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Your search keyword '"Wang, Ji‐Yao"' showing total 314 results
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314 results on '"Wang, Ji‐Yao"'

1. Dynamics of Viscous Phantom Universe

Author

Wang, Ji-Yao, Feng, Chao-Jun, Zhai, Xiang-Hua, and Li, Xin-Zhou

Subjects
General Relativity and Quantum Cosmology, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The phantom dark energy remarkably boosts our prehension of the accelerating Universe. Various models are widely discussed in the phantom Universe without bulk viscosity. From the hydrodynamics' point of view, it is natural to introduce the nonperfect fluid in the study of the Universe, as an ideal fluid just an approximation to the real world after all and using the generalized equation of state (EoS) with bulk viscosity, the early inflationary universe and the accelerated expansion of the late-time universe are described by many authors. In this paper, in order to investigate how the viscosity will influence the evolution of the Universe, we study a class of phantom dark energy models with bulk viscosity by the method of dynamical analysis technique. We show that there are different cosmic late-time behaviors and the stability also brings some constraints on the models. We also plot the evolutionary trajectories of this model in the statefinder parameter-planes to see the different behaviors of the models from the statefinder viewpoint., Comment: 14 pages, 7 figures

Published
2020

2. Solar System Tests of a New Class of $f(z)$ Theory

Author

Wang, Ji-Yao, Feng, Chao-Jun, Zhai, Xiang-Hua, and Li, Xin-Zhou

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, General Relativity and Quantum Cosmology, High Energy Physics - Theory
Abstract

Recently, a new kind of $f(z)$ theory is proposed to provide a different perspective for the development of reliable alternative models of gravity in which the $f(R)$ Lagrangian terms are reformulated as polynomial parameterizations $f(z)$. In the previous study, the parameters in the $f(z)$ models have been constrained by using cosmological data. In this paper, these models will be tested by the observations in the solar system. After solving the Ricci scalar as a function of the redshift, one could obtain $f(R)$ that could be used to calculate the standard Parameterized-Post-Newtonian (PPN) parameters. First, we fit the parametric models with the latest cosmological observational data. Then the tests are performed by solar system observations. And last we combine the constraints of solar system and cosmology together and reconstruct the $f(R)$ actions of the $f(z)$ parametric models., Comment: 15 pages

Published
2019
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11. Submassive hepatic necrosis distinguishes HBV-associated acute on chronic liver failure from cirrhotic patients with acute decompensation

Author

Li, Hai, Xia, Qiang, Zeng, Bo, Li, Shu-Ting, Liu, Heng, Li, Qi, Li, Jun, Yang, Shu-Yin, Dong, Xiao-Jun, Gao, Ting, Munker, Stefan, Liu, Yan, Liebe, Roman, Xue, Feng, Li, Qi-Gen, Chen, Xiao-Song, Liu, Qiang, Zeng, Hui, Wang, Ji-Yao, Xie, Qing, Meng, Qin-Hua, Wang, Jie-Fei, Mertens, Peter R., Lammert, Frank, Singer, Manfred V., Dooley, Steven, Ebert, Matthias P.A., Qiu, De-Kai, Wang, Tai-Ling, and Weng, Hong-Lei

Published
2015
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12. CSH guidelines for the diagnosis and treatment of drug-induced liver injury

Author

Yu, Yue-cheng, Mao, Yi-min, Chen, Cheng-wei, Chen, Jin-jun, Chen, Jun, Cong, Wen-ming, Ding, Yang, Duan, Zhong-ping, Fu, Qing-chun, Guo, Xiao-yan, Hu, Peng, Hu, Xi-qi, Jia, Ji-dong, Lai, Rong-tao, Li, Dong-liang, Liu, Ying-xia, Lu, Lun-gen, Ma, Shi-wu, Ma, Xiong, Nan, Yue-min, Ren, Hong, Shen, Tao, Wang, Hao, Wang, Ji-yao, Wang, Tai-ling, Wang, Xiao-jin, Wei, Lai, Xie, Qing, Xie, Wen, Yang, Chang-qing, Yang, Dong-liang, Yu, Yan-yan, Zeng, Min-de, Zhang, Li, Zhao, Xin-yan, Zhuang, Hui, Drug-induced Liver Injury (DILI) Study Group, Chinese Society of Hepatology (CSH), and Chinese Medical Association (CMA)

Published
2017
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13. Creep and Control of the Deep Soft Rock Roadway (DSRR): Insights from Laboratory Testing and Practice in Pingdingshan Mining Area

Author

Qin Dongdong, Zhang Dongsheng, Wang Ji-yao, Chen Xuyang, Chang Zechao, Wang Ya, and Wang Xufeng

Subjects
business.industry, Coal mining, Geology, Geotechnical Engineering and Engineering Geology, Overburden pressure, Stress (mechanics), Permeability (earth sciences), Creep, Cylinder stress, Coal, Geotechnical engineering, business, Roof, Civil and Structural Engineering
Abstract

