Kim, Doojin, Kitahara, Teppei, Kitano, Ryuichiro, Klamka, Jan, Komamiya, Sachio, Kong, K. C., Konomi, Taro, Kotera, Katsushige, Kou, Emi, Kravchenko, Ilya, Kubo, Kiyoshi, Kubo, Takayuki, Kumaoka, Takuya, Kumar, Ashish, Kumar, Nilanjana, Kunath, Jonas, Kundu, Saumyen, Kunitomo, Hiroshi, Kurata, Masakazu, Kuriki, Masao, Kusenko, Alexander, Lagouri, Theodota, Lankford, Andrew J., Lastovicka-Medin, Gordana, Diberder, Francois Le, Lee, Claire, Liepe, Matthias, Linacre, Jacob, Liptak, Zachary, Lomte, Shivani, Low, Ian, Ma, Yang, Maalouf, Hani, MacFarlane, David, Madison, Brendon, Madlener, Thomas, Maeda, Tomohito, Malek, Paul, Mandal, Sanjoy, Markiewicz, Thomas, Marshall, John, Martens, Aurelien, Martin, Victoria, Martinello, Martina, Rivero, Celso Martinez, Maru, Nobuhito, Matheson, John, Matsumoto, Shigeki, Matsunaga, Hiroyuki, Matsuo, Yutaka, Mawatari, Kentarou, Mbagwu, Johnpaul, McIntosh, Peter, McKeown, Peter, Meade, Patrick, Mekala, Krzysztof, Merkel, Petra, Mihara, Satoshi, Miralles, Víctor, Lopez, Marcos Miralles, Mishima, Go, Mishima, Satoshi, Mistlberger, Bernhard, Mitov, Alexander, Miyabayashi, Kenkichi, Miyamoto, Akiya, Mohanty, Gagan, Monaco, Laura, Mondragon, Myriam, Montgomery, Hugh E., Moortgat-Pick, Gudrid, Morange, Nicolas, Llacer, María Moreno, Moretti, Stefano, Mori, Toshinori, Morii, Toshiyuki, Moroi, Takeo, Morrissey, David, Nachman, Benjamin, Nagano, Kunihiro, Nakajima, Jurina, Nakamura, Eiji, Narita, Shinya, Nath, Pran, Nelson, Timothy, Newbold, David, Niki, Atsuya, Nishimura, Yasuhiro, Nishiyama, Eisaku, Nomura, Yasunori, Nowak, Kacper, Nozaki, Mitsuaki, de Vera, María Teresa Nunez Pardo, Ochoa, Ines, Ogata, Masahito, Ohashi, Satoru, Ohta, Hikaru, Ohta, Shigemi, Ohuchi, Norihito, Oide, Hideyuki, Okada, Nobuchika, Okada, Yasuhiro, Okawa, Shohei, Okayasu, Yuichi, Okugawa, Yuichi, Okugi, Toshiyuki, Okui, Takemichi, Okuyama, Yoshitaka, Omet, Mathieu, Omori, Tsunehiko, Ono, Hiroaki, Onoe, Tomoki, Ootani, Wataru, Otono, Hidetoshi, Ozawa, Shuhei, Griso, Simone Pagan, Papa, Alessandro, Paparella, Rocco, Park, Eun-Kyung, Perez, Gilad, Perez-Lorenzana, Abdel, Peters, Yvonne, Petriello, Frank, Piedra, Jonatan, Porod, Werner, Potter, Christopher, Price, Alan, Radkhorrami, Yasser, Reina, Laura, Reuter, Juergen, Richard, Francois, Riemann, Sabine, Rimmer, Robert, Rizzo, Thomas, Robens, Tania, Ruber, Roger, Jimeno, Alberto Ruiz, Saeki, Takayuki, Saha, Ipsita, Saito, Tomoyuki, Sakaguchi, Makoto, Sakai, Tadakatsu, Sakaki, Yasuhito, Sakurai, Kodai, Salvatico, Riccardo, Salvatore, Fabrizio, San, Yik