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Basic quantitative and population genetics topics are typically taught in introductory plant breeding courses and are critical for success in upper-level study. Active learning, including simulations and games, may be useful for instruction of these concepts, which rely heavily on theory and may be more challenging for students. The statistical computing language "R" is now routinely used in the analysis of plant breeding experiments, but the command-line interface of the language may be unsuitable for an introductory course. Here we describe "qgshiny" (quantitative genetics in "shiny"), an interactive application for performing simulations to understand basic theory in quantitative and population genetics. The initial version of the application includes modules on three core topics in quantitative genetics: randomly mating populations, genetic variance, and response to selection. Students can specify parameters and initiate simulations to assess their impact on responses such as allele frequency, genetic variance, and genetic gain, which together can be used to reinforce more general learning objectives. Feedback collected from students after engaging with the application suggests this tool can have a positive impact on student learning. The application is bundled in an R package, "qgshiny," which is available through the Comprehensive R Archive Network (CRAN), on GitHub (https://github.com/neyhartj/qgshiny), or interactively through the shinyapps.io platform (http://neyhartj.shinyapps.io/qgshiny).

Hard fescue is an allo‐hexaploid, caespitose, cool‐season grass that is part of the fine‐leaved ovina complex of the Lolium–Festuca clade in Poaceae. It is predominantly used as a low‐maintenance turfgrass and soil stabilization grass in situations with reduced inputs of nitrogen and water. While often recommended for use under tree canopies, prolonged foliar shade can thin turf stands and reduce their functionality; furthermore, gray snow mold caused by Typhula incarnata can further affect hard fescue turfgrass functionality. In this study, we gathered a diverse population of hard fescue collections and varieties, which fit into four genetic structures. Because no genomic reference sequences exist for this species, a contig‐level pseudohaploid genomic reference was assembled from a plant of the hard fescue variety Beacon. With 98% benchmarking universal single‐copy orthologs (BUSCO) coverage from 241 contigs, this reference assembly was used to conduct genome‐wide association analysis. Thirty‐eight single‐nucleotide polymorphism (SNP) markers were associated with foliar shade response phenotypes, including SNPs near molybdate transporter and cytochrome P450 genes. Three SNP markers were associated with gray snow mold responses, with one located near a Protein Kinase G11 gene and corresponding to a 20% improvement in gray snow mold resistance. Core Ideas: A primary contig‐level genome of Beacon hard fescue was assembled.A GWAS for shade tolerance resulted in 38 significant loci, with some loci shared among traits.A GWAS for gray snow mold resistance found three loci, two of which were near candidate genes [ABSTRACT FROM AUTHOR]

It is well known that during his pre-Critical period, Kant was a major proponent of Newtonian physics, for the project of the Universal Natural History explicitly uses "Newtonian principles" to explain the formation of the various bodies that constitute our solar system as well as those that lie beyond. What has not been widely noted, however, is that the early Kant also developed a major criticism of Newton, one that is based on subtle metaphysical issues pertaining to God, which are most at home in philosophical theology. Interestingly, this criticism is neither an inchoate precursor of his later criticisms of Newton's account of absolute space, nor isolated to the abstract realm of metaphysics, but has a wide range of implications for the way in which a scientific account of the formation and constitution of the heavenly bodies ought to be developed, that is, for the kind of argument Newton offered in the Principia. That Kant remained interested in this set of issues later in his Critical period suggests that, alongside the revolutionary changes that comprise transcendental idealism, there are deep continuities not only in his Newtonian commitments, but in his anti-Newtonian tendencies as well. © 2012 Elsevier Ltd.