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477 results on '"Wachowiak, J"'

1. Outcomes of allogeneic haematopoietic cell transplantation for myelofibrosis in children and adolescents: the retrospective study of the EBMT Paediatric Diseases WP

Author: Wachowiak, J, Galimard, J, Dalissier, A, Rihani, R, Alsaedi, H, Wynn, R, Dalle, J, Peffault de Latour, R, Sedlacek, P, Balduzzi, A, Schroeder, T, Bodova, I, Gonzalez Vicent, M, Gruhn, B, Hamladji, R, Krivan, G, Patrick, K, Sobkowiak-Sobierajska, A, Stepensky, P, Unal, A, Amrolia, P, Perez Martinez, A, Rialland, F, Aljurf, M, Isgro, A, Toren, A, Bierings, M, Corbacioglu, S, Kalwak, K, Wachowiak J., Galimard J. -E., Dalissier A., Rihani R., AlSaedi H., Wynn R. F., Dalle J. -H., Peffault de Latour R., Sedlacek P., Balduzzi A., Schroeder T., Bodova I., Gonzalez Vicent M., Gruhn B., Hamladji R. -M., Krivan G., Patrick K., Sobkowiak-Sobierajska A., Stepensky P., Unal A., Amrolia P., Perez Martinez A., Rialland F., Aljurf M., Isgro A., Toren A., Bierings M., Corbacioglu S., Kalwak K., Wachowiak, J, Galimard, J, Dalissier, A, Rihani, R, Alsaedi, H, Wynn, R, Dalle, J, Peffault de Latour, R, Sedlacek, P, Balduzzi, A, Schroeder, T, Bodova, I, Gonzalez Vicent, M, Gruhn, B, Hamladji, R, Krivan, G, Patrick, K, Sobkowiak-Sobierajska, A, Stepensky, P, Unal, A, Amrolia, P, Perez Martinez, A, Rialland, F, Aljurf, M, Isgro, A, Toren, A, Bierings, M, Corbacioglu, S, Kalwak, K, Wachowiak J., Galimard J. -E., Dalissier A., Rihani R., AlSaedi H., Wynn R. F., Dalle J. -H., Peffault de Latour R., Sedlacek P., Balduzzi A., Schroeder T., Bodova I., Gonzalez Vicent M., Gruhn B., Hamladji R. -M., Krivan G., Patrick K., Sobkowiak-Sobierajska A., Stepensky P., Unal A., Amrolia P., Perez Martinez A., Rialland F., Aljurf M., Isgro A., Toren A., Bierings M., Corbacioglu S., and Kalwak K.
Abstract: This retrospective study evaluated 35 children (median age 5.2 years; range 0.4–18) with myelofibrosis (MF), including 33 with primary myelofibrosis and 2 with secondary myelofibrosis transplanted from matched sibling donor (MSD) (n = 17) or non-MSD (n = 18) between 2000 and 2022. Conditioning was usually chemotherapy-based (n = 33) and myeloablative (n = 32). Fifteen patients received bone marrow (BM), 14 haematopoietic cells (HC) from peripheral blood (PB), and 6 from cord blood (CB). Day +100 acute GvHD II–IV incidence was significantly lower after MSD-haematopoietic cell transplantation (MSD-HCT) than after non-MSD-HCT [18.8% (4.3–41.1) vs 58.8% (31–78.6); p = 0.01]. Six-year non-relapse mortality (NRM) was 18% (7.1–32.8), relapse incidence was 15.9% (5.6–30.9), progression-free survival (PFS) was 66.1% (47–79.7), GvHD-free relapse-free survival was 50% (30.6–66.7), and overall survival (OS) was 71.1% (51.4–84). Six-year PFS and OS were significantly higher after BM transplantation compared to HCT from other sources [85.1% (52.3–96.1) vs 50.8% (26.3–71), p = 0.03, and 90.9% (50.8–98.7) vs 54% (28.1–74.2), p = 0.01, respectively], whereas NRM was significantly lower [0% vs 32% (12.3–53.9); p = 0.02]. This first multicentre study on outcomes of allogeneic HCT in children with myelofibrosis proves feasibility and curative effect of transplantation in these children, suggests that bone marrow transplantation is associated with better outcomes, and indicates the need for further studies.
Published: 2024

2. Multiple Reactivations of Viral Infections Followed by Cerebral Toxoplasmosis After Allogeneic Hematopoietic Stem Cell Transplantation in an Adolescent With Ph(+) Acute Lymphoblastic Leukemia: A Case Report

Author: Zając-Spychała, O., Pieczonka, A., Janura-Szymańska, J., Jończyk-Potoczna, K., and Wachowiak, J.
Published: 2021
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3. Low rate of nonrelapse mortality in under 4-year-olds with ALL given chemo-conditioning for HSCT: Phase III FORUM study

Author: Bader, P, Poetschger, U, Dalle, J, Moser, L, Balduzzi, A, Ansari, M, Buechner, J, Güngör, T, Ifversen, M, Kriván, G, Pichler, H, Renard, M, Staciuk, R, Sedlacek, P, Stein, J, Heusel, J, Truong, T, Wachowiak, J, Yeşilipek, M, Locatelli, F, Peters, C, Bader, Peter, Poetschger, Ulrike, Dalle, Jean-Hugues, Moser, Laura M, Balduzzi, Adriana Cristina, Ansari, Marc, Buechner, Jochen, Güngör, Tayfun, Ifversen, Marianne, Kriván, Gergely, Pichler, Herbert, Renard, Marleen, Staciuk, Raquel, Sedlacek, Petr, Stein, Jerry, Heusel, Jan Robert, Truong, Tony, Wachowiak, Jacek, Yeşilipek, M Akif, Locatelli, Franco, Peters, Christina, Bader, P, Poetschger, U, Dalle, J, Moser, L, Balduzzi, A, Ansari, M, Buechner, J, Güngör, T, Ifversen, M, Kriván, G, Pichler, H, Renard, M, Staciuk, R, Sedlacek, P, Stein, J, Heusel, J, Truong, T, Wachowiak, J, Yeşilipek, M, Locatelli, F, Peters, C, Bader, Peter, Poetschger, Ulrike, Dalle, Jean-Hugues, Moser, Laura M, Balduzzi, Adriana Cristina, Ansari, Marc, Buechner, Jochen, Güngör, Tayfun, Ifversen, Marianne, Kriván, Gergely, Pichler, Herbert, Renard, Marleen, Staciuk, Raquel, Sedlacek, Petr, Stein, Jerry, Heusel, Jan Robert, Truong, Tony, Wachowiak, Jacek, Yeşilipek, M Akif, Locatelli, Franco, and Peters, Christina
Abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) is highly effective for treating pediatric high-risk or relapsed acute lymphoblastic leukemia (ALL). For young children, total body irradiation (TBI) is associated with severe late sequelae. In the FORUMstudy (NCT01949129), we assessed safety, event-free survival (EFS), and overall survival (OS) of 2 TBIfree conditioning regimens in children aged <4 years with ALL. Patients received fludarabine (Flu), thiotepa (Thio), and either busulfan (Bu) or treosulfan (Treo) before HSCT. From 2013 to 2021, 191 children received transplantation and were observed for ≥6 months (median followup: 3 years). The 3-year OS was 0.63 (95% confidence interval [95% CI], 0.52-0.72) and 0.76 (95% CI, 0.64-0.84) for Flu/Thio/Bu and Flu/Thio/Treo (P = .075), respectively. Three-year EFSwas 0.52 (95% CI, 0.41-0.61) and 0.51 (95% CI, 0.39-0.62), respectively (P = .794). Cumulative incidence of nonrelapse mortality (NRM)and relapse at 3 years were 0.06 (95% CI, 0.02-0.12) vs 0.03 (95%CI: [removed]1 acute graft-versus-host disease (GVHD) occurred in 29% of patients receiving Flu/Thio/ Bu and 17% of those receiving Flu/Thio/Treo (P = .049), whereas grade 3/4 occurred in 10% and 9%, respectively (P = .813). The 3-year incidence of chronic GVHD was 0.07 (95% CI, 0.03-0.13) vs 0.05 (95% CI, 0.02-0.11), respectively (P = .518). In conclusion, both chemotherapeutic conditioning regimens were well tolerated and NRM was low. However, relapse was the major cause of treatment failure.
Published: 2024

4. Upper and/or Lower Respiratory Tract Infection Caused by Human Metapneumovirus After Allogeneic Hematopoietic Stem Cell Transplantation

Author: Piñana, J.L., Tridello, G., Xhaard, A., Wendel, L., Montoro, J., Vazquez, L., Heras, I., Ljungman, P., Mikulska, M., Salmenniemi, U., Perez, A., Kröger, N., Cornelissen, J, Sala, E., Martino, R., Geurten, C., Byrne, J., Maertens, J., Kerre, T., Martin, M, Pascual, M.J., Yeshurun, M., Finke, J., Groll, A.H., Shaw, P.J., Blijlevens, N.M.A., Arcese, W., Ganser, A., Suarez-Lledo, M., Alzahrani, M., Choi, G., Forcade, E., Paviglianiti, A., Solano, C., Wachowiak, J., Zuckerman, T., Bader, P., Clausen, J., Mayer, J., Schroyens, W., Metafuni, E., Knelange, N., Averbuch, D., Camara, R. de la, Piñana, J.L., Tridello, G., Xhaard, A., Wendel, L., Montoro, J., Vazquez, L., Heras, I., Ljungman, P., Mikulska, M., Salmenniemi, U., Perez, A., Kröger, N., Cornelissen, J, Sala, E., Martino, R., Geurten, C., Byrne, J., Maertens, J., Kerre, T., Martin, M, Pascual, M.J., Yeshurun, M., Finke, J., Groll, A.H., Shaw, P.J., Blijlevens, N.M.A., Arcese, W., Ganser, A., Suarez-Lledo, M., Alzahrani, M., Choi, G., Forcade, E., Paviglianiti, A., Solano, C., Wachowiak, J., Zuckerman, T., Bader, P., Clausen, J., Mayer, J., Schroyens, W., Metafuni, E., Knelange, N., Averbuch, D., and Camara, R. de la
Abstract: Contains fulltext : 304925.pdf (Publisher’s version ) (Closed access), BACKGROUND: Human metapneumovirus (hMPV) epidemiology, clinical characteristics and risk factors for poor outcome after allogeneic stem cell transplantation (allo-HCT) remain a poorly investigated area. METHODS: This retrospective multicenter cohort study examined the epidemiology, clinical characteristics, and risk factors for poor outcomes associated with human metapneumovirus (hMPV) infections in recipients of allo-HCT. RESULTS: We included 428 allo-HCT recipients who developed 438 hMPV infection episodes between January 2012 and January 2019. Most recipients were adults (93%). hMPV infections were diagnosed at a median of 373 days after allo-HCT. The infections were categorized as upper respiratory tract disease (URTD) or lower respiratory tract disease (LRTD), with 60% and 40% of cases, respectively. Patients with hMPV LRTD experienced the infection earlier in the transplant course and had higher rates of lymphopenia, neutropenia, corticosteroid use, and ribavirin therapy. Multivariate analysis identified lymphopenia and corticosteroid use (>30 mg/d) as independent risk factors for LRTD occurrence. The overall mortality at day 30 after hMPV detection was 2% for URTD, 12% for possible LRTD, and 21% for proven LRTD. Lymphopenia was the only independent risk factor associated with day 30 mortality in LRTD cases. CONCLUSIONS: These findings highlight the significance of lymphopenia and corticosteroid use in the development and severity of hMPV infections after allo-HCT, with lymphopenia being a predictor of higher mortality in LRTD cases.
Published: 2024

5. Impairment of Immune Function in Children with Familial Hemophagocytic Lymphohistiocytosis

Author: Popko, K., Jasińska, J., Górska, E., Demkow, U., Balwierz, W., Maciejka-Kembłowska, L., Badowska, W., Wachowiak, J., Drabko, K., Malinowska, I., and Pokorski, Mieczyslaw, Series editor
Published: 2016
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6. Petrographic and mineralogical studies of fossil charcoal from Sierra de Bahoruco (Barahona Province, Dominican Republic)

Author: Wagner, M., Wachowiak, J., Kowalczyk, J., Natkaniec-Nowak, L., Heflik, W., and Georges, C.
Published: 2017
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7. Global effort to evacuate Ukrainian children with cancer and blood disorders who have been affected by war