Chuen, Sandick, Pearl, Sanuki, Tomoyuki, Sasikumar, Kollassery Swathi, Schaefer, Oliver, Schaefer, Ruth, Schneekloth, Uwe, Schoerner-Sadenius, Thomas, Schroeder, Carl, Schuster, Philip, Schwartzman, Ariel, Schwienhorst, Reinhard, Sefkow, Felix, Seiya, Yoshihiro, Sekiguchi, Motoo, Sekizawa, Kazuyuki, Senyo, Katsumi, Sert, Hale, Sertore, Danielev, Settles, Ronald, Shafi, Qaisar, Shahdara, Tetsuo, Haghi, Barmak Shams Es, Sharma, Ashish, Shelton, Jessie, Shepherd-Themistocleous, Claire, Shibuya, Hiroto, Shidara, Tetsuo, Shimomura, Takashi, Shindou, Tetsuo, Shoji, Yutaro, Shu, Jing, Sievers, Ian, Simon, Frank, Singh, Rajeev, Soreq, Yotam, Stanitzki, Marcel, Stapnes, Steinar, Steinhebel, Amanda, Stupak, John, Su, Shufang, Suekane, Fumihiko, Sugamoto, Akio, Sugawara, Yuji, Sugimoto, Satoru, Sugimoto, Yasuhiro, Sugiyama, Hiroaki, Sumino, Yukinari, Sundrum, Raman, Suzuki, Atsuto, Suzuki, Shin, Swiatlowski, Maximilian, Tait, Tim M. P., Takahashi, Shota, Takahashi, Tohru, Takeshita, Tohru, Takeuchi, Michihisa, Takubo, Yosuke, Tanabe, Tomohiko, Tanedo, Philip, Tanimoto, Morimitsu, Tao, Shuichiro, Tata, Xerxes, Tauchi, Toshiaki, Taylor, Geoffrey, Terada, Takahiro, Terunuma, Nobuhiro, Thaler, Jesse, Thea, Alessandro, Tillinger, Finn, Timmermans, Jan, Tobioka, Kohsaku, Toda, Kouichi, Tokiyasu, Atsushi, Toma, Takashi, Torndal, Julie, Tosun, Mehmet, Tsai, Yu-Dai, Tseng, Shih-Yen, Tsumura, Koji, Tuckler, Douglas, Uchida, Yoshiki, Uchiyama, Yusuke, Ueda, Daiki, Ukegawa, Fumihiko, Umemori, Kensei, Urakawa, Junji, Vallee, Claude, Vega, Roberto, Velasco, Liliana, Verdu-Andres, Silvia, Vernieri, Caterina, Vila, Anna, Alvarez, Ivan Vila, Vossebeld, Joost, Vsrms, Raghava, Vukasinovic, Natasa, Wackeroth, Doreen, Wakida, Moe, Wang, Liantao, Washio, Masakazu, Watanabe, Takashi, Watson, Nigel, Watts, Gordon, Weiglein, Georg, Wells, James D., Wenskat, Marc, Westhoff, Susanne, White, Glen, Williams, Ciaran, Willocq, Stephane, Wing, Matthew, Winter, Alasdair, Winter, Marc, Wu, Yongcheng, Xie, Keping, Xu, Tao, Yakovlev, Vyacheslav, Yamada, Shuei, Yamamoto, Akira, Yamamoto, Hitoshi, Yamamoto, Kei, Yamamoto, Yasuchika, Yamanaka, Masato, Yamashita, Satoru, Yamatani, Masahiro, Yamatsu, Naoki, Yasui, Shigehiro, Yoda, Takuya, Yonamine, Ryo, Yoshihara, Keisuke, Yoshioka, Masakazu, Yoshioka, Tamaki, Yuasa, Fukuko, Yumino, Keita, Zerwas, Dirk, Zheng, Ya-Juan, Zhou, Jia, Zhu, Hua Xing, Zobov, Mikhail, and Zomer, Fabian

