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Your search keyword '"Xiang, Dairong"' showing total 21 results
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21 results on '"Xiang, Dairong"'

6. Immunomodulatory and Antiviral Therapy Improved Functional Cure Rate in CHB Patients with High HBsAg Level Experienced NA

Author

Jia, Hongyu, primary, Yu, Guodong, additional, Yu, Jiong, additional, Zhang, Xiaoli, additional, Yang, Lisha, additional, Wang, Bin, additional, Zhang, Jiming, additional, Bai, Lang, additional, Zhang, Xinxin, additional, Wang, Kai, additional, Zhao, Ping, additional, Yang, Dongliang, additional, Zhao, Yingren, additional, Yu, Yanyan, additional, Zhang, Yimin, additional, Gu, Jueqing, additional, Ye, Chanyuan, additional, Cai, Huan, additional, Lu, Yingfeng, additional, Xiang, Dairong, additional, Yu, Liang, additional, Lian, Jiangshan, additional, Hu, Jianhua, additional, Zhang, Shanyan, additional, Jin, Ciliang, additional, and Yang, Yida, additional

Published
2023
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11. COVID-19 is more severe in patients with hypertension; ACEI/ARB treatment does not influence clinical severity and outcome

Author

Hu, Jianhua, primary, Zhang, Xiaoli, additional, Zhang, Xuan, additional, Zhao, Hong, additional, Lian, Jiangshan, additional, Hao, Shaorui, additional, Jia, Hongyu, additional, Yang, Meifang, additional, Lu, Yingfeng, additional, Xiang, Dairong, additional, Cai, Huan, additional, Zhang, Shanyan, additional, Gu, Jueqing, additional, Ye, Chanyuan, additional, Yu, Guodong, additional, Jin, Ciliang, additional, Zheng, Lin, additional, Yang, Yida, additional, and Sheng, Jifang, additional

Published
2020
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13. Decreased B Cells on Admission Associated With Prolonged Viral RNA Shedding From the Respiratory Tract in Coronavirus Disease 2019: A Case-Control Study

Author

Hao, Shaorui, primary, Lian, Jiangshan, primary, Lu, Yingfeng, primary, Jia, Hongyu, primary, Hu, Jianhua, primary, Yu, Guodong, primary, Wang, Xiaoyan, primary, Xu, Kaijin, primary, Ni, Qin, primary, Li, Yongtao, primary, Liu, Jun, primary, Zhao, Hong, primary, Zhang, Xuan, primary, Yu, Liang, primary, Yu, Xiaopeng, primary, Xiang, Dairong, primary, Chen, Yu, primary, Zheng, Shufa, primary, Qiu, Yunqing, primary, Li, Lanjuan, primary, Liang, Tingbo, primary, Yang, Yida, primary, and Sheng, Jifang, primary

Published
2020
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14. Epidemiological, clinical, and virological characteristics of 465 hospitalized cases of coronavirus disease 2019 (COVID‐19) from Zhejiang province in China

Author

Lian, Jiangshan, primary, Jin, Xi, additional, Hao, Shaorui, additional, Jia, Hongyu, additional, Cai, Huan, additional, Zhang, Xiaoli, additional, Hu, Jianhua, additional, Zheng, Lin, additional, Wang, Xiaoyan, additional, Zhang, Shanyan, additional, Ye, Chanyuan, additional, Jin, Ciliang, additional, Yu, Guodong, additional, Gu, Jueqing, additional, Lu, Yingfeng, additional, Yu, Xiaopeng, additional, Xiang, Dairong, additional, Li, Lanjuan, additional, Liang, Tingbo, additional, Sheng, Jifang, additional, and Yang, Yida, additional

Published
2020
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15. Virus strain of a mild COVID-19 patient in Hangzhou represents a new trend in SARS-CoV-2 evolution related to Furin cleavage site