Author: Agulnik, A, Kizyma, R, Salek, M, Wlodarski, M, Pogorelyy, M, Oszer, A, Yakimkova, T, Nogovitsyna, Y, Dutkiewicz, M, Dalle, J, Dirksen, U, Eggert, A, Fernandez-Teijeiro, A, Greiner, J, Kraal, K, Mueller, A, Sramkova, L, Zecca, M, Wise, P, Mlynarski, W, Avula, M, Adyrov, M, Berlanga, P, Blackwood, C, Bouffet, E, Czauderna, P, de Koning, L, dos Reis Farinha, N, Foster, W, Graetz, D, Gupta, S, Holter, W, Hough, R, Kliuchkivska, K, Kolenova, A, Kolodrubiec, J, Moreira, D, Mukkada, S, Mykychak, I, Raciborska, A, Salman, Z, Sopilnyak, A, Tyupa, S, Vinitsky, A, Wobst, N, Miller, B, Rasul, S, Rodriguez-Galindo, C, Alanbousi, I, Alexander, S, Apel, A, Bal, W, Balwierz, W, Basset-Salom, L, Bastardo Blanco, D, Bauer, K, Bayazitov, I, Bhakta, N, Bien, E, Bieniek, K, Blair, S, Bodak, K, Bordeianu, I, Braganca, J, Bucurenci, M, Budny, E, Budzyn, A, Bumgardner, C, Burditt, R, Burnside Clapp, V, Bykov, V, Canete, A, Carnelli, M, Cela, E, Cepowska, Z, Chaber, R, Cherner-Drieux, A, Chubata, M, Clough, H, Czernicka - Siwecka, J, Czyzewski, K, Dashchakovska, O, Dembowska-Baginska, B, Derwich, K, Dommett, R, Dorosh, O, Drabko, K, Dragomir, M, Dworzak, M, Dyma, S, Earl, J, English, M, Evseev, D, Farren, B, Fedyk, N, Ferneza, S, Fox Irwin, L, Galazkowski, R, Ganieva, G, Garanzha, V, Gelman, M, Godzinski, J, Goeres, A, Golban, R, Griksaitis, M, Hampel, M, Hastings, S, Heenen, D, Hill, M, Holiuk, I, Hutnik, L, Irga-Jaworska, N, Istomin, O, Janczar, S, Kacharian, A, Kalwak, K, Karolczyk, G, Karpenko, N, Katsubo, H, Kaznowska, B, Kentsis, A, Ketteler, P, Kienesberger, A, Kiselev, R, Kizyma, Z, Klymniuk, H, Kostiuk, Y, Kowalik, T, Kozlova, O, Kozubenko, V, Kramar, T, Krawczuk-Rybak, M, Kulemzina, I, Kurkowska, P, Kuzyk, A, Ladenstein, R, Laguna, P, Lassaletta, A, Lehmberg, K, Leontieva, O, Liashenko, S, Loizou, L, Lucchetta, S, Lupo, M, Lysytsia, L, Lysytsia, O, Machnik, K, Mainland, J, Matczak, K, Matysiak, M, Mayeur, P, Minervina, A, Mishkova, V, Mizia-Malarz, A, Morales La Madrid, A, Moreno, L, Moskvin, V, Muszynska-Roslan, K, Nelson, A, Ociepa, T, Oltolini, S, Onipko, N, Pappas, A, Patel, A, Patrahau, A, Pauley, J, Pavlenko, Y, Pavlovych, A, Peregud-Pogorzelski, J, Perek-Polnik, M, Perez, V, Perez-Martinez, A, Pikman, Y, Pitozzi, G, Portugal, R, Posternak, V, Prete, A, Pritchard-Jones, K, Radaelli, A, Reeves, T, Reinhardt, D, Reshetnyak, A, Rider, A, Rizzari, C, Rizzi, D, Rodriguez Hermosillo, K, Ronenko, O, Rostowska, A, Rudko, L, Sakaan, F, Sakhar, N, Savva, N, Scaccaglia, D, Schaeffer, E, Schneider, C, Scobie, N, Semeniuk, O, Shevchyk, R, Shuler, A, Shvets, S, Skoczen, S, Smeal, W, Sokolowski, I, Sonkin, A, Stepanjuk, A, Spota, A, Sterba, J, Styczynski, J, Svintsova, O, Synyuta, A, Szczepanski, T, Szczucinski, P, Szmyd, B, Tasso Cereceda, M, Teliuk, A, Tomanek, I, Topping, P, Torrent, M, Trelinska, J, Troyanovska, O, Trubnikova, E, Tsurkan, L, Tsymbalyuk-Voloshyn, I, Urasinski, T, Urbanek-Dadela, A, Vasilieva, N, Vasilyeva, A, Verdu-Amoros, J, Vilcu-Bajurean, N, Vinitsky, L, Volpe, G, Vorobel, O, Wachowiak, J, Wasiak, M, Wiedower, L, Wuenschel, L, Wysocki, M, Yurieva, M, Zagurska, A, Zakharenko, S, Zakharenko, A, Zapotochna, K, Zawitkowska, J, Agulnik A., Kizyma R., Salek M., Wlodarski M. W., Pogorelyy M., Oszer A., Yakimkova T., Nogovitsyna Y., Dutkiewicz M., Dalle J. -H., Dirksen U., Eggert A., Fernandez-Teijeiro A., Greiner J., Kraal K., Mueller A., Sramkova L., Zecca M., Wise P. H., Mlynarski W., Avula M., Adyrov M. V., Berlanga P., Blackwood C. A., Bouffet E., Czauderna P. S., de Koning L. A., dos Reis Farinha N. J., Foster W. B., Graetz D. E., Gupta S., Holter W., Hough R. E., Kliuchkivska K., Kolenova A., Kolodrubiec J., Moreira D. C., Mukkada S. T., Mykychak I., Raciborska A., Salman Z. S., Sopilnyak A., Tyupa S., Vinitsky A., Wobst N. M., Miller B. A., Rasul S. S., Rodriguez-Galindo C., Alanbousi I., Alexander S. W., Apel A., Bal W. A., Balwierz W. A., Basset-Salom L., Bastardo Blanco D., Bauer K. J., Bayazitov I. T., Bhakta N. H., Bien E. I., Bieniek K. A., Blair S. J., Bodak K. I., Bordeianu I. M., Braganca J. M., Bucurenci M. S., Budny E. B., Budzyn A., Bumgardner C. C., Burditt R. N., Burnside Clapp V. G., Bykov V., Canete A., Carnelli M., Cela E., Cepowska Z. P., Chaber R., Cherner-Drieux A., Chubata M., Clough H. M., Czernicka - Siwecka J., Czyzewski K., Dashchakovska O., Dembowska-Baginska B. M., Derwich K., Dommett R., Dorosh O., Drabko K. A., Dragomir M. D., Dworzak M., Dyma S., Earl J. D., English M. W., Evseev D. A., Farren B. S., Fedyk N., Ferneza S., Fox Irwin L. E., Galazkowski R. M., Ganieva G., Garanzha V., Gelman M. S., Godzinski J. K., Goeres A. F., Golban R., Griksaitis M. J., Hampel M. A., Hastings S. G., Heenen D. L., Hill M. C., Holiuk I., Hutnik L. M., Irga-Jaworska N., Istomin O., Janczar S. L., Kacharian A., Kalwak K., Karolczyk G. M., Karpenko N. M., Katsubo H., Kaznowska B. J., Kentsis A., Ketteler P., Kienesberger A., Kiselev R., Kizyma Z., Klymniuk H., Kostiuk Y., Kowalik T., Kozlova O., Kozubenko V., Kramar T., Krawczuk-Rybak M., Kulemzina I., Kurkowska P., Kuzyk A. S., Ladenstein R. L., Laguna P. J., Lassaletta A., Lehmberg K., Leontieva O., Liashenko S., Loizou L. G., Lucchetta S. A., Lupo M. W., Lysytsia L., Lysytsia O., Machnik K. A., Mainland J. A., Matczak K. E., Matysiak M. J., Mayeur P., Minervina A. A., Mishkova V., Mizia-Malarz A. J., Morales La Madrid A., Moreno L., Moskvin V. P., Muszynska-Roslan K. M., Nelson A. J., Ociepa T., Oltolini S., Onipko N., Pappas A., Patel A. B., Patrahau A., Pauley J. L., Pavlenko Y., Pavlovych A., Peregud-Pogorzelski J., Perek-Polnik M., Perez V., Perez-Martinez A., Pikman Y., Pitozzi G., Portugal R. G., Posternak V. V., Prete A., Pritchard-Jones K., Radaelli A., Reeves T., Reinhardt D., Reshetnyak A. V., Rider A. J., Rizzari C., Rizzi D., Rodriguez Hermosillo K. G., Ronenko O., Rostowska A. O., Rudko L., Sakaan F. M., Sakhar N., Savva N. N., Scaccaglia D., Schaeffer E. H., Schneider C. U., Scobie N., Semeniuk O., Shevchyk R., Shuler A. I., Shvets S., Skoczen S. P., Smeal W. J., Sokolowski I., Sonkin A. A., Stepanjuk A. I., Spota A., Sterba J., Styczynski J., Svintsova O., Synyuta A. V., Szczepanski T., Szczucinski P. K., Szmyd B. M., Tasso Cereceda M., Teliuk A., Tomanek I., Topping P., Torrent M., Trelinska J., Troyanovska O., Trubnikova E., Tsurkan L. G., Tsymbalyuk-Voloshyn I., Urasinski T. F., Urbanek-Dadela A., Vasilieva N., Vasilyeva A., Verdu-Amoros J., Vilcu-Bajurean N., Vinitsky L., Volpe G., Vorobel O., Wachowiak J. T., Wasiak M. S., Wiedower L. A., Wuenschel L. I., Wysocki M. S., Yurieva M., Zagurska A., Zakharenko S. S., Zakharenko A. V., Zapotochna K., Zawitkowska J. E., Agulnik, A, Kizyma, R, Salek, M, Wlodarski, M, Pogorelyy, M, Oszer, A, Yakimkova, T, Nogovitsyna, Y, Dutkiewicz, M, Dalle, J, Dirksen, U, Eggert, A, Fernandez-Teijeiro, A, Greiner, J, Kraal, K, Mueller, A, Sramkova, L, Zecca, M, Wise, P, Mlynarski, W, Avula, M, Adyrov, M, Berlanga, P, Blackwood, C, Bouffet, E, Czauderna, P, de Koning, L, dos Reis Farinha, N, Foster, W, Graetz, D, Gupta, S, Holter, W, Hough, R, Kliuchkivska, K, Kolenova, A, Kolodrubiec, J, Moreira, D, Mukkada, S, Mykychak, I, Raciborska, A, Salman, Z, Sopilnyak, A, Tyupa, S, Vinitsky, A, Wobst, N, Miller, B, Rasul, S, Rodriguez-Galindo, C, Alanbousi, I, Alexander, S, Apel, A, Bal, W, Balwierz, W, Basset-Salom, L, Bastardo Blanco, D, Bauer, K, Bayazitov, I, Bhakta, N, Bien, E, Bieniek, K, Blair, S, Bodak, K, Bordeianu, I, Braganca, J, Bucurenci, M, Budny, E, Budzyn, A, Bumgardner, C, Burditt, R, Burnside Clapp, V, Bykov, V, Canete, A, Carnelli, M, Cela, E, Cepowska, Z, Chaber, R, Cherner-Drieux, A, Chubata, M, Clough, H, Czernicka - Siwecka, J, Czyzewski, K, Dashchakovska, O, Dembowska-Baginska, B, Derwich, K, Dommett, R, Dorosh, O, Drabko, K, Dragomir, M, Dworzak, M, Dyma, S, Earl, J, English, M, Evseev, D, Farren, B, Fedyk, N, Ferneza, S, Fox Irwin, L, Galazkowski, R, Ganieva, G, Garanzha, V, Gelman, M, Godzinski, J, Goeres, A, Golban, R, Griksaitis, M, Hampel, M, Hastings, S, Heenen, D, Hill, M, Holiuk, I, Hutnik, L, Irga-Jaworska, N, Istomin, O, Janczar, S, Kacharian, A, Kalwak, K, Karolczyk, G, Karpenko, N, Katsubo, H, Kaznowska, B, Kentsis, A, Ketteler, P, Kienesberger, A, Kiselev, R, Kizyma, Z, Klymniuk, H, Kostiuk, Y, Kowalik, T, Kozlova, O, Kozubenko, V, Kramar, T, Krawczuk-Rybak, M, Kulemzina, I, Kurkowska, P, Kuzyk, A, Ladenstein, R, Laguna, P, Lassaletta, A, Lehmberg, K, Leontieva, O, Liashenko, S, Loizou, L, Lucchetta, S, Lupo, M, Lysytsia, L, Lysytsia, O, Machnik, K, Mainland, J, Matczak, K, Matysiak, M, Mayeur, P, Minervina, A, Mishkova, V, Mizia-Malarz, A, Morales La Madrid, A, Moreno, L, Moskvin, V, Muszynska-Roslan, K, Nelson, A, Ociepa, T, Oltolini, S, Onipko, N, Pappas, A, Patel, A, Patrahau, A, Pauley, J, Pavlenko, Y, Pavlovych, A, Peregud-Pogorzelski, J, Perek-Polnik, M, Perez, V, Perez-Martinez, A, Pikman, Y, Pitozzi, G, Portugal, R, Posternak, V, Prete, A, Pritchard-Jones, K, Radaelli, A, Reeves, T, Reinhardt, D, Reshetnyak, A, Rider, A, Rizzari, C, Rizzi, D, Rodriguez Hermosillo, K, Ronenko, O, Rostowska, A, Rudko, L, Sakaan, F, Sakhar, N, Savva, N, Scaccaglia, D, Schaeffer, E, Schneider, C, Scobie, N, Semeniuk, O, Shevchyk, R, Shuler, A, Shvets, S, Skoczen, S, Smeal, W, Sokolowski, I, Sonkin, A, Stepanjuk, A, Spota, A, Sterba, J, Styczynski, J, Svintsova, O, Synyuta, A, Szczepanski, T, Szczucinski, P, Szmyd, B, Tasso Cereceda, M, Teliuk, A, Tomanek, I, Topping, P, Torrent, M, Trelinska, J, Troyanovska, O, Trubnikova, E, Tsurkan, L, Tsymbalyuk-Voloshyn, I, Urasinski, T, Urbanek-Dadela, A, Vasilieva, N, Vasilyeva, A, Verdu-Amoros, J, Vilcu-Bajurean, N, Vinitsky, L, Volpe, G, Vorobel, O, Wachowiak, J, Wasiak, M, Wiedower, L, Wuenschel, L, Wysocki, M, Yurieva, M, Zagurska, A, Zakharenko, S, Zakharenko, A, Zapotochna, K, Zawitkowska, J, Agulnik A., Kizyma R., Salek M., Wlodarski M. W., Pogorelyy M., Oszer A., Yakimkova T., Nogovitsyna Y., Dutkiewicz M., Dalle J. -H., Dirksen U., Eggert A., Fernandez-Teijeiro A., Greiner J., Kraal K., Mueller A., Sramkova L., Zecca M., Wise P. H., Mlynarski W., Avula M., Adyrov M. V., Berlanga P., Blackwood C. A., Bouffet E., Czauderna P. S., de Koning L. A., dos Reis Farinha N. J., Foster W. B., Graetz D. E., Gupta S., Holter W., Hough R. E., Kliuchkivska K., Kolenova A., Kolodrubiec J., Moreira D. C., Mukkada S. T., Mykychak I., Raciborska A., Salman Z. S., Sopilnyak A., Tyupa S., Vinitsky A., Wobst N. M., Miller B. A., Rasul S. S., Rodriguez-Galindo C., Alanbousi I., Alexander S. W., Apel A., Bal W. A., Balwierz W. A., Basset-Salom L., Bastardo Blanco D., Bauer K. J., Bayazitov I. T., Bhakta N. H., Bien E. I., Bieniek K. A., Blair S. J., Bodak K. I., Bordeianu I. M., Braganca J. M., Bucurenci M. S., Budny E. B., Budzyn A., Bumgardner C. C., Burditt R. N., Burnside Clapp V. G., Bykov V., Canete A., Carnelli M., Cela E., Cepowska Z. P., Chaber R., Cherner-Drieux A., Chubata M., Clough H. M., Czernicka - Siwecka J., Czyzewski K., Dashchakovska O., Dembowska-Baginska B. M., Derwich K., Dommett R., Dorosh O., Drabko K. A., Dragomir M. D., Dworzak M., Dyma S., Earl J. D., English M. W., Evseev D. A., Farren B. S., Fedyk N., Ferneza S., Fox Irwin L. E., Galazkowski R. M., Ganieva G., Garanzha V., Gelman M. S., Godzinski J. K., Goeres A. F., Golban R., Griksaitis M. J., Hampel M. A., Hastings S. G., Heenen D. L., Hill M. C., Holiuk I., Hutnik L. M., Irga-Jaworska N., Istomin O., Janczar S. L., Kacharian A., Kalwak K., Karolczyk G. M., Karpenko N. M., Katsubo H., Kaznowska B. J., Kentsis A., Ketteler P., Kienesberger A., Kiselev R., Kizyma Z., Klymniuk H., Kostiuk Y., Kowalik T., Kozlova O., Kozubenko V., Kramar T., Krawczuk-Rybak M., Kulemzina I., Kurkowska P., Kuzyk A. S., Ladenstein R. L., Laguna P. J., Lassaletta A., Lehmberg K., Leontieva O., Liashenko S., Loizou L. G., Lucchetta S. A., Lupo M. W., Lysytsia L., Lysytsia O., Machnik K. A., Mainland J. A., Matczak K. E., Matysiak M. J., Mayeur P., Minervina A. A., Mishkova V., Mizia-Malarz A. J., Morales La Madrid A., Moreno L., Moskvin V. P., Muszynska-Roslan K. M., Nelson A. J., Ociepa T., Oltolini S., Onipko N., Pappas A., Patel A. B., Patrahau A., Pauley J. L., Pavlenko Y., Pavlovych A., Peregud-Pogorzelski J., Perek-Polnik M., Perez V., Perez-Martinez A., Pikman Y., Pitozzi G., Portugal R. G., Posternak V. V., Prete A., Pritchard-Jones K., Radaelli A., Reeves T., Reinhardt D., Reshetnyak A. V., Rider A. J., Rizzari C., Rizzi D., Rodriguez Hermosillo K. G., Ronenko O., Rostowska A. O., Rudko L., Sakaan F. M., Sakhar N., Savva N. N., Scaccaglia D., Schaeffer E. H., Schneider C. U., Scobie N., Semeniuk O., Shevchyk R., Shuler A. I., Shvets S., Skoczen S. P., Smeal W. J., Sokolowski I., Sonkin A. A., Stepanjuk A. I., Spota A., Sterba J., Styczynski J., Svintsova O., Synyuta A. V., Szczepanski T., Szczucinski P. K., Szmyd B. M., Tasso Cereceda M., Teliuk A., Tomanek I., Topping P., Torrent M., Trelinska J., Troyanovska O., Trubnikova E., Tsurkan L. G., Tsymbalyuk-Voloshyn I., Urasinski T. F., Urbanek-Dadela A., Vasilieva N., Vasilyeva A., Verdu-Amoros J., Vilcu-Bajurean N., Vinitsky L., Volpe G., Vorobel O., Wachowiak J. T., Wasiak M. S., Wiedower L. A., Wuenschel L. I., Wysocki M. S., Yurieva M., Zagurska A., Zakharenko S. S., Zakharenko A. V., Zapotochna K., and Zawitkowska J. E.
Published: 2022