Subjects
Physics - Accelerator Physics, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

The International Linear Collider (ILC) is on the table now as a new global energy-frontier accelerator laboratory taking data in the 2030s. The ILC addresses key questions for our current understanding of particle physics. It is based on a proven accelerator technology. Its experiments will challenge the Standard Model of particle physics and will provide a new window to look beyond it. This document brings the story of the ILC up to date, emphasizing its strong physics motivation, its readiness for construction, and the opportunity it presents to the US and the global particle physics community., Comment: 356 pages, Large pdf file (40 MB) submitted to Snowmass 2021; v2 references to Snowmass contributions added, additional authors; v3 references added, some updates, additional authors

Published
2022

7. Kidney transplant and Klippel-Trenaunay-Weber syndrome: an unusual association

Author

Riera-Sadurní Josep, Cañameras Carles, Molina María, Urrutia Marina, Paul-Martínez Javier, Graterol Fredzzia, Perezpayá Inés, Omar Taco, Gelpi Rosana, Casas Ángela, Cañas Laura, Juega Javier, Tovar Gerardo, Sampere Jaume, Esteban Carlos, Areal Joan, González Satué Carlos, Bover Jordi, and Vila Anna

Subjects
Diseases of the genitourinary system. Urology, RC870-923
Published
2023
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9. Safety and efficacy of leriglitazone for preventing disease progression in men with adrenomyeloneuropathy (ADVANCE): a randomised, double-blind, multi-centre, placebo-controlled phase 2–3 trial

Author

Mc Govern, Eavan, Yazbeck, Elise, Barbier, Magali, Luton, Marie-Pierre, Pousset, Françoise, Hogrel, Jean-Yves, Adanyeguh, Isaac, Then Bergh, Florian, Bergner, Caroline, Unterlauft, Astrid, Roicke, Hannes, Hoffmann, Karl-Titus, Scherlach, Cordula, Kalb, Andrea, Meilick, Bianca, Reuschel, Mandy, Fenu, Silvia, Mauro, Elena, Murphy, Elaine, Krishna, Gauri, Beyene, Tiggy, Sierra, Alba, Quiñoa, Sara, Belen Canovas, Anna, Grosz, Zoltan, Györgyi, Báthori, van de Stadt, S.I., Huffnagel, I.C., van Ballegoij, W.J.C., Voermans, M.M.C., Seyedsadjadi, Reza, Corre, Camille, Godbole, Neha, Grant, Natalie Rose, Brito Pires, Claudia Maria, Trovato, Melissa, Yeh, Nancy, Goodman, Jordan, Keller, Jennifer, Joseph, Chris, Van Haren, Keith, Sakamuri, Sarada, Duong, Tina, Perrone, Lila, Tran, Stephanie, Dunaway Young, Sally, Hashmi, Syed, Köhler, Wolfgang, Engelen, Marc, Eichler, Florian, Lachmann, Robin, Fatemi, Ali, Sampson, Jacinda, Salsano, Ettore, Gamez, Josep, Molnar, Maria Judit, Pascual, Sílvia, Rovira, Maria, Vilà, Anna, Pina, Guillem, Martín-Ugarte, Itziar, Mantilla, Adriana, Pizcueta, Pilar, Rodríguez-Pascau, Laura, Traver, Estefania, Vilalta, Anna, Pascual, María, Martinell, Marc, Meya, Uwe, and Mochel, Fanny

Published
2023
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10. Diabetes Mellitus in Kidney Transplant Recipients: New Horizons in Treatment.

Author

Sanchez-Baya, Maya, Bolufer, Mónica, Vázquez, Federico, Alonso, Nuria, Massó, Elisabet, Paul, Javier, Coll-Brito, Veronica, Taco, Omar, Anton-Pampols, Paula, Gelpi, Rosana, DaSilva, Iara, Casas, Ángela, Rodríguez, Rosely, Molina, Maria, Cañas, Laura, Vila, Anna, Ara, Jordi, and Bover, Jordi

Abstract

Diabetes mellitus (DM) in kidney transplant recipients (KTR) is a risk factor for mortality, increases the risk of infections and, in the long term, can lead to graft loss due to diabetic kidney disease. A preventive approach applied to those on the waiting list could decrease the incidence of post-transplant DM (PTDM) by detecting those patients at risk, thus allowing strategies to minimize the probability of developing a New Onset Diabetes After Transplant (NODAT). On the other hand, modifications of immunosuppressive therapy may improve glucose control in patients with KTR. In recent years, two new classes of antidiabetic drugs and non-steroidal mineralocorticoid receptor antagonists have demonstrated cardiovascular and renal benefits in randomized clinical trials where the transplant population has not been represented. Because of the potential benefit expected in this population, the clinical use of glucagon-like peptide-1 receptor agonists (GLP-1RA), sodium-glucose cotransporter 2 inhibitors (SGLT2i) and finerenone is increasing in the kidney transplant setting. This review focuses on comprehensive pharmacological interventions in KTR with glucose metabolism disorders. In-depth knowledge in this area will allow prevention and identification of potential adverse effects or drug interactions in the clinical course of KTR with DM. [ABSTRACT FROM AUTHOR]

Published
2025
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12. Immunotherapy for Cancer in Kidney Transplant Patients: A Difficult Balance Between Risks and Benefits.