Author

Jin, Xi, primary, Xu, Kangli, additional, Jiang, Penglei, additional, Lian, Jiangshan, additional, Hao, Shaorui, additional, Yao, Hangping, additional, Jia, Hongyu, additional, Zhang, Yimin, additional, Zheng, Lin, additional, zheng, Nuoheng, additional, Chen, Dong, additional, Yao, Jinmei, additional, Hu, Jianhua, additional, Gao, Jianguo, additional, Wen, Liang, additional, Shen, Jian, additional, Ren, Yue, additional, Yu, Guodong, additional, Wang, Xiaoyan, additional, Lu, Yingfeng, additional, Yu, Xiaopeng, additional, Yu, Liang, additional, Xiang, Dairong, additional, Wu, Nanping, additional, Lu, Xiangyun, additional, Cheng, Linfang, additional, Liu, Fumin, additional, Wu, Haibo, additional, Jin, Changzhong, additional, Yang, Xiaofeng, additional, Qian, Pengxu, additional, Qiu, Yunqing, additional, Sheng, Jifang, additional, Liang, Tingbo, additional, Li, Lanjuan, additional, and Yang, Yida, additional

Published
2020
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16. Virus strain from a mild COVID-19 patient in Hangzhou represents a new trend in SARS-CoV-2 evolution potentially related to Furin cleavage site

Author

Jin, Xi, primary, Xu, Kangli, additional, Jiang, Penglei, additional, Lian, Jiangshan, additional, Hao, Shaorui, additional, Yao, Hangping, additional, Jia, Hongyu, additional, Zhang, Yimin, additional, Zheng, Lin, additional, Zheng, Nuoheng, additional, Chen, Dong, additional, Yao, Jinmei, additional, Hu, Jianhua, additional, Gao, Jianguo, additional, Wen, Liang, additional, Shen, Jian, additional, Ren, Yue, additional, Yu, Guodong, additional, Wang, Xiaoyan, additional, Lu, Yingfeng, additional, Yu, Xiaopeng, additional, Yu, Liang, additional, Xiang, Dairong, additional, Wu, Nanping, additional, Lu, Xiangyun, additional, Cheng, Linfang, additional, Liu, Fumin, additional, Wu, Haibo, additional, Jin, Changzhong, additional, Yang, Xiaofeng, additional, Qian, Pengxu, additional, Qiu, Yunqing, additional, Sheng, Jifang, additional, Liang, Tingbo, additional, Li, Lanjuan, additional, and Yang, Yida, additional

Published
2020
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17. Decreased B Cells on Admission was Associated with Prolonged Virus Shedding from Respiratory Tract in Coronavirus Disease 2019: A Case Control Study

Author

Hao, Shaorui, primary, Lian, Jiangshan, additional, Jin, Xi, additional, Lu, Yingfeng, additional, Jia, Hongyu, additional, Zheng, Lin, additional, Hu, Jianhua, additional, Yu, Guodong, additional, Wang, Xiaoyan, additional, Xu, Kaijin, additional, Ni, Qin, additional, Li, Yongtao, additional, Liu, Jun, additional, Zhao, Hong, additional, Zhang, Xuan, additional, Yu, Liang, additional, Yu, Xiaopeng, additional, Xiang, Dairong, additional, Li, Lanjuan, additional, Liang, Tingbo, additional, Yang, Yida, additional, and Sheng, Jifang, additional

Published
2020
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18. Immunostimulatory activities of dendritic cells loaded with adenovirus vector carrying HBcAg/HBsAg

Author

Jia, Hongyu, Li, Chunling, Zhang, Yimin, Yu, Liang, Xiang, Dairong, Liu, Jun, Chen, Fengzhe, and Han, Xiaochun

Subjects
virus diseases, hemic and immune systems, chemical and pharmacologic phenomena, Original Article, digestive system diseases
Abstract