8. First-Line Immunosuppressive Treatment in Children with Aplastic Anemia: Rabbit Antithymocyte Globulin

Author: Pawelec, K., Salamonowicz, M., Panasiuk, A., Demkow, U., Kowalczyk, J., Balwierz, W., Zaleska-Czepko, E., Chybicka, A., Szmyd, K., Szczepanski, T., Bubala, H., Wysocki, M., Kurylak, A., Wachowiak, J., Szpecht, D., Młynarski, W., Bulas, M., Krawczuk-Rybak, M., Leszczynska, E., Urasinski, T., Peregud-Pogorzelski, J., Balcerska, A., Kaczorowska-Hac, B., Matysiak, M., and Pokorski, Mieczyslaw, Series editor
Published: 2015
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9. Incidence, course, and outcome of Clostridium difficile infection in children with hematological malignancies or undergoing hematopoietic stem cell transplantation

Author: Salamonowicz, Małgorzata, Ociepa, T., Frączkiewicz, J., Szmydki-Baran, A., Matysiak, M., Czyżewski, K., Wysocki, M., Gałązka, P., Zalas-Więcek, P., Irga-Jaworska, N., Drożyńska, E., Zając-Spychała, O., Wachowiak, J., Gryniewicz-Kwiatkowska, O., Czajńska-Deptuła, A., Dembowska-Bagińska, B., Chełmecka-Wiktorczyk, L., Balwierz, W., Bartnik, M., Zielezińska, K., Urasiński, T., Tomaszewska, R., Szczepański, T., Płonowski, M., Krawczuk-Rybak, M., Pierlejewski, F., Młynarski, W., Gamrot-Pyka, Z., Woszczyk, M., Małas, Z., Badowska, W., Urbanek-Dądela, A., Karolczyk, G., Stolpa, W., Sobol-Milejska, G., Zaucha-Prażmo, A., Kowalczyk, J., Goździk, J., Gorczyńska, E., Jermakow, K., Król, A., Chybicka, A., Ussowicz, M., Kałwak, K., and Styczyński, J.
Published: 2018
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10. Fertility preservation issues in pediatric hematopoietic stem cell transplantation: practical approaches from the consensus of the Pediatric Diseases Working Party of the EBMT and the International BFM Study Group

Author: Balduzzi, A, Dalle, J-H, Jahnukainen, K, von Wolff, M, Lucchini, G, Ifversen, M, Macklon, K T, Poirot, C, Diesch, T, Jarisch, A, Bresters, D, Yaniv, I, Gibson, B, Willasch, A M, Fadini, R, Ferrari, L, Lawitschka, A, Ahler, A, Sänger, N, Corbacioglu, S, Ansari, M, Moffat, R, Dalissier, A, Beohou, E, Sedlacek, P, Lankester, A, De Heredia Rubio, C D, Vettenranta, K, Wachowiak, J, Yesilipek, A, Trigoso, E, Klingebiel, T, Peters, C, and Bader, P
Published: 2017
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11. State-of-the-art fertility preservation in children and adolescents undergoing haematopoietic stem cell transplantation: a report on the expert meeting of the Paediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) in Baden, Austria, 29–30 September 2015

Author: Dalle, J-H, Lucchini, G, Balduzzi, A, Ifversen, M, Jahnukainen, K, Macklon, K T, Ahler, A, Jarisch, A, Ansari, M, Beohou, E, Bresters, D, Corbacioglu, S, Dalissier, A, Diaz de Heredia Rubio, C, Diesch, T, Gibson, B, Klingebiel, T, Lankester, A, Lawitschka, A, Moffat, R, Peters, C, Poirot, C, Saenger, N, Sedlacek, P, Trigoso, E, Vettenranta, K, Wachowiak, J, Willasch, A, von Wolff, M, Yaniv, I, Yesilipek, A, and Bader, P
Published: 2017
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12. Supportive Care During Pediatric Hematopoietic Stem Cell Transplantation: Prevention of Infections. A Report From Workshops on Supportive Care of the Paediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Author: Ifversen, M, Meisel, R, Sedlacek, P, Kalwak, K, Sisinni, L, Hutt, D, Lehrnbecher, T, Balduzzi, A, Diesch, T, Jarisch, A, Gungor, T, Stein, J, Yaniv, I, Bonig, H, Kuhlen, M, Ansari, M, Nava, T, Dalle, J, Diaz-de-Heredia, C, Trigoso, E, Falkenberg, U, Hartmann, M, Deiana, M, Canesi, M, Broggi, C, Bertaina, A, Gibson, B, Krivan, G, Vettenranta, K, Matic, T, Buechner, J, Lawitschka, A, Peters, C, Yesilipek, A, Yalcin, K, Lucchini, G, Bakhtiar, S, Turkiewicz, D, Niinimaki, R, Wachowiak, J, Cesaro, S, Dalissier, A, Corbacioglu, S, Willasch, A, Bader, P, Ifversen M., Meisel R., Sedlacek P., Kalwak K., Sisinni L., Hutt D., Lehrnbecher T., Balduzzi A., Diesch T., Jarisch A., Gungor T., Stein J., Yaniv I., Bonig H., Kuhlen M., Ansari M., Nava T., Dalle J. -H., Diaz-de-Heredia C., Trigoso E., Falkenberg U., Hartmann M., Deiana M., Canesi M., Broggi C., Bertaina A., Gibson B., Krivan G., Vettenranta K., Matic T., Buechner J., Lawitschka A., Peters C., Yesilipek A., Yalcin K., Lucchini G., Bakhtiar S., Turkiewicz D., Niinimaki R., Wachowiak J., Cesaro S., Dalissier A., Corbacioglu S., Willasch A. M., Bader P., Ifversen, M, Meisel, R, Sedlacek, P, Kalwak, K, Sisinni, L, Hutt, D, Lehrnbecher, T, Balduzzi, A, Diesch, T, Jarisch, A, Gungor, T, Stein, J, Yaniv, I, Bonig, H, Kuhlen, M, Ansari, M, Nava, T, Dalle, J, Diaz-de-Heredia, C, Trigoso, E, Falkenberg, U, Hartmann, M, Deiana, M, Canesi, M, Broggi, C, Bertaina, A, Gibson, B, Krivan, G, Vettenranta, K, Matic, T, Buechner, J, Lawitschka, A, Peters, C, Yesilipek, A, Yalcin, K, Lucchini, G, Bakhtiar, S, Turkiewicz, D, Niinimaki, R, Wachowiak, J, Cesaro, S, Dalissier, A, Corbacioglu, S, Willasch, A, Bader, P, Ifversen M., Meisel R., Sedlacek P., Kalwak K., Sisinni L., Hutt D., Lehrnbecher T., Balduzzi A., Diesch T., Jarisch A., Gungor T., Stein J., Yaniv I., Bonig H., Kuhlen M., Ansari M., Nava T., Dalle J. -H., Diaz-de-Heredia C., Trigoso E., Falkenberg U., Hartmann M., Deiana M., Canesi M., Broggi C., Bertaina A., Gibson B., Krivan G., Vettenranta K., Matic T., Buechner J., Lawitschka A., Peters C., Yesilipek A., Yalcin K., Lucchini G., Bakhtiar S., Turkiewicz D., Niinimaki R., Wachowiak J., Cesaro S., Dalissier A., Corbacioglu S., Willasch A. M., and Bader P.
Abstract: Specific protocols define eligibility, conditioning, donor selection, graft composition and prophylaxis of graft vs. host disease for children and young adults undergoing hematopoietic stem cell transplant (HSCT). However, international protocols rarely, if ever, detail supportive care, including pharmaceutical infection prophylaxis, physical protection with face masks and cohort isolation or food restrictions. Supportive care suffers from a lack of scientific evidence and implementation of practices in the transplant centers brings extensive restrictions to the child's and family's daily life after HSCT. Therefore, the Board of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) held a series of dedicated workshops since 2017 with the aim of initiating the production of a set of minimal recommendations. The present paper describes the consensus reached within the field of infection prophylaxis.
Published: 2021

13. The impact of donor type on the outcome of pediatric patients with very high risk acute lymphoblastic leukemia. A study of the ALL SCT 2003 BFM-SG and 2007-BFM-International SG