Author

Bolufer, Mónica, Soler, Jordi, Molina, María, Taco, Omar, Vila, Anna, and Macía, Manuel

Subjects
IMMUNE checkpoint inhibitors, KIDNEY transplantation, ANTINEOPLASTIC agents, NEPHROLOGISTS, CLINICAL trials
Abstract

Cancer is a major cause of morbidity and mortality in kidney transplant patients. Unfortunately, the use of new anti-cancer therapies such as immune checkpoint inhibitors (ICPIs) in this population has been associated with rejection rates up to 40%, in retrospective studies. The main challenge is to maintain the patient in a delicate immunologic balance in which, while antitumor therapy defeats cancer the graft is safely protected from rejection. Recent clinical trials with ICPI have included kidney transplant recipients (KTRs) and the results advocate for a paradigm shift in the management of basal immunosuppression. This suggests that downward adjustments should be avoided or, even better, that this adjustment should be "dynamic." This review summarizes the latest scientific evidence available in renal transplantation under ICPI treatment: case series, prospective studies, histopathologic diagnosis, immunosuppression regimens and new biomarkers. This article will provide the latest information in on this specific field, allowing nephrologists to gain valuable knowledge and to be aware of new approaches to immunosuppression management in oncological kidney transplant patients. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Pooling of urine samples for molecular detection of Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium as a screening strategy among young adults in Catalonia

Author

Crespo, Nayade, Garrofe, M. Jose, Alzuria, Rosa, Bureu, Elena, Fernandez, Isabel, Piquet, Montserrat, Florensa, Yolanda, Sarroca, Carme, Mari, Judit, Mitjans, Elisabet, Jorda, Ivana, Garcia, Sonia, Mausbach, Hildegard, Gomez, Teresa, Borras, Ainhoa, Llobera, Alba, Estruch, Ana, Cayuela, Mabel, Grau, Josep, Tarres, Judit, Guix, Dolors, Serrano, Lorena, Amezcua, Paula, Angelet, Meritxell, Barrionuevo, Carmen, Calviño, Rocio, Colldeforns, Margarida, Duran, Mercè, Garcia, M. Jose, Gonzalez, Maria, Hernandez, Gemma, Modenes, Jon Ander, Vila, Anna, Basset, Carme, Avecilla, Angels, Blasco, M. Pilar, Burgos, Lucia, Espelt, Ramon, Lopez-Grado, Edith, Molina, M. Ines, Prats, Elisenda, Patricio, Demetria, March, Gemma, Aguilar, Irene, Argiles, Sonia, Bayarri, M. Jose, Bertran, Judith, Burgos, Carmen, Carreres, Montserrat, Corredor, Ana, Fernandez, Victoria, Martinez, Gemma, Moreno, Gracia, Pallie, Alba, Pinto, Teresa, Ramirez, Maria, Rebollo, Cristina, Romano, Eusebia, Muxi, M. Consuelo, Escriche, Rosa, Pelegri, Judit, Caccioppoli, Luciano Carmelo, Grau, Elisabet, Xandri, Jordi, Cid, M. Julia, Aguilar, Laia, Almenar, Helena, Navales, Carlos, Baroja, Jordi, Oliver, M. Paz, Fornells, Carme, Hernandez, Marta, Arranz, Estrella, López-Corbeto, Evelin, González, Victoria, Lugo, Rossie, Rivaya, Belen, Casabona, Jordi, and Matas, Lurdes

Published
2020
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17. Effect of action video games in eye movement behavior: a systematic review

Author

Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, Universitat Politècnica de Catalunya. Doctorat en Enginyeria Òptica, Universitat Politècnica de Catalunya. GREO - Grup de Recerca en Enginyeria Òptica, Universitat Politècnica de Catalunya. VOS - Visió, Optometria i Salut, Montolio Vila, Anna, Argilés Sans, Marc, Sunyer Grau, Bernat, Quevedo Junyent, Luisa Jesús, Erickson, Graham, Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, Universitat Politècnica de Catalunya. Doctorat en Enginyeria Òptica, Universitat Politècnica de Catalunya. GREO - Grup de Recerca en Enginyeria Òptica, Universitat Politècnica de Catalunya. VOS - Visió, Optometria i Salut, Montolio Vila, Anna, Argilés Sans, Marc, Sunyer Grau, Bernat, Quevedo Junyent, Luisa Jesús, and Erickson, Graham