Coal mines in Pingdingshan mining area, Henan province, China, are commonly mined at a great depth up to 1000 m, and inevitably reside in high temperature, high pressure, high permeability, strong mining disturbance, and strong time effect environment. Support structures of the mines in the area are vulnerable to failure and destruction while roadway stability has been a long-standing issue in the region. Based on the specimens collected from the roof of the return-air rise at Pingdingshan No.1 coal mine, here, we investigated the creep characteristics of sandy mudstone under triaxial conditions and developed a constitutive relationship to predict the creep behavior. Parameter identification and sensitivity analysis were performed to determine the influential factors of creep deformation. We showed that the creep deformation and steady-state creep rate at Pingdingshan coal region grow as axial stress is elevated while descend with increased confining pressure. However, the maximum creep deformation of sandy mudstone increases with a higher confining pressure. Thereby, stress difference, elastic modulus and coefficient of viscosity are the major parameters controlling creep deformation. Hence, it is important to enhance the support strength and mechanical properties of the surrounding rock, to better the roadway stability. In addition, numerical simulation was also conducted for simple excavation geometries to analyze different support structures. On this basis, the “cable bolts steel arch, deep and shallow reinjection, floor pressure relief and local reinforcement” scheme was proposed and field practice showed promising results. The findings in this study can be used to guide the support design for the deep soft rock roadway (DSRR).

Published
2021

17. The use of melittin to enhance transgene expression mediated by recombinant adeno-associated virus serotype 2 vectors both in vitroand in vivo

Author

Xie, Yi-lin, Wang, Ji-yao, He, Yun, Yu, Xiao-min, Zheng, Qing-yun, Ling, Chen, Feng, Xi-lin, and Zhu, Li-qing

Abstract

Melittin, a cell-penetrating peptide, improves the efficiency of many non-viral gene delivery vectors, yet its application in viral vectors has not been well studied. The non-pathogenic recombinant adeno-associated virus (rAAV) vector is an ideal in vivogene delivery vector. However, its full potential will only be achieved after improvement of its transduction efficiency. To improve the transduction efficiency of rAAV2 vectors, we attempted to develop a melittin-based rAAV2 vector delivery strategy.

Published
2023
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18. Adding Pegylated Interferon to Entecavir for Hepatitis B e Antigen–Positive Chronic Hepatitis B: a Multicenter Randomized Trial (ARES Study)

Author

Brouwer, Willem Pieter, Xie, Qing, Sonneveld, Milan J., Zhang, Ningping, Zhang, Qin, Tabak, Fehmi, Streinu-Cercel, Adrian, Wang, Ji-Yao, Idilman, Ramazan, Reesink, Hendrik W., Diculescu, Mircea, Simon, Krzysztof, Voiculescu, Mihai, Akdogan, Meral, Mazur, Wlodzimierz, Reijnders, Jurrien G.P., Verhey, Elke, Hansen, Bettina E., and Janssen, Harry L.A.

Published
2015
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24. Peptic ulcer bleeding in China: A multicenter endoscopic survey of 1006 patients

Author

BAI, Yu, DU, Yi Qi, WANG, Dong, ZOU, Duo Wu, JIN, Zhen Dong, ZHAN, Xian Bao, ZHAO, Xiao Yan, SHA, Wei Hong, WANG, Jiang Bin, YU, Weng Fei, JIANG, Yi, YE, Li Ping, ZHANG, Shu Tian, ZHOU, Li Ya, CHEN, Min Hu, YU, Xiao Feng, ZHENG, Jian Wei, WANG, Rong Quan, HUANG, Xiao Jun, CHEN, Dong Feng, WANG, Hua Hong, TIAN, De An, LU, Nong Hua, HOU, Xiao Hua, JI, Feng, WANG, Ji Yao, YUAN, Yao Zong, FAN, Dai Ming, WU, Kai Chun, JIANG, Bo, and LI, Zhao Shen

Published
2014
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35. Lactulose improves cognition, quality of life, and gut microbiota in minimal hepatic encephalopathy: A multicenter, randomized controlled trial

Author

Wang, Ji Yao, primary, Bajaj, Jasmohan S., additional, Wang, Jiang Bin, additional, Shang, Jia, additional, Zhou, Xin Min, additional, Guo, Xiao Lin, additional, Zhu, Xuan, additional, Meng, Li Na, additional, Jiang, Hai Xing, additional, Mi, Yu Qiang, additional, Xu, Jian Ming, additional, Yang, Jin Hui, additional, Wang, Bai Song, additional, and Zhang, Ning Ping, additional

Published
2019
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38. Phosphocreatine attenuates Gynura segetum-induced hepatocyte apoptosis via a SIRT3-SOD2-mitochondrial reactive oxygen species pathway