Author: Dalle, J, Balduzzi, A, Bader, P, Pieczonka, A, Yaniv, I, Lankester, A, Bierings, M, Yesilipek, A, Sedlacek, P, Ifversen, M, Svec, P, Toporski, J, Gungor, T, Wachowiak, J, Glogova, E, Poetschger, U, Peters, C, Dalle J. -H., Balduzzi A., Bader P., Pieczonka A., Yaniv I., Lankester A., Bierings M., Yesilipek A., Sedlacek P., Ifversen M., Svec P., Toporski J., Gungor T., Wachowiak J., Glogova E., Poetschger U., Peters C., Dalle, J, Balduzzi, A, Bader, P, Pieczonka, A, Yaniv, I, Lankester, A, Bierings, M, Yesilipek, A, Sedlacek, P, Ifversen, M, Svec, P, Toporski, J, Gungor, T, Wachowiak, J, Glogova, E, Poetschger, U, Peters, C, Dalle J. -H., Balduzzi A., Bader P., Pieczonka A., Yaniv I., Lankester A., Bierings M., Yesilipek A., Sedlacek P., Ifversen M., Svec P., Toporski J., Gungor T., Wachowiak J., Glogova E., Poetschger U., and Peters C.
Abstract: Allogeneic HSCT represents the only potentially curative treatment for very high risk (VHR) ALL. Two consecutive international prospective studies, ALL-SCT-(I)BFM 2003 and 2007 were conducted in 1150 pediatric patients. 569 presented with VHR disease leading to any kind of HSCT. All patients >2 year old were transplanted after TBI-based MAC. The median follow-up was 5 years. 463 patients were transplanted from matched donor (MD) and 106 from mismatched donor (MMD). 214 were in CR1. Stem cell source was unmanipulated BM for 330 patients, unmanipulated PBSC for 135, ex vivo T-cell depleted PBSC for 62 and cord-blood for 26. There were more advanced disease, more ex vivo T-cell depletion, and more chemotherapy based conditioning regimen for patients transplanted from MMD as compared to those transplanted from MSD or MD. Median follow up (reversed Kaplan Meier estimator) was 4.99 years, median follow up of survivals was 4.88, range (0.01–11.72) years. The 4-year CI of extensive cGvHD was 13 ± 2% and 17 ± 4% (p = NS) for the patients transplanted from MD and MMD, respectively. 4-year EFS was statistically better for patients transplanted from MD (60 ± 2% vs. 42 ± 5%, p < 0.001) for the whole cohort. This difference does not exist if considering separately patients treated in the most recent study. There was no difference in 4-year CI of relapse. The 4-year NRM was lower for patients transplanted from MD (9 ± 1% vs. 23 ± 4%, p < 0.001). In multivariate analysis, donor-type appears as a negative risk-factor for OS, EFS, and NRM. This paper demonstrates the impact of donor type on overall results of allogeneic stem cell transplantation for very-high risk pediatric acute lymphoblastic leukemia with worse results when using MMD stem cell source.
Published: 2021

14. Correction: ABO incompatibile graft management in pediatric transplantation (Bone Marrow Transplantation, (2020), 10.1038/s41409-020-0981-7)

Author: Balduzzi A., Balduzzi, A, Bonig, H, Jarisch, A, Nava, T, Ansari, M, Cattoni, A, Prunotto, G, Lucchini, G, Krivan, G, Matic, T, Kalwak, K, Yesilipek, A, Ifversen, M, Svec, P, Buechner, J, Vettenranta, K, Meisel, R, Lawitschka, A, Peters, C, Gibson, B, Dalissier, A, Corbacioglu, S, Willasch, A, Dalle, J, Bader, P, Bielorai, B, Cesaro, S, Diesch, T, Kato, K, Gomez, S, Mellgren, K, Palma, J, Rossig, C, Sauer, M, Sedlacek, P, Shaw, P, Schultz, K, Stein, J, Tayfun, G, Turkiewicz, D, Wachowiak, J, Balduzzi A., Bonig H., Jarisch A., Nava T., Ansari M., Cattoni A., Prunotto G., Lucchini G., Krivan G., Matic T., Kalwak K., Yesilipek A., Ifversen M., Svec P., Buechner J., Vettenranta K., Meisel R., Lawitschka A., Peters C., Gibson B., Dalissier A., Corbacioglu S., Willasch A., Dalle J. -H., Bader P., Bielorai B., Cesaro S., Diesch T., Kato K., Gomez S., Mellgren K., Palma J., Rossig C., Sauer M., Sedlacek P., Shaw P., Schultz K., Stein J., Tayfun G., Turkiewicz D., Wachowiak J., Balduzzi A., Balduzzi, A, Bonig, H, Jarisch, A, Nava, T, Ansari, M, Cattoni, A, Prunotto, G, Lucchini, G, Krivan, G, Matic, T, Kalwak, K, Yesilipek, A, Ifversen, M, Svec, P, Buechner, J, Vettenranta, K, Meisel, R, Lawitschka, A, Peters, C, Gibson, B, Dalissier, A, Corbacioglu, S, Willasch, A, Dalle, J, Bader, P, Bielorai, B, Cesaro, S, Diesch, T, Kato, K, Gomez, S, Mellgren, K, Palma, J, Rossig, C, Sauer, M, Sedlacek, P, Shaw, P, Schultz, K, Stein, J, Tayfun, G, Turkiewicz, D, Wachowiak, J, Balduzzi A., Bonig H., Jarisch A., Nava T., Ansari M., Cattoni A., Prunotto G., Lucchini G., Krivan G., Matic T., Kalwak K., Yesilipek A., Ifversen M., Svec P., Buechner J., Vettenranta K., Meisel R., Lawitschka A., Peters C., Gibson B., Dalissier A., Corbacioglu S., Willasch A., Dalle J. -H., Bader P., Bielorai B., Cesaro S., Diesch T., Kato K., Gomez S., Mellgren K., Palma J., Rossig C., Sauer M., Sedlacek P., Shaw P., Schultz K., Stein J., Tayfun G., Turkiewicz D., and Wachowiak J.
Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Published: 2021

15. Correction: Myeloablative conditioning for allo-HSCT in pediatric ALL: FTBI or chemotherapy?—A multicenter EBMT-PDWP study (Bone Marrow Transplantation, (2020), 55, 8, (1540-1551), 10.1038/s41409-020-0854-0)

Author: Willasch A. M., Willasch, A, Peters, C, Sedlacek, P, Dalle, J, Kitra-Roussou, V, Yesilipek, A, Wachowiak, J, Lankester, A, Prete, A, Hamidieh, A, Ifversen, M, Buechner, J, Krivan, G, Hamladji, R, Diaz-de-Heredia, C, Skorobogatova, E, Michel, G, Locatelli, F, Bertaina, A, Veys, P, Dupont, S, Or, R, Gungor, T, Aleinikova, O, Sufliarska, S, Sundin, M, Rascon, J, Kaare, A, Nemet, D, Fagioli, F, Klingebiel, T, Styczynski, J, Bierings, M, Nagy, K, Abecasis, M, Afanasyev, B, Ansari, M, Vettenranta, K, Alseraihy, A, Chybicka, A, Robinson, S, Bertrand, Y, Kupesiz, A, Ghavamzadeh, A, Campos, A, Pichler, H, Dalissier, A, Labopin, M, Corbacioglu, S, Balduzzi, A, Galimard, J, Bader, P, Willasch A. M., Peters C., Sedlacek P., Dalle J. -H., Kitra-Roussou V., Yesilipek A., Wachowiak J., Lankester A., Prete A., Hamidieh A. A., Ifversen M., Buechner J., Krivan G., Hamladji R. -M., Diaz-de-Heredia C., Skorobogatova E., Michel G., Locatelli F., Bertaina A., Veys P., Dupont S., Or R., Gungor T., Aleinikova O., Sufliarska S., Sundin M., Rascon J., Kaare A., Nemet D., Fagioli F., Klingebiel T. E., Styczynski J., Bierings M., Nagy K., Abecasis M., Afanasyev B., Ansari M., Vettenranta K., Alseraihy A., Chybicka A., Robinson S., Bertrand Y., Kupesiz A., Ghavamzadeh A., Campos A., Pichler H., Dalissier A., Labopin M., Corbacioglu S., Balduzzi A., Galimard J. -E., Bader P., Willasch A. M., Willasch, A, Peters, C, Sedlacek, P, Dalle, J, Kitra-Roussou, V, Yesilipek, A, Wachowiak, J, Lankester, A, Prete, A, Hamidieh, A, Ifversen, M, Buechner, J, Krivan, G, Hamladji, R, Diaz-de-Heredia, C, Skorobogatova, E, Michel, G, Locatelli, F, Bertaina, A, Veys, P, Dupont, S, Or, R, Gungor, T, Aleinikova, O, Sufliarska, S, Sundin, M, Rascon, J, Kaare, A, Nemet, D, Fagioli, F, Klingebiel, T, Styczynski, J, Bierings, M, Nagy, K, Abecasis, M, Afanasyev, B, Ansari, M, Vettenranta, K, Alseraihy, A, Chybicka, A, Robinson, S, Bertrand, Y, Kupesiz, A, Ghavamzadeh, A, Campos, A, Pichler, H, Dalissier, A, Labopin, M, Corbacioglu, S, Balduzzi, A, Galimard, J, Bader, P, Willasch A. M., Peters C., Sedlacek P., Dalle J. -H., Kitra-Roussou V., Yesilipek A., Wachowiak J., Lankester A., Prete A., Hamidieh A. A., Ifversen M., Buechner J., Krivan G., Hamladji R. -M., Diaz-de-Heredia C., Skorobogatova E., Michel G., Locatelli F., Bertaina A., Veys P., Dupont S., Or R., Gungor T., Aleinikova O., Sufliarska S., Sundin M., Rascon J., Kaare A., Nemet D., Fagioli F., Klingebiel T. E., Styczynski J., Bierings M., Nagy K., Abecasis M., Afanasyev B., Ansari M., Vettenranta K., Alseraihy A., Chybicka A., Robinson S., Bertrand Y., Kupesiz A., Ghavamzadeh A., Campos A., Pichler H., Dalissier A., Labopin M., Corbacioglu S., Balduzzi A., Galimard J. -E., and Bader P.
Abstract: The article “Myeloablative conditioning for allo-HSCT in pediatric ALL: FTBI or chemotherapy?—A multicenter EBMT-PDWP study,” written by Andre Manfred Willasch, Christina Peters, Petr Sedlácek, Jean-Hugues Dalle, Vassiliki Kitra-Roussou, Akif Yesilipek, Jacek Wachowiak, Arjan Lankester, Arcangelo Prete, Amir Ali Hamidieh, Marianne Ifversen, Jochen Buechner, Gergely Kriván, Rose-Marie Hamladji, Cristina Diaz-de-Heredia, Elena Skorobogatova, Gérard Michel, Franco Locatelli, Alice Bertaina, Paul Veys, Sophie Dupont, Reuven Or, Tayfun Güngör, Olga Aleinikova, Sabina Sufliarska, Mikael Sundin, Jelena Rascon, Ain Kaare, Damir Nemet, Franca Fagioli, Thomas Erich Klingebiel, Jan Styczynski, Marc Bierings, Kálmán Nagy, Manuel Abecasis, Boris Afanasyev, Marc Ansari, Kim Vettenranta, Amal Alseraihy, Alicja Chybicka, Stephen Robinson, Yves Bertrand, Alphan Kupesiz, Ardeshir Ghavamzadeh, Antonio Campos, Herbert Pichler, Arnaud Dalissier, Myriam Labopin, Selim Corbacioglu, Adriana Balduzzi, Jacques-Emmanuel Galimard, Peter Bader, on behalf of the EBMT Paediatric Diseases Working Party, was originally published online first without Open Access. After publication in volume 55, issue 8, page 1540–1551, the author decided to opt for Open Choice and to make the article an Open Access publication. Therefore, the copyright of the article has been changed to © The Author(s) 2020 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 InternationalS License, which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third-party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Comm
Published: 2021

16. Correction: Supportive care during pediatric hematopoietic stem cell transplantation: beyond infectious diseases. A report from workshops on supportive care of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) (Bone Marrow Transplantation, (2020), 55, 6, (1126-1136), 10.1038/s41409-020-0818-4)

Author: Nava T., Nava, T, Ansari, M, Dalle, J, de Heredia, C, Gungor, T, Trigoso, E, Falkenberg, U, Bertaina, A, Gibson, B, Jarisch, A, Balduzzi, A, Boenig, H, Krivan, G, Vettenranta, K, Matic, T, Buechner, J, Kalwak, K, Lawitschka, A, Yesilipek, A, Lucchini, G, Peters, C, Turkiewicz, D, Niinimaki, R, Diesch, T, Lehrnbecher, T, Sedlacek, P, Hutt, D, Dalissier, A, Wachowiak, J, Yaniv, I, Stein, J, Yalcin, K, Sisinni, L, Deiana, M, Ifversen, M, Kuhlen, M, Meisel, R, Bakhtiar, S, Cesaro, S, Willasch, A, Corbacioglu, S, Bader, P, Nava T., Ansari M., Dalle J. -H., de Heredia C. D., Gungor T., Trigoso E., Falkenberg U., Bertaina A., Gibson B., Jarisch A., Balduzzi A., Boenig H., Krivan G., Vettenranta K., Matic T., Buechner J., Kalwak K., Lawitschka A., Yesilipek A., Lucchini G., Peters C., Turkiewicz D., Niinimaki R., Diesch T., Lehrnbecher T., Sedlacek P., Hutt D., Dalissier A., Wachowiak J., Yaniv I., Stein J., Yalcin K., Sisinni L., Deiana M., Ifversen M., Kuhlen M., Meisel R., Bakhtiar S., Cesaro S., Willasch A., Corbacioglu S., Bader P., Nava T., Nava, T, Ansari, M, Dalle, J, de Heredia, C, Gungor, T, Trigoso, E, Falkenberg, U, Bertaina, A, Gibson, B, Jarisch, A, Balduzzi, A, Boenig, H, Krivan, G, Vettenranta, K, Matic, T, Buechner, J, Kalwak, K, Lawitschka, A, Yesilipek, A, Lucchini, G, Peters, C, Turkiewicz, D, Niinimaki, R, Diesch, T, Lehrnbecher, T, Sedlacek, P, Hutt, D, Dalissier, A, Wachowiak, J, Yaniv, I, Stein, J, Yalcin, K, Sisinni, L, Deiana, M, Ifversen, M, Kuhlen, M, Meisel, R, Bakhtiar, S, Cesaro, S, Willasch, A, Corbacioglu, S, Bader, P, Nava T., Ansari M., Dalle J. -H., de Heredia C. D., Gungor T., Trigoso E., Falkenberg U., Bertaina A., Gibson B., Jarisch A., Balduzzi A., Boenig H., Krivan G., Vettenranta K., Matic T., Buechner J., Kalwak K., Lawitschka A., Yesilipek A., Lucchini G., Peters C., Turkiewicz D., Niinimaki R., Diesch T., Lehrnbecher T., Sedlacek P., Hutt D., Dalissier A., Wachowiak J., Yaniv I., Stein J., Yalcin K., Sisinni L., Deiana M., Ifversen M., Kuhlen M., Meisel R., Bakhtiar S., Cesaro S., Willasch A., Corbacioglu S., and Bader P.
Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Published: 2020