Abstract

Previous research shows that playing action video games seems to modify the behavior of eye movements such as eye fixations and saccades. The aim of the current work was to determine the effect of playing action video games on eye movements behavior such as fixations, saccades and pursuits. A systematic research review in PubMed and Scopus databases was conducted to identify articles published between 2010 and 2022 which referred to action video games and eye movements, including fixations, saccades and pursuits. We included those that were experimental and quasi-experimental, comparing at least two groups between action vs. non-action video games players. All the studies included used an eye tracker to study eye movements. A total of 97 scientific articles were found in the databases. After inclusion criteria, thirteen articles (N=13) were analyzed for the present work, of which ten (n=10) had a cross-sectional design, and three (n=3) were randomized intervention studies. Playing regularly or training with action video games is not likely to produce changes in eye movements, based on the literature research analyzed. For future research, more interventional studies, with less gender bias, more sample participants and general consensus on the distinction between the action and non-action video games is needed., This publication is part of the project PID2020-112527RB-I00, funded by MCIN/AEI/10.13039/501100011033., Peer Reviewed, Postprint (published version)

Published
2024

18. Benefits of Living Over Deceased Donor Kidney Transplantation in Elderly Recipients. A Propensity Score Matched Analysis of a Large European Registry Cohort.

Author

Toapanta, Néstor, Comas, Jordi, Revuelta, Ignacio, Manonelles, Anna, Facundo, Carme, Pérez-Saez, María José, Vila, Anna, Arcos, Emma, Tort, Jaume, Giral, Magali, Naesens, Maarten, Kuypers, Dirk, Asberg, Anders, Moreso, Francesc, and Bestard, Oriol

Subjects
PROPENSITY score matching, KIDNEY transplantation, BRAIN death, TREATMENT effectiveness, GRAFT survival
Abstract

Although kidney transplantation from living donors (LD) offers better long-term results than from deceased donors (DD), elderly recipients are less likely to receive LD transplants than younger ones. We analyzed renal transplant outcomes from LD versus DD in elderly recipients with a propensity-matched score. This retrospective, observational study included the first single kidney transplants in recipients aged =65 years from two European registry cohorts (2013-2020, n = 4,257). Recipients of LD (n = 408), brain death donors (BDD, n = 3,072), and controlled cardiocirculatory death donors (cDCD, n = 777) were matched for donor and recipient age, sex, dialysis time and recipient diabetes. Major graft and patient outcomes were investigated. Unmatched analyses showed that LD recipients were more likely to be transplanted preemptively and had shorter dialysis times than any DD type. The propensity score matched Cox's regression analysis between LD and BDD (387-pairs) and LD and cDCD (259-pairs) revealing a higher hazard ratio for graft failure with BDD (2.19 [95% CI: 1.16-4.15], p = 0.016) and cDCD (3.38 [95% CI: 1.79-6.39], p < 0.001). One-year eGFR was higher in LD transplants than in BDD and cDCD recipients. In elderly recipients, LD transplantation offers superior graft survival and renal function compared to BDD or cDCD. This strategy should be further promoted to improve transplant outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Effect of Action Video Games in Eye Movement Behavior: A Systematic Review.

Author

Montolio-Vila, Anna, Argilés, Marc, Quevedo, Lluïsa, Sunyer-Grau, Bernat, and Erickson, Graham

Subjects
*EYE movements, *CLINICAL trials, *EYE tracking, *VIDEO games, *SEX discrimination
Abstract

Previous research shows that playing action video games seems to modify the behavior of eye movements such as eye fixations and saccades. The aim of the current work was to determine the effect of playing action video games on eye movements behavior such as fixations, saccades and pursuits. A systematic research review in PubMed and Scopus databases was conducted to identify articles published between 2010 and 2022 which referred to action video games and eye movements, including fixations, saccades and pursuits. We included those that were experimental and quasi-experimental, comparing at least two groups between action vs. non-action video games players. All the studies included used an eye tracker to study eye movements. A total of 97 scientific articles were found in the databases. After inclusion criteria, thirteen articles (N=13) were analyzed for the present work, of which ten (n=10) had a cross-sectional design, and three (n=3) were randomized intervention studies. Playing regularly or training with action video games is not likely to produce changes in eye movements, based on the literature research analyzed. For future research, more interventional studies, with less gender bias, more sample participants and general consensus on the distinction between the action and non-action video games is needed. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Integrated Health and Social Home Care Services in Catalonia: Professionals' Perception of its Implementation, Barriers, and Facilitators.

