Search

Environmental stressors present negative consequences for development. However, their impact on relevant neurocognitive processes, particularly in underrepresented samples, is less clear. The current project aims to examine how adverse experiences influence efficiency of evidence accumulation and neural connectivity in adolescents. The study included 199 adolescents from the Future of Families and Child Wellbeing Study, a population-based longitudinal cohort study with substantial representation of youths from disadvantaged backgrounds. Participants completed an emotional-faces, gender-identification task while undergoing functional MRI. Reaction times (RT) and responses were recorded and fitted with a drift diffusion model. Parameters were estimated using the Dynamic Model of Choice software, which provides a better characterization of the underlying cognitive mechanisms compared with using RTs or cognitive batteries. Analyses investigating the impact of adverse experiences to drift rate and functional connectivity are underway. Results from this study will provide a better understanding of adversity on neurocognitive mechanisms in adolescents.

Adolescence is a period of growth in cognitive performance and functioning. Recently, data-driven measures of brain-age gap, which can index cognitive decline in older populations, have been utilized in adolescent data with mixed findings. Instead of using a data-driven approach, here we assess the maturation status of the brain functional landscape in early adolescence by directly comparing an individual's resting-state functional connectivity (rsFC) to the canonical early-life and adulthood communities. Specifically, we hypothesized that the degree to which a youth's connectome is better captured by adult networks compared to infant/toddler networks is predictive of their cognitive development. To test this hypothesis across individuals and longitudinally, we utilized the Adolescent Brain Cognitive Development (ABCD) Study at baseline (9-10 years; n = 6,489) and 2-year-follow-up (Y2: 11-12 years; n = 5,089). Adjusted for demographic factors, our anchored rsFC score (AFC) was associated with better task performance both across and within participants. AFC was related to age and aging across youth, and change in AFC statistically mediated the age-related change in task performance. In conclusion, we showed that a model-fitting-free index of the brain at rest that is anchored to both adult and baby connectivity landscapes predicts cognitive performance and development in youth.