17. Results of Stem Cell Transplantation in Children with CML in Comparison with Treatment with Cytostatics alone or with Interferon alfa. Report of the Polish Children’s Leukemia/ Lymphoma Study Group

Author: Chybicka, A., Kalwak, K., Boguslawska-Jaworska, J., Balcerska, A., Balwierz, W., Cwiklinska, M., Hicke, A., Kaczmarek-Kanold, M., Kolecki, P., Kowalczyk, J., Krauze, A., Matysiak, M., Ploszynska, A., Rokicka-Milewska, R., Sonta-Jakimczyk, D., Sikorska-Fic, B., Wisniewska-Slusarz, H., Wysocki, M., Wachowiak, J., Berdel, W. E., editor, Büchner, Th., editor, Kienast, J., editor, Jürgens, H., editor, Ritter, J., editor, and Vormoor, J., editor
Published: 2003
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18. Recommendations on hematopoietic stem cell transplantation for inherited bone marrow failure syndromes

Author: Peffault de Latour, R, Peters, C, Gibson, B, Strahm, B, Lankester, A, de Heredia, C D, Longoni, D, Fioredda, F, Locatelli, F, Yaniv, I, Wachowiak, J, Donadieu, J, Lawitschka, A, Bierings, M, Wlodarski, M, Corbacioglu, S, Bonanomi, S, Samarasinghe, S, Leblanc, T, Dufour, C, and Dalle, J-H
Published: 2015
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19. Paediatric reduced intensity conditioning: analysis of centre strategies on regimens and definitions by the EBMT Paediatric Diseases and Complications and Quality of Life WP

Author: Lawitschka, A, Faraci, M, Yaniv, I, Veys, P, Bader, P, Wachowiak, J, Socie, G, Aljurf, M D, Arat, M, Boelens, J J, Duarte, R, Tichelli, A, and Peters, C
Published: 2015
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20. Adoptive therapy with donor lymphocyte infusion after allogenic hematopoietic SCT in pediatric patients

Author: Gozdzik, J, Rewucka, K, Krasowska-Kwiecien, A, Pieczonka, A, Debski, R, Zaucha-Prazmo, A, Drabko, K, Krukowska-Jaros, J, Wozniak, M, Kowalczyk, J, Wysocki, M, Gorczynska, E, Kalwak, K, Chybicka, A, and Wachowiak, J
Published: 2015
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21. The Results of Treatment of Acute Lymphoblastic Leukemia Relapses in the Polish Children’s Leukemia/Lymphoma Study Group

Author: Bogusławska-Jaworska, J., Pisarek, J., Chybicka, A., Kazanowska, B., Armata, J., Balwierz, W., Bubała, H., Jackowska, T., Michalewska, D., Ochocka, M., Radwanska, U., Milewska, R. Rokicka, Rytlewska, M., Skomra, S., Sladkowska, G., Wachowiak, J., Wieczorek, M., Zelenay, E., Sońta-Jakimczuk, D., Woźniak, A., Neth, Rolf, editor, Frolova, Elena, editor, Gallo, Robert C., editor, Greaves, Melvyn F., editor, Afanasiev, Boris V., editor, and Elstner, Elena, editor
Published: 1992
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22. Transplantation in Children and Adolescents with Acute Lymphoblastic Leukemia from a Matched Donor versus an HLA-Identical Sibling: Is the Outcome Comparable? Results from the International BFM ALL SCT 2007 Study

Author: Balduzzi, A, Dalle, J, Wachowiak, J, Yaniv, I, Yesilipek, A, Sedlacek, P, Bierings, M, Ifversen, M, Sufliarska, S, Kalwak, K, Lankester, A, Toporski, J, Di Maio, L, Glogova, E, Poetschger, U, Peters, C, Balduzzi A., Dalle J. -H., Wachowiak J., Yaniv I., Yesilipek A., Sedlacek P., Bierings M., Ifversen M., Sufliarska S., Kalwak K., Lankester A., Toporski J., Di Maio L., Glogova E., Poetschger U., Peters C., Balduzzi, A, Dalle, J, Wachowiak, J, Yaniv, I, Yesilipek, A, Sedlacek, P, Bierings, M, Ifversen, M, Sufliarska, S, Kalwak, K, Lankester, A, Toporski, J, Di Maio, L, Glogova, E, Poetschger, U, Peters, C, Balduzzi A., Dalle J. -H., Wachowiak J., Yaniv I., Yesilipek A., Sedlacek P., Bierings M., Ifversen M., Sufliarska S., Kalwak K., Lankester A., Toporski J., Di Maio L., Glogova E., Poetschger U., and Peters C.
Abstract: Eligibility criteria for hematopoietic stem cell transplantation (HSCT) in acute lymphoblastic leukemia (ALL) vary according to disease characteristics, response to treatment, and type of available donor. As the risk profile of the patient worsens, a wider degree of HLA mismatching is considered acceptable. A total of 138 children and adolescents who underwent HSCT from HLA-identical sibling donors (MSDs) and 210 who underwent HSCT from matched donors (MDs) (median age, 9 years; 68% male) in 10 countries were enrolled in the International-BFM ALL SCT 2007 prospective study to assess the impact of donor type in HSCT for pediatric ALL. The 4-year event-free survival (65 ± 5% vs 61 ± 4%; P =.287), overall survival (72 ± 4% versus 68 ± 4%; P =.235), cumulative incidence of relapse (24 ± 4% versus 25 ± 3%; P =.658) and nonrelapse mortality (10 ± 3% versus 14 ± 3%; P =.212) were not significantly different between MSD and MD graft recipients. The risk of extensive chronic (cGVHD) was lower in MD graft recipients than in MSD graft recipients (hazard ratio [HR],.38; P =.002), and the risks of severe acute GVHD (aGVHD) and cGVHD were higher in peripheral blood stem cell graft recipients than in bone marrow graft recipients (HR, 2.06; P =.026). Compared with the absence of aGVHD, grade I-II aGVHD was associated with a lower risk of graft failure (HR,.63; P =.042) and grade III-IV aGVHD was associated with a higher risk of graft failure (HR, 1.85; P =.020) and nonleukemic death (HR, 8.76; P <.0001), despite a lower risk of relapse (HR,.32; P =.021). Compared with the absence of cGVHD, extensive cGVHD was associated with a higher risk of nonleukemic death (HR, 8.12; P <.0001). Because the outcomes of transplantation from a matched donor were not inferior to those of transplantation from an HLA-identical sibling, eligibility criteria for transplantation might be reviewed in pediatric ALL and possibly in other malignancies as well. Bone marrow should be the preferred stem c
Published: 2019

23. The Relationship Between GI symptoms, State and Trait Anxiety, and Lifestyle Factors in Males and Females During the SARS-CoV-2 Pandemic

Author: Evenson, A., primary, Johnson, K., additional, Berens, B., additional, Wachowiak, J., additional, Knapek, J., additional, Giachino, C., additional, Keyler, T., additional, and Bohn-Gettler, C., additional
Published: 2021
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24. Recommendations on hematopoietic stem cell transplantation for inherited bone marrow failure syndromes

Author: de Latour, Peffault R, Peters, C, Gibson, B, Strahm, B, Lankester, A, de Heredia, CD, Longoni, D, Fioredda, F, Locatelli, F, Yaniv, I, Wachowiak, J, Donadieu, J, Lawitschka, A, Bierings, M, Wlodarski, M, Corbacioglu, S, Bonanomi, S, Samarasinghe, S, Leblanc, T, Dufour, C, and Dalle, J-H
Published: 2015
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25. Increased risk of infections and infection-related mortality in children undergoing haematopoietic stem cell transplantation compared to conventional anticancer therapy: a multicentre nationwide study

Author: Styczynski, J., Czyzewski, K., Wysocki, M., Gryniewicz-Kwiatkowska, O., Kolodziejczyk-Gietka, A., Salamonowicz, M., Hutnik, L., Zajac-Spychala, O., Zaucha-Prazmo, A., Chelmecka-Wiktorczyk, L., Siewiera, K., Fraczkiewicz, J., Malas, Z., Tomaszewska, R., Irga-Jaworska, N., Plonowski, M., Ociepa, T., Pierlejewski, F., Gamrot, Z., Urbanek-Dadela, A., Gozdzik, J., Stolpa, W., Dembowska-Baginska, B., Perek, D., Matysiak, M., Wachowiak, J., Kowalczyk, J., Balwierz, W., Kalwak, K., Chybicka, A., Badowska, W., Szczepanski, T., Drozynska, E., Krawczuk-Rybak, M., Urasinski, T., Mlynarski, W., Woszczyk, M., Karolczyk, G., Sobol-Milejska, G., and Gil, L.
Published: 2016
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26. First-Line Immunosuppressive Treatment in Children with Aplastic Anemia: Rabbit Antithymocyte Globulin

Author: Pawelec, K., primary, Salamonowicz, M., additional, Panasiuk, A., additional, Demkow, U., additional, Kowalczyk, J., additional, Balwierz, W., additional, Zaleska-Czepko, E., additional, Chybicka, A., additional, Szmyd, K., additional, Szczepanski, T., additional, Bubala, H., additional, Wysocki, M., additional, Kurylak, A., additional, Wachowiak, J., additional, Szpecht, D., additional, Młynarski, W., additional, Bulas, M., additional, Krawczuk-Rybak, M., additional, Leszczynska, E., additional, Urasinski, T., additional, Peregud-Pogorzelski, J., additional, Balcerska, A., additional, Kaczorowska-Hac, B., additional, and Matysiak, M., additional
Published: 2014
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27. Correction: Myeloablative conditioning for allo-HSCT in pediatric ALL: FTBI or chemotherapy?—A multicenter EBMT-PDWP study (Bone Marrow Transplantation, (2020), 55, 8, (1540-1551), 10.1038/s41409-020-0854-0)

Author: Willasch, A. M., Peters, C., Sedlacek, P., Dalle, J. -H., Kitra-Roussou, V., Yesilipek, A., Wachowiak, J., Lankester, A., Prete, A., Hamidieh, A. A., Ifversen, M., Buechner, J., Krivan, G., Hamladji, R. -M., Diaz-de-Heredia, C., Skorobogatova, E., Michel, G., Locatelli, F., Bertaina, A., Veys, P., Dupont, S., Or, R., Gungor, T., Aleinikova, O., Sufliarska, S., Sundin, M., Rascon, J., Kaare, A., Nemet, D., Fagioli, F., Klingebiel, T. E., Styczynski, J., Bierings, M., Nagy, K., Abecasis, M., Afanasyev, B., Ansari, M., Vettenranta, K., Alseraihy, A., Chybicka, A., Robinson, S., Bertrand, Y., Kupesiz, A., Ghavamzadeh, A., Campos, A., Pichler, H., Dalissier, A., Labopin, M., Corbacioglu, S., Balduzzi, A., Galimard, J. -E., and Bader, P.
Subjects: Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, conditioning regimens
Published: 2021

28. Supportive care during pediatric hematopoietic stem cell transplantation: prevention of infections:a report from workshops on supportive care of the Paediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Author: Ifversen, M. (Marianne), Meisel, R. (Roland), Sedlacek, P. (Petr), Kalwak, K. (Krzysztof), Sisinni, L. (Luisa), Hutt, D. (Daphna), Lehrnbecher, T. (Thomas), Balduzzi, A. (Adriana), Diesch, T. (Tamara), Jarisch, A. (Andrea), Güngör, T. (Tayfun), Stein, J. (Jerry), Yaniv, I. (Isaac), Bonig, H. (Halvard), Kuhlen, M. (Michaela), Ansari, M. (Marc), Nava, T. (Tiago), Dalle, J.-H. (Jean-Hugues), Diaz-de-Heredia, C. (Cristina), Trigoso, E. (Eugenia), Falkenberg, U. (Ulrike), Hartmann, M. (Mihaela), Deiana, M. (Marco), Canesi, M. (Marta), Broggi, C. (Chiara), Bertaina, A. (Alice), Gibson, B. (Brenda), Krivan, G. (Gergely), Vettenranta, K. (Kim), Matic, T. (Toni), Buechner, J. (Jochen), Lawitschka, A. (Anita), Peters, C. (Christina), Yesilipek, A. (Akif), Yalçin, K. (Koray), Lucchini, G. (Giovanna), Bakhtiar, S. (Shahrzad), Turkiewicz, D. (Dominik), Niinimäki, R. (Riitta), Wachowiak, J. (Jacek), Cesaro, S. (Simone), Dalissier, A. (Arnaud), Corbacioglu, S. (Selim), Willasch, A. M. (Andre Manfred), Bader, P. (Peter), Ifversen, M. (Marianne), Meisel, R. (Roland), Sedlacek, P. (Petr), Kalwak, K. (Krzysztof), Sisinni, L. (Luisa), Hutt, D. (Daphna), Lehrnbecher, T. (Thomas), Balduzzi, A. (Adriana), Diesch, T. (Tamara), Jarisch, A. (Andrea), Güngör, T. (Tayfun), Stein, J. (Jerry), Yaniv, I. (Isaac), Bonig, H. (Halvard), Kuhlen, M. (Michaela), Ansari, M. (Marc), Nava, T. (Tiago), Dalle, J.-H. (Jean-Hugues), Diaz-de-Heredia, C. (Cristina), Trigoso, E. (Eugenia), Falkenberg, U. (Ulrike), Hartmann, M. (Mihaela), Deiana, M. (Marco), Canesi, M. (Marta), Broggi, C. (Chiara), Bertaina, A. (Alice), Gibson, B. (Brenda), Krivan, G. (Gergely), Vettenranta, K. (Kim), Matic, T. (Toni), Buechner, J. (Jochen), Lawitschka, A. (Anita), Peters, C. (Christina), Yesilipek, A. (Akif), Yalçin, K. (Koray), Lucchini, G. (Giovanna), Bakhtiar, S. (Shahrzad), Turkiewicz, D. (Dominik), Niinimäki, R. (Riitta), Wachowiak, J. (Jacek), Cesaro, S. (Simone), Dalissier, A. (Arnaud), Corbacioglu, S. (Selim), Willasch, A. M. (Andre Manfred), and Bader, P. (Peter)
Abstract: Specific protocols define eligibility, conditioning, donor selection, graft composition and prophylaxis of graft vs. host disease for children and young adults undergoing hematopoietic stem cell transplant (HSCT). However, international protocols rarely, if ever, detail supportive care, including pharmaceutical infection prophylaxis, physical protection with face masks and cohort isolation or food restrictions. Supportive care suffers from a lack of scientific evidence and implementation of practices in the transplant centers brings extensive restrictions to the child’s and family’s daily life after HSCT. Therefore, the Board of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) held a series of dedicated workshops since 2017 with the aim of initiating the production of a set of minimal recommendations. The present paper describes the consensus reached within the field of infection prophylaxis.
Published: 2021