Author

Hilarión, Pilar, Vila, Anna, Contel, Joan C., Santaeugènia, Sebastià J., Amblàs-Novellas, Jordi, Suñol, Rosa, Barbeta, Conxita, Plaza, Aina, and Vela, Emili

Subjects
*HOME care services, *HEALTH services accessibility, *MEDICAL personnel, *INTERPROFESSIONAL relations, *SOCIAL workers, *RESEARCH funding, *SOCIAL services, *EVALUATION of human services programs, *QUESTIONNAIRES, *DESCRIPTIVE statistics, *SOCIAL worker attitudes, *PRIMARY nursing, *NURSE practitioners, *EMPLOYEE participation in management, *GOVERNMENT programs, *ATTITUDES of medical personnel, *DATA analysis software, *INTEGRATED health care delivery, *PSYCHOSOCIAL factors
Abstract

Introduction: This study aimed to assess the implementation of integrated social and health home care services (HCS) offered by the Government of Catalonia, and to identify the main barriers and facilitators of integrated HCS. Methods: Analysis of the degree of implementation of integrated social and health HCS perceived by social care services (SCS) and primary health care centers (PHCs) between December 2020 and June 2021 in two phases. First, the perception of integration by social workers within SCS and PHCs was assessed using a screening questionnaire. Then, SCS in counties with the highest integration scores received a customized questionnaire for an in-depth assessment. Results: A total of 105 (100%) SCS and 94 (25%) PHCs answered the screening questionnaire, and 48 (45.7%) SCS received a customized questionnaire. The most frequent barrier identified was the lack of shared protocols, with the most frequent facilitator being the recognition of the importance of integrated HCS. Conclusions: Our study showed that the degree of implementation of integrated health and social HCS offered by the Government of Catalonia was perceived as low. The identified barriers and facilitators can be used to facilitate such implementation. Further studies should include professionals other than social workers in PHC assessments. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Excess mortality among older adults institutionalized in long-term care facilities during the COVID-19 pandemic: a population-based analysis in Catalonia

Author

Cases, Laia, primary, Vela, Emili, additional, Santaeugènia Gonzàlez, Sebastià J., additional, Contel, Joan Carles, additional, Carot-Sans, Gerard, additional, Coca, Marc, additional, Pastor, Marta, additional, Carrasco, Ignasi, additional, Barbeta, Conxita, additional, Vila, Anna, additional, Amil, Paloma, additional, Plaza, Aina, additional, Pontes, Caridad, additional, Piera-Jiménez, Jordi, additional, and Amblàs, Jordi, additional

Published
2023
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27. DERIVACIÓN DUODENAL-ILEAL CON IMANES AUTOENSAMBLABLES EN PACIENTES CON PÉRDIDA DE PESO INSUFICIENTE O RECUPERACIÓN PONDERAL TRAS UN SLEEVE GÁSTRICO: ANALISIS INTERMEDIO A LOS 12 MESES.

Author

Turró, Román, primary, Ortega, Antonio, additional, Díez-Caballero, Alberto, additional, Mata, Alfredo, additional, Vila, Anna, additional, Rosinach, Maria de las Mercedes, additional, Temiño, Rocío, additional, Uchima, Hugo, additional, Valero, Sandra, additional, and Espinós, Jorge Carlos, additional

Published
2023
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31. Revisió sistemàtica en la modificació dels paràmetres de moviments oculars a través dels videojocs d'acció

Author

Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, Argilés Sans, Marc, Montolio Vila, Anna, Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, Argilés Sans, Marc, and Montolio Vila, Anna