Author

Li,Dong-Ping, Chen,Ying-Ling, Jiang,Hong-Yue, Chen,Yun, Zeng,Xiao-Qing, Xu,Li-Li, Ye,Yang, Ke,Chang-Qiang, Lin,Ge, Wang,Ji-Yao, and Gao,Hong

Subjects
Drug Design, Development and Therapy
Abstract

Dong-Ping Li,1,* Ying-Ling Chen,1,* Hong-Yue Jiang,1,* Yun Chen,1 Xiao-Qing Zeng,1 Li-Li Xu,1 Yang Ye,2 Chang-Qiang Ke,2 Ge Lin,3 Ji-Yao Wang,1,4 Hong Gao1,41Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 2State Key Laboratory of Drug Research & Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Pudong, People’s Republic of China; 3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR; 4Evidance-based Medicine Center of Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this work Purpose: To investigate the mitochondria-related mechanism of Gynura segetum (GS)-induced apoptosis and the protective effect of phosphocreatine (PCr), a mitochondrial respiration regulator.Methods: First, the mechanism was explored in human hepatocyte cell line. The mitochondrial oxidative stress was determined by fluorescence assay. The level of sirtuin 3 (SIRT3), acetylated superoxide dismutase 2 (Ac-SOD2), SOD2, and apoptosis were detected by Western blotting. Mito-TEMPO and cell lines of viral vector-mediated overexpression of SIRT3 and SIRT3H248Y, were used to further verify the mechanism of GS-induced apoptosis. GS-induced liver injury mice models were built by GS through intragastric administration and interfered by PCr through intraperitoneal injection. A total of 30 C57BL/6J mice were assigned to 5 groups and treated with either saline, PCr (100 mg/kg), GS (30 g/kg), or PCr (50 or 100 mg/kg)+GS (30 g/kg). Liver hematoxylin and eosin (HE) staining, immunohistochemical analysis, and blood biochemical evaluation were performed.Results: GS induced hepatocyte apoptosis and elevated levels of mitochondrial ROS in L-02 cells. The expression of SIRT3 was decreased. Downregulation of SIRT3 was associated with increased levels of Ac-SOD2, which is the inactivated enzymatic form of SOD2. Conversely, when overexpressing SIRT3 in GS-treated cells, SOD2 activity was restored, and mitochondrial ROS levels and hepatocyte apoptosis declined. Upon administration of PCr to GS-treated cells, they exhibited a significant upregulation of SIRT3 and were protected against apoptosis. In animal experiments, serum ALT level and mitochondrial ROS of the mice treated with GS and 50 mg/kg PCr were significantly attenuated compared with only GS treated. The changes in SIRT3 expression were also consistent with the in vitro results. In addition, immunohistochemical analysis of the mouse liver showed that Ac-SOD2 was decreased in the PCr and GS co-treated group compared with GS treated group.Conclusion: GS caused liver injury by dysregulating mitochondrial ROS generation via a SIRT3-SOD2 pathway. PCr is a potential agent to treat GS-induced liver injury by mitochondrial protection.Keywords: Gynura segetum, apoptosis, mitochondrial, ROS, SIRT3, phosphocreatine

Published
2019

43. Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats

Author

Yao Qun-yan, Xu Bei-li, Wang Ji-yao, Liu Hong-chun, Zhang Shun-cai, and Tu Chuan-tao

Subjects
Curcumin, Hepatic stellate cells, Liver fibrosis, Transforming growth factor-beta, Smads, Connective tissue growth factor, Other systems of medicine, RZ201-999
Abstract

Abstract Background At present there is no effective and accepted therapy for hepatic fibrosis. Transforming growth factor (TGF)-β1 signaling pathway contributes greatly to hepatic fibrosis. Reducing TGF-β synthesis or inhibiting components of its complex signaling pathway represent important therapeutic targets. The aim of the study was to investigate the effect of curcumin on liver fibrosis and whether curcumin attenuates the TGF-β1 signaling pathway. Methods Sprague–Dawley rat was induced liver fibrosis by carbon tetrachloride (CCl4) for six weeks together with or without curcumin, and hepatic histopathology and collagen content were employed to quantify liver necro-inflammation and fibrosis. Moreover, the mRNA and protein expression levels of TGF-β1, Smad2, phosphorylated Smad2, Smad3, Smad7 and connective tissue growth factor (CTGF) were determined by quantitative real time-PCR, Western blot, or immunohistochemistry. Results Rats treated with curcumin improved liver necro-inflammation, and reduced liver fibrosis in association with decreased α-smooth muscle actin expression, and decreased collagen deposition. Furthermore, curcumin significantly attenuated expressions of TGFβ1, Smad2, phosphorylated Smad2, Smad3, and CTGF and induced expression of the Smad7. Conclusions Curcumin significantly attenuated the severity of CCl4-induced liver inflammation and fibrosis through inhibition of TGF-β1/Smad signalling pathway and CTGF expression. These data suggest that curcumin might be an effective antifibrotic drug in the prevention of liver disease progression.

Published
2012
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