29. Treatment and Outcome Analysis of 639 Relapsed Non-Hodgkin Lymphomas in Children and Adolescents and Resulting Treatment Recommendations

Author: Burkhardt, B, Taj, M, Garnier, N, Minard-Colin, V, Hazar, V, Mellgren, K, Osumi, T, Fedorova, A, Myakova, N, Verdu-Amoros, J, Andres, M, Kabickova, E, Attarbaschi, A, Chiang, A, Bubanska, E, Donska, S, Hjalgrim, L, Wachowiak, J, Pieczonka, A, Uyttebroeck, A, Lazic, J, Loeffen, J, Buechner, J, Niggli, F, Csoka, M, Krivan, G, Palma, J, Burke, G, Beishuizen, A, Koeppen, K, Mueller, S, Herbrueggen, H, Woessmann, W, Zimmermann, M, Balduzzi, A, Pillon, M, Burkhardt, Birgit, Taj, Mary, Garnier, Nathalie, Minard-Colin, Veronique, Hazar, Volkan, Mellgren, Karin, Osumi, Tomoo, Fedorova, Alina, Myakova, Natalia, Verdu-Amoros, Jaime, Andres, Mara, Kabickova, Edita, Attarbaschi, Andishe, Chiang, Alan Kwok Shing, Bubanska, Eva, Donska, Svetlana, Hjalgrim, Lisa Lyngsie, Wachowiak, Jacek, Pieczonka, Anna, Uyttebroeck, Anne, Lazic, Jelena, Loeffen, Jan, Buechner, Jochen, Niggli, Felix, Csoka, Monika, Krivan, Gergely, Palma, Julia, Burke, G A Amos, Beishuizen, Auke, Koeppen, Kristin, Mueller, Stephanie, Herbrueggen, Heidi, Woessmann, Wilhelm, Zimmermann, Martin, Balduzzi, Adriana, Pillon, Marta, Burkhardt, B, Taj, M, Garnier, N, Minard-Colin, V, Hazar, V, Mellgren, K, Osumi, T, Fedorova, A, Myakova, N, Verdu-Amoros, J, Andres, M, Kabickova, E, Attarbaschi, A, Chiang, A, Bubanska, E, Donska, S, Hjalgrim, L, Wachowiak, J, Pieczonka, A, Uyttebroeck, A, Lazic, J, Loeffen, J, Buechner, J, Niggli, F, Csoka, M, Krivan, G, Palma, J, Burke, G, Beishuizen, A, Koeppen, K, Mueller, S, Herbrueggen, H, Woessmann, W, Zimmermann, M, Balduzzi, A, Pillon, M, Burkhardt, Birgit, Taj, Mary, Garnier, Nathalie, Minard-Colin, Veronique, Hazar, Volkan, Mellgren, Karin, Osumi, Tomoo, Fedorova, Alina, Myakova, Natalia, Verdu-Amoros, Jaime, Andres, Mara, Kabickova, Edita, Attarbaschi, Andishe, Chiang, Alan Kwok Shing, Bubanska, Eva, Donska, Svetlana, Hjalgrim, Lisa Lyngsie, Wachowiak, Jacek, Pieczonka, Anna, Uyttebroeck, Anne, Lazic, Jelena, Loeffen, Jan, Buechner, Jochen, Niggli, Felix, Csoka, Monika, Krivan, Gergely, Palma, Julia, Burke, G A Amos, Beishuizen, Auke, Koeppen, Kristin, Mueller, Stephanie, Herbrueggen, Heidi, Woessmann, Wilhelm, Zimmermann, Martin, Balduzzi, Adriana, and Pillon, Marta
Abstract: Despite poor survival, controversies remain in the treatment for refractory or relapsed pediatric non-Hodgkin lymphoma (r/r NHL). The current project aimed to collect international experience on the re-induction treatment of r/r NHL, hematopoietic stem cell transplantation (HSCT), risk factors associated with outcome, and to suggest treatment recommendations. Inclusion criteria were (i) refractory disease, disease progression or relapse of any NHL subtype except anaplastic large cell lymphoma, (ii) age < 18 years at initial diagnosis, (iii) diagnosis in/after January 2000. Data from 639 eligible patients were evaluable. The eight-year probability of overall survival was 34 ± 2% with highly significant differences according to NHL subtypes: 28 ± 3% for 254 Burkitt lymphoma/leukemia, 50 ± 6% for 98 diffuse large B-cell lymphomas, 57 ± 8% for 41 primary mediastinal large B-cell lymphomas, 27 ± 3% for 177 T-lymphoblastic lymphomas, 52 ± 10% for 34 precursor-B-cell lymphoblastic lymphomas and 30 ± 9% for 35 patients with rare NHL subtypes. Subtype-specific factors associated with survival and treatment recommendations are suggested. There were no survivors without HSCT, except in few very small subgroups. Conclusions: There is an urgent need to further improve survival in r/r NHL. The current study provides the largest real-world series, which underlines the role of HSCT and suggests treatment recommendations.
Published: 2021

30. Treosulfan-based preparative regimens for allo-HSCT in childhood hematological malignancies: a retrospective study on behalf of the EBMT pediatric diseases working party

Author: Wachowiak, J, Sykora, K-W, Cornish, J, Chybicka, A, Kowalczyk, J R, Gorczyńska, E, Choma, M, Grund, G, and Peters, C
Published: 2011
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31. Long-term results in children with standard risk acute lymphoblastic leukaemia treated with 5.0 g/m2 versus 3.0 g/m2 methotrexate i.v. according to the modified ALL-BFM 90 protocol. The report of Polish paediatric Leukemia/lymphoma study group

Author: Derwich, K., Wachowiak, J., Zając-Spychała, O., Balcerska, A., Balwierz, W., Chybicka, A., Kowalczyk, J. R., Matysiak, M., Jackowska, T., Sońta-Jakimczyk, D., Szczepański, T., and Wysocki, M.
Published: 2011
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32. RESULTS OF MUD-HSCT IN CHILDREN WITH AML IN CR2 TREATED BETWEEN 2005-2013 - REPORT OF THE POLISH PEDIATRIC STUDY GROUPS FOR LEUKEMIA/LYMPHOMA AND FOR HEMATOPOIETIC STEM CELL TRANSPLANTATION: PH-AB192

Author: Skalska-Sadowska, J., Pieczonka, A., Balwierz, W., Pawińska-Wąsikowska, K., Goździk, J., Chybicka, A., Gorczyńska, E., Kalwak, K., Potocka, K., Kowalczyk, J., Drabko, K., Wójcik, B., Wysocki, M., Kołtan, S., Styczyński, J., and Wachowiak, J.
Published: 2014

33. NON-TBI CONDITIONING FOR CHILDREN WITH ALL BEFORE FIRST ALLOGENEIC HSCT: PH-P562

Author: Zubarovskaya, N., de Heredia, Diaz C., Locatelli, F., Dalle, J.-H., Bader, P., Wachowiak, J., Yesilipek, A., and Peters, C.
Published: 2014

34. A PRELIMINARY POPULATION PHARMACOKINETIC MODEL FOR DOSE SELECTION OF TREOSULFAN USED IN CONDITIONING TREATMENT PRIOR TO HAEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) IN CHILDREN: PH-P543

Author: Van Den Berg, P. J, Ruppert, M., Sykora, K.-W., Beier, R., Beelen, D. W, Hilger, R. A, Scheulen, M. E, Wachowiak, J., Nemecek, E. R, Spaans, E., Lioznov, M., Pichlmeier, U., Wullf, B., and Baumgart, J.
Published: 2014

35. Pharmacokinetics of high-dose i.v. treosulfan in children undergoing treosulfan-based preparative regimen for allogeneic haematopoietic SCT

Author: Główka, F K, Karaźniewicz-łada, M, Grund, G, Wróbel, T, and Wachowiak, J
Published: 2008
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36. Haematopoietic stem cell transplantation in children in eastern European countries 1985–2004: development, recent activity and role of the EBMT/ESH Outreach Programme

Author: Wachowiak, J, Labopin, M, Miano, M, Chybicka, A, Stary, J, Sterba, J, Masszi, T, Labar, B, Maschan, A, Kowalczyk, J R, Lange, A, Holowiecki, J, Kalman, N, Afanassiev, B V, and Dini, G
Published: 2008
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37. Allogeneic Stem Cell Transplantation from HLA-Mismatched Donors for Pediatric Patients with Acute Lymphoblastic Leukemia Treated According to the 2003 BFM and 2007 International BFM Studies: Impact of Disease Risk on Outcomes

Author: Dalle, J, Balduzzi, A, Bader, P, Lankester, A, Yaniv, I, Wachowiak, J, Pieczonka, A, Bierings, M, Yesilipek, A, Sedlaçek, P, Ifversen, M, Sufliarska, S, Toporski, J, Glogova, E, Poetschger, U, Peters, C, Dalle JH, Balduzzi A, Bader P, Lankester A, Yaniv I, Wachowiak J, Pieczonka A, Bierings M, Yesilipek A, Sedlaçek P, Ifversen M, Sufliarska S, Toporski J, Glogova E, Poetschger U, Peters C, Dalle, J, Balduzzi, A, Bader, P, Lankester, A, Yaniv, I, Wachowiak, J, Pieczonka, A, Bierings, M, Yesilipek, A, Sedlaçek, P, Ifversen, M, Sufliarska, S, Toporski, J, Glogova, E, Poetschger, U, Peters, C, Dalle JH, Balduzzi A, Bader P, Lankester A, Yaniv I, Wachowiak J, Pieczonka A, Bierings M, Yesilipek A, Sedlaçek P, Ifversen M, Sufliarska S, Toporski J, Glogova E, Poetschger U, and Peters C
Abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) is beneficial for pediatric patients with relapsed or (very) high-risk acute lymphoblastic leukemia (ALL) in remission. A total of 1115 consecutive patients were included in the ALL SCT 2003 BFM study and the ALL SCT 2007 I-BFM study and were stratified according to relapse risk (standard versus high versus very high risk of relapse) and donor type (matched sibling versus matched donor versus mismatched donor). A total of 148 patients (60% boys; median age, 8.7 years; B cell precursor ALL, 75%) were transplanted from mismatched donors, which was defined as either less than 9/10 HLA-compatible donors or less than 5/6 unrelated cord blood after myeloablative conditioning regimen (total body irradiation based, 67%) for high relapse risk (HRR; n = 42) or very HRR (VHRR) disease (n = 106). The stem cell source was either bone marrow (n = 31), unmanipulated peripheral stem cells (n = 28), T cell ex vivo depleted peripheral stem cells (n = 59), or cord blood (n = 25). The median follow-up was 5.1 years. The 4-year rates of overall survival (OS) and event-free survival were 56% ± 4% and 52% ± 4%, respectively, for the entire cohort. Patients transplanted from mismatched donors for HRR disease obtained remarkable 4-year OS and event-free survival values of 82% ± 6% and 80% ± 6%, respectively, whereas VHRR patients obtained values of 45% ± 5% and 42% ± 5% (P <.001), respectively. The cumulative incidence of relapse was 29% ± 4% and that of nonrelapse mortality 19% ± 3%. The cumulative incidence of limited and extensive chronic graft-versus-host disease was 13% ± 3% and 15% ± 4%, respectively, among the 120 patients living beyond day 100. Multivariate analysis showed that OS was lower for transplanted VHRR patients (P =.002; hazard ratio [HR], 3.62; 95% confidence interval [CI], 1.60 to 8.20) and for patients beyond second complete remission (CR2) versus first complete remission (P <.001; HR, 3.68; 95% CI, 1.79 to 7.56)
Published: 2018

38. Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: A new classification from the European society for blood and marrow transplantation