Abstract

L'objectiu d'aquesta revisió sistemàtica va ser analitzar els estudis relacionats amb la modificació dels paràmetres de moviments oculars a través de l'experiència en videojocs, concretament en videojocs d'acció, i extreure informació del seu efecte. La recerca es va dur a terme en les bases de dades de PubMed i Scopus. Aquesta revisió es va inscriure al registre internacional de revisions sistemàtiques PROSPERO (número de registre CRD42022358557). L'eina que es va utilitzar per estudiar els risc de biaix en els estudis d'intervenció aleatoritzats va ser ROB-2. Es van identificar 304 articles científics dels quals 13 van complir els criteris d'inclusió d'aquesta revisió. Es van analitzar els resultats en les fixacions oculars, moviments sacàdics i moviments de seguiment de cada article. Dels 13 articles seleccionats, 10 eren estudis transversals i 3 estudis d'intervenció. El número tan petit d'estudis d'intervenció fa que no es pugui arribar a cap conclusió ferma. Segons aquesta revisió sembla que els videojocs d'acció produeixen canvis en els moviments oculars cap a la direcció de fer més resolutius i eficients als jugadors de videojocs d’acció en la tasca que se'ls demana. Per la futura recerca es necessiten estudis amb la metodologia més clara i un consens més general del que es necessita mesurar., El objetivo de esta revisión sistemática fue analizar los estudios relacionados con la modificación de parámetros de movimientos oculares a través de la experiencia en videojuegos, concretamente en videojuegos de acción, extrayendo información de su efecto. La investigación se llevó a cabo en las bases de datos de PubMed y Scopus. Esta revisión se inscribió en el registro internacional de revisiones sistemáticas PROSPERO (número de registro CRD42022358557). La herramienta usada para estudiar el riesgo de sesgo en los estudios de intervención aleatorizados fue ROB-2. Se identificaron 304 artículos científicos de los que 13 cumplieron los criterios de inclusión de esta revisión. Se analizaron los resultados en las fijaciones oculares, movimientos sacádicos y movimientos de seguimiento de cada artículo. De los 13 seleccionados, 10 eran estudios transversales y 3 estudios de intervención. El número tan pequeño de estudios de intervención hace que no se pueda llegar a ninguna conclusión firme. Según esta revisión, parece que los videojuegos de acción producen cambios en los movimientos oculares hacia la dirección de hacer más resolutivos y eficientes a los jugadores de videojuegos de acción en la tarea que se les pide. Para la futura investigación se necesitan estudios con la metodología más clara y un consenso más general de lo que se necesita medir., The aim of this systematic review was to analyze studies related to the modification of eye movement parameters through experience in video games, specifically in action video games, and to extract information about their effect. The search was carried out in the Pubmed and Scopus databases. This review was registered in the international registry of systematic reviews PROSPERO (registration number CRD42022358557). The tool used to study the risk of bias in the randomized intervention studies was ROB-2. A total of 304 scientific articles were identified, 13 of them met the inclusion criteria for this review. Results were analyzed for eye fixations, saccadic movements, and pursuits. Ten of the selected articles were cross-sectional studies and three intervention studies. The small number of intervention studies means that no firm conclusions can be reached. According to this review, it appears that action video games produce changes in eye movements in the direction of making action video game players more decisive and efficient in the task at hand. For future research, studies with a clearer methodology and a more general consensus of what needs to be measured are needed.

Published
2023

32. Pathophysiology of bone disease in chronic kidney disease: from basics to renal osteodystrophy and osteoporosis

Author

Aguilar, Armando, primary, Gifre, Laia, additional, Ureña-Torres, Pablo, additional, Carrillo-López, Natalia, additional, Rodriguez-García, Minerva, additional, Massó, Elisabeth, additional, da Silva, Iara, additional, López-Báez, Víctor, additional, Sánchez-Bayá, Maya, additional, Prior-Español, Águeda, additional, Urrutia, Marina, additional, Paul, Javier, additional, Bustos, Misael C., additional, Vila, Anna, additional, Garnica-León, Isa, additional, Navarro-González, Juan F., additional, Mateo, Lourdes, additional, and Bover, Jordi, additional

Published
2023
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38. Revisió sistemàtica en la modificació dels paràmetres de moviments oculars a través dels videojocs d'acció

Author

Montolio Vila, Anna, Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, and Argilés Sans, Marc

Subjects
Video games, Ciències de la visió::Optometria [Àrees temàtiques de la UPC], Videojocs, Eye--Movements, Ulls--Moviments
Abstract

