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31 results on '"Xiaoli, Lingzi"'

2. Toxigenic Corynebacterium diphtheriae Infection in Cat, Texas, USA

Author

Tyler, Ronald, Jr., Rincon, Layda, Weigand, Michael R., Xiaoli, Lingzi, Acosta, Anna M., Kurien, Daniel, Ju, Hong, Lingsweiler, Sonia, and Prot, Emilie Yvonne

Subjects
Diphtheria -- Diagnosis -- Causes of, Corynebacteria -- Identification and classification -- Genetic aspects, Cats -- Diseases, Health
Abstract

Diphtheria, caused by toxigenic strains of the bacterium Corynebacterium diphtheriae, can result in life-threatening respiratory disease or cutaneous infections. Toxigenicity is contingent on successful bacterial expression of diphtheria toxin, encoded [...]

Published
2022
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5. Genomic characterization of cocirculating Corynebacterium diphtheriae and non-diphtheritic Corynebacterium species among forcibly displaced Myanmar nationals, 2017–2019

Author

Xiaoli, Lingzi, primary, Peng, Yanhui, additional, Williams, Margaret M., additional, Lawrence, Marlon, additional, Cassiday, Pamela K., additional, Aneke, Janessa S., additional, Pawloski, Lucia C., additional, Shil, Sadhona Rani, additional, Rashid, Mamun Or, additional, Bhowmik, Proshanta, additional, Weil, Lauren M., additional, Acosta, Anna M., additional, Shirin, Tahmina, additional, Habib, Zakir Hossain, additional, Tondella, M. Lucia, additional, and Weigand, Michael R., additional

Published
2023
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8. Benchmark datasets for SARS-CoV-2 surveillance bioinformatics

Author

Xiaoli, Lingzi, primary, Hagey, Jill V., additional, Park, Daniel J., additional, Gulvik, Christopher A., additional, Young, Erin L., additional, Alikhan, Nabil-Fareed, additional, Lawsin, Adrian, additional, Hassell, Norman, additional, Knipe, Kristen, additional, Oakeson, Kelly F., additional, Retchless, Adam C., additional, Shakya, Migun, additional, Lo, Chien-Chi, additional, Chain, Patrick, additional, Page, Andrew J., additional, Metcalf, Benjamin J., additional, Su, Michelle, additional, Rowell, Jessica, additional, Vidyaprakash, Eshaw, additional, Paden, Clinton R., additional, Huang, Andrew D., additional, Roellig, Dawn, additional, Patel, Ketan, additional, Winglee, Kathryn, additional, Weigand, Michael R., additional, and Katz, Lee S., additional

Published
2022
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10. Genomic epidemiology of nontoxigenic Corynebacterium diphtheriae from King County, Washington State, USA between July 2018 and May 2019

Author

Xiaoli, Lingzi, primary, Benoliel, Eileen, additional, Peng, Yanhui, additional, Aneke, Janessa, additional, Cassiday, Pamela K., additional, Kay, Meagan, additional, McKeirnan, Shelly, additional, Duchin, Jeffery S., additional, Kawakami, Vance, additional, Lindquist, Scott, additional, Acosta, Anna M., additional, DeBolt, Chas, additional, Tondella, Maria Lucia, additional, and Weigand, Michael R., additional

Published
2020
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11. Detection and Characterization of Diphtheria Toxin Gene-Bearing Corynebacterium Species through a New Real-Time PCR Assay

Author

Williams, Margaret M., primary, Waller, Jessica L., additional, Aneke, Janessa S., additional, Weigand, Michael R., additional, Diaz, Maureen H., additional, Bowden, Katherine E., additional, Simon, Ashley K., additional, Peng, Yanhui, additional, Xiaoli, Lingzi, additional, Cassiday, Pamela K., additional, Winchell, Jonas, additional, and Tondella, M. Lucia, additional

Published
2020
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21. Whole‐genome sequencing reveals resistome of highly drug‐resistant retail meat and human Salmonella Dublin.

Author

Eyler, Andrea B., M'ikanatha, Nkuchia M., Xiaoli, Lingzi, and Dudley, Edward G.