Author: Corbacioglu, S, Carreras, E, Ansari, M, Balduzzi, A, Cesaro, S, Dalle, J, Dignan, F, Gibson, B, Guengoer, T, Gruhn, B, Lankester, A, Locatelli, F, Pagliuca, A, Peters, C, Richardson, P, Schulz, A, Sedlacek, P, Stein, J, Sykora, K, Toporski, J, Trigoso, E, Vetteranta, K, Wachowiak, J, Wallhult, E, Wynn, R, Yaniv, I, Yesilipek, A, Mohty, M, Bader, P, Corbacioglu, S., Carreras, E., Ansari, M., Balduzzi, A., Cesaro, S., Dalle, J. -H., Dignan, F., Gibson, B., Guengoer, T., Gruhn, B., Lankester, A., Locatelli, F., Pagliuca, A., Peters, C., Richardson, P. G., Schulz, A. S., Sedlacek, P., Stein, J., Sykora, K. -W., Toporski, J., Trigoso, E., Vetteranta, K., Wachowiak, J., Wallhult, E., Wynn, R., Yaniv, I., Yesilipek, A., Mohty, M., Bader, P., Corbacioglu, S, Carreras, E, Ansari, M, Balduzzi, A, Cesaro, S, Dalle, J, Dignan, F, Gibson, B, Guengoer, T, Gruhn, B, Lankester, A, Locatelli, F, Pagliuca, A, Peters, C, Richardson, P, Schulz, A, Sedlacek, P, Stein, J, Sykora, K, Toporski, J, Trigoso, E, Vetteranta, K, Wachowiak, J, Wallhult, E, Wynn, R, Yaniv, I, Yesilipek, A, Mohty, M, Bader, P, Corbacioglu, S., Carreras, E., Ansari, M., Balduzzi, A., Cesaro, S., Dalle, J. -H., Dignan, F., Gibson, B., Guengoer, T., Gruhn, B., Lankester, A., Locatelli, F., Pagliuca, A., Peters, C., Richardson, P. G., Schulz, A. S., Sedlacek, P., Stein, J., Sykora, K. -W., Toporski, J., Trigoso, E., Vetteranta, K., Wachowiak, J., Wallhult, E., Wynn, R., Yaniv, I., Yesilipek, A., Mohty, M., and Bader, P.
Abstract: The advances in hematopoietic cell transplantation (HCT) over the last decade have led to a transplant-related mortality below 15%. Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication of HCT that belongs to a group of diseases increasingly identified as transplant-related, systemic endothelial diseases. In most cases, SOS/VOD resolves within weeks; however, severe SOS/VOD results in multi-organ dysfunction/failure with a mortality rate >80%. A timely diagnosis of SOS/VOD is of critical importance, given the availability of therapeutic options with favorable tolerability. Current diagnostic criteria are used for adults and children. However, over the last decade it has become clear that SOS/VOD is significantly different between the age groups in terms of incidence, genetic predisposition, clinical presentation, prevention, treatment and outcome. Improved understanding of SOS/VOD and the availability of effective treatment questions the use of the Baltimore and Seattle criteria for diagnosing SOS/VOD in children. The aim of this position paper is to propose new diagnostic and severity criteria for SOS/VOD in children on behalf of the European Society for Blood and Marrow Transplantation.
Published: 2018

39. Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children

Author: Uden, T., Bertaina, A., Abrahamsson, J., Ansari, M., Balduzzi, A., Bourquin, J. -P., Gerhardt, C., Bierings, M., Hasle, H., Lankester, A., Mischke, K., Moore, A. S., Nivison-Smith, I., Pieczonka, A., Peters, C., Sedlacek, P., Reinhardt, D., Stein, J., Versluys, B., Wachowiak, J., Willems, L., Zimmermann, M., Locatelli, Franco, Sauer, M. G., Locatelli F. (ORCID:0000-0002-7976-3654), Uden, T., Bertaina, A., Abrahamsson, J., Ansari, M., Balduzzi, A., Bourquin, J. -P., Gerhardt, C., Bierings, M., Hasle, H., Lankester, A., Mischke, K., Moore, A. S., Nivison-Smith, I., Pieczonka, A., Peters, C., Sedlacek, P., Reinhardt, D., Stein, J., Versluys, B., Wachowiak, J., Willems, L., Zimmermann, M., Locatelli, Franco, Sauer, M. G., and Locatelli F. (ORCID:0000-0002-7976-3654)
Abstract: Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0·046) and donor choice (matched family vs. matched unrelated donor, P = 0·029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%.
Published: 2020

40. Myeloablative conditioning for allo-HSCT in pediatric ALL: FTBI or chemotherapy?—A multicenter EBMT-PDWP study

Author: Willasch, A. M., Peters, C., Sedlacek, P., Dalle, J. -H., Kitra-Roussou, V., Yesilipek, A., Wachowiak, J., Lankester, A., Prete, A., Hamidieh, A. A., Ifversen, M., Buechner, J., Krivan, G., Hamladji, R. -M., Diaz-de-Heredia, C., Skorobogatova, E., Michel, G., Locatelli, Franco, Bertaina, A., Veys, P., Dupont, S., Or, R., Gungor, T., Aleinikova, O., Sufliarska, S., Sundin, M., Rascon, J., Kaare, A., Nemet, D., Fagioli, F., Klingebiel, T. E., Styczynski, J., Bierings, M., Nagy, K., Abecasis, M., Afanasyev, B., Ansari, M., Vettenranta, K., Alseraihy, A., Chybicka, A., Robinson, S., Bertrand, Y., Kupesiz, A., Ghavamzadeh, A., Campos, A., Pichler, H., Dalissier, A., Labopin, M., Corbacioglu, S., Balduzzi, A., Galimard, J. -E., Bader, P., Locatelli F. (ORCID:0000-0002-7976-3654), Willasch, A. M., Peters, C., Sedlacek, P., Dalle, J. -H., Kitra-Roussou, V., Yesilipek, A., Wachowiak, J., Lankester, A., Prete, A., Hamidieh, A. A., Ifversen, M., Buechner, J., Krivan, G., Hamladji, R. -M., Diaz-de-Heredia, C., Skorobogatova, E., Michel, G., Locatelli, Franco, Bertaina, A., Veys, P., Dupont, S., Or, R., Gungor, T., Aleinikova, O., Sufliarska, S., Sundin, M., Rascon, J., Kaare, A., Nemet, D., Fagioli, F., Klingebiel, T. E., Styczynski, J., Bierings, M., Nagy, K., Abecasis, M., Afanasyev, B., Ansari, M., Vettenranta, K., Alseraihy, A., Chybicka, A., Robinson, S., Bertrand, Y., Kupesiz, A., Ghavamzadeh, A., Campos, A., Pichler, H., Dalissier, A., Labopin, M., Corbacioglu, S., Balduzzi, A., Galimard, J. -E., Bader, P., and Locatelli F. (ORCID:0000-0002-7976-3654)
Abstract: Although most children with acute lymphoblastic leukemia (ALL) receive fractionated total body irradiation (FTBI) as myeloablative conditioning (MAC) for allogeneic hematopoietic stem cell transplantation (allo-HSCT), it is an important matter of debate if chemotherapy can effectively replace FTBI. To compare outcomes after FTBI versus chemotherapy-based conditioning (CC), we performed a retrospective EBMT registry study. Children aged 2–18 years after MAC for first allo-HSCT of bone marrow (BM) or peripheral blood stem cells (PBSC) from matched-related (MRD) or unrelated donors (UD) in first (CR1) or second remission (CR2) between 2000 and 2012 were included. Propensity score weighting was used to control pretreatment imbalances of the observed variables. 3.054 patients were analyzed. CR1 (1.498): median follow-up (FU) after FTBI (1.285) and CC (213) was 6.8 and 6.1 years. Survivals were not significantly different. CR2 (1.556): median FU after FTBI (1.345) and CC (211) was 6.2 years. Outcomes after FTBI were superior as compared with CC with regard to overall survival (OS), leukemia-free survival (LFS), relapse incidence (RI), and nonrelapse mortality (NRM). However, we must emphasize the preliminary character of the results of this retrospective “real-world-practice” study. These findings will be prospectively assessed in the ALL SCTped 2012 FORUM trial.
Published: 2020

41. Myeloablative conditioning for allo-HSCT in pediatric ALL: FTBI or chemotherapy?—A multicenter EBMT-PDWP study

Author: Willasch, A, Peters, C, Sedláček, P, Dalle, J, Kitra-Roussou, V, Yesilipek, A, Wachowiak, J, Lankester, A, Prete, A, Hamidieh, A, Ifversen, M, Buechner, J, Kriván, G, Hamladji, R, Diaz-de-Heredia, C, Skorobogatova, E, Michel, G, Locatelli, F, Bertaina, A, Veys, P, Dupont, S, Or, R, Güngör, T, Aleinikova, O, Sufliarska, S, Sundin, M, Rascon, J, Kaare, A, Nemet, D, Fagioli, F, Klingebiel, T, Styczynski, J, Bierings, M, Nagy, K, Abecasis, M, Afanasyev, B, Ansari, M, Vettenranta, K, Alseraihy, A, Chybicka, A, Robinson, S, Bertrand, Y, Kupesiz, A, Ghavamzadeh, A, Campos, A, Pichler, H, Dalissier, A, Labopin, M, Corbacioglu, S, Balduzzi, A, Galimard, J, Bader, P, Willasch, Andre Manfred, Peters, Christina, Sedláček, Petr, Dalle, Jean-Hugues, Kitra-Roussou, Vassiliki, Yesilipek, Akif, Wachowiak, Jacek, Lankester, Arjan, Prete, Arcangelo, Hamidieh, Amir Ali, Ifversen, Marianne, Buechner, Jochen, Kriván, Gergely, Hamladji, Rose-Marie, Diaz-de-Heredia, Cristina, Skorobogatova, Elena, Michel, Gérard, Locatelli, Franco, Bertaina, Alice, Veys, Paul, Dupont, Sophie, Or, Reuven, Güngör, Tayfun, Aleinikova, Olga, Sufliarska, Sabina, Sundin, Mikael, Rascon, Jelena, Kaare, Ain, Nemet, Damir, Fagioli, Franca, Klingebiel, Thomas Erich, Styczynski, Jan, Bierings, Marc, Nagy, Kálmán, Abecasis, Manuel, Afanasyev, Boris, Ansari, Marc, Vettenranta, Kim, Alseraihy, Amal, Chybicka, Alicja, Robinson, Stephen, Bertrand, Yves, Kupesiz, Alphan, Ghavamzadeh, Ardeshir, Campos, Antonio, Pichler, Herbert, Dalissier, Arnaud, Labopin, Myriam, Corbacioglu, Selim, Balduzzi, Adriana, Galimard, Jacques-Emmanuel, Bader, Peter, Willasch, A, Peters, C, Sedláček, P, Dalle, J, Kitra-Roussou, V, Yesilipek, A, Wachowiak, J, Lankester, A, Prete, A, Hamidieh, A, Ifversen, M, Buechner, J, Kriván, G, Hamladji, R, Diaz-de-Heredia, C, Skorobogatova, E, Michel, G, Locatelli, F, Bertaina, A, Veys, P, Dupont, S, Or, R, Güngör, T, Aleinikova, O, Sufliarska, S, Sundin, M, Rascon, J, Kaare, A, Nemet, D, Fagioli, F, Klingebiel, T, Styczynski, J, Bierings, M, Nagy, K, Abecasis, M, Afanasyev, B, Ansari, M, Vettenranta, K, Alseraihy, A, Chybicka, A, Robinson, S, Bertrand, Y, Kupesiz, A, Ghavamzadeh, A, Campos, A, Pichler, H, Dalissier, A, Labopin, M, Corbacioglu, S, Balduzzi, A, Galimard, J, Bader, P, Willasch, Andre Manfred, Peters, Christina, Sedláček, Petr, Dalle, Jean-Hugues, Kitra-Roussou, Vassiliki, Yesilipek, Akif, Wachowiak, Jacek, Lankester, Arjan, Prete, Arcangelo, Hamidieh, Amir Ali, Ifversen, Marianne, Buechner, Jochen, Kriván, Gergely, Hamladji, Rose-Marie, Diaz-de-Heredia, Cristina, Skorobogatova, Elena, Michel, Gérard, Locatelli, Franco, Bertaina, Alice, Veys, Paul, Dupont, Sophie, Or, Reuven, Güngör, Tayfun, Aleinikova, Olga, Sufliarska, Sabina, Sundin, Mikael, Rascon, Jelena, Kaare, Ain, Nemet, Damir, Fagioli, Franca, Klingebiel, Thomas Erich, Styczynski, Jan, Bierings, Marc, Nagy, Kálmán, Abecasis, Manuel, Afanasyev, Boris, Ansari, Marc, Vettenranta, Kim, Alseraihy, Amal, Chybicka, Alicja, Robinson, Stephen, Bertrand, Yves, Kupesiz, Alphan, Ghavamzadeh, Ardeshir, Campos, Antonio, Pichler, Herbert, Dalissier, Arnaud, Labopin, Myriam, Corbacioglu, Selim, Balduzzi, Adriana, Galimard, Jacques-Emmanuel, and Bader, Peter
Abstract: Although most children with acute lymphoblastic leukemia (ALL) receive fractionated total body irradiation (FTBI) as myeloablative conditioning (MAC) for allogeneic hematopoietic stem cell transplantation (allo-HSCT), it is an important matter of debate if chemotherapy can effectively replace FTBI. To compare outcomes after FTBI versus chemotherapy-based conditioning (CC), we performed a retrospective EBMT registry study. Children aged 2-18 years after MAC for first allo-HSCT of bone marrow (BM) or peripheral blood stem cells (PBSC) from matched-related (MRD) or unrelated donors (UD) in first (CR1) or second remission (CR2) between 2000 and 2012 were included. Propensity score weighting was used to control pretreatment imbalances of the observed variables. 3.054 patients were analyzed. CR1 (1.498): median follow-up (FU) after FTBI (1.285) and CC (213) was 6.8 and 6.1 years. Survivals were not significantly different. CR2 (1.556): median FU after FTBI (1.345) and CC (211) was 6.2 years. Outcomes after FTBI were superior as compared with CC with regard to overall survival (OS), leukemia-free survival (LFS), relapse incidence (RI), and nonrelapse mortality (NRM). However, we must emphasize the preliminary character of the results of this retrospective "real-world-practice" study. These findings will be prospectively assessed in the ALL SCTped 2012 FORUM trial.
Published: 2020