L'objectiu d'aquesta revisió sistemàtica va ser analitzar els estudis relacionats amb la modificació dels paràmetres de moviments oculars a través de l'experiència en videojocs, concretament en videojocs d'acció, i extreure informació del seu efecte. La recerca es va dur a terme en les bases de dades de PubMed i Scopus. Aquesta revisió es va inscriure al registre internacional de revisions sistemàtiques PROSPERO (número de registre CRD42022358557). L'eina que es va utilitzar per estudiar els risc de biaix en els estudis d'intervenció aleatoritzats va ser ROB-2. Es van identificar 304 articles científics dels quals 13 van complir els criteris d'inclusió d'aquesta revisió. Es van analitzar els resultats en les fixacions oculars, moviments sacàdics i moviments de seguiment de cada article. Dels 13 articles seleccionats, 10 eren estudis transversals i 3 estudis d'intervenció. El número tan petit d'estudis d'intervenció fa que no es pugui arribar a cap conclusió ferma. Segons aquesta revisió sembla que els videojocs d'acció produeixen canvis en els moviments oculars cap a la direcció de fer més resolutius i eficients als jugadors de videojocs d’acció en la tasca que se'ls demana. Per la futura recerca es necessiten estudis amb la metodologia més clara i un consens més general del que es necessita mesurar. El objetivo de esta revisión sistemática fue analizar los estudios relacionados con la modificación de parámetros de movimientos oculares a través de la experiencia en videojuegos, concretamente en videojuegos de acción, extrayendo información de su efecto. La investigación se llevó a cabo en las bases de datos de PubMed y Scopus. Esta revisión se inscribió en el registro internacional de revisiones sistemáticas PROSPERO (número de registro CRD42022358557). La herramienta usada para estudiar el riesgo de sesgo en los estudios de intervención aleatorizados fue ROB-2. Se identificaron 304 artículos científicos de los que 13 cumplieron los criterios de inclusión de esta revisión. Se analizaron los resultados en las fijaciones oculares, movimientos sacádicos y movimientos de seguimiento de cada artículo. De los 13 seleccionados, 10 eran estudios transversales y 3 estudios de intervención. El número tan pequeño de estudios de intervención hace que no se pueda llegar a ninguna conclusión firme. Según esta revisión, parece que los videojuegos de acción producen cambios en los movimientos oculares hacia la dirección de hacer más resolutivos y eficientes a los jugadores de videojuegos de acción en la tarea que se les pide. Para la futura investigación se necesitan estudios con la metodología más clara y un consenso más general de lo que se necesita medir. The aim of this systematic review was to analyze studies related to the modification of eye movement parameters through experience in video games, specifically in action video games, and to extract information about their effect. The search was carried out in the Pubmed and Scopus databases. This review was registered in the international registry of systematic reviews PROSPERO (registration number CRD42022358557). The tool used to study the risk of bias in the randomized intervention studies was ROB-2. A total of 304 scientific articles were identified, 13 of them met the inclusion criteria for this review. Results were analyzed for eye fixations, saccadic movements, and pursuits. Ten of the selected articles were cross-sectional studies and three intervention studies. The small number of intervention studies means that no firm conclusions can be reached. According to this review, it appears that action video games produce changes in eye movements in the direction of making action video game players more decisive and efficient in the task at hand. For future research, studies with a clearer methodology and a more general consensus of what needs to be measured are needed.

Published
2023

44. The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults

Author

Allsopp, Philip, Crowe, William, Bahar, Bojlul, Harnedy, Pádraigín A., Brown, Emma S., Taylor, Sonja S., Smyth, Thomas J., Soler-Vila, Anna, Magee, Pamela J., Gill, Chris I. R., Strain, Conall R., Hegan, Vicky, Devaney, Martin, Wallace, Julie M. W., Cherry, Paul, FitzGerald, Richard J., Strain, J. J., O’Doherty, John V., and McSorley, Emeir M.

Published
2016
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46. Trasplante renal y síndrome de Klippel-Trenaunay-Weber: una asociación insólita

Author

Riera-Sadurní, Josep, primary, Cañameras, Carles, additional, Molina, María, additional, Urrutia, Marina, additional, Paul-Martínez, Javier, additional, Graterol, Fredzzia, additional, Perezpayá, Inés, additional, Omar, Taco, additional, Gelpi, Rosana, additional, Casas, Ángela, additional, Cañas, Laura, additional, Juega, Javier, additional, Tovar, Gerardo, additional, Sampere, Jaume, additional, Esteban, Carlos, additional, Areal, Joan, additional, Satué, Carlos González, additional, Bover, Jordi, additional, and Vila, Anna, additional

Published
2022
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47. Evolving Concepts on Inflammatory Biomarkers and Malnutrition in Chronic Kidney Disease

Author

Graterol Torres, Fredzzia, primary, Molina, María, additional, Soler-Majoral, Jordi, additional, Romero-González, Gregorio, additional, Rodríguez Chitiva, Néstor, additional, Troya-Saborido, Maribel, additional, Socias Rullan, Guillem, additional, Burgos, Elena, additional, Paúl Martínez, Javier, additional, Urrutia Jou, Marina, additional, Cañameras, Carles, additional, Riera Sadurní, Josep, additional, Vila, Anna, additional, and Bover, Jordi, additional

Published
2022
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