Subjects
SALMONELLA, SINGLE nucleotide polymorphisms, FOODBORNE diseases, NOROVIRUS diseases, SYMPTOMS, MEAT, GASTROENTERITIS
Abstract

Non‐typhoidal Salmonella (NTS) are a significant source of foodborne illness worldwide, with disease symptoms most often presenting as self‐limiting gastroenteritis; however, occasionally the infection spreads and becomes invasive, frequently requiring anti‐microbial treatment. The cattle‐adapted Dublin serovar of NTS has commonly been associated with invasive illness and anti‐microbial resistance (AMR). Here, the enhanced resolution conferred by whole‐genome sequencing was utilized to elucidate and compare the resistome and genetic relatedness of 14 multidrug‐resistant (MDR) and one pan‐susceptible S. Dublin, isolated primarily in Pennsylvania, from fresh retail meat (one isolate) and humans (14 isolates). Twelve different genetic AMR determinants, including both acquired and chromosomal, were identified. Furthermore, comparative plasmid analysis indicated that AMR was primarily conferred by a putative IncA/C2 plasmid. A single pan‐susceptible S. Dublin isolate, collected from the same timeframe and geographical region as the MDR isolates, did not carry an IncA/C2 replicon sequence within its genome. Moreover, the pan‐susceptible isolate was genetically distinct from its MDR counterparts, as it was separated by ≥267 single nucleotide polymorphisms (SNPs), whereas there was a ≤38 SNP distance between the MDR isolates. Collectively, this data set advances our understanding of the genetic basis of the highly drug‐resistant nature of S. Dublin, a serovar with significant public health implications. [ABSTRACT FROM AUTHOR]

Published
2020
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22. Detection of CTX-M-1 extended-spectrum beta-lactamase among ceftiofur-resistant Salmonella enterica clinical isolates of poultry.

Author

Denagamage, Thomas N., Wallner-Pendleton, Eva, Jayarao, Bhushan M., Xiaoli, Lingzi, Dudley, Edward G., Wolfgang, David, and Kariyawasam, Subhashinie

Subjects
BETA lactamases, SALMONELLA enterica, ENTEROBACTERIACEAE, POULTRY, FOOD animals, U.S. states, PLASMIDS, FOOD chains
Abstract

Salmonella enterica resistance to extended-spectrum cephalosporins (ESC) conferred by cefotaximases (bla CTX-M) is a growing concern in the United States. Among food-producing animals, poultry are a major reservoir of ESC-resistant Salmonella. A retrospective study was carried out to further characterize 38 ceftiofur-resistant clinical Salmonella enterica isolates obtained from poultry during 2007–2018. Of the isolates tested, 31 displayed resistance to ceftriaxone and harbored bla CMY-2, whereas 7 isolates demonstrated resistance or reduced susceptibility to cefepime in addition to ceftriaxone resistance. These 7 isolates displayed extended-spectrum β-lactamase activity, harbored bla CTX-M-1, and were recovered only from recent poultry diagnostic submissions made in 2011–2018 as opposed to the 31 isolates that were recovered in 2007–2018. Further characterization of the bla CTX-M-1 gene determined that it was located on conjugative IncN/ST1 and IncI1/ST87 plasmids in the isolates from commercial turkeys and broilers, respectively. These plasmids have been responsible for extensive spread of bla CTX-M-1 in livestock, poultry, and humans in Europe. Potential transfer of IncN and IncI1 plasmids and/or nontyphoidal Salmonella carrying these plasmids through the food chain, or by other means to humans, may result in treatment failures. Our study demonstrates the importance of further characterization of ceftiofur-resistant S. enterica isolates detected by veterinary diagnostic laboratories to identify the sources of bla CTX-M-1 and to mitigate the spread of ESC-resistant Salmonella in the poultry production pyramid. [ABSTRACT FROM AUTHOR]

Published
2019
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27. Detection of CTX-M-1 extended-spectrum beta-lactamase among ceftiofur-resistant Salmonella entericaclinical isolates of poultry

Author

Denagamage, Thomas N., Wallner-Pendleton, Eva, Jayarao, Bhushan M., Xiaoli, Lingzi, Dudley, Edward G., Wolfgang, David, and Kariyawasam, Subhashinie