42. Pediatric acute graft-versus-host disease prophylaxis and treatment: surveyed real-life approach reveals dissimilarities compared to published recommendations

Author: Lawitschka, A, Lucchini, G, Strahm, B, Dalle, J, Balduzzi, A, Gibson, B, Diaz De Heredia, C, Wachowiak, J, Dalissier, A, Vettenranta, K, Yaniv, I, Bordon, V, Bauer, D, Bader, P, Meisel, R, Peters, C, Corbacioglu, S, Lawitschka, Anita, Lucchini, Giovanna, Strahm, Brigitte, Dalle, Jean-Hugues, Balduzzi, Adriana, Gibson, Brenda, Diaz De Heredia, Cristina, Wachowiak, Jacek, Dalissier, Arnaud, Vettenranta, Kim, Yaniv, Isaac, Bordon, Victoria, Bauer, Dorothea, Bader, Peter, Meisel, Roland, Peters, Christina, Corbacioglu, Selim, Lawitschka, A, Lucchini, G, Strahm, B, Dalle, J, Balduzzi, A, Gibson, B, Diaz De Heredia, C, Wachowiak, J, Dalissier, A, Vettenranta, K, Yaniv, I, Bordon, V, Bauer, D, Bader, P, Meisel, R, Peters, C, Corbacioglu, S, Lawitschka, Anita, Lucchini, Giovanna, Strahm, Brigitte, Dalle, Jean-Hugues, Balduzzi, Adriana, Gibson, Brenda, Diaz De Heredia, Cristina, Wachowiak, Jacek, Dalissier, Arnaud, Vettenranta, Kim, Yaniv, Isaac, Bordon, Victoria, Bauer, Dorothea, Bader, Peter, Meisel, Roland, Peters, Christina, and Corbacioglu, Selim
Abstract: Pediatric allogeneic hematopoietic cell transplantation (HCT) practices differ from those of adults, particularly the heterogeneity of transplantable nonmalignant diseases and the lower incidence of graft-versus-host disease (GVHD). Several guidelines regarding the management of acute (a) GVHD in adult HCT have been published. We aimed to capture the real-life approaches for pediatric aGVHD prophylaxis/treatment, and data from 75/193 (response rate 39%) EBMT centers (26 countries) were included, representing half (48%) of the pediatric EBMT-HCT activity. Results with ≥75% approval from respondents (74/75) for GVHD prophylaxis after myeloablative HCT for malignancies partially contradict published guidelines: Single-agent cyclosporine A (CsA) was used for matched sibling donor HCT in 47%; blood CsA levels were reported lower; the relapse risk in malignant diseases influenced GVHD prophylaxis with early withdrawal of CsA; distinct longer duration of CsA was employed in nonmalignant diseases. Most centers used additional anti-thymocyte globulin for matched unrelated and mismatched donor HCT, but not for matched siblings. Regarding prophylaxis in nonmyeloablative conditioning (mainly for nonmalignant diseases), responses showed broad heterogeneity. High conformity was found for first-line treatment; however, results regarding steroid-refractory aGVHD indicate an earlier diagnosis in children. Our findings highlight the need for standardized pediatric approaches toward aGVHD prophylaxis/treatment differentiated for malignant and nonmalignant underlying diseases.
Published: 2020

43. Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children

Author: Uden, T, Bertaina, A, Abrahamsson, J, Ansari, M, Balduzzi, A, Bourquin, J, Gerhardt, C, Bierings, M, Hasle, H, Lankester, A, Mischke, K, Moore, A, Nivison-Smith, I, Pieczonka, A, Peters, C, Sedlacek, P, Reinhardt, D, Stein, J, Versluys, B, Wachowiak, J, Willems, L, Zimmermann, M, Locatelli, F, Sauer, M, Uden, Theodor, Bertaina, Alice, Abrahamsson, Jonas, Ansari, Marc, Balduzzi, Adriana, Bourquin, Jean-Pierre, Gerhardt, Corinne, Bierings, Marc, Hasle, Henrik, Lankester, Arjan, Mischke, Kirsten, Moore, Andrew S, Nivison-Smith, Ian, Pieczonka, Anna, Peters, Christina, Sedlacek, Petr, Reinhardt, Dirk, Stein, Jerry, Versluys, Birgitta, Wachowiak, Jacek, Willems, Leen, Zimmermann, Martin, Locatelli, Franco, Sauer, Martin G, Uden, T, Bertaina, A, Abrahamsson, J, Ansari, M, Balduzzi, A, Bourquin, J, Gerhardt, C, Bierings, M, Hasle, H, Lankester, A, Mischke, K, Moore, A, Nivison-Smith, I, Pieczonka, A, Peters, C, Sedlacek, P, Reinhardt, D, Stein, J, Versluys, B, Wachowiak, J, Willems, L, Zimmermann, M, Locatelli, F, Sauer, M, Uden, Theodor, Bertaina, Alice, Abrahamsson, Jonas, Ansari, Marc, Balduzzi, Adriana, Bourquin, Jean-Pierre, Gerhardt, Corinne, Bierings, Marc, Hasle, Henrik, Lankester, Arjan, Mischke, Kirsten, Moore, Andrew S, Nivison-Smith, Ian, Pieczonka, Anna, Peters, Christina, Sedlacek, Petr, Reinhardt, Dirk, Stein, Jerry, Versluys, Birgitta, Wachowiak, Jacek, Willems, Leen, Zimmermann, Martin, Locatelli, Franco, and Sauer, Martin G
Abstract: Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0·046) and donor choice (matched family vs. matched unrelated donor, P = 0·029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%.
Published: 2020

44. Supportive care during pediatric hematopoietic stem cell transplantation: beyond infectious diseases. A report from workshops on supportive care of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Author: Nava, T, Ansari, M, Dalle, J, de Heredia, C, Güngör, T, Trigoso, E, Falkenberg, U, Bertaina, A, Gibson, B, Jarisch, A, Balduzzi, A, Boenig, H, Krivan, G, Vettenranta, K, Matic, T, Büchner, J, Kalwak, K, Lawitschka, A, Yesilipek, A, Lucchini, G, Peters, C, Turkiewicz, D, Niinimäki, R, Diesch, T, Lehrnbecher, T, Sedlacek, P, Hutt, D, Dalissier, A, Wachowiak, J, Yaniv, I, Stein, J, Yalçin, K, Sisinni, L, Deiana, M, Ifversen, M, Kuhlen, M, Miesel, R, Bakhtiar, S, Cesaro, S, Willasch, A, Corbacioglu, S, Bader, P, Nava, Tiago, Ansari, Marc, Dalle, Jean-Hugues, de Heredia, Christina Diaz, Güngör, Tayfun, Trigoso, Eugenia, Falkenberg, Ulrike, Bertaina, Alice, Gibson, Brenda, Jarisch, Andrea, Balduzzi, Adriana, Boenig, Halvard, Krivan, Gergely, Vettenranta, Kim, Matic, Toni, Büchner, Jochen, Kalwak, Krzysztof, Lawitschka, Anita, Yesilipek, Akif, Lucchini, Giovanna, Peters, Christina, Turkiewicz, Dominik, Niinimäki, Riitta, Diesch, Tamara, Lehrnbecher, Thomas, Sedlacek, Petr, Hutt, Daphna, Dalissier, Arnaud, Wachowiak, Jacek, Yaniv, Isaac, Stein, Jerry, Yalçin, Koray, Sisinni, Luisa, Deiana, Marco, Ifversen, Marianne, Kuhlen, Michaela, Miesel, Roland, Bakhtiar, Shahrzad, Cesaro, Simone, Willasch, Andre, Corbacioglu, Selim, Bader, Peter, Nava, T, Ansari, M, Dalle, J, de Heredia, C, Güngör, T, Trigoso, E, Falkenberg, U, Bertaina, A, Gibson, B, Jarisch, A, Balduzzi, A, Boenig, H, Krivan, G, Vettenranta, K, Matic, T, Büchner, J, Kalwak, K, Lawitschka, A, Yesilipek, A, Lucchini, G, Peters, C, Turkiewicz, D, Niinimäki, R, Diesch, T, Lehrnbecher, T, Sedlacek, P, Hutt, D, Dalissier, A, Wachowiak, J, Yaniv, I, Stein, J, Yalçin, K, Sisinni, L, Deiana, M, Ifversen, M, Kuhlen, M, Miesel, R, Bakhtiar, S, Cesaro, S, Willasch, A, Corbacioglu, S, Bader, P, Nava, Tiago, Ansari, Marc, Dalle, Jean-Hugues, de Heredia, Christina Diaz, Güngör, Tayfun, Trigoso, Eugenia, Falkenberg, Ulrike, Bertaina, Alice, Gibson, Brenda, Jarisch, Andrea, Balduzzi, Adriana, Boenig, Halvard, Krivan, Gergely, Vettenranta, Kim, Matic, Toni, Büchner, Jochen, Kalwak, Krzysztof, Lawitschka, Anita, Yesilipek, Akif, Lucchini, Giovanna, Peters, Christina, Turkiewicz, Dominik, Niinimäki, Riitta, Diesch, Tamara, Lehrnbecher, Thomas, Sedlacek, Petr, Hutt, Daphna, Dalissier, Arnaud, Wachowiak, Jacek, Yaniv, Isaac, Stein, Jerry, Yalçin, Koray, Sisinni, Luisa, Deiana, Marco, Ifversen, Marianne, Kuhlen, Michaela, Miesel, Roland, Bakhtiar, Shahrzad, Cesaro, Simone, Willasch, Andre, Corbacioglu, Selim, and Bader, Peter
Abstract: Hematopoietic stem cell transplantation (HSCT) is currently the standard of care for many malignant and nonmalignant blood diseases. As several treatment-emerging acute toxicities are expected, optimal supportive measurements critically affect HSCT outcomes. The paucity of good clinical studies in supportive practices gives rise to the establishment of heterogeneous guidelines across the different centers, which hampers direct clinical comparison in multicentric studies. Aiming to harmonize the supportive care provided during the pediatric HSCT in Europe, the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) promoted dedicated workshops during the years 2017 and 2018. The present paper describes the resulting consensus on the management of sinusoidal obstructive syndrome, mucositis, enteral and parenteral nutrition, iron overload, and emesis during HSCT.
Published: 2020

45. Twenty years of Polish experience with three consecutive protocols for treatment of childhood acute myelogenous leukemia

Author: Dluzniewska, A, Balwierz, W, Armata, J, Balcerska, A, Chybicka, A, Kowalczyk, J, Matysiak, M, Ochocka, M, Radwanska, U, Rokicka-Milewska, R, Sonta-Jakimczyk, D, Wachowiak, J, and Wysocki, M
Published: 2005
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46. Prothrombotic microparticles concentration after percutaneous coronary intervention and stent implantation: PO 249

Author: Zawilska, K M and Wachowiak, J
Published: 2013

47. Thrombomodulin early after allogeneic haematopoietic stem cell transplantation in children conditioned with FTBI versus busulphan-based regimen - preliminary results: P589

Author: Szpecht, D., Kurosz, J., Jaworski, J., Regdos, A., Zawilska, K., Machowska, L., and Wachowiak, J.
Published: 2011

48. Clinical outcome of patients with X-linked adrenoleucodystrophy who underwent allogeneic stem cell transplantation. Report from three Polish paediatric centres: P575

Author: Kulej, D., Porwolik, J., Gorczynska, E., Owoc-Lempach, J., Dyla, A., Musial, J., Ussowicz, M., Mielcarek, M., Biel, A., Bladowska, J., Zaleska-Dorobisz, U., Drabko, K., Pieczonka, A., Wachowiak, J., Chybicka, A., and Kalwak, K.
Published: 2011

49. Risk of complications of haematopoietic stem cell collection in paediatric sibling donors: an EBMT Paediatric Diseases Working Party prospective observational study: O404

Author: Styczynski, J., Balduzzi, A., Gil, L., Ehlert, K., Fagioli, F., Hamladji, R.-M., Marktel, S., Yesilipek, A., Matulova, M., Dalle, J.-H., Wachowiak, J., Miano, M., Varotto, S., Diaz, M. A., Vermylen, C., Eyrich, M., Badell, I., Dreger, P., Gozdzik, J., Hutt, D., Rascon, J., Labopin, M., Elarouci, N., Dini, G., and Peters, C.
Published: 2011

50. Adenovirus infection among pediatric patients with cancer and in pediatric recipients of hematopoietic stem cell: A multicenter nationwide study

Author: Zając‐Spychała, O., primary, Pieczonka, A., additional, Wachowiak, J., additional, Frączkiewicz, J., additional, Salamonowicz, M., additional, Kałwak, K., additional, Gorczyńska, E., additional, Kazanowska, B., additional, Wróbel, G., additional, Chybicka, A., additional, Czyżewski, K., additional, Dziedzic, M., additional, Wysocki, M., additional, Zalas‐Więcek, P., additional, Szmydki‐Baran, A., additional, Hutnik, Ł., additional, Matysiak, M., additional, Irga‐Jaworska, N., additional, Bień, E., additional, Drożyńska, E., additional, Stolpa, W., additional, Sobol‐Milejska, G., additional, Pierlejewski, F., additional, Młynarski, W., additional, Gryniewicz–Kwiatkowska, O., additional, Gietka, A., additional, Dembowska‐Bagińska, B., additional, Semczuk, K., additional, Dzierżanowska‐Fangrat, K., additional, Gamrot‐Pyka, Z., additional, Woszczyk, M., additional, Urbanek‐Dądela, A., additional, Karolczyk, G., additional, Płonowski, M., additional, Krawczuk‐Rybak, M., additional, Zaucha‐Prażmo, A., additional, Kowalczyk, J., additional, Goździk, J., additional, and Styczyński, J., additional
Published: 2020
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