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Your search keyword '"Wozniak, David M."' showing total 11 results
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11 results on '"Wozniak, David M."'

3. Unique human immune signature of Ebola virus disease in Guinea

Author

Ruibal, Paula, Oestereich, Lisa, Ldtke, Anja, Becker-Ziaja, Beate, Wozniak, David M., Kerber, Romy, Korva, Mia, Cabeza-Cabrerizo, Mar, Bore, Joseph A., Koundouno, Fara Raymond, Duraffour, Sophie, Weller, Romy, Thorenz, Anja, Cimini, Eleonora, Viola, Domenico, Agrati, Chiara, Repits, Johanna, Afrough, Babak, Cowley, Lauren A., Ngabo, Didier, Hinzmann, Julia, Mertens, Marc, Vitoriano, Ins, Logue, Christopher H., Boettcher, Jan Peter, Pallasch, Elisa, Sachse, Andreas, Bah, Amadou, Nitzsche, Katja, Kuisma, Eeva, Michel, Janine, Holm, Tobias, Zekeng, Elsa-Gayle, Garca-Dorival, Isabel, Wlfel, Roman, Stoecker, Kilian, Fleischmann, Erna, Strecker, Thomas, Di Caro, Antonino, Avi-upanc, Tatjana, Kurth, Andreas, Meschi, Silvia, Mly, Stephane, Newman, Edmund, Bocquin, Anne, Kis, Zoltan, Kelterbaum, Anne, Molkenthin, Peter, Carletti, Fabrizio, Portmann, Jasmine, Wolff, Svenja, Castilletti, Concetta, Schudt, Gordian, Fizet, Alexandra, Ottowell, Lisa J., Herker, Eva, Jacobs, Thomas, Kretschmer, Birte, Severi, Ettore, Ouedraogo, Nobila, Lago, Mar, Negredo, Anabel, Franco, Leticia, Anda, Pedro, Schmiedel, Stefan, Kreuels, Benno, Wichmann, Dominic, Addo, Marylyn M., Lohse, Ansgar W., De Clerck, Hilde, Nanclares, Carolina, Jonckheere, Sylvie, Van Herp, Michel, Sprecher, Armand, Xiaojiang, Gao, Carrington, Mary, Miranda, Osvaldo, Castro, Carlos M., Gabriel, Martin, Drury, Patrick, Formenty, Pierre, Diallo, Boubacar, Koivogui, Lamine, Magassouba, NFaly, Carroll, Miles W., Gnther, Stephan, and Muoz-Fontela, Csar

Subjects
Ebola hemorrhagic fever -- Physiological aspects, Medical research, Immune response -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Paula Ruibal [1, 2, 3, 4]; Lisa Oestereich [2, 3, 4]; Anja Ldtke [1, 2, 3, 4]; Beate Becker-Ziaja [2, 3, 4]; David M. Wozniak [2, 3, 4]; Romy [...]

Published
2016
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5. Severe Human Lassa Fever Is Characterized by Nonspecific T-Cell Activation and Lymphocyte Homing to Inflamed Tissues

Author

Port, Julia R., primary, Wozniak, David M., additional, Oestereich, Lisa, additional, Pallasch, Elisa, additional, Becker-Ziaja, Beate, additional, Müller, Jonas, additional, Rottstegge, Monika, additional, Olal, Catherine, additional, Gómez-Medina, Sergio, additional, Oyakhliome, Jennifer, additional, Ighodalo, Yemisi, additional, Omomoh, Emmanuel, additional, Olokor, Thomas, additional, Adomeh, Donatus I., additional, Asogun, Danny, additional, Ogbani-Emovon, Ephraim, additional, Hartmann, Kristin, additional, Krasemann, Susanne, additional, Nelson, Emily V., additional, Escudero-Pérez, Beatriz, additional, McElroy, Anita K., additional, Günther, Stephan, additional, and Muñoz-Fontela, César, additional

Published
2020
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7. Severe human Lassa fever is characterized by non-specific T-cell activation and lymphocyte homing to inflamed tissues.

Author

Port, Julia R., Wozniak, David M., Oestereich, Lisa, Pallasch, Elisa, Becker-Ziaja, Beate, Müller, Jonas, Rottstegge, Monika, Olal, Catherine, Gómez-Medina, Sergio, Oyakhliome, Jennifer, Ighodalo, Yemisi, Omomoh, Emmanuel, Olokor, Thomas, Adomeh, Donatus I., Asogun, Danny, Ogbani-Emovon, Ephraim, Hartmann, Kristin, Krasemann, Susanne, Nelson, Emily V., and Escudero-Pérez, Beatriz

Subjects
*LASSA fever, *LYMPHOCYTE transformation, *HEMORRHAGIC fever, *PATHOLOGY, *CLINICAL immunology, *T cells
Abstract