Abstract

Salmonella entericaresistance to extended-spectrum cephalosporins (ESC) conferred by cefotaximases (blaCTX-M) is a growing concern in the United States. Among food-producing animals, poultry are a major reservoir of ESC-resistant Salmonella. A retrospective study was carried out to further characterize 38 ceftiofur-resistant clinical Salmonella entericaisolates obtained from poultry during 2007–2018. Of the isolates tested, 31 displayed resistance to ceftriaxone and harbored blaCMY-2, whereas 7 isolates demonstrated resistance or reduced susceptibility to cefepime in addition to ceftriaxone resistance. These 7 isolates displayed extended-spectrum β-lactamase activity, harbored blaCTX-M-1, and were recovered only from recent poultry diagnostic submissions made in 2011–2018 as opposed to the 31 isolates that were recovered in 2007–2018. Further characterization of the blaCTX-M-1gene determined that it was located on conjugative IncN/ST1 and IncI1/ST87 plasmids in the isolates from commercial turkeys and broilers, respectively. These plasmids have been responsible for extensive spread of blaCTX-M-1in livestock, poultry, and humans in Europe. Potential transfer of IncN and IncI1 plasmids and/or nontyphoidal Salmonellacarrying these plasmids through the food chain, or by other means to humans, may result in treatment failures. Our study demonstrates the importance of further characterization of ceftiofur-resistant S. entericaisolates detected by veterinary diagnostic laboratories to identify the sources of blaCTX-M-1and to mitigate the spread of ESC-resistant Salmonellain the poultry production pyramid.

Published
2019
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30. Coculture of Escherichia coliO157:H7 with a Nonpathogenic E. coliStrain Increases Toxin Production and Virulence in a Germfree Mouse Model

Author

Goswami, Kakolie, Chen, Chun, Xiaoli, Lingzi, Eaton, Kathryn A., and Dudley, Edward G.

Abstract

ABSTRACTEscherichia coliO157:H7 is a notorious foodborne pathogen due to its low infectious dose and the disease symptoms it causes, which include bloody diarrhea and severe abdominal cramps. In some cases, the disease progresses to hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS), due to the expression of one or more Shiga toxins (Stx). Isoforms of Stx, including Stx2a, are encoded within temperate prophages. In the presence of certain antibiotics, phage induction occurs, which also increases the expression of toxin genes. Additionally, increased Stx2 accumulation has been reported when O157:H7 was cocultured with phage-susceptible nonpathogenic E. coli. This study characterized an E. coliO157:H7 strain, designated PA2, that belongs to the hypervirulent clade 8 cluster. Stx2a levels after ciprofloxacin induction were lower for PA2 than for the prototypical outbreak strains Sakai and EDL933. However, during coculture with the nonpathogenic strain E. coliC600, PA2 produced Stx2a levels that were 2- to 12-fold higher than those observed during coculture with EDL933 and Sakai, respectively. Germfree mice cocolonized by PA2 and C600 showed greater kidney damage, increased Stx2a accumulation in feces, and more visible signs of disease than mice given PA2 or C600 alone. These data suggest one mechanism by which microorganisms associated with the colonic microbiota could enhance the virulence of E. coliO157:H7, particularly a subset of clade 8 strains.

Published
2015
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31. Detection and Characterization of Diphtheria Toxin Gene-Bearing CorynebacteriumSpecies through a New Real-Time PCR Assay

Author

Williams, Margaret M., Waller, Jessica L., Aneke, Janessa S., Weigand, Michael R., Diaz, Maureen H., Bowden, Katherine E., Simon, Ashley K., Peng, Yanhui, Xiaoli, Lingzi, Cassiday, Pamela K., Winchell, Jonas, and Tondella, M. Lucia

Abstract

Respiratory diphtheria, characterized by a firmly adherent pseudomembrane, is caused by toxin-producing strains of Corynebacterium diphtheriae, with similar illness produced occasionally by toxigenic Corynebacterium ulceransor, rarely, Corynebacterium pseudotuberculosis. While diphtheria laboratory confirmation requires culture methods to determine toxigenicity, real-time PCR (RT-PCR) provides a faster method to detect the toxin gene (tox).

Published
2020
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