Objective: This study is to investigate the immunostimulatory activities of dendritic cells (DCs) transfected with HBcAg and/or HBsAg recombinant adenovirus (rAd). Methods: DCs were transfected with rAd (DC/Ad-C+Ad-S, DC/Ad-C, and DC/Ad-S), or pulsed with HBcAg antigen (DC/HBcAg). Flow cytometry was used to detect the phenotype of DCs and the cytokine production of T lymphocytes. Mice were vaccinated with DCs transfected with rAd or pulsed with antigen, and DNA vaccine. Mixed lymphocyte reaction (MLR) was used to evaluate the T-cell stimulatory capacity, and HBcAg-specific cytotoxic T lymphocyte (CTL) activity was assessed. Results: Phenotypic analysis showed that DCs transfected with rAd or pulsed with HBcAg antigen exhibited mature phenotypes. MLR indicated no significant differences in stimulating T-cell proliferation between the DC/rAd and DC/HBcAg groups. When mixed with DCs, Th and Tc cells mainly secreted IFN-γ, indicating type I immune responses. In vaccinated mice, DCs transduced with rAd and pulsed with HBcAg induced significantly more IFN-γ secretion from Th cells, compared with DNA vaccine, indicating stronger Th1 response. Moreover, DCs transduced with rAd stimulated Tc cells to produce more IFN-γ, indicating stronger Tc1 response. In vaccinated mice, HBcAg-specific CTL activities were decreased in the following order: the DC/Ad-C+Ad-S, DC/Ad-C, DC/Ad-S, DC/HBcAg, and DNA vaccine groups. Conclusion: DCs transfected with rAd induce stronger Th1/Tc1 (type I) cell immune responses and specific CTL response than HBcAg-pulsed DCs or DNA vaccine. Our findings suggest that DCs transfected with rAd-C/rAd-S might provide an effective approach in the treatment of persistent hepatitis B virus infection.

Published
2015

21. Immunostimulatory activities of dendritic cells loaded with adenovirus vector carrying HBcAg/HBsAg.

Author

Jia H, Li C, Zhang Y, Yu L, Xiang D, Liu J, Chen F, and Han X

Abstract

Objective: This study is to investigate the immunostimulatory activities of dendritic cells (DCs) transfected with HBcAg and/or HBsAg recombinant adenovirus (rAd)., Methods: DCs were transfected with rAd (DC/Ad-C+Ad-S, DC/Ad-C, and DC/Ad-S), or pulsed with HBcAg antigen (DC/HBcAg). Flow cytometry was used to detect the phenotype of DCs and the cytokine production of T lymphocytes. Mice were vaccinated with DCs transfected with rAd or pulsed with antigen, and DNA vaccine. Mixed lymphocyte reaction (MLR) was used to evaluate the T-cell stimulatory capacity, and HBcAg-specific cytotoxic T lymphocyte (CTL) activity was assessed., Results: Phenotypic analysis showed that DCs transfected with rAd or pulsed with HBcAg antigen exhibited mature phenotypes. MLR indicated no significant differences in stimulating T-cell proliferation between the DC/rAd and DC/HBcAg groups. When mixed with DCs, Th and Tc cells mainly secreted IFN-γ, indicating type I immune responses. In vaccinated mice, DCs transduced with rAd and pulsed with HBcAg induced significantly more IFN-γ secretion from Th cells, compared with DNA vaccine, indicating stronger Th1 response. Moreover, DCs transduced with rAd stimulated Tc cells to produce more IFN-γ, indicating stronger Tc1 response. In vaccinated mice, HBcAg-specific CTL activities were decreased in the following order: the DC/Ad-C+Ad-S, DC/Ad-C, DC/Ad-S, DC/HBcAg, and DNA vaccine groups., Conclusion: DCs transfected with rAd induce stronger Th1/Tc1 (type I) cell immune responses and specific CTL response than HBcAg-pulsed DCs or DNA vaccine. Our findings suggest that DCs transfected with rAd-C/rAd-S might provide an effective approach in the treatment of persistent hepatitis B virus infection.

Published
2015

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