Lassa fever (LF) is a zoonotic viral hemorrhagic fever caused by Lassa virus (LASV), which is endemic to West African countries. Previous studies have suggested an important role for T cell-mediated immunopathology in LF pathogenesis, but the mechanisms by which T cells influence disease severity and outcome are not well understood. Here we present a multiparametric analysis of clinical immunology data collected during the 2017-2018 Lassa fever outbreak in Nigeria. During the acute phase of LF we observed robust activation of the polyclonal T-cell repertoire, which included LASV-specific as well as antigenically-unrelated T cells. However, severe and fatal LF were characterized by poor LASV-specific effector T-cell responses. Severe LF was also characterized by the presence of circulating T cells with homing capacity to inflamed tissues, including the gut mucosa. These findings in LF patients were recapitulated in a mouse model of LASV infection, in which mucosal exposure resulted in remarkably high lethality compared to skin exposure. Taken together, our findings indicate that poor LASV-specific T-cell responses and activation of non-specific T cells with homing capacity to inflamed tissues are associated with severe LF. [ABSTRACT FROM AUTHOR]

Published
2020
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8. Different features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections

Author

Cimini, Eleonora, primary, Viola, Domenico, additional, Cabeza-Cabrerizo, Mar, additional, Romanelli, Antonella, additional, Tumino, Nicola, additional, Sacchi, Alessandra, additional, Bordoni, Veronica, additional, Casetti, Rita, additional, Turchi, Federica, additional, Martini, Federico, additional, Bore, Joseph A., additional, Koundouno, Fara Raymond, additional, Duraffour, Sophie, additional, Michel, Janine, additional, Holm, Tobias, additional, Zekeng, Elsa Gayle, additional, Cowley, Lauren, additional, Garcia Dorival, Isabel, additional, Doerrbecker, Juliane, additional, Hetzelt, Nicole, additional, Baum, Jonathan H. J., additional, Portmann, Jasmine, additional, Wölfel, Roman, additional, Gabriel, Martin, additional, Miranda, Osvaldo, additional, Díaz, Graciliano, additional, Díaz, José E., additional, Fleites, Yoel A., additional, Piñeiro, Carlos A., additional, Castro, Carlos M., additional, Koivogui, Lamine, additional, Magassouba, N’Faly, additional, Diallo, Boubacar, additional, Ruibal, Paula, additional, Oestereich, Lisa, additional, Wozniak, David M., additional, Lüdtke, Anja, additional, Becker-Ziaja, Beate, additional, Capobianchi, Maria R., additional, Ippolito, Giuseppe, additional, Carroll, Miles W., additional, Günther, Stephan, additional, Di Caro, Antonino, additional, Muñoz-Fontela, César, additional, and Agrati, Chiara, additional

Published
2017
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9. Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination

Author

Lüdtke, Anja, primary, Ruibal, Paula, additional, Wozniak, David M., additional, Pallasch, Elisa, additional, Wurr, Stephanie, additional, Bockholt, Sabrina, additional, Gómez-Medina, Sergio, additional, Qiu, Xiangguo, additional, Kobinger, Gary P., additional, Rodríguez, Estefanía, additional, Günther, Stephan, additional, Krasemann, Susanne, additional, Idoyaga, Juliana, additional, Oestereich, Lisa, additional, and Muñoz-Fontela, César, additional

Published
2017
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10. Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16 + Monocytes

Author

Lüdtke, Anja, primary, Ruibal, Paula, additional, Becker-Ziaja, Beate, additional, Rottstegge, Monika, additional, Wozniak, David M., additional, Cabeza-Cabrerizo, Mar, additional, Thorenz, Anja, additional, Weller, Romy, additional, Kerber, Romy, additional, Idoyaga, Juliana, additional, Magassouba, N'Faly, additional, Gabriel, Martin, additional, Günther, Stephan, additional, Oestereich, Lisa, additional, and Muñoz-Fontela, César, additional

Published
2016
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11. Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes.

Author

Lüdtke, Anja, Ruibal, Paula, Becker-Ziaja, Beate, Rottstegge, Monika, Wozniak, David M., Cabeza-Cabrerizo, Mar, Thorenz, Anja, Weller, Romy, Kerber, Romy, Idoyaga, Juliana, Magassouba, N'Faly, Gabriel, Martin, Günther, Stephan, Oestereich, Lisa, and Muñoz-Fontela, César

Subjects
EBOLA virus disease, CD antigens, VIRUS inactivation, MONOCYTES, DENDRITIC cells, NEUTROPHILS, DIAGNOSIS
Abstract

A number of previous studies have identified antigen-presenting cells (APCs) as key targets of Ebola virus (EBOV), but the role of APCs in human Ebola virus disease (EVD) is not known. We have evaluated the phenotype and kinetics of monocytes, neutrophils, and dendritic cells (DCs) in peripheral blood of patients for whom EVD was diagnosed by the European Mobile Laboratory in Guinea. Acute EVD was characterized by reduced levels of circulating nonclassical CD16+ monocytes with a poor activation profile. In survivors, CD16+ monocytes were activated during recovery, coincident with viral clearance, suggesting an important role of this cell subset in EVD pathophysiology. [ABSTRACT FROM AUTHOR]

Published
2016
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